Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL6R
  • Mouse genes Il6ra
  • Rat genes Il6r
  • Zfish genes il6r
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il6ra

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070119	ciliary neurotrophic factor binding	IL6R	IPI	UniProtKB:P26441	Human	PMID:12643274
Molecular Function	GO:0004897	ciliary neurotrophic factor receptor activity	IL6R	IMP		Human	PMID:12643274
Molecular Function	GO:0019899	enzyme binding	IL6R	IPI	UniProtKB:Q9NZ08	Human	PMID:12748171
Molecular Function	GO:0019981	interleukin-6 binding	IL6R	IPI	UniProtKB:P05231	Human	PMID:12829785
Molecular Function	GO:0004915	interleukin-6 receptor activity	IL6R	IDA		Human	PMID:2261637
Molecular Function	GO:0004915	interleukin-6 receptor activity	Il6ra	IDA		Mouse	MGI:MGI:6142555|PMID:27893700
Molecular Function	GO:0005138	interleukin-6 receptor binding	IL6R	IPI	UniProtKB:P40189	Human	PMID:12829785
Molecular Function	GO:0005515	protein binding	IL6R	IPI	UniProtKB:P05231	Human	PMID:11238858
Molecular Function	GO:0005515	protein binding	IL6R	IPI	UniProtKB:Q2HRC7	Human	PMID:11238858
Molecular Function	GO:0005515	protein binding	IL6R	IPI	UniProtKB:P05231	Human	PMID:12829785
Molecular Function	GO:0005515	protein binding	IL6R	IPI	UniProtKB:P78536	Human	PMID:16034137
Molecular Function	GO:0005515	protein binding	IL6R	IPI	UniProtKB:P05231	Human	PMID:18775332
Molecular Function	GO:0005515	protein binding	IL6R	IPI	UniProtKB:P05231	Human	PMID:28265003
Molecular Function	GO:0005515	protein binding	IL6R	IPI	UniProtKB:Q92673	Human	PMID:28265003
Molecular Function	GO:0005515	protein binding	IL6R	IPI	UniProtKB:Q96EQ0	Human	PMID:32296183
Molecular Function	GO:0042803	protein homodimerization activity	IL6R	IPI	UniProtKB:P08887	Human	PMID:12633863
Cellular Component	GO:0016324	apical plasma membrane	IL6R	IDA		Human	PMID:16034137
Cellular Component	GO:0070110	ciliary neurotrophic factor receptor complex	IL6R	IDA		Human	PMID:12643274
Cellular Component	GO:0005576	extracellular region	IL6R	IDA		Human	PMID:12748171
Cellular Component	GO:0005615	extracellular space	Il6r	IDA		Rat	PMID:11448096|RGD:1625446
Cellular Component	GO:0005896	interleukin-6 receptor complex	IL6R	IDA		Human	PMID:12829785
Cellular Component	GO:0005896	interleukin-6 receptor complex	IL6R	IDA		Human	PMID:2261637
Cellular Component	GO:0005896	interleukin-6 receptor complex	Il6ra	IDA		Mouse	MGI:MGI:6142555|PMID:27893700
Cellular Component	GO:0032809	neuronal cell body membrane	Il6r	IDA		Rat	PMID:8921254|RGD:5686896
Biological Process	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway	IL6R	IMP		Human	PMID:12643274
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IL6R	IDA		Human	PMID:2261637
Biological Process	GO:0048589	developmental growth	Il6r	IMP		Rat	PMID:23855552|RGD:10402824
Biological Process	GO:0031018	endocrine pancreas development	IL6R	IMP		Human	PMID:18719127
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	IL6R	IMP		Human	PMID:12643274
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	Il6ra	IDA		Mouse	MGI:MGI:6142555|PMID:27893700
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	Il6ra	IDA		Mouse	PMID:1312474
Biological Process	GO:0008284	positive regulation of cell population proliferation	IL6R	IMP		Human	PMID:18719127
Biological Process	GO:0008284	positive regulation of cell population proliferation	IL6R	IDA		Human	PMID:2261637
Biological Process	GO:0008284	positive regulation of cell population proliferation	Il6r	IMP		Rat	PMID:19961020|RGD:5128678
Biological Process	GO:0032722	positive regulation of chemokine production	IL6R	IDA		Human	PMID:10510402
Biological Process	GO:0072126	positive regulation of glomerular mesangial cell proliferation	IL6R	IMP		Human	PMID:26563755
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IL6R	IDA		Human	PMID:10510402
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	il6r	IMP	ZFIN:ZDB-GENO-220803-7	Zfish	PMID:33196024
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IL6R	IDA		Human	PMID:11884403
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	IL6R	IDA		Human	PMID:10510402
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IL6R	IMP		Human	PMID:12643274
Biological Process	GO:0051591	response to cAMP	Il6r	IEP		Rat	PMID:7814800|RGD:1625445
Biological Process	GO:0034097	response to cytokine	IL6R	IDA		Human	PMID:2261637
Biological Process	GO:0045471	response to ethanol	Il6r	IEP		Rat	PMID:15084893|RGD:1625438
Biological Process	GO:0010332	response to gamma radiation	Il6r	IEP		Rat	PMID:14751512|RGD:1625440
Biological Process	GO:0051384	response to glucocorticoid	Il6r	IEP		Rat	PMID:7814800|RGD:1625445
Biological Process	GO:0032496	response to lipopolysaccharide	Il6r	IEP		Rat	PMID:7814800|RGD:1625445
Biological Process	GO:0043434	response to peptide hormone	Il6r	IEP		Rat	PMID:11171594|RGD:1625448
Biological Process	GO:0072540	T-helper 17 cell lineage commitment	Il6ra	IDA		Mouse	MGI:MGI:6142555|PMID:27893700
Biological Process	GO:0010573	vascular endothelial growth factor production	IL6R	IDA		Human	PMID:12794819

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern