Source |
Alliance of Genome Resources |
Category | ID | Classification term | Gene | Evidence | Inferred from | Organism | Reference |
---|---|---|---|---|---|---|---|
Molecular Function | GO:0005125 | cytokine activity | IL18 | IDA | Human | PMID:14528293 | |
Molecular Function | GO:0005125 | cytokine activity | IL18 | IDA | Human | PMID:25500532 | |
Molecular Function | GO:0005125 | cytokine activity | Il18 | IMP | Mouse | MGI:MGI:3608083|PMID:12829194 | |
Molecular Function | GO:0005125 | cytokine activity | Il18 | IDA | Mouse | PMID:11894098 | |
Molecular Function | GO:0045515 | interleukin-18 receptor binding | IL18 | IDA | Human | PMID:14528293 | |
Molecular Function | GO:0045515 | interleukin-18 receptor binding | IL18 | IDA | Human | PMID:25500532 | |
Molecular Function | GO:0005515 | protein binding | IL18 | IPI | UniProtKB:Q9IW12 | Human | PMID:19104048 |
Molecular Function | GO:0005515 | protein binding | IL18 | IPI | UniProtKB:Q13478 | Human | PMID:25261253 |
Molecular Function | GO:0005515 | protein binding | IL18 | IPI | UniProtKB:Q15847 | Human | PMID:32296183 |
Molecular Function | GO:0005515 | protein binding | Il18 | IPI | RGD:620042 | Rat | PMID:12034039|RGD:633082 |
Cellular Component | GO:0016324 | apical plasma membrane | Il18 | IDA | Rat | PMID:12032269|RGD:729222 | |
Cellular Component | GO:0005737 | cytoplasm | Il18 | IDA | Rat | PMID:12032269|RGD:729222 | |
Cellular Component | GO:0005615 | extracellular space | IL18 | IDA | Human | PMID:33883744 | |
Cellular Component | GO:0005615 | extracellular space | IL18 | IDA | Human | PMID:21323571 | |
Cellular Component | GO:0005615 | extracellular space | Il18 | IDA | Mouse | MGI:MGI:6259277|PMID:30392956 | |
Cellular Component | GO:0005615 | extracellular space | Il18 | IDA | Mouse | PMID:16949315 | |
Cellular Component | GO:0005615 | extracellular space | Il18 | IDA | Mouse | PMID:15220916 | |
Cellular Component | GO:0005615 | extracellular space | Il18 | IDA | Rat | PMID:16002206|RGD:4889501 | |
Cellular Component | GO:0005615 | extracellular space | Il18 | IDA | Rat | PMID:19717152|RGD:4889401 | |
Cellular Component | GO:0005615 | extracellular space | Il18 | IDA | Rat | PMID:24412291|RGD:14696652 | |
Biological Process | GO:0032148 | activation of protein kinase B activity | IL18 | IDA | Human | PMID:21321938 | |
Biological Process | GO:0001525 | angiogenesis | IL18 | IDA | Human | PMID:11466388 | |
Biological Process | GO:0008283 | cell population proliferation | Il18 | IDA | Mouse | PMID:15843532 | |
Biological Process | GO:0008283 | cell population proliferation | Il18 | IGI | MGI:MGI:96540 | Mouse | PMID:15843532 |
Biological Process | GO:0008283 | cell population proliferation | Il18 | IGI | MGI:MGI:96539 | Mouse | PMID:15843532 |
Biological Process | GO:0071320 | cellular response to cAMP | Il18 | IEP | Rat | PMID:12490070|RGD:4889506 | |
Biological Process | GO:0070301 | cellular response to hydrogen peroxide | Il18 | IEP | Rat | PMID:12684057|RGD:4889505 | |
Biological Process | GO:0071222 | cellular response to lipopolysaccharide | Il18 | IEP | Rat | PMID:11739527|RGD:729357 | |
Biological Process | GO:0071260 | cellular response to mechanical stimulus | Il18 | IEP | Rat | PMID:18320471|RGD:4889461 | |
Biological Process | GO:0071407 | cellular response to organic cyclic compound | IL18 | IDA | Human | PMID:21147091 | |
Biological Process | GO:0071374 | cellular response to parathyroid hormone stimulus | Il18 | IEP | Rat | PMID:18165223|RGD:4889468 | |
Biological Process | GO:0071375 | cellular response to peptide hormone stimulus | Il18 | IMP | Rat | PMID:12490070|RGD:4889506 | |
Biological Process | GO:0071356 | cellular response to tumor necrosis factor | Il18 | IEP | Rat | PMID:18547159|RGD:4889457 | |
Biological Process | GO:0071346 | cellular response to type II interferon | Il18 | IEP | Rat | PMID:18547159|RGD:4889457 | |
Biological Process | GO:0042632 | cholesterol homeostasis | Il18 | IMP | Mouse | MGI:MGI:3608083|PMID:12829194 | |
Biological Process | GO:0050830 | defense response to Gram-positive bacterium | Il18 | IDA | Mouse | MGI:MGI:6259277|PMID:30392956 | |
Biological Process | GO:0050966 | detection of mechanical stimulus involved in sensory perception of pain | Il18 | IDA | Rat | PMID:19853379|RGD:2315887 | |
Biological Process | GO:0048546 | digestive tract morphogenesis | Il18 | IEP | Rat | PMID:21088234|RGD:4889157 | |
Biological Process | GO:0061436 | establishment of skin barrier | Il18 | IMP | Mouse | MGI:MGI:5704236|PMID:26638073 | |
Biological Process | GO:0006954 | inflammatory response | IL18 | IDA | Human | PMID:21147091 | |
Biological Process | GO:0006954 | inflammatory response | Il18 | IGI | MGI:MGI:96698 | Mouse | PMID:23132931 |
Biological Process | GO:0035655 | interleukin-18-mediated signaling pathway | IL18 | IDA | Human | PMID:14528293 | |
Biological Process | GO:0035655 | interleukin-18-mediated signaling pathway | IL18 | IDA | Human | PMID:21321938 | |
Biological Process | GO:0035655 | interleukin-18-mediated signaling pathway | IL18 | IDA | Human | PMID:25500532 | |
Biological Process | GO:0035655 | interleukin-18-mediated signaling pathway | Il18 | IDA | Mouse | MGI:MGI:6259277|PMID:30392956 | |
Biological Process | GO:0035655 | interleukin-18-mediated signaling pathway | Il18 | IDA | Mouse | PMID:15843532 | |
Biological Process | GO:0032635 | interleukin-6 production | Il18 | IDA | Mouse | PMID:15843532 | |
Biological Process | GO:0031663 | lipopolysaccharide-mediated signaling pathway | IL18 | IDA | Human | PMID:21147091 | |
Biological Process | GO:0097421 | liver regeneration | Il18 | IEP | Rat | PMID:24412291|RGD:14696652 | |
Biological Process | GO:0030324 | lung development | Il18 | IEP | Rat | PMID:18952566|RGD:2307417 | |
Biological Process | GO:0000165 | MAPK cascade | IL18 | IMP | Human | PMID:21147091 | |
Biological Process | GO:0030101 | natural killer cell activation | Il18 | IDA | Mouse | PMID:10227969 | |
Biological Process | GO:0042267 | natural killer cell mediated cytotoxicity | Il18 | IDA | Mouse | PMID:15843532 | |
Biological Process | GO:0045662 | negative regulation of myoblast differentiation | Il18 | IMP | Mouse | PMID:23844157 | |
Biological Process | GO:0033030 | negative regulation of neutrophil apoptotic process | Il18 | IMP | Rat | PMID:20844839|RGD:8655995 | |
Biological Process | GO:0050732 | negative regulation of peptidyl-tyrosine phosphorylation | Il18 | IMP | Rat | PMID:22001439|RGD:8655996 | |
Biological Process | GO:0042119 | neutrophil activation | Il18 | IDA | Mouse | PMID:15843532 | |
Biological Process | GO:0038061 | NIK/NF-kappaB signaling | Il18 | IDA | Mouse | PMID:10227969 | |
Biological Process | GO:0001649 | osteoblast differentiation | Il18 | IEP | Rat | PMID:18165223|RGD:4889468 | |
Biological Process | GO:0042104 | positive regulation of activated T cell proliferation | IL18 | IDA | Human | PMID:8766574 | |
Biological Process | GO:0043065 | positive regulation of apoptotic process | Il18 | IMP | Rat | PMID:22001439|RGD:8655996 | |
Biological Process | GO:2000504 | positive regulation of blood vessel remodeling | Il18 | IDA | Rat | PMID:19717152|RGD:4889401 | |
Biological Process | GO:0032722 | positive regulation of chemokine production | Il18 | IMP | Rat | PMID:19497959|RGD:4889403 | |
Biological Process | GO:0120162 | positive regulation of cold-induced thermogenesis | Il18 | IMP | Mouse | MGI:MGI:6101026|PMID:26656097 | |
Biological Process | GO:0032967 | positive regulation of collagen biosynthetic process | Il18 | IDA | Rat | PMID:20644901|RGD:4889158 | |
Biological Process | GO:0010628 | positive regulation of gene expression | Il18 | IDA | Mouse | PMID:19666510 | |
Biological Process | GO:0032725 | positive regulation of granulocyte macrophage colony-stimulating factor production | IL18 | IDA | Human | PMID:20027291 | |
Biological Process | GO:2000347 | positive regulation of hepatocyte proliferation | Il18 | IDA | Rat | PMID:24412291|RGD:14696652 | |
Biological Process | GO:0050729 | positive regulation of inflammatory response | Il18 | IMP | Mouse | MGI:MGI:5704236|PMID:26638073 | |
Biological Process | GO:0032731 | positive regulation of interleukin-1 beta production | Il18 | IEP | Rat | PMID:17623049|RGD:4889480 | |
Biological Process | GO:0032740 | positive regulation of interleukin-17 production | IL18 | IDA | Human | PMID:16482511 | |
Biological Process | GO:0032757 | positive regulation of interleukin-8 production | Il18 | IDA | Rat | PMID:18547159|RGD:4889457 | |
Biological Process | GO:0010744 | positive regulation of macrophage derived foam cell differentiation | Il18 | IMP | Mouse | MGI:MGI:3608083|PMID:12829194 | |
Biological Process | GO:2000256 | positive regulation of male germ cell proliferation | Il18 | IDA | Rat | PMID:16002206|RGD:4889501 | |
Biological Process | GO:0032819 | positive regulation of natural killer cell proliferation | IL18 | IDA | Human | PMID:19088061 | |
Biological Process | GO:0043525 | positive regulation of neuron apoptotic process | Il18 | IMP | Rat | PMID:17188500|RGD:2315917 | |
Biological Process | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | IL18 | IDA | Human | PMID:25500532 | |
Biological Process | GO:1901224 | positive regulation of NIK/NF-kappaB signaling | Il18 | IDA | Mouse | PMID:10227969 | |
Biological Process | GO:0051142 | positive regulation of NK T cell proliferation | IL18 | IDA | Human | PMID:19088061 | |
Biological Process | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling | IL18 | IDA | Human | PMID:21321938 | |
Biological Process | GO:0051897 | positive regulation of protein kinase B signaling | IL18 | IDA | Human | PMID:21321938 | |
Biological Process | GO:0014911 | positive regulation of smooth muscle cell migration | Il18 | IMP | Rat | PMID:22636674|RGD:8655954 | |
Biological Process | GO:0048661 | positive regulation of smooth muscle cell proliferation | IL18 | IDA | Human | PMID:21321938 | |
Biological Process | GO:0048661 | positive regulation of smooth muscle cell proliferation | Il18 | IMP | Rat | PMID:22636674|RGD:8655954 | |
Biological Process | GO:0032930 | positive regulation of superoxide anion generation | Il18 | IMP | Rat | PMID:19497959|RGD:4889403 | |
Biological Process | GO:2000556 | positive regulation of T-helper 1 cell cytokine production | IL18 | IDA | Human | PMID:10653850 | |
Biological Process | GO:0045630 | positive regulation of T-helper 2 cell differentiation | Il18 | IMP | Mouse | MGI:MGI:3608083|PMID:12829194 | |
Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II | IL18 | IDA | Human | PMID:24615654 | |
Biological Process | GO:0032760 | positive regulation of tumor necrosis factor production | Il18 | IMP | Rat | PMID:17623049|RGD:4889480 | |
Biological Process | GO:0032729 | positive regulation of type II interferon production | IL18 | IDA | Human | PMID:10653850 | |
Biological Process | GO:0032729 | positive regulation of type II interferon production | IL18 | IDA | Human | PMID:14528293 | |
Biological Process | GO:0032729 | positive regulation of type II interferon production | IL18 | IDA | Human | PMID:19088061 | |
Biological Process | GO:0032729 | positive regulation of type II interferon production | IL18 | IDA | Human | PMID:20027291 | |
Biological Process | GO:0032729 | positive regulation of type II interferon production | Il18 | IMP | Mouse | MGI:MGI:3687928|PMID:11907086 | |
Biological Process | GO:0032729 | positive regulation of type II interferon production | Il18 | IDA | Mouse | PMID:15843532 | |
Biological Process | GO:0032729 | positive regulation of type II interferon production | Il18 | IDA | Mouse | PMID:11894097 | |
Biological Process | GO:0032729 | positive regulation of type II interferon production | Il18 | IGI | MGI:MGI:96539 | Mouse | PMID:15843532 |
Biological Process | GO:0032729 | positive regulation of type II interferon production | Il18 | IGI | MGI:MGI:96540 | Mouse | PMID:15843532 |
Biological Process | GO:0032729 | positive regulation of type II interferon production | Il18 | IDA | Mouse | PMID:10227969 | |
Biological Process | GO:0032729 | positive regulation of type II interferon production | Il18 | IDA | Mouse | PMID:11894098 | |
Biological Process | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein | IL18 | IDA | Human | PMID:10903731 | |
Biological Process | GO:0043117 | positive regulation of vascular permeability | Il18 | IMP | Rat | PMID:11739527|RGD:729357 | |
Biological Process | GO:0030155 | regulation of cell adhesion | IL18 | IDA | Human | PMID:11477102 | |
Biological Process | GO:0009409 | response to cold | Il18 | IEP | Rat | PMID:8999896|RGD:69858 | |
Biological Process | GO:0055093 | response to hyperoxia | Il18 | IEP | Rat | PMID:19672068|RGD:4889402 | |
Biological Process | GO:0001666 | response to hypoxia | Il18 | IMP | Rat | PMID:12122053|RGD:628353 | |
Biological Process | GO:0043434 | response to peptide hormone | Il18 | IEP | Rat | PMID:11086064|RGD:4889540 | |
Biological Process | GO:0009314 | response to radiation | Il18 | IEP | Rat | PMID:19955748|RGD:4889159 | |
Biological Process | GO:0030431 | sleep | Il18 | IDA | Rat | PMID:11506998|RGD:8554500 | |
Biological Process | GO:0035744 | T-helper 1 cell cytokine production | Il18 | IGI | MGI:MGI:96540 | Mouse | PMID:15843532 |
Biological Process | GO:0035744 | T-helper 1 cell cytokine production | Il18 | IGI | MGI:MGI:96539 | Mouse | PMID:15843532 |
Biological Process | GO:0035744 | T-helper 1 cell cytokine production | Il18 | IDA | Mouse | PMID:15843532 | |
Biological Process | GO:0042088 | T-helper 1 type immune response | IL18 | IDA | Human | PMID:8766574 | |
Biological Process | GO:0070328 | triglyceride homeostasis | Il18 | IMP | Mouse | MGI:MGI:3608083|PMID:12829194 | |
Biological Process | GO:0032609 | type II interferon production | Il18 | IDA | Mouse | PMID:11894098 | |
Biological Process | GO:0032609 | type II interferon production | Il18 | IDA | Mouse | PMID:11894097 | |
Biological Process | GO:0032609 | type II interferon production | Il18 | IDA | Mouse | PMID:10227969 |
EXP Inferred from experiment |
IDA Inferred from direct assay |
IEP Inferred from expression pattern |
IGI Inferred from genetic interaction |
IMP Inferred from mutant phenotype |
IPI Inferred from physical interaction |
HTP Inferred from High Throughput Experiment |
HDA Inferred from High Throughput Direct Assay |
HMP Inferred from High Throughput Mutant Phenotype |
HGI Inferred from High Throughput Genetic Interaction |
HEP Inferred from High Throughput Expression Pattern |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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