Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL17A
  • Mouse genes Il17a
  • Rat genes Il17a
  • Zfish genes il17a/f3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il17a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	IL17A	IDA		Human	PMID:12297109
Molecular Function	GO:0005125	cytokine activity	Il17a	IDA		Mouse	PMID:27830702
Molecular Function	GO:0005515	protein binding	IL17A	IPI	UniProtKB:Q96F46	Human	PMID:23695682
Molecular Function	GO:0005515	protein binding	IL17A	IPI	UniProtKB:Q9BQC3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	IL17A	IPI	UniProtKB:Q8NAC3	Human	PMID:28827714
Molecular Function	GO:0005515	protein binding	IL17A	IPI	UniProtKB:Q96F46	Human	PMID:28827714
Molecular Function	GO:0005515	protein binding	IL17A	IPI	UniProtKB:Q96PD4	Human	PMID:28827714
Molecular Function	GO:0005515	protein binding	IL17A	IPI	UniProtKB:Q6PIL6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Il17a	IPI	UniProtKB:Q7TNI7	Mouse	MGI:MGI:4412246|PMID:18025225
Molecular Function	GO:0046982	protein heterodimerization activity	Il17a	IDA		Mouse	MGI:MGI:4412246|PMID:18025225
Molecular Function	GO:0042803	protein homodimerization activity	Il17a	IDA		Mouse	MGI:MGI:4412246|PMID:18025225
Cellular Component	GO:0005737	cytoplasm	Il17a	IDA		Rat	PMID:24117055|RGD:9074484
Cellular Component	GO:0009897	external side of plasma membrane	Il17a	IDA		Mouse	PMID:20706986
Cellular Component	GO:0009897	external side of plasma membrane	Il17a	IDA		Mouse	PMID:18792410
Cellular Component	GO:0009897	external side of plasma membrane	Il17a	IDA		Mouse	PMID:23034280
Cellular Component	GO:0009897	external side of plasma membrane	Il17a	IDA		Mouse	PMID:19838199
Cellular Component	GO:0005615	extracellular space	IL17A	IDA		Human	PMID:12297109
Cellular Component	GO:0005615	extracellular space	Il17a	IDA		Mouse	MGI:MGI:4412246|PMID:18025225
Cellular Component	GO:0005615	extracellular space	Il17a	IDA		Mouse	PMID:27830702
Cellular Component	GO:0005615	extracellular space	Il17a	IDA		Mouse	PMID:17982105
Cellular Component	GO:0005615	extracellular space	Il17a	IDA		Mouse	PMID:16239543
Cellular Component	GO:0005615	extracellular space	Il17a	IDA		Mouse	PMID:18997793
Cellular Component	GO:0005615	extracellular space	Il17a	IDA		Mouse	PMID:25470037
Cellular Component	GO:0005615	extracellular space	Il17a	IDA		Rat	PMID:21043049|RGD:4781440
Biological Process	GO:0071385	cellular response to glucocorticoid stimulus	Il17a	IMP		Rat	PMID:20003332|RGD:4888522
Biological Process	GO:0071347	cellular response to interleukin-1	Il17a	IDA		Mouse	PMID:19666510
Biological Process	GO:0071222	cellular response to lipopolysaccharide	il17a/f3	IDA		Zfish	PMID:16677828
Biological Process	GO:0050832	defense response to fungus	Il17a	IMP		Mouse	MGI:MGI:4462077|PMID:20554964
Biological Process	GO:0050829	defense response to Gram-negative bacterium	Il17a	IMP		Mouse	MGI:MGI:3828868|PMID:19144317
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Il17a	IDA		Mouse	MGI:MGI:4459373|PMID:20364087
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Il17a	IMP		Mouse	MGI:MGI:3828868|PMID:19144317
Biological Process	GO:0072537	fibroblast activation	IL17A	IDA		Human	PMID:21145111
Biological Process	GO:0010467	gene expression	Il17a	IDA		Mouse	PMID:31164412
Biological Process	GO:0097530	granulocyte migration	Il17a	IGI	UniProtKB:P97797	Mouse	MGI:MGI:6189453|PMID:24026300
Biological Process	GO:0097400	interleukin-17-mediated signaling pathway	IL17A	IDA		Human	PMID:21350122
Biological Process	GO:0038173	interleukin-17A-mediated signaling pathway	IL17A	IDA		Human	PMID:12297109
Biological Process	GO:0060729	intestinal epithelial structure maintenance	Il17a	IMP		Mouse	MGI:MGI:5788042|PMID:26431948
Biological Process	GO:0030216	keratinocyte differentiation	Il17a	IDA		Mouse	PMID:31164412
Biological Process	GO:0043616	keratinocyte proliferation	Il17a	IMP		Mouse	PMID:31164412
Biological Process	GO:0106015	negative regulation of inflammatory response to wounding	Il17a	IDA		Mouse	PMID:27830702
Biological Process	GO:0007219	Notch signaling pathway	Il17a	IDA		Mouse	PMID:28561022
Biological Process	GO:0002225	positive regulation of antimicrobial peptide production	Il17a	IDA		Mouse	MGI:MGI:3828868|PMID:19144317
Biological Process	GO:1903348	positive regulation of bicellular tight junction assembly	Il17a	IMP		Mouse	MGI:MGI:5788042|PMID:26431948
Biological Process	GO:2000340	positive regulation of chemokine (C-X-C motif) ligand 1 production	IL17A	IDA		Human	PMID:21350122
Biological Process	GO:2000340	positive regulation of chemokine (C-X-C motif) ligand 1 production	Il17a	IDA		Mouse	MGI:MGI:4412246|PMID:18025225
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	IL17A	IDA		Human	PMID:29734196
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	Il17a	IDA		Mouse	PMID:17982105
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	Il17a	IGI	MGI:MGI:107399	Mouse	PMID:16785495
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	Il17a	IGI	MGI:MGI:2159336	Mouse	PMID:16785495
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IL17A	IDA		Human	PMID:29734196
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IL17A	IDA		Human	PMID:29734196
Biological Process	GO:0032739	positive regulation of interleukin-16 production	IL17A	IDA		Human	PMID:29734196
Biological Process	GO:0032747	positive regulation of interleukin-23 production	IL17A	IDA		Human	PMID:21145111
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IL17A	IDA		Human	PMID:21350122
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Il17a	IMP		Mouse	MGI:MGI:4462077|PMID:20554964
Biological Process	GO:0010940	positive regulation of necrotic cell death	Il17a	IDA		Rat	PMID:22990529|RGD:9068935
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	IL17A	IDA		Human	PMID:17888176
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IL17A	IDA		Human	PMID:16982811
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Il17a	IGI	MGI:MGI:1355307	Mouse	PMID:16982811
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Il17a	IDA		Rat	PMID:22990529|RGD:9068935
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IL17A	IDA		Human	PMID:29734196
Biological Process	GO:0043200	response to amino acid	Il17a	IEP		Rat	PMID:22673595|RGD:9109565

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern