Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IMPDH1
  • Mouse genes Impdh1
  • Rat genes Impdh1
  • Zfish genes impdh1a,impdh1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Impdh1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	IMPDH1	IDA		Human	PMID:14766016
Molecular Function	GO:0003938	IMP dehydrogenase activity	Impdh1	IDA		Mouse	PMID:31838626
Molecular Function	GO:0003938	IMP dehydrogenase activity	Impdh1	IDA		Mouse	PMID:12944494
Molecular Function	GO:0003676	nucleic acid binding	IMPDH1	IDA		Human	PMID:14766016
Cellular Component	GO:0005737	cytoplasm	IMPDH1	IDA		Human	PMID:14766016
Cellular Component	GO:0005829	cytosol	IMPDH1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	IMPDH1	IDA		Human	PMID:14766016
Biological Process	GO:0097294	'de novo' XMP biosynthetic process	Impdh1	IMP	MGI:MGI:2678364	Mouse	PMID:12944494
Biological Process	GO:0048066	developmental pigmentation	impdh1a	IMP	ZFIN:ZDB-MRPHLNO-150519-1	Zfish	PMID:25714999
Biological Process	GO:0001654	eye development	impdh1a	IMP	ZFIN:ZDB-MRPHLNO-150519-1	Zfish	PMID:25714999
Biological Process	GO:0006177	GMP biosynthetic process	Impdh1	IMP	MGI:MGI:2678364	Mouse	PMID:12944494
Biological Process	GO:0046651	lymphocyte proliferation	Impdh1	IMP	MGI:MGI:2678364	Mouse	PMID:12944494
Biological Process	GO:0006164	purine nucleotide biosynthetic process	Impdh1	IMP	MGI:MGI:2678364	Mouse	PMID:12944494
Biological Process	GO:0009409	response to cold	Impdh1	IEP		Rat	PMID:18036333|RGD:5144140
Biological Process	GO:0060041	retina development in camera-type eye	Impdh1	IEP		Rat	PMID:18295529|RGD:5144133

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern