Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL6ST
  • Mouse genes Il6st
  • Rat genes Il6st
  • Zfish genes il6st
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il6st

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004897	ciliary neurotrophic factor receptor activity	IL6ST	IDA		Human	PMID:12643274
Molecular Function	GO:0005127	ciliary neurotrophic factor receptor binding	IL6ST	IPI	UniProtKB:P26992	Human	PMID:12707266
Molecular Function	GO:0015026	coreceptor activity	IL6ST	IDA		Human	PMID:8637716
Molecular Function	GO:0019838	growth factor binding	IL6ST	IPI	UniProtKB:P15018	Human	PMID:8999038
Molecular Function	GO:0019838	growth factor binding	IL6ST	IPI	UniProtKB:P13725	Human	PMID:8999038
Molecular Function	GO:0042802	identical protein binding	IL6ST	IPI	UniProtKB:P40189	Human	PMID:24501689
Molecular Function	GO:0019970	interleukin-11 binding	Il6st	IDA		Mouse	PMID:7957045
Molecular Function	GO:0004921	interleukin-11 receptor activity	Il6st	IDA		Mouse	PMID:7957045
Molecular Function	GO:0019981	interleukin-6 binding	IL6ST	IPI	UniProtKB:P05231	Human	PMID:12829785
Molecular Function	GO:0004915	interleukin-6 receptor activity	IL6ST	IDA		Human	PMID:12643274
Molecular Function	GO:0004915	interleukin-6 receptor activity	IL6ST	IDA		Human	PMID:2261637
Molecular Function	GO:0005138	interleukin-6 receptor binding	IL6ST	IPI	UniProtKB:P08887	Human	PMID:12829785
Molecular Function	GO:0004923	leukemia inhibitory factor receptor activity	IL6ST	IDA		Human	PMID:12643274
Molecular Function	GO:0004923	leukemia inhibitory factor receptor activity	IL6ST	IDA		Human	PMID:8999038
Molecular Function	GO:0004924	oncostatin-M receptor activity	IL6ST	IDA		Human	PMID:8999038
Molecular Function	GO:0005515	protein binding	IL6ST	IPI	UniProtKB:P42227	Human	PMID:10982829
Molecular Function	GO:0005515	protein binding	IL6ST	IPI	UniProtKB:Q2HRC7	Human	PMID:11238858
Molecular Function	GO:0005515	protein binding	IL6ST	IPI	UniProtKB:P15018	Human	PMID:14527405
Molecular Function	GO:0005515	protein binding	IL6ST	IPI	UniProtKB:P13725	Human	PMID:16051226
Molecular Function	GO:0005515	protein binding	IL6ST	IPI	UniProtKB:P15018	Human	PMID:16051226
Molecular Function	GO:0005515	protein binding	IL6ST	IPI	UniProtKB:P26441	Human	PMID:16051226
Molecular Function	GO:0005515	protein binding	IL6ST	IPI	UniProtKB:P26441	Human	PMID:18775332
Molecular Function	GO:0005515	protein binding	IL6ST	IPI	UniProtKB:Q9ULZ3	Human	PMID:24407287
Molecular Function	GO:0005515	protein binding	IL6ST	IPI	UniProtKB:Q99650	Human	PMID:24501689
Molecular Function	GO:0005515	protein binding	IL6ST	IPI	UniProtKB:P07947	Human	PMID:25731159
Molecular Function	GO:0005515	protein binding	IL6ST	IPI	UniProtKB:P12931	Human	PMID:25731159
Molecular Function	GO:0005515	protein binding	IL6ST	IPI	UniProtKB:P13725	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	IL6ST	IPI	UniProtKB:Q96EQ0	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	IL6ST	IPI	UniProtKB:O43765	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IL6ST	IPI	UniProtKB:P43364	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IL6ST	IPI	UniProtKB:Q96EQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IL6ST	IPI	UniProtKB:Q9NZI2-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IL6ST	IPI	UniProtKB:Q9Y2W7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IL6ST	IPI	UniProtKB:P42227	Human	PMID:8662591
Molecular Function	GO:0005515	protein binding	IL6ST	IPI	UniProtKB:P15018	Human	PMID:8999038
Molecular Function	GO:0005515	protein binding	Il6st	IPI	UniProtKB:O35718	Mouse	MGI:MGI:6695675|PMID:23454976
Molecular Function	GO:0005515	protein binding	Il6st	IPI	UniProtKB:O35718	Mouse	MGI:MGI:5512848|PMID:16905102
Molecular Function	GO:0005515	protein binding	Il6st	IPI	PR:P42703	Mouse	PMID:16452727
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	IL6ST	IDA		Human	PMID:12829785
Molecular Function	GO:0097110	scaffold protein binding	IL6ST	IPI	UniProtKB:P40763	Human	PMID:31145836
Cellular Component	GO:0044297	cell body	Il6st	IDA		Mouse	PMID:10989258
Cellular Component	GO:0070110	ciliary neurotrophic factor receptor complex	IL6ST	IDA		Human	PMID:12707266
Cellular Component	GO:0030425	dendrite	Il6st	IDA		Mouse	PMID:10989258
Cellular Component	GO:0009897	external side of plasma membrane	Il6st	IDA		Mouse	PMID:11275690
Cellular Component	GO:0070062	extracellular exosome	IL6ST	HDA		Human	PMID:23533145
Cellular Component	GO:0005896	interleukin-6 receptor complex	IL6ST	IDA		Human	PMID:12643274
Cellular Component	GO:0005896	interleukin-6 receptor complex	IL6ST	IDA		Human	PMID:12829785
Cellular Component	GO:0005896	interleukin-6 receptor complex	IL6ST	IDA		Human	PMID:2261637
Cellular Component	GO:0016020	membrane	IL6ST	HDA		Human	PMID:19946888
Cellular Component	GO:0045121	membrane raft	IL6ST	IDA		Human	PMID:31145836
Cellular Component	GO:0043025	neuronal cell body	Il6st	IDA		Mouse	PMID:10989258
Cellular Component	GO:0032809	neuronal cell body membrane	Il6st	IDA		Rat	PMID:8921254|RGD:5686896
Cellular Component	GO:0005900	oncostatin-M receptor complex	IL6ST	IDA		Human	PMID:8999038
Cellular Component	GO:0005886	plasma membrane	IL6ST	IDA		Human	PMID:19915009
Biological Process	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway	IL6ST	IDA		Human	PMID:12643274
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IL6ST	IDA		Human	PMID:2261637
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Il6st	IDA		Mouse	PMID:7957045
Biological Process	GO:0005977	glycogen metabolic process	Il6st	IMP	MGI:MGI:2176787	Mouse	PMID:10205167
Biological Process	GO:0038154	interleukin-11-mediated signaling pathway	IL6ST	IDA		Human	PMID:8637716
Biological Process	GO:0070106	interleukin-27-mediated signaling pathway	IL6ST	IMP		Human	PMID:14764690
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	IL6ST	IMP		Human	PMID:12643274
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	IL6ST	IDA		Human	PMID:12829785
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	IL6ST	IMP		Human	PMID:2261637
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	IL6ST	IDA		Human	PMID:25731159
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	Il6st	IDA		Mouse	MGI:MGI:5629863|PMID:25731159
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	Il6st	IMP		Rat	PMID:18280048|RGD:5686900
Biological Process	GO:0060576	intestinal epithelial cell development	IL6ST	IDA		Human	PMID:25731159
Biological Process	GO:0060576	intestinal epithelial cell development	Il6st	IDA		Mouse	MGI:MGI:5629863|PMID:25731159
Biological Process	GO:0048861	leukemia inhibitory factor signaling pathway	IL6ST	IDA		Human	PMID:12643274
Biological Process	GO:0048861	leukemia inhibitory factor signaling pathway	IL6ST	IDA		Human	PMID:8999038
Biological Process	GO:0051481	negative regulation of cytosolic calcium ion concentration	Il6st	IMP		Rat	PMID:17437036|RGD:1626700
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IL6ST	IMP		Human	PMID:19386761
Biological Process	GO:0038165	oncostatin-M-mediated signaling pathway	IL6ST	IMP		Human	PMID:8999038
Biological Process	GO:0048711	positive regulation of astrocyte differentiation	Il6st	IMP		Mouse	PMID:10486560
Biological Process	GO:0048680	positive regulation of axon regeneration	il6st	IMP	ZFIN:ZDB-MRPHLNO-140620-3	Zfish	PMID:24523552
Biological Process	GO:0008284	positive regulation of cell population proliferation	IL6ST	IDA		Human	PMID:2261637
Biological Process	GO:0008284	positive regulation of cell population proliferation	IL6ST	IGI		Human	PMID:8999038
Biological Process	GO:0008284	positive regulation of cell population proliferation	Il6st	IGI	MGI:MGI:2684607	Mouse	PMID:15051883
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	IL6ST	IDA		Human	PMID:25731159
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	Il6st	IDA		Mouse	MGI:MGI:5629863|PMID:25731159
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IL6ST	IMP		Human	PMID:12372336
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	Il6st	IMP		Rat	PMID:17322172|RGD:1626703
Biological Process	GO:0042102	positive regulation of T cell proliferation	IL6ST	IMP		Human	PMID:14764690
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IL6ST	IMP		Human	PMID:14764690
Biological Process	GO:0008593	regulation of Notch signaling pathway	Il6st	IDA		Mouse	PMID:12629177
Biological Process	GO:0034097	response to cytokine	IL6ST	IDA		Human	PMID:2261637
Biological Process	GO:0034097	response to cytokine	IL6ST	IDA		Human	PMID:8999038
Biological Process	GO:0007584	response to nutrient	Il6st	IEP		Rat	PMID:15371280|RGD:1627569
Biological Process	GO:0007165	signal transduction	Il6st	IDA		Mouse	PMID:12147685
Biological Process	GO:0006642	triglyceride mobilization	Il6st	IMP		Rat	PMID:8843746|RGD:1626687

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern