Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes INPP5K
  • Mouse genes Inpp5k
  • Rat genes Inpp5k
  • Zfish genes inpp5ka,inpp5kb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Inpp5k

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016312	inositol bisphosphate phosphatase activity	INPP5K	IDA		Human	PMID:10753883
Molecular Function	GO:0016312	inositol bisphosphate phosphatase activity	Inpp5k	IMP		Mouse	MGI:MGI:5294535|PMID:19250614
Molecular Function	GO:0046030	inositol trisphosphate phosphatase activity	INPP5K	IDA		Human	PMID:10753883
Molecular Function	GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	INPP5K	IMP		Human	PMID:18774950
Molecular Function	GO:0034594	phosphatidylinositol trisphosphate phosphatase activity	INPP5K	IDA		Human	PMID:12556481
Molecular Function	GO:0034485	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	INPP5K	IDA		Human	PMID:21712384
Molecular Function	GO:0034485	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	Inpp5k	IDA		Mouse	MGI:MGI:5299272|PMID:21938401
Molecular Function	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	INPP5K	IMP		Human	PMID:28190456
Molecular Function	GO:0005515	protein binding	INPP5K	IPI	UniProtKB:Q8TBB1	Human	PMID:16002321
Molecular Function	GO:0005515	protein binding	INPP5K	IPI	UniProtKB:Q15041	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	INPP5K	IPI	UniProtKB:Q8CI61	Human	PMID:21712384
Molecular Function	GO:0005515	protein binding	INPP5K	IPI	UniProtKB:Q15013	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	INPP5K	IPI	UniProtKB:Q15323	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	INPP5K	IPI	UniProtKB:Q969F0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	INPP5K	IPI	UniProtKB:Q13153	Human	PMID:26940976
Molecular Function	GO:0005515	protein binding	INPP5K	IPI	UniProtKB:Q96P69	Human	PMID:26940976
Molecular Function	GO:0005515	protein binding	INPP5K	IPI	UniProtKB:Q15013	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	INPP5K	IPI	UniProtKB:Q15041	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	INPP5K	IPI	UniProtKB:Q969F0	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	INPP5K	IPI	UniProtKB:O95562	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INPP5K	IPI	UniProtKB:P18859	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INPP5K	IPI	UniProtKB:Q15013	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INPP5K	IPI	UniProtKB:Q15041	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INPP5K	IPI	UniProtKB:Q15323	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INPP5K	IPI	UniProtKB:Q8N9I5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INPP5K	IPI	UniProtKB:Q969F0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INPP5K	IPI	UniProtKB:Q96AL5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INPP5K	IPI	UniProtKB:Q9UBN6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INPP5K	IPI	UniProtKB:Q9Y3E0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INPP5K	IPI	UniProtKB:Q92876	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Inpp5k	IPI	UniProtKB:O88643	Mouse	MGI:MGI:5442248|PMID:22751929
Molecular Function	GO:0005000	vasopressin receptor activity	Inpp5k	IDA		Mouse	MGI:MGI:5299272|PMID:21938401
Cellular Component	GO:0005737	cytoplasm	Inpp5k	IDA		Mouse	MGI:MGI:5299272|PMID:21938401
Cellular Component	GO:0005829	cytosol	INPP5K	IDA		Human	PMID:10753883
Cellular Component	GO:0005829	cytosol	INPP5K	IDA		Human	PMID:21712384
Cellular Component	GO:0005783	endoplasmic reticulum	INPP5K	IDA		Human	PMID:12536145
Cellular Component	GO:0005783	endoplasmic reticulum	INPP5K	IDA		Human	PMID:18774950
Cellular Component	GO:0005783	endoplasmic reticulum	INPP5K	IDA		Human	PMID:26940976
Cellular Component	GO:0005783	endoplasmic reticulum	INPP5K	IDA		Human	PMID:28190456
Cellular Component	GO:0005783	endoplasmic reticulum	Inpp5k	IDA		Mouse	MGI:MGI:5427321|PMID:22247557
Cellular Component	GO:0005783	endoplasmic reticulum	Inpp5k	IDA		Mouse	MGI:MGI:5442248|PMID:22751929
Cellular Component	GO:0016020	membrane	INPP5K	IDA		Human	PMID:12536145
Cellular Component	GO:0016020	membrane	INPP5K	HDA		Human	PMID:19946888
Cellular Component	GO:0043005	neuron projection	INPP5K	IDA		Human	PMID:10753883
Cellular Component	GO:0005634	nucleus	INPP5K	IDA		Human	PMID:18774950
Cellular Component	GO:0048471	perinuclear region of cytoplasm	INPP5K	IDA		Human	PMID:18774950
Cellular Component	GO:0048471	perinuclear region of cytoplasm	INPP5K	IDA		Human	PMID:21712384
Cellular Component	GO:0005886	plasma membrane	INPP5K	IDA		Human	PMID:12556481
Cellular Component	GO:0005886	plasma membrane	INPP5K	IDA		Human	PMID:21712384
Cellular Component	GO:0001726	ruffle	INPP5K	IDA		Human	PMID:12536145
Cellular Component	GO:0032587	ruffle membrane	INPP5K	IDA		Human	PMID:12556481
Cellular Component	GO:0005802	trans-Golgi network	INPP5K	IDA		Human	PMID:12556481
Biological Process	GO:0043010	camera-type eye development	inpp5ka	IGI	ZFIN:ZDB-MRPHLNO-170505-10,ZFIN:ZDB-MRPHLNO-170505-9	Zfish	PMID:28190456
Biological Process	GO:0043010	camera-type eye development	inpp5kb	IGI	ZFIN:ZDB-MRPHLNO-170505-10,ZFIN:ZDB-MRPHLNO-170505-9	Zfish	PMID:28190456
Biological Process	GO:0071320	cellular response to cAMP	Inpp5k	IDA		Mouse	MGI:MGI:5299272|PMID:21938401
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	INPP5K	IDA		Human	PMID:21712384
Biological Process	GO:0032870	cellular response to hormone stimulus	Inpp5k	IDA		Mouse	MGI:MGI:5299272|PMID:21938401
Biological Process	GO:0032869	cellular response to insulin stimulus	INPP5K	IDA		Human	PMID:12556481
Biological Process	GO:0071356	cellular response to tumor necrosis factor	INPP5K	IDA		Human	PMID:21712384
Biological Process	GO:0016311	dephosphorylation	INPP5K	IMP		Human	PMID:18774950
Biological Process	GO:0016311	dephosphorylation	INPP5K	IDA		Human	PMID:21712384
Biological Process	GO:0016311	dephosphorylation	Inpp5k	IDA		Mouse	MGI:MGI:5299272|PMID:21938401
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Inpp5k	IDA		Mouse	MGI:MGI:5299272|PMID:21938401
Biological Process	GO:0042593	glucose homeostasis	Inpp5k	IMP		Mouse	MGI:MGI:5294535|PMID:19250614
Biological Process	GO:0042593	glucose homeostasis	Inpp5k	IMP	MGI:MGI:3810936	Mouse	PMID:18573875
Biological Process	GO:0001701	in utero embryonic development	Inpp5k	IMP	MGI:MGI:3810936	Mouse	PMID:18573875
Biological Process	GO:0002088	lens development in camera-type eye	inpp5ka	IMP	ZFIN:ZDB-GENO-180719-7	Zfish	PMID:28940338
Biological Process	GO:0002088	lens development in camera-type eye	inpp5ka	IMP	ZFIN:ZDB-MRPHLNO-170505-2	Zfish	PMID:28190459
Biological Process	GO:0043922	negative regulation by host of viral transcription	INPP5K	IDA		Human	PMID:18774950
Biological Process	GO:0051926	negative regulation of calcium ion transport	INPP5K	IDA		Human	PMID:12556481
Biological Process	GO:0035305	negative regulation of dephosphorylation	Inpp5k	IMP		Mouse	MGI:MGI:5294535|PMID:19250614
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Inpp5k	IDA		Mouse	MGI:MGI:5299272|PMID:21938401
Biological Process	GO:0010829	negative regulation of glucose transmembrane transport	INPP5K	IDA		Human	PMID:12556481
Biological Process	GO:2000466	negative regulation of glycogen (starch) synthase activity	Inpp5k	IMP		Mouse	MGI:MGI:5294535|PMID:19250614
Biological Process	GO:0045719	negative regulation of glycogen biosynthetic process	INPP5K	IDA		Human	PMID:12556481
Biological Process	GO:0045719	negative regulation of glycogen biosynthetic process	Inpp5k	IMP		Mouse	MGI:MGI:5294535|PMID:19250614
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	INPP5K	IDA		Human	PMID:12556481
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	Inpp5k	IMP		Mouse	MGI:MGI:5294535|PMID:19250614
Biological Process	GO:0043407	negative regulation of MAP kinase activity	INPP5K	IDA		Human	PMID:12556481
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	INPP5K	IDA		Human	PMID:12556481
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	Inpp5k	IMP		Mouse	MGI:MGI:5294535|PMID:19250614
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	Inpp5k	IMP	MGI:MGI:3810936	Mouse	PMID:18573875
Biological Process	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	INPP5K	IDA		Human	PMID:12556481
Biological Process	GO:0006469	negative regulation of protein kinase activity	INPP5K	IDA		Human	PMID:12556481
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	INPP5K	IDA		Human	PMID:12556481
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	Inpp5k	IMP		Mouse	MGI:MGI:5294535|PMID:19250614
Biological Process	GO:0001933	negative regulation of protein phosphorylation	Inpp5k	IDA		Mouse	MGI:MGI:5299272|PMID:21938401
Biological Process	GO:0090315	negative regulation of protein targeting to membrane	INPP5K	IDA		Human	PMID:12556481
Biological Process	GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	INPP5K	IDA		Human	PMID:18774950
Biological Process	GO:0051497	negative regulation of stress fiber assembly	INPP5K	IDA		Human	PMID:12556481
Biological Process	GO:0098529	neuromuscular junction development, skeletal muscle fiber	inpp5ka	IMP	ZFIN:ZDB-MRPHLNO-170505-2	Zfish	PMID:28190459
Biological Process	GO:0046856	phosphatidylinositol dephosphorylation	INPP5K	IDA		Human	PMID:12536145
Biological Process	GO:0046856	phosphatidylinositol dephosphorylation	INPP5K	IDA		Human	PMID:12556481
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Inpp5k	IDA		Mouse	MGI:MGI:5299272|PMID:21938401
Biological Process	GO:2001153	positive regulation of renal water transport	Inpp5k	IDA		Mouse	MGI:MGI:5299272|PMID:21938401
Biological Process	GO:0035810	positive regulation of urine volume	Inpp5k	IDA		Mouse	MGI:MGI:5299272|PMID:21938401
Biological Process	GO:0072659	protein localization to plasma membrane	Inpp5k	IDA		Mouse	MGI:MGI:5299272|PMID:21938401
Biological Process	GO:0005979	regulation of glycogen biosynthetic process	Inpp5k	IMP		Mouse	MGI:MGI:5294535|PMID:19250614
Biological Process	GO:0032868	response to insulin	Inpp5k	IMP	MGI:MGI:3810936	Mouse	PMID:18573875
Biological Process	GO:0097178	ruffle assembly	INPP5K	IDA		Human	PMID:12556481
Biological Process	GO:0048741	skeletal muscle fiber development	inpp5ka	IGI	ZFIN:ZDB-MRPHLNO-170505-10,ZFIN:ZDB-MRPHLNO-170505-9	Zfish	PMID:28190456
Biological Process	GO:0048741	skeletal muscle fiber development	inpp5ka	IMP	ZFIN:ZDB-GENO-180719-7	Zfish	PMID:28940338
Biological Process	GO:0048741	skeletal muscle fiber development	inpp5kb	IGI	ZFIN:ZDB-MRPHLNO-170505-10,ZFIN:ZDB-MRPHLNO-170505-9	Zfish	PMID:28190456
Biological Process	GO:0061053	somite development	inpp5ka	IMP	ZFIN:ZDB-MRPHLNO-170505-2	Zfish	PMID:28190459

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern