Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL18
  • Mouse genes Il18
  • Rat genes Il18
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il18

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	IL18	IDA		Human	PMID:14528293
Molecular Function	GO:0005125	cytokine activity	IL18	IDA		Human	PMID:25500532
Molecular Function	GO:0005125	cytokine activity	Il18	IMP		Mouse	MGI:MGI:3608083|PMID:12829194
Molecular Function	GO:0005125	cytokine activity	Il18	IDA		Mouse	PMID:11894098
Molecular Function	GO:0045515	interleukin-18 receptor binding	IL18	IDA		Human	PMID:14528293
Molecular Function	GO:0045515	interleukin-18 receptor binding	IL18	IDA		Human	PMID:25500532
Molecular Function	GO:0005515	protein binding	IL18	IPI	UniProtKB:Q9IW12	Human	PMID:19104048
Molecular Function	GO:0005515	protein binding	IL18	IPI	UniProtKB:Q13478	Human	PMID:25261253
Molecular Function	GO:0005515	protein binding	IL18	IPI	UniProtKB:Q15847	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Il18	IPI	RGD:620042	Rat	PMID:12034039|RGD:633082
Cellular Component	GO:0016324	apical plasma membrane	Il18	IDA		Rat	PMID:12032269|RGD:729222
Cellular Component	GO:0005737	cytoplasm	Il18	IDA		Rat	PMID:12032269|RGD:729222
Cellular Component	GO:0005615	extracellular space	IL18	IDA		Human	PMID:33883744
Cellular Component	GO:0005615	extracellular space	IL18	IDA		Human	PMID:21323571
Cellular Component	GO:0005615	extracellular space	Il18	IDA		Mouse	MGI:MGI:6259277|PMID:30392956
Cellular Component	GO:0005615	extracellular space	Il18	IDA		Mouse	PMID:16949315
Cellular Component	GO:0005615	extracellular space	Il18	IDA		Mouse	PMID:15220916
Cellular Component	GO:0005615	extracellular space	Il18	IDA		Rat	PMID:16002206|RGD:4889501
Cellular Component	GO:0005615	extracellular space	Il18	IDA		Rat	PMID:19717152|RGD:4889401
Cellular Component	GO:0005615	extracellular space	Il18	IDA		Rat	PMID:24412291|RGD:14696652
Biological Process	GO:0032148	activation of protein kinase B activity	IL18	IDA		Human	PMID:21321938
Biological Process	GO:0001525	angiogenesis	IL18	IDA		Human	PMID:11466388
Biological Process	GO:0008283	cell population proliferation	Il18	IDA		Mouse	PMID:15843532
Biological Process	GO:0008283	cell population proliferation	Il18	IGI	MGI:MGI:96540	Mouse	PMID:15843532
Biological Process	GO:0008283	cell population proliferation	Il18	IGI	MGI:MGI:96539	Mouse	PMID:15843532
Biological Process	GO:0071320	cellular response to cAMP	Il18	IEP		Rat	PMID:12490070|RGD:4889506
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Il18	IEP		Rat	PMID:12684057|RGD:4889505
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Il18	IEP		Rat	PMID:11739527|RGD:729357
Biological Process	GO:0071260	cellular response to mechanical stimulus	Il18	IEP		Rat	PMID:18320471|RGD:4889461
Biological Process	GO:0071407	cellular response to organic cyclic compound	IL18	IDA		Human	PMID:21147091
Biological Process	GO:0071374	cellular response to parathyroid hormone stimulus	Il18	IEP		Rat	PMID:18165223|RGD:4889468
Biological Process	GO:0071375	cellular response to peptide hormone stimulus	Il18	IMP		Rat	PMID:12490070|RGD:4889506
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Il18	IEP		Rat	PMID:18547159|RGD:4889457
Biological Process	GO:0071346	cellular response to type II interferon	Il18	IEP		Rat	PMID:18547159|RGD:4889457
Biological Process	GO:0042632	cholesterol homeostasis	Il18	IMP		Mouse	MGI:MGI:3608083|PMID:12829194
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Il18	IDA		Mouse	MGI:MGI:6259277|PMID:30392956
Biological Process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	Il18	IDA		Rat	PMID:19853379|RGD:2315887
Biological Process	GO:0048546	digestive tract morphogenesis	Il18	IEP		Rat	PMID:21088234|RGD:4889157
Biological Process	GO:0061436	establishment of skin barrier	Il18	IMP		Mouse	MGI:MGI:5704236|PMID:26638073
Biological Process	GO:0006954	inflammatory response	IL18	IDA		Human	PMID:21147091
Biological Process	GO:0006954	inflammatory response	Il18	IGI	MGI:MGI:96698	Mouse	PMID:23132931
Biological Process	GO:0035655	interleukin-18-mediated signaling pathway	IL18	IDA		Human	PMID:14528293
Biological Process	GO:0035655	interleukin-18-mediated signaling pathway	IL18	IDA		Human	PMID:21321938
Biological Process	GO:0035655	interleukin-18-mediated signaling pathway	IL18	IDA		Human	PMID:25500532
Biological Process	GO:0035655	interleukin-18-mediated signaling pathway	Il18	IDA		Mouse	MGI:MGI:6259277|PMID:30392956
Biological Process	GO:0035655	interleukin-18-mediated signaling pathway	Il18	IDA		Mouse	PMID:15843532
Biological Process	GO:0032635	interleukin-6 production	Il18	IDA		Mouse	PMID:15843532
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IL18	IDA		Human	PMID:21147091
Biological Process	GO:0097421	liver regeneration	Il18	IEP		Rat	PMID:24412291|RGD:14696652
Biological Process	GO:0030324	lung development	Il18	IEP		Rat	PMID:18952566|RGD:2307417
Biological Process	GO:0000165	MAPK cascade	IL18	IMP		Human	PMID:21147091
Biological Process	GO:0030101	natural killer cell activation	Il18	IDA		Mouse	PMID:10227969
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	Il18	IDA		Mouse	PMID:15843532
Biological Process	GO:0045662	negative regulation of myoblast differentiation	Il18	IMP		Mouse	PMID:23844157
Biological Process	GO:0033030	negative regulation of neutrophil apoptotic process	Il18	IMP		Rat	PMID:20844839|RGD:8655995
Biological Process	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	Il18	IMP		Rat	PMID:22001439|RGD:8655996
Biological Process	GO:0042119	neutrophil activation	Il18	IDA		Mouse	PMID:15843532
Biological Process	GO:0038061	NIK/NF-kappaB signaling	Il18	IDA		Mouse	PMID:10227969
Biological Process	GO:0001649	osteoblast differentiation	Il18	IEP		Rat	PMID:18165223|RGD:4889468
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	IL18	IDA		Human	PMID:8766574
Biological Process	GO:0043065	positive regulation of apoptotic process	Il18	IMP		Rat	PMID:22001439|RGD:8655996
Biological Process	GO:2000504	positive regulation of blood vessel remodeling	Il18	IDA		Rat	PMID:19717152|RGD:4889401
Biological Process	GO:0032722	positive regulation of chemokine production	Il18	IMP		Rat	PMID:19497959|RGD:4889403
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Il18	IMP		Mouse	MGI:MGI:6101026|PMID:26656097
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	Il18	IDA		Rat	PMID:20644901|RGD:4889158
Biological Process	GO:0010628	positive regulation of gene expression	Il18	IDA		Mouse	PMID:19666510
Biological Process	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	IL18	IDA		Human	PMID:20027291
Biological Process	GO:2000347	positive regulation of hepatocyte proliferation	Il18	IDA		Rat	PMID:24412291|RGD:14696652
Biological Process	GO:0050729	positive regulation of inflammatory response	Il18	IMP		Mouse	MGI:MGI:5704236|PMID:26638073
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Il18	IEP		Rat	PMID:17623049|RGD:4889480
Biological Process	GO:0032740	positive regulation of interleukin-17 production	IL18	IDA		Human	PMID:16482511
Biological Process	GO:0032757	positive regulation of interleukin-8 production	Il18	IDA		Rat	PMID:18547159|RGD:4889457
Biological Process	GO:0010744	positive regulation of macrophage derived foam cell differentiation	Il18	IMP		Mouse	MGI:MGI:3608083|PMID:12829194
Biological Process	GO:2000256	positive regulation of male germ cell proliferation	Il18	IDA		Rat	PMID:16002206|RGD:4889501
Biological Process	GO:0032819	positive regulation of natural killer cell proliferation	IL18	IDA		Human	PMID:19088061
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Il18	IMP		Rat	PMID:17188500|RGD:2315917
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IL18	IDA		Human	PMID:25500532
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	Il18	IDA		Mouse	PMID:10227969
Biological Process	GO:0051142	positive regulation of NK T cell proliferation	IL18	IDA		Human	PMID:19088061
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IL18	IDA		Human	PMID:21321938
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IL18	IDA		Human	PMID:21321938
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	Il18	IMP		Rat	PMID:22636674|RGD:8655954
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	IL18	IDA		Human	PMID:21321938
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Il18	IMP		Rat	PMID:22636674|RGD:8655954
Biological Process	GO:0032930	positive regulation of superoxide anion generation	Il18	IMP		Rat	PMID:19497959|RGD:4889403
Biological Process	GO:2000556	positive regulation of T-helper 1 cell cytokine production	IL18	IDA		Human	PMID:10653850
Biological Process	GO:0045630	positive regulation of T-helper 2 cell differentiation	Il18	IMP		Mouse	MGI:MGI:3608083|PMID:12829194
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IL18	IDA		Human	PMID:24615654
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Il18	IMP		Rat	PMID:17623049|RGD:4889480
Biological Process	GO:0032729	positive regulation of type II interferon production	IL18	IDA		Human	PMID:10653850
Biological Process	GO:0032729	positive regulation of type II interferon production	IL18	IDA		Human	PMID:14528293
Biological Process	GO:0032729	positive regulation of type II interferon production	IL18	IDA		Human	PMID:19088061
Biological Process	GO:0032729	positive regulation of type II interferon production	IL18	IDA		Human	PMID:20027291
Biological Process	GO:0032729	positive regulation of type II interferon production	Il18	IMP		Mouse	MGI:MGI:3687928|PMID:11907086
Biological Process	GO:0032729	positive regulation of type II interferon production	Il18	IDA		Mouse	PMID:15843532
Biological Process	GO:0032729	positive regulation of type II interferon production	Il18	IDA		Mouse	PMID:11894097
Biological Process	GO:0032729	positive regulation of type II interferon production	Il18	IGI	MGI:MGI:96539	Mouse	PMID:15843532
Biological Process	GO:0032729	positive regulation of type II interferon production	Il18	IGI	MGI:MGI:96540	Mouse	PMID:15843532
Biological Process	GO:0032729	positive regulation of type II interferon production	Il18	IDA		Mouse	PMID:10227969
Biological Process	GO:0032729	positive regulation of type II interferon production	Il18	IDA		Mouse	PMID:11894098
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IL18	IDA		Human	PMID:10903731
Biological Process	GO:0043117	positive regulation of vascular permeability	Il18	IMP		Rat	PMID:11739527|RGD:729357
Biological Process	GO:0030155	regulation of cell adhesion	IL18	IDA		Human	PMID:11477102
Biological Process	GO:0009409	response to cold	Il18	IEP		Rat	PMID:8999896|RGD:69858
Biological Process	GO:0055093	response to hyperoxia	Il18	IEP		Rat	PMID:19672068|RGD:4889402
Biological Process	GO:0001666	response to hypoxia	Il18	IMP		Rat	PMID:12122053|RGD:628353
Biological Process	GO:0043434	response to peptide hormone	Il18	IEP		Rat	PMID:11086064|RGD:4889540
Biological Process	GO:0009314	response to radiation	Il18	IEP		Rat	PMID:19955748|RGD:4889159
Biological Process	GO:0030431	sleep	Il18	IDA		Rat	PMID:11506998|RGD:8554500
Biological Process	GO:0035744	T-helper 1 cell cytokine production	Il18	IGI	MGI:MGI:96540	Mouse	PMID:15843532
Biological Process	GO:0035744	T-helper 1 cell cytokine production	Il18	IGI	MGI:MGI:96539	Mouse	PMID:15843532
Biological Process	GO:0035744	T-helper 1 cell cytokine production	Il18	IDA		Mouse	PMID:15843532
Biological Process	GO:0042088	T-helper 1 type immune response	IL18	IDA		Human	PMID:8766574
Biological Process	GO:0070328	triglyceride homeostasis	Il18	IMP		Mouse	MGI:MGI:3608083|PMID:12829194
Biological Process	GO:0032609	type II interferon production	Il18	IDA		Mouse	PMID:11894098
Biological Process	GO:0032609	type II interferon production	Il18	IDA		Mouse	PMID:11894097
Biological Process	GO:0032609	type II interferon production	Il18	IDA		Mouse	PMID:10227969

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern