Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL4R
  • Mouse genes Il4ra
  • Rat genes Il4r
  • Zfish genes il4r.1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il4ra

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019979	interleukin-4 binding	il4r.1	IDA		Zfish	PMID:22547699
Molecular Function	GO:0004913	interleukin-4 receptor activity	IL4R	IDA		Human	PMID:10219247
Molecular Function	GO:0005515	protein binding	IL4R	IPI	UniProtKB:P05112	Human	PMID:10219247
Molecular Function	GO:0005515	protein binding	IL4R	IPI	UniProtKB:P05112	Human	PMID:18243101
Molecular Function	GO:0005515	protein binding	IL4R	IPI	UniProtKB:P05112	Human	PMID:23597562
Molecular Function	GO:0005515	protein binding	IL4R	IPI	UniProtKB:P05112	Human	PMID:8266078
Molecular Function	GO:0005515	protein binding	IL4R	IPI	UniProtKB:P42226	Human	PMID:8816495
Molecular Function	GO:0005515	protein binding	IL4R	IPI	UniProtKB:P42226	Human	PMID:9392697
Molecular Function	GO:0005515	protein binding	IL4R	IPI	UniProtKB:P42226	Human	PMID:9651359
Molecular Function	GO:0005515	protein binding	Il4ra	IPI	UniProtKB:O54928	Mouse	MGI:MGI:3687909|PMID:12242343
Cellular Component	GO:0034451	centriolar satellite	IL4R	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005615	extracellular space	Il4r	IDA		Rat	PMID:10525162|RGD:633123
Cellular Component	GO:0005654	nucleoplasm	IL4R	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	IL4R	IDA		Human	PMID:23321270
Cellular Component	GO:0005886	plasma membrane	IL4R	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	il4r.1	IDA		Zfish	PMID:22547699
Cellular Component	GO:0043235	receptor complex	IL4R	IDA		Human	PMID:23382219
Biological Process	GO:0042832	defense response to protozoan	Il4ra	IMP		Mouse	PMID:7927664
Biological Process	GO:0016064	immunoglobulin mediated immune response	Il4ra	IMP	MGI:MGI:1861951	Mouse	PMID:15944273
Biological Process	GO:0035771	interleukin-4-mediated signaling pathway	IL4R	IDA		Human	PMID:10219247
Biological Process	GO:0045626	negative regulation of T-helper 1 cell differentiation	Il4ra	IGI	MGI:MGI:96109	Mouse	PMID:16424184
Biological Process	GO:0022008	neurogenesis	il4r.1	IMP	ZFIN:ZDB-MRPHLNO-161221-1	Zfish	PMID:27760324
Biological Process	GO:0030728	ovulation	Il4r	IEP		Rat	PMID:11420249|RGD:4889984
Biological Process	GO:0032722	positive regulation of chemokine production	Il4ra	IMP		Mouse	MGI:MGI:4430159|PMID:19841166
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Il4ra	IMP		Mouse	MGI:MGI:5603000|PMID:24906148
Biological Process	GO:0002639	positive regulation of immunoglobulin production	Il4ra	IMP	MGI:MGI:1861951	Mouse	PMID:15944273
Biological Process	GO:0043032	positive regulation of macrophage activation	Il4ra	IMP		Mouse	MGI:MGI:4430159|PMID:19841166
Biological Process	GO:0043306	positive regulation of mast cell degranulation	Il4ra	IMP	MGI:MGI:1861951	Mouse	PMID:15944273
Biological Process	GO:1901741	positive regulation of myoblast fusion	Il4ra	IMP	MGI:MGI:1861951	Mouse	PMID:12757709
Biological Process	GO:0045630	positive regulation of T-helper 2 cell differentiation	Il4ra	IGI	MGI:MGI:96109	Mouse	PMID:16424184
Biological Process	GO:0031099	regeneration	il4r.1	IMP	ZFIN:ZDB-MRPHLNO-161221-1	Zfish	PMID:27760324
Biological Process	GO:0042127	regulation of cell population proliferation	Il4r	IDA		Rat	PMID:10525162|RGD:633123
Biological Process	GO:0043627	response to estrogen	Il4r	IEP		Rat	PMID:17652031|RGD:4889982
Biological Process	GO:1990834	response to odorant	Il4r	IEP		Rat	PMID:23103411|RGD:11530015
Biological Process	GO:0045063	T-helper 1 cell differentiation	Il4ra	IGI	MGI:MGI:96109	Mouse	PMID:16424184
Biological Process	GO:0045064	T-helper 2 cell differentiation	Il4ra	IGI	MGI:MGI:96109	Mouse	PMID:16424184

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern