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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Ilk

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ilk
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0005178integrin bindingIlkIPIRGD:2927RatPMID:11133699|RGD:2302097
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:P48059HumanPMID:11331308
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q9NVD7HumanPMID:11331308
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q9H0C8HumanPMID:11331582
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q9NVD7HumanPMID:12432066
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:P49024HumanPMID:15817463
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q9NVD7HumanPMID:15817463
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q9NVD7HumanPMID:16189514
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:P55211HumanPMID:16936772
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q14790HumanPMID:16936772
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q9NWT6HumanPMID:17003112
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q9BWU0HumanPMID:17553790
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q9NVD7HumanPMID:17553790
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:P48059HumanPMID:18339839
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q6R327HumanPMID:18339839
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:P48059HumanPMID:19074270
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:P48059HumanPMID:20926685
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q9NVD7HumanPMID:21516116
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q9UMS6HumanPMID:21643011
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:P08238HumanPMID:22939624
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:P48059HumanPMID:23414517
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:P48059HumanPMID:23455922
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q9NVD7HumanPMID:23455922
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:P48059HumanPMID:23877428
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q9NVD7HumanPMID:23877428
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:P14373HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:P48059HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q9HBI0HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q9NVD7HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q9NVD7HumanPMID:25502805
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:P48059HumanPMID:25852190
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q9NVD7HumanPMID:25852190
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q9NVD7HumanPMID:26496610
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q9NWT6HumanPMID:26972000
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:P48059HumanPMID:28514442
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q9HBI0HumanPMID:28514442
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q9NVD7HumanPMID:28514442
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q96AC1HumanPMID:30254023
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q9NVD7HumanPMID:30254023
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:P14373HumanPMID:31515488
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:P48059HumanPMID:31515488
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q9HBI0HumanPMID:31515488
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q9NVD7HumanPMID:31515488
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:P48059-3HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q9HBI0HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q9NVD7HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:P08238HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:P48059HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingILKIPIUniProtKB:Q9NVD7HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingIlkIPIUniProtKB:Q9EPC1|UniProtKB:Q9ES46MouseMGI:MGI:4368016|PMID:19798050
Molecular FunctionGO:0005515protein bindingIlkIPIUniProtKB:Q9EPC1|UniProtKB:Q9ES46MouseMGI:MGI:4367148|PMID:19829382
Molecular FunctionGO:0005515protein bindingIlkIPIUniProtKB:P48059MouseMGI:MGI:5493221|PMID:10574708
Molecular FunctionGO:0005515protein bindingIlkIPIUniProtKB:Q9EPC1|UniProtKB:Q9ES46MouseMGI:MGI:5499269|PMID:23612611
Molecular FunctionGO:0005515protein bindingIlkIPIUniProtKB:P48059|UniProtKB:Q9EPC1|UniProtKB:Q9NVD7MouseMGI:MGI:6368070|PMID:11331308
Molecular FunctionGO:0005515protein bindingIlkIPIUniProtKB:Q9WUD1MouseMGI:MGI:5499269|PMID:23612611
Molecular FunctionGO:0005515protein bindingIlkIPIPR:Q9EPC1MousePMID:12432066
Molecular FunctionGO:0005515protein bindingIlkIPIPR:Q99JW4MousePMID:12432066
Molecular FunctionGO:0005515protein bindingIlkIPIPR:Q8VI36MousePMID:14699151
Molecular FunctionGO:0005515protein bindingIlkIPIPR:P20065MousePMID:15565145
Molecular FunctionGO:0005515protein bindingIlkIPIRGD:1305759RatPMID:14581460|RGD:2302070
Molecular FunctionGO:0019904protein domain specific bindingIlkIDARatPMID:11304546|RGD:633110
Molecular FunctionGO:0004672protein kinase activityIlkIDARatPMID:14581460|RGD:2302070
Molecular FunctionGO:0004672protein kinase activityIlkIDARatPMID:18535176|RGD:2301740
Molecular FunctionGO:0004672protein kinase activityilkIMPZfishPMID:16921028
Molecular FunctionGO:0004672protein kinase activityilkIDAZfishPMID:16921028
Molecular FunctionGO:0019901protein kinase bindingILKIPIUniProtKB:P21709HumanPMID:19118217
Molecular FunctionGO:0004674protein serine/threonine kinase activityILKIDAHumanPMID:10871859
Molecular FunctionGO:0004674protein serine/threonine kinase activityILKIDAHumanPMID:9366252
Molecular FunctionGO:0004674protein serine/threonine kinase activityIlkIMPRatPMID:14581460|RGD:2302070
Molecular FunctionGO:0044877protein-containing complex bindingIlkIPIRGD:71021|RGD:1560732RatPMID:16170337|RGD:2302069
Molecular FunctionGO:0044877protein-containing complex bindingIlkIDARatPMID:17167118|RGD:2302524
Molecular FunctionGO:0044877protein-containing complex bindingIlkIPIRGD:71021|RGD:1560732RatPMID:17934340|RGD:2301743
Molecular FunctionGO:0017124SH3 domain bindingIlkIDARatPMID:18252715|RGD:2301742
Cellular ComponentGO:0030424axonIlkIDARatPMID:17490631|RGD:2301744
Cellular ComponentGO:0005911cell-cell junctionIlkIDARatPMID:11133699|RGD:2302097
Cellular ComponentGO:0043034costamereIlkIDARatPMID:16170337|RGD:2302069
Cellular ComponentGO:0005737cytoplasmIlkIDARatPMID:17234816|RGD:2301768
Cellular ComponentGO:0005737cytoplasmilkIDAZfishPMID:18436206
Cellular ComponentGO:0005829cytosolILKIDAHumanGO_REF:0000052
Cellular ComponentGO:0043198dendritic shaftIlkIDARatPMID:17490631|RGD:2301744
Cellular ComponentGO:0005925focal adhesionILKIDAHumanGO_REF:0000052
Cellular ComponentGO:0005925focal adhesionILKHDAHumanPMID:21423176
Cellular ComponentGO:0005925focal adhesionILKIDAHumanPMID:30254023
Cellular ComponentGO:0005925focal adhesionIlkIDAMousePMID:23658024
Cellular ComponentGO:0005925focal adhesionIlkIDAMousePMID:15565145
Cellular ComponentGO:0005925focal adhesionIlkIDAMousePMID:12432066
Cellular ComponentGO:0005925focal adhesionIlkIDARatPMID:11304546|RGD:633110
Cellular ComponentGO:0005925focal adhesionIlkIDARatPMID:14581460|RGD:2302070
Cellular ComponentGO:0005925focal adhesionIlkIDARatPMID:16170337|RGD:2302069
Cellular ComponentGO:0005925focal adhesionIlkIDARatPMID:18535176|RGD:2301740
Cellular ComponentGO:0030027lamellipodiumIlkIDAMouseMGI:MGI:5447607|PMID:18325335
Cellular ComponentGO:0016020membraneILKHDAHumanPMID:19946888
Cellular ComponentGO:0043025neuronal cell bodyIlkIDARatPMID:17490631|RGD:2301744
Cellular ComponentGO:0005654nucleoplasmILKIDAHumanGO_REF:0000052
Cellular ComponentGO:0032991protein-containing complexIlkIDARatPMID:16170337|RGD:2302069
Cellular ComponentGO:0032991protein-containing complexIlkIDARatPMID:17167118|RGD:2302524
Cellular ComponentGO:0032991protein-containing complexIlkIDARatPMID:17934340|RGD:2301743
Cellular ComponentGO:0042383sarcolemmailkIDAZfishPMID:16921028
Cellular ComponentGO:0001725stress fiberIlkIDARatPMID:18535176|RGD:2301740
Cellular ComponentGO:0043195terminal boutonIlkIDARatPMID:17490631|RGD:2301744
Cellular ComponentGO:0030018Z discilkIDAZfishPMID:16921028
Cellular ComponentGO:0030018Z discilkIDAZfishPMID:21670146
Biological ProcessGO:0001568blood vessel developmentilkIMPZFIN:ZDB-MRPHLNO-061222-1ZfishPMID:15340074
Biological ProcessGO:0001658branching involved in ureteric bud morphogenesisIlkIDAMousePMID:15831470
Biological ProcessGO:0055013cardiac muscle cell developmentilkIMPZFIN:ZDB-GENO-080130-1ZfishPMID:17646580
Biological ProcessGO:0003211cardiac ventricle formationilkIMPZFIN:ZDB-GENO-080130-1ZfishPMID:17646580
Biological ProcessGO:0000902cell morphogenesisILKIMPHumanPMID:30254023
Biological ProcessGO:0008283cell population proliferationIlkIMPMGI:MGI:2668459MousePMID:12835312
Biological ProcessGO:0030030cell projection organizationIlkIMPMGI:MGI:3653044,MGI:MGI:4359600MousePMID:19349584
Biological ProcessGO:0007160cell-matrix adhesionilkIMPZFIN:ZDB-MRPHLNO-061219-1ZfishPMID:18436206
Biological ProcessGO:0001885endothelial cell developmentilkIMPZFIN:ZDB-GENO-080130-1ZfishPMID:17646580
Biological ProcessGO:0001885endothelial cell developmentilkIGIZFIN:ZDB-GENO-080130-1,ZFIN:ZDB-MRPHLNO-060119-6ZfishPMID:17646580
Biological ProcessGO:0045197establishment or maintenance of epithelial cell apical/basal polarityIlkIMPMGI:MGI:2655774MousePMID:12670870
Biological ProcessGO:0010761fibroblast migrationIlkIMPMousePMID:23658024
Biological ProcessGO:0060047heart contractionilkIMPZFIN:ZDB-MRPHLNO-060921-4ZfishPMID:19800866
Biological ProcessGO:0060047heart contractionilkIGIZFIN:ZDB-MRPHLNO-110907-6ZfishPMID:21670146
Biological ProcessGO:0060047heart contractionilkIGIZFIN:ZDB-MRPHLNO-110907-4ZfishPMID:21670146
Biological ProcessGO:0007507heart developmentilkIMPZFIN:ZDB-MRPHLNO-060921-4ZfishPMID:25355883
Biological ProcessGO:0007229integrin-mediated signaling pathwayILKIDAHumanPMID:9366252
Biological ProcessGO:0007229integrin-mediated signaling pathwayIlkIMPRatPMID:12629168|RGD:2302091
Biological ProcessGO:0016203muscle attachmentilkIMPZFIN:ZDB-GENO-080130-1ZfishPMID:22859503
Biological ProcessGO:0016203muscle attachmentilkIGIZFIN:ZDB-GENO-080130-1,ZFIN:ZDB-GENO-091008-3ZfishPMID:22859503
Biological ProcessGO:0016203muscle attachmentilkIGIZFIN:ZDB-GENO-070608-1,ZFIN:ZDB-GENO-080130-1ZfishPMID:22859503
Biological ProcessGO:0016203muscle attachmentilkIMPZFIN:ZDB-MRPHLNO-061219-1ZfishPMID:18436206
Biological ProcessGO:0016203muscle attachmentilkIGIZFIN:ZDB-GENO-080130-1,ZFIN:ZDB-GENO-100507-10ZfishPMID:22859503
Biological ProcessGO:0016203muscle attachmentilkIGIZFIN:ZDB-GENO-080130-1,ZFIN:ZDB-MRPHLNO-051215-1ZfishPMID:18436206
Biological ProcessGO:0016203muscle attachmentilkIMPZFIN:ZDB-GENO-080130-1ZfishPMID:18436206
Biological ProcessGO:0032288myelin assemblyIlkIMPRatPMID:14581460|RGD:2302070
Biological ProcessGO:0022011myelination in peripheral nervous systemIlkIMPMGI:MGI:3653044,MGI:MGI:4359600MousePMID:19349584
Biological ProcessGO:0043066negative regulation of apoptotic processIlkIMPRatPMID:16941698|RGD:2302063
Biological ProcessGO:0010667negative regulation of cardiac muscle cell apoptotic processIlkIMPRatPMID:16170337|RGD:2302069
Biological ProcessGO:2000178negative regulation of neural precursor cell proliferationIlkIGIMGI:MGI:103040MousePMID:24719101
Biological ProcessGO:2000178negative regulation of neural precursor cell proliferationIlkIMPMGI:MGI:3653044,MGI:MGI:3767432MousePMID:24719101
Biological ProcessGO:0043524negative regulation of neuron apoptotic processIlkIMPRatPMID:12629168|RGD:2302091
Biological ProcessGO:0006469negative regulation of protein kinase activityIlkIMPRatPMID:12629168|RGD:2302091
Biological ProcessGO:0014912negative regulation of smooth muscle cell migrationIlkIMPRatPMID:18535176|RGD:2301740
Biological ProcessGO:0048662negative regulation of smooth muscle cell proliferationIlkIMPRatPMID:18535176|RGD:2301740
Biological ProcessGO:0021675nerve developmentIlkIMPMGI:MGI:3653044,MGI:MGI:4359600MousePMID:19349584
Biological ProcessGO:0061351neural precursor cell proliferationIlkIMPMGI:MGI:3653044,MGI:MGI:3767432MousePMID:24719101
Biological ProcessGO:0061351neural precursor cell proliferationIlkIGIMGI:MGI:103040MousePMID:24719101
Biological ProcessGO:0048812neuron projection morphogenesisIlkIMPRatPMID:12629168|RGD:2302091
Biological ProcessGO:0003151outflow tract morphogenesisIlkIMPMouseMGI:MGI:5619428|PMID:24131868
Biological ProcessGO:0018105peptidyl-serine phosphorylationIlkIMPMGI:MGI:3653044,MGI:MGI:4359600MousePMID:19349584
Biological ProcessGO:0018105peptidyl-serine phosphorylationIlkIMPRatPMID:14581460|RGD:2302070
Biological ProcessGO:0070527platelet aggregationILKHMPHumanPMID:23382103
Biological ProcessGO:0045773positive regulation of axon extensionIlkIMPRatPMID:17490631|RGD:2301744
Biological ProcessGO:0050772positive regulation of axonogenesisIlkIMPRatPMID:17490631|RGD:2301744
Biological ProcessGO:0030513positive regulation of BMP signaling pathwayIlkIMPMouseMGI:MGI:5009350|PMID:20675382
Biological ProcessGO:0090263positive regulation of canonical Wnt signaling pathwayILKIMPHumanPMID:20018240
Biological ProcessGO:0030335positive regulation of cell migrationIlkIMPRatPMID:16941698|RGD:2302063
Biological ProcessGO:0008284positive regulation of cell population proliferationIlkIMPMGI:MGI:2668459MousePMID:12835312
Biological ProcessGO:0008284positive regulation of cell population proliferationIlkIMPRatPMID:16941698|RGD:2302063
Biological ProcessGO:0001954positive regulation of cell-matrix adhesionIlkIMPRatPMID:18535176|RGD:2301740
Biological ProcessGO:2000774positive regulation of cellular senescenceIlkIMPRatPMID:17234816|RGD:2301768
Biological ProcessGO:0050775positive regulation of dendrite morphogenesisIlkIMPRatPMID:17182785|RGD:2301767
Biological ProcessGO:0050775positive regulation of dendrite morphogenesisIlkIMPRatPMID:18602949|RGD:2301736
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionILKIMPHumanPMID:20018240
Biological ProcessGO:0043406positive regulation of MAP kinase activityIlkIMPRatPMID:17182785|RGD:2301767
Biological ProcessGO:0043410positive regulation of MAPK cascadeIlkIMPRatPMID:16941698|RGD:2302063
Biological ProcessGO:0045663positive regulation of myoblast differentiationIlkIMPRatPMID:14550274|RGD:2302089
Biological ProcessGO:1901224positive regulation of NIK/NF-kappaB signalingILKIMPHumanPMID:21343177
Biological ProcessGO:0045669positive regulation of osteoblast differentiationIlkIMPMouseMGI:MGI:5009350|PMID:20675382
Biological ProcessGO:0042327positive regulation of phosphorylationILKIMPHumanPMID:20018240
Biological ProcessGO:0051897positive regulation of protein kinase B signalingIlkIMPRatPMID:16941698|RGD:2302063
Biological ProcessGO:0001934positive regulation of protein phosphorylationILKIMPHumanPMID:10637513
Biological ProcessGO:0009967positive regulation of signal transductionILKIMPHumanPMID:10637513
Biological ProcessGO:1900026positive regulation of substrate adhesion-dependent cell spreadingILKIGIUniProtKB:Q96AC1HumanPMID:30254023
Biological ProcessGO:0043491protein kinase B signalingIlkIMPMGI:MGI:3653044,MGI:MGI:4359600MousePMID:19349584
Biological ProcessGO:0006468protein phosphorylationILKIDAHumanPMID:10871859
Biological ProcessGO:0006468protein phosphorylationIlkIDARatPMID:14581460|RGD:2302070
Biological ProcessGO:0006468protein phosphorylationIlkIDARatPMID:18535176|RGD:2301740
Biological ProcessGO:0032956regulation of actin cytoskeleton organizationIlkIMPRatPMID:17234816|RGD:2301768
Biological ProcessGO:0051726regulation of cell cycleIlkIMPRatPMID:17234816|RGD:2301768
Biological ProcessGO:0001558regulation of cell growthIlkIMPRatPMID:16170337|RGD:2302069
Biological ProcessGO:0008016regulation of heart contractionilkIMPZFIN:ZDB-MRPHLNO-060921-4ZfishPMID:16921028
Biological ProcessGO:0008016regulation of heart contractionilkIMPZFIN:ZDB-GENO-980202-366ZfishPMID:16921028
Biological ProcessGO:0008016regulation of heart contractionilkIMPZFIN:ZDB-MRPHLNO-061219-1ZfishPMID:16921028
Biological ProcessGO:0014044Schwann cell developmentIlkIMPMGI:MGI:3653044,MGI:MGI:4359600MousePMID:19349584
Biological ProcessGO:0034446substrate adhesion-dependent cell spreadingILKIMPHumanPMID:19118217
Biological ProcessGO:0034446substrate adhesion-dependent cell spreadingIlkIMPRatPMID:16941698|RGD:2302063
Biological ProcessGO:0097435supramolecular fiber organizationIlkIMPRatPMID:17234816|RGD:2301768
Biological ProcessGO:0097435supramolecular fiber organizationIlkIMPRatPMID:18535176|RGD:2301740
Biological ProcessGO:0035989tendon developmentilkIGIZFIN:ZDB-GENO-080130-1,ZFIN:ZDB-MRPHLNO-140905-1ZfishPMID:24941943
Biological ProcessGO:0035989tendon developmentilkIMPZFIN:ZDB-GENO-080130-1ZfishPMID:24941943
Biological ProcessGO:0033209tumor necrosis factor-mediated signaling pathwayILKIMPHumanPMID:21343177

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory