Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes INSIG2
  • Mouse genes Insig2
  • Rat genes Insig2
  • Zfish genes insig2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Insig2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008142	oxysterol binding	INSIG2	IDA		Human	PMID:17428920
Molecular Function	GO:0008142	oxysterol binding	INSIG2	IDA		Human	PMID:32322062
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:P97260	Human	PMID:12242332
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q12770	Human	PMID:17428920
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q99942	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:O14524-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:O60883	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:P11912	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:P15151	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:P15941-11	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:P16471	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:P25942	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:P38484	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:P41181	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:P43628	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:P48165	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q13323	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q13571	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q13586	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q15125	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q3ZAQ7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q4KMG9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q5JX71	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q7Z5P4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q7Z7G2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q8N4V1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q8NBJ4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q8TAF8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q8TB40	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q8TDT2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q8TED1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q8TF71	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q96B21	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q96BA8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q96Q45-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q99437	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q99942	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q9BQA9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q9NUH8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q9NY72	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INSIG2	IPI	UniProtKB:Q9Y320	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Insig2	IPI	UniProtKB:Q925C2	Mouse	PMID:12242332
Molecular Function	GO:0005515	protein binding	Insig2	IPI	EMBL:AK035432	Mouse	PMID:12242332
Molecular Function	GO:0140311	protein sequestering activity	INSIG2	IDA		Human	PMID:15899885
Molecular Function	GO:0140311	protein sequestering activity	INSIG2	IDA		Human	PMID:32322062
Cellular Component	GO:0005783	endoplasmic reticulum	INSIG2	IDA		Human	PMID:32322062
Cellular Component	GO:0005783	endoplasmic reticulum	Insig2	IDA		Rat	PMID:12624180|RGD:724448
Cellular Component	GO:0005789	endoplasmic reticulum membrane	INSIG2	IDA		Human	PMID:32322062
Cellular Component	GO:0032937	SREBP-SCAP-Insig complex	INSIG2	IDA		Human	PMID:12242332
Biological Process	GO:0006695	cholesterol biosynthetic process	INSIG2	IDA		Human	PMID:32322062
Biological Process	GO:0006695	cholesterol biosynthetic process	Insig2	IGI	MGI:MGI:1916289	Mouse	PMID:16955138
Biological Process	GO:0008203	cholesterol metabolic process	Insig2	IGI	MGI:MGI:1916289	Mouse	PMID:16100574
Biological Process	GO:0060363	cranial suture morphogenesis	Insig2	IGI	MGI:MGI:1916289	Mouse	PMID:16955138
Biological Process	GO:0042472	inner ear morphogenesis	Insig2	IGI	MGI:MGI:1916289	Mouse	PMID:16955138
Biological Process	GO:0042474	middle ear morphogenesis	Insig2	IGI	MGI:MGI:1916289	Mouse	PMID:16955138
Biological Process	GO:0045717	negative regulation of fatty acid biosynthetic process	Insig2	IGI	MGI:MGI:1916289	Mouse	PMID:16100574
Biological Process	GO:0010894	negative regulation of steroid biosynthetic process	Insig2	IGI	MGI:MGI:1916289	Mouse	PMID:16100574
Biological Process	GO:0070542	response to fatty acid	Insig2	IEP		Rat	PMID:16222032|RGD:2308856
Biological Process	GO:0032868	response to insulin	Insig2	IEP		Rat	PMID:16222032|RGD:2308856
Biological Process	GO:0033993	response to lipid	Insig2	IEP		Rat	PMID:17709436|RGD:2308819
Biological Process	GO:0006991	response to sterol depletion	Insig2	IDA		Mouse	PMID:12354157
Biological Process	GO:0060021	roof of mouth development	Insig2	IGI	MGI:MGI:1916289	Mouse	PMID:16955138
Biological Process	GO:0032933	SREBP signaling pathway	INSIG2	IDA		Human	PMID:12242332
Biological Process	GO:0032933	SREBP signaling pathway	INSIG2	IDA		Human	PMID:17428920
Biological Process	GO:0032933	SREBP signaling pathway	INSIG2	IDA		Human	PMID:32322062
Biological Process	GO:0036316	SREBP-SCAP complex retention in endoplasmic reticulum	INSIG2	IDA		Human	PMID:15899885
Biological Process	GO:0036316	SREBP-SCAP complex retention in endoplasmic reticulum	INSIG2	IDA		Human	PMID:32322062
Biological Process	GO:0016126	sterol biosynthetic process	Insig2	IGI	MGI:MGI:1916289	Mouse	PMID:16955138
Biological Process	GO:0006641	triglyceride metabolic process	Insig2	IGI	MGI:MGI:1916289	Mouse	PMID:16100574

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern