Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL2RA
  • Mouse genes Il2ra
  • Rat genes Il2ra
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il2ra

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019976	interleukin-2 binding	Il2ra	IPI	PR:P04351	Mouse	PMID:8262055
Molecular Function	GO:0019976	interleukin-2 binding	Il2ra	IPI	UniProtKB:P60568	Mouse	PMID:8262055
Molecular Function	GO:0004911	interleukin-2 receptor activity	IL2RA	IMP		Human	PMID:2467293
Molecular Function	GO:0004911	interleukin-2 receptor activity	IL2RA	IDA		Human	PMID:16293754
Molecular Function	GO:0004911	interleukin-2 receptor activity	Il2ra	IMP	MGI:MGI:1857192	Mouse	PMID:7584142
Molecular Function	GO:0004911	interleukin-2 receptor activity	Il2ra	IPI	RGD:620047	Rat	PMID:2592769|RGD:1600131
Molecular Function	GO:0005515	protein binding	IL2RA	IPI	UniProtKB:P60568	Human	PMID:16477002
Molecular Function	GO:0005515	protein binding	IL2RA	IPI	UniProtKB:P60568	Human	PMID:17032757
Molecular Function	GO:0005515	protein binding	Il2ra	IPI	PR:Q61508	Mouse	PMID:21217760
Cellular Component	GO:0009986	cell surface	Il2ra	IDA		Rat	PMID:10210776|RGD:1600126
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:8769481
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:16973387
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:15368291
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:21460847
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:15240714
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:10072077
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:15728238
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:21508411
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:15843532
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:16227984
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:10760791
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:15294943
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:15909309
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:18792410
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:18641307
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:19723499
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:16301745
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:7688139
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:7584142
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:18958875
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:8262055
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:14990792
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:8755570
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:19934022
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:8125140
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:17082577
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:12867038
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:22072979
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:18628982
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:7477352
Cellular Component	GO:0009897	external side of plasma membrane	Il2ra	IDA		Mouse	PMID:19008373
Biological Process	GO:0050798	activated T cell proliferation	Il2ra	IMP	MGI:MGI:1857192	Mouse	PMID:7584142
Biological Process	GO:0006924	activation-induced cell death of T cells	Il2ra	IMP	MGI:MGI:1857192	Mouse	PMID:7584142
Biological Process	GO:0002437	inflammatory response to antigenic stimulus	Il2ra	IMP		Rat	PMID:10389888|RGD:1600145
Biological Process	GO:0038110	interleukin-2-mediated signaling pathway	IL2RA	IDA		Human	PMID:16293754
Biological Process	GO:0046651	lymphocyte proliferation	Il2ra	IMP	MGI:MGI:1857192	Mouse	PMID:16227984
Biological Process	GO:0050728	negative regulation of inflammatory response	Il2ra	IMP	MGI:MGI:1857192	Mouse	PMID:7584142
Biological Process	GO:0050728	negative regulation of inflammatory response	Il2ra	IMP	MGI:MGI:1857192	Mouse	PMID:12702495
Biological Process	GO:0050672	negative regulation of lymphocyte proliferation	Il2ra	IMP	MGI:MGI:1857192	Mouse	PMID:16227984
Biological Process	GO:0042130	negative regulation of T cell proliferation	Il2ra	IMP	MGI:MGI:1857192	Mouse	PMID:12702495
Biological Process	GO:0007219	Notch signaling pathway	Il2ra	IGI	MGI:MGI:1277162	Mouse	PMID:21508411
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	Il2ra	IMP	MGI:MGI:1857192	Mouse	PMID:7584142
Biological Process	GO:0045582	positive regulation of T cell differentiation	Il2ra	IMP		Rat	PMID:9352365|RGD:1600138
Biological Process	GO:0042102	positive regulation of T cell proliferation	Il2ra	IMP		Rat	PMID:9352365|RGD:1600138
Biological Process	GO:2000561	regulation of CD4-positive, alpha-beta T cell proliferation	Il2ra	IMP	MGI:MGI:1857192	Mouse	PMID:16227984
Biological Process	GO:0046013	regulation of T cell homeostatic proliferation	Il2ra	IMP	MGI:MGI:1857192	Mouse	PMID:16227984
Biological Process	GO:0002664	regulation of T cell tolerance induction	IL2RA	IMP		Human	PMID:23416241
Biological Process	GO:0043029	T cell homeostasis	Il2ra	IMP	MGI:MGI:1857192	Mouse	PMID:12702495

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern