Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL21
  • Mouse genes Il21
  • Rat genes Il21
  • Zfish genes il21
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il21

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005126	cytokine receptor binding	Il21	IDA		Mouse	PMID:11081504
Molecular Function	GO:0005134	interleukin-2 receptor binding	IL21	IPI	UniProtKB:P31785	Human	PMID:12504082
Molecular Function	GO:0005515	protein binding	IL21	IPI	UniProtKB:Q12797-6	Human	PMID:32296183
Biological Process	GO:0048469	cell maturation	IL21	IDA		Human	PMID:14635054
Biological Process	GO:0098586	cellular response to virus	Il21	IMP		Mouse	MGI:MGI:5450752|PMID:23045607
Biological Process	GO:0002314	germinal center B cell differentiation	Il21	IMP		Mouse	MGI:MGI:5450752|PMID:23045607
Biological Process	GO:0032613	interleukin-10 production	Il21	IDA		Mouse	PMID:14764669
Biological Process	GO:0002370	natural killer cell cytokine production	Il21	IDA		Mouse	PMID:14764669
Biological Process	GO:0001779	natural killer cell differentiation	Il21	IDA		Mouse	PMID:14764669
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	Il21	IDA		Mouse	PMID:14764669
Biological Process	GO:0030890	positive regulation of B cell proliferation	IL21	IDA		Human	PMID:17673207
Biological Process	GO:0008284	positive regulation of cell population proliferation	IL21	IDA		Human	PMID:17673207
Biological Process	GO:0001819	positive regulation of cytokine production	IL21	IDA		Human	PMID:19322899
Biological Process	GO:0002639	positive regulation of immunoglobulin production	Il21	IMP		Mouse	MGI:MGI:5450752|PMID:23045607
Biological Process	GO:0032733	positive regulation of interleukin-10 production	Il21	IDA		Mouse	PMID:14764669
Biological Process	GO:0032740	positive regulation of interleukin-17 production	IL21	IDA		Human	PMID:16482511
Biological Process	GO:0002729	positive regulation of natural killer cell cytokine production	Il21	IDA		Mouse	PMID:14764669
Biological Process	GO:0032825	positive regulation of natural killer cell differentiation	Il21	IDA		Mouse	PMID:14764669
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	IL21	IDA		Human	PMID:18005035
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	Il21	IDA		Mouse	PMID:14764669
Biological Process	GO:0042102	positive regulation of T cell proliferation	IL21	IDA		Human	PMID:17673207
Biological Process	GO:0042102	positive regulation of T cell proliferation	IL21	IDA		Human	PMID:15207081
Biological Process	GO:0032729	positive regulation of type II interferon production	Il21	IDA		Mouse	PMID:14764669
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IL21	IDA		Human	PMID:17673207
Biological Process	GO:0061470	T follicular helper cell differentiation	Il21	IMP		Mouse	MGI:MGI:5450752|PMID:23045607
Biological Process	GO:0032609	type II interferon production	Il21	IDA		Mouse	PMID:14764669
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	IL21	IDA		Human	PMID:12244150

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern