Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL2RG
  • Mouse genes Il2rg
  • Rat genes Il2rg
  • Zfish genes il2rga,il2rgb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il2rg

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015026	coreceptor activity	IL2RG	IDA		Human	PMID:18829468
Molecular Function	GO:0015026	coreceptor activity	IL2RG	IDA		Human	PMID:7568005
Molecular Function	GO:0015026	coreceptor activity	IL2RG	IDA		Human	PMID:8026467
Molecular Function	GO:0015026	coreceptor activity	IL2RG	IDA		Human	PMID:8624802
Molecular Function	GO:0042010	interleukin-15 receptor activity	IL2RG	IDA		Human	PMID:15123770
Molecular Function	GO:0019976	interleukin-2 binding	Il2rg	IPI	PR:P04351	Mouse	PMID:8262055
Molecular Function	GO:0005515	protein binding	IL2RG	IPI	UniProtKB:Q9HBE4	Human	PMID:12504082
Molecular Function	GO:0005515	protein binding	IL2RG	IPI	UniProtKB:Q7Z3S9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	IL2RG	IPI	UniProtKB:Q7Z3S9	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	IL2RG	IPI	UniProtKB:P60410	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IL2RG	IPI	UniProtKB:Q6L8G8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IL2RG	IPI	UniProtKB:P13232	Human	PMID:8266077
Cellular Component	GO:0009986	cell surface	IL2RG	IDA		Human	PMID:15123770
Cellular Component	GO:0005783	endoplasmic reticulum	IL2RG	IDA		Human	GO_REF:0000052
Cellular Component	GO:0009897	external side of plasma membrane	Il2rg	IDA		Mouse	PMID:8262055
Cellular Component	GO:0016020	membrane	IL2RG	HDA		Human	PMID:19946888
Cellular Component	GO:0005654	nucleoplasm	IL2RG	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	IL2RG	IDA		Human	PMID:18829468
Cellular Component	GO:0005886	plasma membrane	IL2RG	IDA		Human	PMID:8524310
Cellular Component	GO:0005886	plasma membrane	IL2RG	IDA		Human	GO_REF:0000052
Biological Process	GO:0030183	B cell differentiation	Il2rg	IMP	MGI:MGI:2429736	Mouse	PMID:9252128
Biological Process	GO:0002361	CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	Il2rg	IMP	MGI:MGI:1857455	Mouse	PMID:16227984
Biological Process	GO:0010467	gene expression	Il2rg	IMP	MGI:MGI:2429736	Mouse	PMID:18958875
Biological Process	GO:0035723	interleukin-15-mediated signaling pathway	IL2RG	IMP		Human	PMID:15123770
Biological Process	GO:0038110	interleukin-2-mediated signaling pathway	IL2RG	IDA		Human	PMID:7568005
Biological Process	GO:0038113	interleukin-9-mediated signaling pathway	IL2RG	IDA		Human	PMID:18829468
Biological Process	GO:0030098	lymphocyte differentiation	Il2rg	IMP	MGI:MGI:5544783	Mouse	PMID:23918385
Biological Process	GO:0030098	lymphocyte differentiation	il2rga	IMP	ZFIN:ZDB-MRPHLNO-160527-1	Zfish	PMID:26590317
Biological Process	GO:0030098	lymphocyte differentiation	il2rga	IMP	ZFIN:ZDB-GENO-170105-6	Zfish	PMID:26590317
Biological Process	GO:0030098	lymphocyte differentiation	il2rga	IMP	ZFIN:ZDB-MRPHLNO-160527-2	Zfish	PMID:26590317
Biological Process	GO:0002335	mature B cell differentiation	Il2rg	IMP	MGI:MGI:5544783	Mouse	PMID:23918385
Biological Process	GO:0045579	positive regulation of B cell differentiation	Il2rg	IMP	MGI:MGI:2429736	Mouse	PMID:9252128
Biological Process	GO:0045579	positive regulation of B cell differentiation	Il2rg	IMP	MGI:MGI:5544783	Mouse	PMID:23918385
Biological Process	GO:0032831	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	Il2rg	IMP	MGI:MGI:1857455	Mouse	PMID:16227984
Biological Process	GO:0010628	positive regulation of gene expression	Il2rg	IMP	MGI:MGI:2429736	Mouse	PMID:18958875
Biological Process	GO:0050766	positive regulation of phagocytosis	IL2RG	IMP		Human	PMID:15123770
Biological Process	GO:0033089	positive regulation of T cell differentiation in thymus	Il2rg	IMP	MGI:MGI:1857455	Mouse	PMID:9916699
Biological Process	GO:0033089	positive regulation of T cell differentiation in thymus	Il2rg	IMP	MGI:MGI:2429736	Mouse	PMID:9252128
Biological Process	GO:0010468	regulation of gene expression	Il2rg	IMP	MGI:MGI:1857455	Mouse	PMID:9916699
Biological Process	GO:0033077	T cell differentiation in thymus	Il2rg	IMP	MGI:MGI:2429736	Mouse	PMID:9252128
Biological Process	GO:0033077	T cell differentiation in thymus	Il2rg	IMP	MGI:MGI:1857455	Mouse	PMID:9916699

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern