Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL4
  • Mouse genes Il4
  • Rat genes Il4
  • Zfish genes il4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	IL4	IDA		Human	PMID:10219247
Molecular Function	GO:0005125	cytokine activity	Il4	IDA		Mouse	PMID:10549626
Molecular Function	GO:0005125	cytokine activity	Il4	IDA		Mouse	PMID:11027433
Molecular Function	GO:0005125	cytokine activity	Il4	IDA		Mouse	PMID:10485657
Molecular Function	GO:0005125	cytokine activity	Il4	IDA		Mouse	PMID:10979977
Molecular Function	GO:0005125	cytokine activity	Il4	IDA		Mouse	PMID:1588041
Molecular Function	GO:0005125	cytokine activity	Il4	IDA		Mouse	PMID:9841920
Molecular Function	GO:0005515	protein binding	IL4	IPI	UniProtKB:P24394	Human	PMID:10219247
Molecular Function	GO:0005515	protein binding	IL4	IPI	UniProtKB:P24394	Human	PMID:18243101
Molecular Function	GO:0005515	protein binding	IL4	IPI	UniProtKB:P78552	Human	PMID:18243101
Molecular Function	GO:0005515	protein binding	IL4	IPI	UniProtKB:P24394	Human	PMID:23597562
Molecular Function	GO:0005515	protein binding	IL4	IPI	UniProtKB:P24394	Human	PMID:8266078
Cellular Component	GO:0009897	external side of plasma membrane	Il4	IDA		Mouse	PMID:19666510
Cellular Component	GO:0009897	external side of plasma membrane	Il4	IDA		Mouse	PMID:20399120
Cellular Component	GO:0009897	external side of plasma membrane	Il4	IDA		Mouse	PMID:20956546
Cellular Component	GO:0009897	external side of plasma membrane	Il4	IDA		Mouse	PMID:21217760
Cellular Component	GO:0009897	external side of plasma membrane	Il4	IDA		Mouse	PMID:21613615
Cellular Component	GO:0005615	extracellular space	IL4	IDA		Human	PMID:3279117
Cellular Component	GO:0005615	extracellular space	Il4	IDA		Mouse	PMID:19139201
Cellular Component	GO:0005615	extracellular space	Il4	IDA		Mouse	PMID:21460847
Cellular Component	GO:0005615	extracellular space	Il4	IDA		Mouse	PMID:17082577
Cellular Component	GO:0005615	extracellular space	Il4	IDA		Mouse	PMID:17277142
Cellular Component	GO:0005615	extracellular space	Il4	IDA		Mouse	PMID:11894098
Cellular Component	GO:0005615	extracellular space	Il4	IDA		Mouse	PMID:16769892
Cellular Component	GO:0005615	extracellular space	Il4	IDA		Mouse	PMID:15087456
Cellular Component	GO:0005615	extracellular space	Il4	IDA		Mouse	PMID:16275384
Cellular Component	GO:0005615	extracellular space	Il4	IDA		Mouse	PMID:11057672
Cellular Component	GO:0005615	extracellular space	Il4	IDA		Rat	PMID:18557728|RGD:2317286
Biological Process	GO:0050798	activated T cell proliferation	Il4	IDA		Mouse	PMID:10485657
Biological Process	GO:0050798	activated T cell proliferation	Il4	IDA		Mouse	PMID:9841920
Biological Process	GO:0042976	activation of Janus kinase activity	IL4	IGI	UniProtKB:P08575	Human	PMID:12574355
Biological Process	GO:0042113	B cell activation	Il4	IDA		Mouse	PMID:8566034
Biological Process	GO:0031296	B cell costimulation	Il4	IDA		Mouse	PMID:18762567
Biological Process	GO:0042100	B cell proliferation	Il4	IDA		Mouse	PMID:14607964
Biological Process	GO:0042100	B cell proliferation	Il4	IDA		Mouse	PMID:10979977
Biological Process	GO:0042100	B cell proliferation	il4	IDA		Zfish	PMID:22547699
Biological Process	GO:0071288	cellular response to mercury ion	Il4	IEP		Rat	PMID:19604304|RGD:2317279
Biological Process	GO:0071288	cellular response to mercury ion	Il4	IEP		Rat	PMID:7657819|RGD:2317674
Biological Process	GO:0008203	cholesterol metabolic process	Il4	IMP		Mouse	MGI:MGI:2178917|PMID:11971948
Biological Process	GO:0042832	defense response to protozoan	Il4	IMP		Mouse	PMID:7927664
Biological Process	GO:0097028	dendritic cell differentiation	IL4	IDA		Human	PMID:21149635
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	Il4	IDA		Mouse	PMID:10429671
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Il4	IDA		Mouse	PMID:12115603
Biological Process	GO:0007565	female pregnancy	Il4	IEP		Rat	PMID:19617880|RGD:2317272
Biological Process	GO:0002227	innate immune response in mucosa	Il4	IDA		Mouse	MGI:MGI:5009207|PMID:9973465
Biological Process	GO:0035771	interleukin-4-mediated signaling pathway	IL4	IDA		Human	PMID:10219247
Biological Process	GO:0048289	isotype switching to IgE isotypes	Il4	IDA		Mouse	PMID:14988498
Biological Process	GO:0048291	isotype switching to IgG isotypes	Il4	IDA		Mouse	PMID:14988498
Biological Process	GO:0042116	macrophage activation	IL4	IGI	UniProtKB:P35225	Human	PMID:30634164
Biological Process	GO:0045342	MHC class II biosynthetic process	Il4	IDA		Mouse	PMID:10549626
Biological Process	GO:0001774	microglial cell activation	Il4	IDA		Rat	PMID:23786632|RGD:8142387
Biological Process	GO:0043011	myeloid dendritic cell differentiation	IL4	IDA		Human	PMID:16116184
Biological Process	GO:0002674	negative regulation of acute inflammatory response	Il4	IDA		Rat	PMID:17250684|RGD:2317298
Biological Process	GO:1903845	negative regulation of cellular response to transforming growth factor beta stimulus	IL4	IDA		Human	PMID:11967989
Biological Process	GO:0002677	negative regulation of chronic inflammatory response	Il4	IDA		Rat	PMID:16869003|RGD:2317300
Biological Process	GO:1903660	negative regulation of complement-dependent cytotoxicity	IL4	IMP		Human	PMID:16034134
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IL4	IDA		Human	PMID:16606666
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IL4	IDA		Human	PMID:18579517
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	IL4	IMP		Human	PMID:16034134
Biological Process	GO:0010633	negative regulation of epithelial cell migration	IL4	IDA		Human	PMID:11698262
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	Il4	IDA		Mouse	PMID:10429671
Biological Process	GO:0050728	negative regulation of inflammatory response	IL4	IGI	UniProtKB:P35225	Human	PMID:30634164
Biological Process	GO:0050728	negative regulation of inflammatory response	il4	IGI	ZFIN:ZDB-GENO-211020-1,ZFIN:ZDB-GENO-211021-1	Zfish	PMID:32641385
Biological Process	GO:0050728	negative regulation of inflammatory response	il4	IMP	ZFIN:ZDB-GENO-211020-2	Zfish	PMID:32641385
Biological Process	GO:0043031	negative regulation of macrophage activation	Il4	IMP		Rat	PMID:20623539|RGD:5128562
Biological Process	GO:0045019	negative regulation of nitric oxide biosynthetic process	Il4	IDA		Rat	PMID:18182309|RGD:2317291
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	Il4	IDA		Mouse	PMID:12941478
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	Il4	IDA		Mouse	PMID:17442941
Biological Process	GO:0050868	negative regulation of T cell activation	Il4	IDA		Mouse	PMID:18997793
Biological Process	GO:2000320	negative regulation of T-helper 17 cell differentiation	Il4	IDA		Mouse	PMID:18792410
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IL4	IDA		Human	PMID:11967989
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Il4	IDA		Mouse	MGI:MGI:6304699|PMID:29061364
Biological Process	GO:0070351	negative regulation of white fat cell proliferation	Il4	IDA		Mouse	MGI:MGI:5562974|PMID:24347527
Biological Process	GO:0150076	neuroinflammatory response	Il4	IDA		Rat	PMID:27235345|RGD:14401572
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Il4	IDA		Mouse	PMID:8022486
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	Il4	IDA		Mouse	PMID:9841920
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	Il4	IDA		Mouse	PMID:10485657
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	Il4	IDA		Mouse	MGI:MGI:6272248|PMID:18941241
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	Il4	IDA		Rat	PMID:18941241|RGD:13825436
Biological Process	GO:2001171	positive regulation of ATP biosynthetic process	Il4	IDA		Mouse	MGI:MGI:6304699|PMID:29061364
Biological Process	GO:0050871	positive regulation of B cell activation	Il4	IDA		Mouse	PMID:8566034
Biological Process	GO:0050871	positive regulation of B cell activation	Il4	IDA		Mouse	PMID:16129705
Biological Process	GO:0050871	positive regulation of B cell activation	Il4	IDA		Mouse	PMID:9798653
Biological Process	GO:0030890	positive regulation of B cell proliferation	Il4	IDA		Mouse	PMID:10979977
Biological Process	GO:0030890	positive regulation of B cell proliferation	Il4	IDA		Mouse	PMID:14607964
Biological Process	GO:0030335	positive regulation of cell migration	IL4	IGI	RNAcentral:URS00003CF1AD_9606	Human	PMID:31432141
Biological Process	GO:0008284	positive regulation of cell population proliferation	IL4	IGI	RNAcentral:URS00003CF1AD_9606	Human	PMID:31432141
Biological Process	GO:0008284	positive regulation of cell population proliferation	Il4	IDA		Rat	PMID:17125592|RGD:2317299
Biological Process	GO:1901857	positive regulation of cellular respiration	Il4	IDA		Mouse	MGI:MGI:6304699|PMID:29061364
Biological Process	GO:0032722	positive regulation of chemokine production	Il4	IDA		Mouse	MGI:MGI:85739|PMID:9013979
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Il4	IMP		Mouse	MGI:MGI:5603000|PMID:24906148
Biological Process	GO:0002230	positive regulation of defense response to virus by host	Il4	IDA		Rat	PMID:9721086|RGD:8142392
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	Il4	IDA		Mouse	MGI:MGI:74350|PMID:7749983
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IL4	IDA		Human	PMID:18579517
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IL4	IDA		Human	PMID:19346497
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IL4	IDA		Human	PMID:20554961
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Il4	IDA		Mouse	MGI:MGI:5285154|PMID:20696860
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Il4	IDA		Mouse	MGI:MGI:74350|PMID:7749983
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Il4	IDA		Rat	PMID:11572871|RGD:70786
Biological Process	GO:2000424	positive regulation of eosinophil chemotaxis	Il4	IDA		Rat	PMID:11071660|RGD:4145480
Biological Process	GO:0010628	positive regulation of gene expression	IL4	IGI	UniProtKB:P08575|UniProtKB:P29965|UniProtKB:P42226	Human	PMID:12574355
Biological Process	GO:0010628	positive regulation of gene expression	Il4	IDA		Mouse	MGI:MGI:6304699|PMID:29061364
Biological Process	GO:0010628	positive regulation of gene expression	Il4	IDA		Rat	PMID:18941241|RGD:13825436
Biological Process	GO:0010628	positive regulation of gene expression	Il4	IDA		Rat	PMID:27235345|RGD:14401572
Biological Process	GO:0002639	positive regulation of immunoglobulin production	Il4	IGI	MGI:MGI:96541	Mouse	PMID:15944273
Biological Process	GO:0002639	positive regulation of immunoglobulin production	Il4	IMP	MGI:MGI:1857195	Mouse	PMID:15944273
Biological Process	GO:0032733	positive regulation of interleukin-10 production	IL4	IGI	UniProtKB:P35225	Human	PMID:30634164
Biological Process	GO:0032733	positive regulation of interleukin-10 production	Il4	IDA		Rat	PMID:17125592|RGD:2317299
Biological Process	GO:0032736	positive regulation of interleukin-13 production	IL4	IDA		Human	PMID:19346497
Biological Process	GO:0048295	positive regulation of isotype switching to IgE isotypes	Il4	IDA		Mouse	PMID:14988498
Biological Process	GO:0048304	positive regulation of isotype switching to IgG isotypes	Il4	IDA		Mouse	PMID:12882831
Biological Process	GO:0048304	positive regulation of isotype switching to IgG isotypes	Il4	IDA		Mouse	PMID:14988498
Biological Process	GO:0016239	positive regulation of macroautophagy	Il4	IDA		Mouse	MGI:MGI:5702366|PMID:26416964
Biological Process	GO:0043306	positive regulation of mast cell degranulation	Il4	IMP	MGI:MGI:1857195	Mouse	PMID:15944273
Biological Process	GO:0043306	positive regulation of mast cell degranulation	Il4	IGI	MGI:MGI:96541	Mouse	PMID:15944273
Biological Process	GO:0045348	positive regulation of MHC class II biosynthetic process	Il4	IDA		Mouse	PMID:11027433
Biological Process	GO:0045348	positive regulation of MHC class II biosynthetic process	Il4	IDA		Mouse	PMID:10549626
Biological Process	GO:0071677	positive regulation of mononuclear cell migration	Il4	IDA		Rat	PMID:11071660|RGD:4145480
Biological Process	GO:1901741	positive regulation of myoblast fusion	Il4	IMP	MGI:MGI:1857194	Mouse	PMID:12757709
Biological Process	GO:1901741	positive regulation of myoblast fusion	Il4	IDA		Mouse	PMID:12757709
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Il4	IDA		Mouse	PMID:8022486
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Il4	IDA		Mouse	PMID:12115603
Biological Process	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	Il4	IDA		Rat	PMID:24073824|RGD:10402792
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	Il4	IDA		Mouse	MGI:MGI:6272248|PMID:18941241
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	Il4	IDA		Rat	PMID:18941241|RGD:13825436
Biological Process	GO:0045582	positive regulation of T cell differentiation	IL4	IDA		Human	PMID:20554961
Biological Process	GO:0042102	positive regulation of T cell proliferation	Il4	IDA		Mouse	PMID:1588041
Biological Process	GO:0042102	positive regulation of T cell proliferation	Il4	IDA		Mouse	PMID:18997793
Biological Process	GO:2000553	positive regulation of T-helper 2 cell cytokine production	IL4	IDA		Human	PMID:20554961
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Il4	IDA		Mouse	MGI:MGI:3044839|PMID:15187136
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Il4	IGI	MGI:MGI:103034	Mouse	PMID:9110977
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Il4	IDA		Mouse	PMID:8200916
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Il4	IDA		Mouse	PMID:16493007
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Il4	IDA		Mouse	PMID:18997793
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Il4	IDA		Mouse	PMID:1588041
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IL4	IGI	UniProtKB:P08575	Human	PMID:12574355
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	Il4	IDA		Mouse	PMID:10485657
Biological Process	GO:0050776	regulation of immune response	Il4	IDA		Mouse	PMID:12882831
Biological Process	GO:0050727	regulation of inflammatory response	Il4	IDA		Rat	PMID:17442043|RGD:2317297
Biological Process	GO:0010155	regulation of proton transport	Il4	IDA		Rat	PMID:11739109|RGD:2290361
Biological Process	GO:0034097	response to cytokine	Il4	IEP		Rat	PMID:18231731|RGD:2317289
Biological Process	GO:0045471	response to ethanol	Il4	IEP		Rat	PMID:20116195|RGD:2317269
Biological Process	GO:0007584	response to nutrient	Il4	IEP		Rat	PMID:19608731|RGD:5128779
Biological Process	GO:0014070	response to organic cyclic compound	Il4	IEP		Rat	PMID:18499367|RGD:2317287
Biological Process	GO:0009410	response to xenobiotic stimulus	Il4	IEP		Rat	PMID:18953683|RGD:2317283
Biological Process	GO:0060041	retina development in camera-type eye	Il4	IEP		Rat	PMID:23070471|RGD:7829830
Biological Process	GO:0007165	signal transduction	Il4	IDA		Mouse	MGI:MGI:3033882|PMID:11027433
Biological Process	GO:0042110	T cell activation	IL4	IGI	UniProtKB:P10747	Human	PMID:18337562
Biological Process	GO:0042098	T cell proliferation	Il4	IDA		Mouse	PMID:1588041
Biological Process	GO:0002296	T-helper 1 cell lineage commitment	Il4	IGI	MGI:MGI:103034	Mouse	PMID:20706986
Biological Process	GO:0035745	T-helper 2 cell cytokine production	il4	IDA		Zfish	PMID:22547699
Biological Process	GO:0045064	T-helper 2 cell differentiation	Il4	IDA		Mouse	PMID:20706986
Biological Process	GO:0006366	transcription by RNA polymerase II	Il4	IDA		Mouse	PMID:8200916
Biological Process	GO:0006366	transcription by RNA polymerase II	Il4	IDA		Mouse	PMID:16493007
Biological Process	GO:0006366	transcription by RNA polymerase II	Il4	IDA		Mouse	PMID:1588041
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	Il4	IDA		Mouse	PMID:10485657

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern