Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes INPPL1
  • Mouse genes Inppl1
  • Rat genes Inppl1
  • Zfish genes inppl1a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Inppl1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004445	inositol-polyphosphate 5-phosphatase activity	Inppl1	IDA		Rat	PMID:10381377|RGD:68267
Molecular Function	GO:0004445	inositol-polyphosphate 5-phosphatase activity	Inppl1	IDA		Rat	PMID:12933696|RGD:1626126
Molecular Function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	Inppl1	IDA		Rat	PMID:12933696|RGD:1626126
Molecular Function	GO:0005515	protein binding	INPPL1	IPI	UniProtKB:P56945	Human	PMID:11158326
Molecular Function	GO:0005515	protein binding	INPPL1	IPI	UniProtKB:A0A061I5T4	Human	PMID:12504111
Molecular Function	GO:0005515	protein binding	INPPL1	IPI	UniProtKB:Q9BX66	Human	PMID:12504111
Molecular Function	GO:0005515	protein binding	INPPL1	IPI	UniProtKB:O60504-1	Human	PMID:16302969
Molecular Function	GO:0005515	protein binding	INPPL1	IPI	UniProtKB:Q15811-2	Human	PMID:18692052
Molecular Function	GO:0005515	protein binding	INPPL1	IPI	UniProtKB:P46108	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	INPPL1	IPI	UniProtKB:Q8IV36	Human	PMID:20368287
Molecular Function	GO:0005515	protein binding	INPPL1	IPI	UniProtKB:Q6DN72	Human	PMID:20933011
Molecular Function	GO:0005515	protein binding	INPPL1	IPI	UniProtKB:Q8CI61	Human	PMID:21712384
Molecular Function	GO:0005515	protein binding	INPPL1	IPI	UniProtKB:P08581	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	INPPL1	IPI	UniProtKB:P10275	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	INPPL1	IPI	UniProtKB:Q13480	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	INPPL1	IPI	UniProtKB:P46108	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	INPPL1	IPI	UniProtKB:P26715	Human	PMID:9485206
Molecular Function	GO:0005515	protein binding	Inppl1	IPI	UniProtKB:Q9Z0R4-2	Mouse	MGI:MGI:5512958|PMID:18692052
Molecular Function	GO:0005515	protein binding	Inppl1	IPI	PR:P98083	Mouse	PMID:14502564
Molecular Function	GO:0005515	protein binding	Inppl1	IPI	RGD:620446	Rat	PMID:12933696|RGD:1626126
Molecular Function	GO:0042169	SH2 domain binding	INPPL1	IPI	UniProtKB:P22681	Human	PMID:5668240
Cellular Component	GO:0005737	cytoplasm	Inppl1	IDA		Mouse	PMID:14502564
Cellular Component	GO:0005829	cytosol	INPPL1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	INPPL1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030027	lamellipodium	Inppl1	IDA		Rat	PMID:17535963|RGD:2312439
Cellular Component	GO:0005886	plasma membrane	Inppl1	IDA		Mouse	PMID:14502564
Biological Process	GO:0007015	actin filament organization	INPPL1	IMP		Human	PMID:15668240
Biological Process	GO:0030509	BMP signaling pathway	inppl1a	IMP	ZFIN:ZDB-MRPHLNO-101112-2	Zfish	PMID:20616095
Biological Process	GO:0030509	BMP signaling pathway	inppl1a	IMP	ZFIN:ZDB-MRPHLNO-101112-3	Zfish	PMID:20616095
Biological Process	GO:0007420	brain development	Inppl1	IEP		Rat	PMID:10648902|RGD:68268
Biological Process	GO:0044255	cellular lipid metabolic process	Inppl1	IMP	MGI:MGI:3530363	Mouse	PMID:15654325
Biological Process	GO:0001958	endochondral ossification	INPPL1	IMP		Human	PMID:23273569
Biological Process	GO:0006897	endocytosis	INPPL1	IMP		Human	PMID:15668240
Biological Process	GO:0006006	glucose metabolic process	Inppl1	IMP	MGI:MGI:3531322	Mouse	PMID:11343120
Biological Process	GO:0032957	inositol trisphosphate metabolic process	Inppl1	IDA		Rat	PMID:12933696|RGD:1626126
Biological Process	GO:0008285	negative regulation of cell population proliferation	Inppl1	IDA		Mouse	PMID:14502564
Biological Process	GO:0008156	negative regulation of DNA replication	Inppl1	IMP		Rat	PMID:12933696|RGD:1626126
Biological Process	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	inppl1a	IMP	ZFIN:ZDB-MRPHLNO-101112-3	Zfish	PMID:20616095
Biological Process	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	inppl1a	IMP	ZFIN:ZDB-MRPHLNO-101112-2	Zfish	PMID:20616095
Biological Process	GO:0010629	negative regulation of gene expression	Inppl1	IMP	MGI:MGI:3530363	Mouse	PMID:15654325
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	Inppl1	IMP		Rat	PMID:11692174|RGD:2312443
Biological Process	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway	Inppl1	IMP		Rat	PMID:12933696|RGD:1626126
Biological Process	GO:0043407	negative regulation of MAP kinase activity	Inppl1	IMP		Rat	PMID:12933696|RGD:1626126
Biological Process	GO:0010977	negative regulation of neuron projection development	Inppl1	IMP		Rat	PMID:17535963|RGD:2312439
Biological Process	GO:0090024	negative regulation of neutrophil chemotaxis	inppl1a	IGI	ZFIN:ZDB-MRPHLNO-130225-8,ZFIN:ZDB-MRPHLNO-130311-2	Zfish	PMID:22946052
Biological Process	GO:0090024	negative regulation of neutrophil chemotaxis	inppl1a	IGI	ZFIN:ZDB-MRPHLNO-130225-9,ZFIN:ZDB-MRPHLNO-130311-1	Zfish	PMID:22946052
Biological Process	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway	Inppl1	IMP		Rat	PMID:12933696|RGD:1626126
Biological Process	GO:0006661	phosphatidylinositol biosynthetic process	Inppl1	IMP		Mouse	PMID:21624956
Biological Process	GO:0009791	post-embryonic development	Inppl1	IMP	MGI:MGI:3531322	Mouse	PMID:11343120
Biological Process	GO:0032868	response to insulin	Inppl1	IMP	MGI:MGI:3531322	Mouse	PMID:11343120
Biological Process	GO:0009410	response to xenobiotic stimulus	Inppl1	IEP		Rat	PMID:16155101|RGD:2312441
Biological Process	GO:0097178	ruffle assembly	Inppl1	IMP		Mouse	PMID:21624956

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern