Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL27
  • Mouse genes Il27
  • Rat genes Il27
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il27

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045523	interleukin-27 receptor binding	Il27	IDA		Mouse	PMID:12121660
Molecular Function	GO:0005515	protein binding	IL27	IPI	UniProtKB:O75462	Human	PMID:19933857
Molecular Function	GO:0005515	protein binding	IL27	IPI	UniProtKB:Q14213	Human	PMID:20974977
Molecular Function	GO:0005515	protein binding	Il27	IPI	PR:O35228	Mouse	PMID:12121660
Molecular Function	GO:0005515	protein binding	Il27	IPI	PR:O70394	Mouse	PMID:12121660
Molecular Function	GO:0005102	signaling receptor binding	Il27	IDA		Mouse	PMID:12121660
Cellular Component	GO:0009986	cell surface	Il27	IDA		Rat	PMID:16288719|RGD:5128497
Cellular Component	GO:0005615	extracellular space	Il27	IDA		Mouse	PMID:12121660
Biological Process	GO:0002230	positive regulation of defense response to virus by host	Il27	IDA		Mouse	PMID:25268627
Biological Process	GO:0002230	positive regulation of defense response to virus by host	Il27	IGI	MGI:MGI:107656	Mouse	PMID:25268627
Biological Process	GO:0032729	positive regulation of type II interferon production	IL27	IDA		Human	PMID:12734330
Biological Process	GO:0042129	regulation of T cell proliferation	Il27	IDA		Mouse	PMID:12121660
Biological Process	GO:0045625	regulation of T-helper 1 cell differentiation	IL27	IDA		Human	PMID:12734330
Biological Process	GO:0009617	response to bacterium	Il27	IEP		Rat	PMID:16288719|RGD:5128497
Biological Process	GO:0140459	response to Gram-positive bacterium	Il27	IEP		Rat	PMID:16288719|RGD:5128497

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern