Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL33
  • Mouse genes Il33
  • Rat genes Il33
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il33

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	IL33	IDA		Human	PMID:19841166
Molecular Function	GO:0005125	cytokine activity	Il33	IDA		Mouse	MGI:MGI:4430159|PMID:19841166
Molecular Function	GO:0005125	cytokine activity	Il33	IDA		Mouse	PMID:28811323
Molecular Function	GO:0005125	cytokine activity	Il33	IDA		Mouse	PMID:27830702
Molecular Function	GO:0005125	cytokine activity	Il33	IPI	PR:P14719-2	Mouse	PMID:17623648
Molecular Function	GO:0005125	cytokine activity	Il33	IPI	PR:P14719-1	Mouse	PMID:17623648
Molecular Function	GO:0002112	interleukin-33 receptor binding	Il33	IPI	UniProtKB:P14719	Mouse	MGI:MGI:6141045|PMID:29045903
Molecular Function	GO:0005515	protein binding	IL33	IPI	UniProtKB:Q01638	Human	PMID:16286016
Molecular Function	GO:0005515	protein binding	IL33	IPI	UniProtKB:P0C0S8	Human	PMID:18688256
Molecular Function	GO:0005515	protein binding	IL33	IPI	UniProtKB:A0A3P7XL18	Human	PMID:29045903
Molecular Function	GO:0005515	protein binding	Il33	IPI	UniProtKB:A0A3P7XL18	Mouse	MGI:MGI:6141045|PMID:29045903
Molecular Function	GO:0005515	protein binding	Il33	IPI	RGD:1322462	Rat	PMID:17492053|RGD:40813740
Cellular Component	GO:0005737	cytoplasm	IL33	IDA		Human	PMID:22215666
Cellular Component	GO:0005615	extracellular space	Il33	IDA		Mouse	PMID:28811323
Cellular Component	GO:0005615	extracellular space	Il33	IDA		Mouse	PMID:27830702
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IL33	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	IL33	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	IL33	IDA		Human	PMID:18787100
Cellular Component	GO:0005634	nucleus	IL33	IDA		Human	PMID:18836528
Cellular Component	GO:0005634	nucleus	IL33	IDA		Human	PMID:21357533
Cellular Component	GO:0005634	nucleus	IL33	IDA		Human	PMID:22215666
Cellular Component	GO:0005634	nucleus	Il33	IDA		Mouse	MGI:MGI:6141045|PMID:29045903
Cellular Component	GO:0005634	nucleus	Il33	IDA		Rat	PMID:31165473|RGD:40400907
Biological Process	GO:0071260	cellular response to mechanical stimulus	Il33	IEP		Rat	PMID:17492053|RGD:40813740
Biological Process	GO:0032602	chemokine production	Il33	IDA		Mouse	PMID:32144162
Biological Process	GO:0001816	cytokine production	Il33	IDA		Mouse	PMID:32144162
Biological Process	GO:0051607	defense response to virus	Il33	IDA		Mouse	PMID:23630360
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	Il33	IGI	MGI:MGI:99695	Mouse	PMID:22660580
Biological Process	GO:0010467	gene expression	Il33	IDA		Mouse	PMID:32144162
Biological Process	GO:0010467	gene expression	Il33	IDA		Mouse	PMID:19666510
Biological Process	GO:0038172	interleukin-33-mediated signaling pathway	Il33	IDA		Mouse	MGI:MGI:6414704|PMID:26936882
Biological Process	GO:0002281	macrophage activation involved in immune response	Il33	IDA		Mouse	MGI:MGI:5751675|PMID:21494550
Biological Process	GO:0030225	macrophage differentiation	Il33	IDA		Mouse	MGI:MGI:6856556|PMID:34644537
Biological Process	GO:0002282	microglial cell activation involved in immune response	Il33	IDA		Mouse	MGI:MGI:5008219|PMID:21349253
Biological Process	GO:0061518	microglial cell proliferation	Il33	IDA		Mouse	MGI:MGI:5008219|PMID:21349253
Biological Process	GO:0002638	negative regulation of immunoglobulin production	Il33	IGI	UniProtKB:P08226	Mouse	MGI:MGI:3775141|PMID:18268038
Biological Process	GO:0106015	negative regulation of inflammatory response to wounding	Il33	IDA		Mouse	PMID:27830702
Biological Process	GO:0002686	negative regulation of leukocyte migration	Il33	IGI	UniProtKB:P08226	Mouse	MGI:MGI:3775141|PMID:18268038
Biological Process	GO:0120042	negative regulation of macrophage proliferation	Il33	IDA		Mouse	MGI:MGI:6414704|PMID:26936882
Biological Process	GO:0002826	negative regulation of T-helper 1 type immune response	Il33	IGI	UniProtKB:P08226	Mouse	MGI:MGI:3775141|PMID:18268038
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IL33	IMP		Human	PMID:17185418
Biological Process	GO:0032689	negative regulation of type II interferon production	Il33	IGI	UniProtKB:P08226	Mouse	MGI:MGI:3775141|PMID:18268038
Biological Process	GO:0150145	positive regulation of CD80 production	Il33	IDA		Mouse	MGI:MGI:6414704|PMID:26936882
Biological Process	GO:0150142	positive regulation of CD86 production	Il33	IDA		Mouse	MGI:MGI:6414704|PMID:26936882
Biological Process	GO:0010186	positive regulation of cellular defense response	Il33	IMP		Mouse	MGI:MGI:6414704|PMID:26936882
Biological Process	GO:0032722	positive regulation of chemokine production	IL33	IDA		Human	PMID:19841166
Biological Process	GO:0032722	positive regulation of chemokine production	Il33	IDA		Mouse	MGI:MGI:4430159|PMID:19841166
Biological Process	GO:0010628	positive regulation of gene expression	Il33	IDA		Mouse	MGI:MGI:6414704|PMID:26936882
Biological Process	GO:0010628	positive regulation of gene expression	Il33	IDA		Mouse	PMID:19666510
Biological Process	GO:0002639	positive regulation of immunoglobulin production	Il33	IGI	UniProtKB:P08226	Mouse	MGI:MGI:3775141|PMID:18268038
Biological Process	GO:0050729	positive regulation of inflammatory response	Il33	IDA		Mouse	MGI:MGI:4430159|PMID:19841166
Biological Process	GO:0032736	positive regulation of interleukin-13 production	Il33	IGI	UniProtKB:P08226	Mouse	MGI:MGI:3775141|PMID:18268038
Biological Process	GO:0032753	positive regulation of interleukin-4 production	Il33	IGI	UniProtKB:P08226	Mouse	MGI:MGI:3775141|PMID:18268038
Biological Process	GO:0032754	positive regulation of interleukin-5 production	Il33	IGI	UniProtKB:P08226	Mouse	MGI:MGI:3775141|PMID:18268038
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Il33	IGI	UniProtKB:P08226	Mouse	MGI:MGI:3775141|PMID:18268038
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Il33	IDA		Mouse	MGI:MGI:6414704|PMID:26936882
Biological Process	GO:0043032	positive regulation of macrophage activation	IL33	IDA		Human	PMID:19841166
Biological Process	GO:0043032	positive regulation of macrophage activation	Il33	IDA		Mouse	MGI:MGI:4430159|PMID:19841166
Biological Process	GO:0043032	positive regulation of macrophage activation	Il33	IDA		Mouse	MGI:MGI:6414704|PMID:26936882
Biological Process	GO:0045345	positive regulation of MHC class I biosynthetic process	Il33	IDA		Mouse	MGI:MGI:6414704|PMID:26936882
Biological Process	GO:0045348	positive regulation of MHC class II biosynthetic process	Il33	IDA		Mouse	MGI:MGI:6414704|PMID:26936882
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	Il33	IDA		Mouse	MGI:MGI:6414704|PMID:26936882
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	Il33	IMP		Rat	PMID:31165473|RGD:40400907
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Il33	IDA		Mouse	PMID:22660580
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Il33	IGI	MGI:MGI:1861437	Mouse	PMID:22660580
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Il33	IGI	MGI:MGI:3039600	Mouse	PMID:22660580
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Il33	IDA		Mouse	MGI:MGI:4430159|PMID:19841166
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Il33	IDA		Mouse	MGI:MGI:6414704|PMID:26936882
Biological Process	GO:0002830	positive regulation of type 2 immune response	Il33	IGI	UniProtKB:P08226	Mouse	MGI:MGI:3775141|PMID:18268038
Biological Process	GO:0002830	positive regulation of type 2 immune response	Il33	IDA		Mouse	PMID:23630360
Biological Process	GO:0006606	protein import into nucleus	Il33	IDA		Mouse	PMID:32144162
Biological Process	GO:0051930	regulation of sensory perception of pain	Il33	IMP		Rat	PMID:29329586|RGD:40400909
Biological Process	GO:0007165	signal transduction	Il33	IPI	PR:P14719-1	Mouse	MGI:MGI:3723275|PMID:17623648
Biological Process	GO:0042092	type 2 immune response	Il33	IDA		Mouse	PMID:23630360
Biological Process	GO:0042060	wound healing	Il33	IEP		Rat	PMID:21037074|RGD:40813742

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern