Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL7
  • Mouse genes Il7
  • Rat genes Il7
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	IL7	IDA		Human	PMID:11418668
Molecular Function	GO:0005125	cytokine activity	Il7	IDA		Mouse	PMID:12970760
Molecular Function	GO:0005125	cytokine activity	Il7	IDA		Mouse	PMID:12490655
Molecular Function	GO:0008083	growth factor activity	Il7	IDA		Mouse	PMID:12970760
Molecular Function	GO:0005515	protein binding	IL7	IPI	UniProtKB:P16871	Human	PMID:19141282
Molecular Function	GO:0005515	protein binding	IL7	IPI	UniProtKB:P16871	Human	PMID:8266077
Molecular Function	GO:0005515	protein binding	IL7	IPI	UniProtKB:P31785	Human	PMID:8266077
Cellular Component	GO:0062023	collagen-containing extracellular matrix	IL7	HDA		Human	PMID:28675934
Cellular Component	GO:0005576	extracellular region	IL7	IDA		Human	PMID:11418668
Cellular Component	GO:0005615	extracellular space	Il7	IDA		Mouse	PMID:8950980
Biological Process	GO:0042100	B cell proliferation	Il7	IGI	MGI:MGI:87859	Mouse	PMID:7671324
Biological Process	GO:0045453	bone resorption	Il7	IDA		Mouse	PMID:12490655
Biological Process	GO:0071456	cellular response to hypoxia	Il7	IEP		Rat	PMID:19055876|RGD:10402937
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IL7	IDA		Human	PMID:11418668
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	Il7	IDA		Mouse	PMID:10429671
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	Il7	IMP	MGI:MGI:1857652	Mouse	PMID:9252127
Biological Process	GO:0043086	negative regulation of catalytic activity	Il7	IDA		Mouse	PMID:8950980
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	Il7	IDA		Mouse	PMID:10429671
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	Il7	IDA		Mouse	PMID:8950980
Biological Process	GO:0035265	organ growth	Il7	IGI	MGI:MGI:97849	Mouse	PMID:9252127
Biological Process	GO:0035265	organ growth	Il7	IMP	MGI:MGI:1857652	Mouse	PMID:9252127
Biological Process	GO:0045579	positive regulation of B cell differentiation	Il7	IDA		Mouse	PMID:16797412
Biological Process	GO:0030890	positive regulation of B cell proliferation	Il7	IGI	MGI:MGI:87859	Mouse	PMID:7671324
Biological Process	GO:0030890	positive regulation of B cell proliferation	Il7	IDA		Mouse	PMID:12970760
Biological Process	GO:0032722	positive regulation of chemokine production	IL7	IDA		Human	PMID:11418668
Biological Process	GO:0001961	positive regulation of cytokine-mediated signaling pathway	IL7	IDA		Human	PMID:11418668
Biological Process	GO:0010628	positive regulation of gene expression	Il7	IDA		Mouse	PMID:16797412
Biological Process	GO:0046622	positive regulation of organ growth	Il7	IMP	MGI:MGI:1857652	Mouse	PMID:9252127
Biological Process	GO:0046622	positive regulation of organ growth	Il7	IGI	MGI:MGI:97849	Mouse	PMID:9252127
Biological Process	GO:0045582	positive regulation of T cell differentiation	Il7	IDA		Mouse	PMID:12431371
Biological Process	GO:0010468	regulation of gene expression	Il7	IDA		Mouse	PMID:8950980
Biological Process	GO:0010468	regulation of gene expression	Il7	IMP	MGI:MGI:1857652	Mouse	PMID:9252127
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	Il7	IDA		Mouse	PMID:29581031
Biological Process	GO:0010165	response to X-ray	Il7	IEP		Rat	PMID:15799696|RGD:10402940
Biological Process	GO:0002360	T cell lineage commitment	Il7	IMP	MGI:MGI:1857652	Mouse	PMID:9252127

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern