Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes INSIG1
  • Mouse genes Insig1
  • Rat genes Insig1,LOC120102490
  • Zfish genes insig1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Insig1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008142	oxysterol binding	INSIG1	IDA		Human	PMID:32322062
Molecular Function	GO:0005515	protein binding	INSIG1	IPI	UniProtKB:P97260	Human	PMID:12202038
Molecular Function	GO:0005515	protein binding	INSIG1	IPI	UniProtKB:P97260	Human	PMID:15899885
Molecular Function	GO:0005515	protein binding	INSIG1	IPI	UniProtKB:Q9UKV5	Human	PMID:16168377
Molecular Function	GO:0005515	protein binding	INSIG1	IPI	UniProtKB:P00180	Human	PMID:21081644
Molecular Function	GO:0005515	protein binding	INSIG1	IPI	UniProtKB:P00181	Human	PMID:21081644
Molecular Function	GO:0005515	protein binding	INSIG1	IPI	UniProtKB:P00347	Human	PMID:21343306
Molecular Function	GO:0005515	protein binding	INSIG1	IPI	UniProtKB:Q9UKV5	Human	PMID:21343306
Molecular Function	GO:0005515	protein binding	INSIG1	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG1	IPI	UniProtKB:Q96Q45-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Insig1	IPI	PR:Q6GQT6	Mouse	PMID:12242332
Molecular Function	GO:0005515	protein binding	Insig1	IPI	PR:Q3U1N2	Mouse	PMID:12242332
Molecular Function	GO:0140311	protein sequestering activity	INSIG1	IDA		Human	PMID:15899885
Molecular Function	GO:0140311	protein sequestering activity	INSIG1	IDA		Human	PMID:32322062
Cellular Component	GO:0005783	endoplasmic reticulum	INSIG1	IDA		Human	PMID:12202038
Cellular Component	GO:0005783	endoplasmic reticulum	INSIG1	IDA		Human	PMID:32322062
Cellular Component	GO:0005789	endoplasmic reticulum membrane	INSIG1	IDA		Human	PMID:32322062
Cellular Component	GO:0032937	SREBP-SCAP-Insig complex	INSIG1	IDA		Human	PMID:12202038
Cellular Component	GO:0032937	SREBP-SCAP-Insig complex	INSIG1	IDA		Human	PMID:15899885
Biological Process	GO:0032869	cellular response to insulin stimulus	Insig1	IEP		Rat	PMID:19299314|RGD:2308854
Biological Process	GO:0036315	cellular response to sterol	INSIG1	IMP		Human	PMID:12202038
Biological Process	GO:0006695	cholesterol biosynthetic process	INSIG1	IDA		Human	PMID:32322062
Biological Process	GO:0006695	cholesterol biosynthetic process	Insig1	IGI	MGI:MGI:1920249	Mouse	PMID:16955138
Biological Process	GO:0042632	cholesterol homeostasis	INSIG1	IDA		Human	PMID:12202038
Biological Process	GO:0008203	cholesterol metabolic process	Insig1	IGI	MGI:MGI:1920249	Mouse	PMID:16100574
Biological Process	GO:0060363	cranial suture morphogenesis	Insig1	IGI	MGI:MGI:1920249	Mouse	PMID:16955138
Biological Process	GO:0042472	inner ear morphogenesis	Insig1	IGI	MGI:MGI:1920249	Mouse	PMID:16955138
Biological Process	GO:0042474	middle ear morphogenesis	Insig1	IGI	MGI:MGI:1920249	Mouse	PMID:16955138
Biological Process	GO:1901303	negative regulation of cargo loading into COPII-coated vesicle	INSIG1	IMP		Human	PMID:15899885
Biological Process	GO:0045599	negative regulation of fat cell differentiation	Insig1	IDA		Mouse	PMID:12869692
Biological Process	GO:0045717	negative regulation of fatty acid biosynthetic process	Insig1	IGI	MGI:MGI:1920249	Mouse	PMID:16100574
Biological Process	GO:0070862	negative regulation of protein exit from endoplasmic reticulum	INSIG1	IDA		Human	PMID:12202038
Biological Process	GO:0010894	negative regulation of steroid biosynthetic process	Insig1	IGI	MGI:MGI:1920249	Mouse	PMID:16100574
Biological Process	GO:0032355	response to estradiol	Insig1	IEP		Rat	PMID:12801995|RGD:1582500
Biological Process	GO:0070542	response to fatty acid	Insig1	IEP		Rat	PMID:16222032|RGD:2308856
Biological Process	GO:0033993	response to lipid	Insig1	IEP		Rat	PMID:17709436|RGD:2308819
Biological Process	GO:0043434	response to peptide hormone	Insig1	IEP		Rat	PMID:18801905|RGD:2308855
Biological Process	GO:0006991	response to sterol depletion	Insig1	IDA		Mouse	PMID:12242332
Biological Process	GO:0060021	roof of mouth development	Insig1	IGI	MGI:MGI:1920249	Mouse	PMID:16955138
Biological Process	GO:0032933	SREBP signaling pathway	INSIG1	IDA		Human	PMID:12242332
Biological Process	GO:0032933	SREBP signaling pathway	INSIG1	IDA		Human	PMID:32322062
Biological Process	GO:0036316	SREBP-SCAP complex retention in endoplasmic reticulum	INSIG1	IDA		Human	PMID:12202038
Biological Process	GO:0036316	SREBP-SCAP complex retention in endoplasmic reticulum	INSIG1	IDA		Human	PMID:15899885
Biological Process	GO:0036316	SREBP-SCAP complex retention in endoplasmic reticulum	INSIG1	IDA		Human	PMID:32322062
Biological Process	GO:0016126	sterol biosynthetic process	Insig1	IGI	MGI:MGI:1920249	Mouse	PMID:16955138
Biological Process	GO:0006641	triglyceride metabolic process	Insig1	IGI	MGI:MGI:1920249	Mouse	PMID:16100574

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern