Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes INPP5D
  • Mouse genes Inpp5d
  • Rat genes Inpp5d
  • Zfish genes inpp5d
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Inpp5d

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030487	inositol-4,5-bisphosphate 5-phosphatase activity	Inpp5d	IDA		Rat	PMID:11714805|RGD:633160
Molecular Function	GO:0005515	protein binding	INPP5D	IPI	UniProtKB:P31994	Human	PMID:10382761
Molecular Function	GO:0005515	protein binding	INPP5D	IPI	UniProtKB:Q96B97	Human	PMID:15090612
Molecular Function	GO:0005515	protein binding	INPP5D	IPI	UniProtKB:Q9UGN4	Human	PMID:16339535
Molecular Function	GO:0005515	protein binding	INPP5D	IPI	UniProtKB:Q96P31	Human	PMID:19843936
Molecular Function	GO:0005515	protein binding	INPP5D	IPI	UniProtKB:Q6DN72	Human	PMID:20933011
Molecular Function	GO:0005515	protein binding	INPP5D	IPI	UniProtKB:Q8CI61	Human	PMID:21712384
Molecular Function	GO:0005515	protein binding	INPP5D	IPI	UniProtKB:P31994	Human	PMID:24642916
Molecular Function	GO:0005515	protein binding	INPP5D	IPI	UniProtKB:Q9BZW8	Human	PMID:24642916
Molecular Function	GO:0005515	protein binding	INPP5D	IPI	UniProtKB:O75525	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	INPP5D	IPI	UniProtKB:P60409	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	INPP5D	IPI	UniProtKB:P60411	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	INPP5D	IPI	UniProtKB:Q15323	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	INPP5D	IPI	UniProtKB:Q6A162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	INPP5D	IPI	UniProtKB:Q7Z3S9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	INPP5D	IPI	UniProtKB:Q9BZW8	Human	PMID:26221972
Molecular Function	GO:0005515	protein binding	INPP5D	IPI	UniProtKB:Q6DKI7	Human	PMID:26755705
Molecular Function	GO:0005515	protein binding	INPP5D	IPI	UniProtKB:P31994	Human	PMID:9148918
Molecular Function	GO:0005515	protein binding	INPP5D	IPI	UniProtKB:P26715	Human	PMID:9485206
Molecular Function	GO:0005515	protein binding	Inpp5d	IPI	UniProtKB:Q3TB92	Mouse	MGI:MGI:4461821|PMID:20526344
Molecular Function	GO:0005515	protein binding	Inpp5d	IPI	UniProtKB:Q8CIH5	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Inpp5d	IPI	UniProtKB:P23727	Mouse	MGI:MGI:3765260|PMID:10068665
Molecular Function	GO:0005515	protein binding	Inpp5d	IPI	UniProtKB:Q63850	Mouse	MGI:MGI:3687822|PMID:11031258
Molecular Function	GO:0005515	protein binding	Inpp5d	IPI	PR:Q6SJQ0	Mouse	PMID:12874256
Molecular Function	GO:0005515	protein binding	Inpp5d	IPI	PR:P08101	Mouse	PMID:12893283
Molecular Function	GO:0005515	protein binding	Inpp5d	IPI	PR:Q6SJQ0	Mouse	PMID:12893283
Molecular Function	GO:0005515	protein binding	Inpp5d	IPI	RGD:1332447	Rat	PMID:15661894|RGD:2312435
Molecular Function	GO:0005515	protein binding	Inpp5d	IPI	RGD:1560614	Rat	PMID:15661894|RGD:2312435
Molecular Function	GO:0005515	protein binding	Inpp5d	IPI	UniProtKB:Q15642-1	Rat	PMID:26751515|RGD:13432325
Molecular Function	GO:0005515	protein binding	Inpp5d	IPI	UniProtKB:Q96RU3	Rat	PMID:26751515|RGD:13432325
Cellular Component	GO:0005884	actin filament	Inpp5d	IDA		Rat	PMID:15661894|RGD:2312435
Cellular Component	GO:0030863	cortical cytoskeleton	Inpp5d	IDA		Rat	PMID:15661894|RGD:2312435
Cellular Component	GO:0005829	cytosol	INPP5D	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Inpp5d	IDA		Rat	PMID:15661894|RGD:2312435
Cellular Component	GO:0005886	plasma membrane	Inpp5d	IDA		Rat	PMID:15661894|RGD:2312435
Biological Process	GO:0008340	determination of adult lifespan	Inpp5d	IMP	MGI:MGI:2386884	Mouse	PMID:9620849
Biological Process	GO:0016064	immunoglobulin mediated immune response	Inpp5d	IMP	MGI:MGI:2386884	Mouse	PMID:10704460
Biological Process	GO:0035556	intracellular signal transduction	Inpp5d	IMP	MGI:MGI:2386884	Mouse	PMID:10704460
Biological Process	GO:0050869	negative regulation of B cell activation	Inpp5d	IMP	MGI:MGI:2386884	Mouse	PMID:10704460
Biological Process	GO:0030889	negative regulation of B cell proliferation	Inpp5d	IMP	MGI:MGI:2386884	Mouse	PMID:10704460
Biological Process	GO:0045779	negative regulation of bone resorption	Inpp5d	IMP	MGI:MGI:2386884	Mouse	PMID:12161749
Biological Process	GO:0030853	negative regulation of granulocyte differentiation	Inpp5d	IMP	MGI:MGI:2386884	Mouse	PMID:9620849
Biological Process	GO:0050777	negative regulation of immune response	Inpp5d	IMP	MGI:MGI:2386884	Mouse	PMID:10704460
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Inpp5d	IMP	MGI:MGI:2386884	Mouse	PMID:12161749
Biological Process	GO:0045656	negative regulation of monocyte differentiation	Inpp5d	IMP	MGI:MGI:2386884	Mouse	PMID:9620849
Biological Process	GO:0090024	negative regulation of neutrophil chemotaxis	inpp5d	IGI	ZFIN:ZDB-MRPHLNO-130225-8,ZFIN:ZDB-MRPHLNO-130311-2	Zfish	PMID:22946052
Biological Process	GO:0090024	negative regulation of neutrophil chemotaxis	inpp5d	IGI	ZFIN:ZDB-MRPHLNO-130225-9,ZFIN:ZDB-MRPHLNO-130311-1	Zfish	PMID:22946052
Biological Process	GO:0045659	negative regulation of neutrophil differentiation	Inpp5d	IMP	MGI:MGI:2386884	Mouse	PMID:9620849
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	Inpp5d	IMP	MGI:MGI:2386884	Mouse	PMID:12161749
Biological Process	GO:0009968	negative regulation of signal transduction	Inpp5d	IMP	MGI:MGI:2386884	Mouse	PMID:12161749
Biological Process	GO:0009968	negative regulation of signal transduction	Inpp5d	IMP	MGI:MGI:2386884	Mouse	PMID:10704460
Biological Process	GO:0009968	negative regulation of signal transduction	Inpp5d	IMP	MGI:MGI:2386884	Mouse	PMID:9620849
Biological Process	GO:0043065	positive regulation of apoptotic process	Inpp5d	IMP	MGI:MGI:2386884	Mouse	PMID:12161749
Biological Process	GO:0045579	positive regulation of B cell differentiation	Inpp5d	IMP	MGI:MGI:2386884	Mouse	PMID:9620849
Biological Process	GO:0045579	positive regulation of B cell differentiation	Inpp5d	IMP	MGI:MGI:2386884	Mouse	PMID:10704460
Biological Process	GO:0045648	positive regulation of erythrocyte differentiation	Inpp5d	IMP	MGI:MGI:2386884	Mouse	PMID:9620849
Biological Process	GO:0045621	positive regulation of lymphocyte differentiation	Inpp5d	IMP	MGI:MGI:2386884	Mouse	PMID:9620849

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern