Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL2RB
  • Mouse genes Il2rb
  • Rat genes Il2rb
  • Zfish genes il2rb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il2rb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015026	coreceptor activity	IL2RB	IDA		Human	PMID:7973659
Molecular Function	GO:0015026	coreceptor activity	IL2RB	IDA		Human	PMID:8026467
Molecular Function	GO:0042010	interleukin-15 receptor activity	IL2RB	IDA		Human	PMID:15123770
Molecular Function	GO:0019976	interleukin-2 binding	IL2RB	IMP		Human	PMID:2467293
Molecular Function	GO:0019976	interleukin-2 binding	IL2RB	IMP		Human	PMID:31040184
Molecular Function	GO:0019976	interleukin-2 binding	IL2RB	IMP		Human	PMID:31040185
Molecular Function	GO:0019976	interleukin-2 binding	Il2rb	IPI	PR:P04351	Mouse	PMID:8262055
Molecular Function	GO:0019976	interleukin-2 binding	Il2rb	IMP		Rat	PMID:1469024|RGD:2303496
Molecular Function	GO:0004911	interleukin-2 receptor activity	IL2RB	IMP		Human	PMID:2467293
Molecular Function	GO:0004911	interleukin-2 receptor activity	IL2RB	IMP		Human	PMID:31040184
Molecular Function	GO:0004911	interleukin-2 receptor activity	IL2RB	IMP		Human	PMID:31040185
Molecular Function	GO:0004911	interleukin-2 receptor activity	IL2RB	IDA		Human	PMID:7736574
Molecular Function	GO:0004911	interleukin-2 receptor activity	Il2rb	IMP		Rat	PMID:1469024|RGD:2303496
Molecular Function	GO:0005515	protein binding	IL2RB	IPI	UniProtKB:P60568	Human	PMID:16477002
Molecular Function	GO:0005515	protein binding	IL2RB	IPI	UniProtKB:P60568	Human	PMID:22446627
Molecular Function	GO:0005515	protein binding	IL2RB	IPI	UniProtKB:P40933	Human	PMID:23104097
Molecular Function	GO:0005515	protein binding	IL2RB	IPI	UniProtKB:P40933	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	IL2RB	IPI	UniProtKB:Q15645	Human	PMID:32296183
Cellular Component	GO:0009986	cell surface	IL2RB	IDA		Human	PMID:15123770
Cellular Component	GO:0009986	cell surface	IL2RB	IMP		Human	PMID:31040184
Cellular Component	GO:0009986	cell surface	IL2RB	IMP		Human	PMID:31040185
Cellular Component	GO:0009986	cell surface	Il2rb	IDA		Mouse	PMID:20818394
Cellular Component	GO:0009986	cell surface	Il2rb	IDA		Rat	PMID:8898947|RGD:5684381
Cellular Component	GO:0009897	external side of plasma membrane	Il2rb	IDA		Mouse	PMID:19723499
Cellular Component	GO:0009897	external side of plasma membrane	Il2rb	IDA		Mouse	PMID:15345225
Cellular Component	GO:0009897	external side of plasma membrane	Il2rb	IDA		Mouse	PMID:8262055
Cellular Component	GO:0009897	external side of plasma membrane	Il2rb	IDA		Mouse	PMID:9841920
Cellular Component	GO:0009897	external side of plasma membrane	Il2rb	IDA		Mouse	PMID:23034280
Cellular Component	GO:0009897	external side of plasma membrane	Il2rb	IDA		Mouse	PMID:17082577
Cellular Component	GO:0009897	external side of plasma membrane	Il2rb	IDA		Mouse	PMID:16227984
Cellular Component	GO:0016020	membrane	IL2RB	HDA		Human	PMID:19946888
Cellular Component	GO:0005886	plasma membrane	IL2RB	IMP		Human	PMID:31040184
Cellular Component	GO:0005886	plasma membrane	IL2RB	IMP		Human	PMID:31040185
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IL2RB	IDA		Human	PMID:7736574
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Il2rb	IEP		Rat	PMID:1889461|RGD:728928
Biological Process	GO:0035723	interleukin-15-mediated signaling pathway	IL2RB	IMP		Human	PMID:15123770
Biological Process	GO:0035723	interleukin-15-mediated signaling pathway	IL2RB	IMP		Human	PMID:31040184
Biological Process	GO:0038110	interleukin-2-mediated signaling pathway	IL2RB	IMP		Human	PMID:31040184
Biological Process	GO:0038110	interleukin-2-mediated signaling pathway	IL2RB	IDA		Human	PMID:7973659
Biological Process	GO:0030101	natural killer cell activation	Il2rb	IMP		Rat	PMID:1469024|RGD:2303496
Biological Process	GO:0043066	negative regulation of apoptotic process	IL2RB	IDA		Human	PMID:7736574
Biological Process	GO:0050766	positive regulation of phagocytosis	IL2RB	IMP		Human	PMID:15123770

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern