Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Insr

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes INSR
- Mouse genes Insr
- Rat genes Insr
- Zfish genes insra,insrb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Insr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043423	3-phosphoinositide-dependent protein kinase binding	Insr	IDA		Rat	PMID:16314505\|RGD:1581774
Molecular Function	GO:0001540	amyloid-beta binding	INSR	IPI	UniProtKB:P05067:PRO_0000000092	Human	PMID:19406747
Molecular Function	GO:0005524	ATP binding	INSR	IDA		Human	PMID:6849137
Molecular Function	GO:0038024	cargo receptor activity	Insr	IMP		Rat	PMID:19406747\|RGD:13210538
Molecular Function	GO:0005525	GTP binding	INSR	IDA		Human	PMID:9092559
Molecular Function	GO:0043559	insulin binding	INSR	IDA		Human	PMID:8440175
Molecular Function	GO:0043559	insulin binding	INSR	IPI	UniProtKB:P01308	Human	PMID:8452530
Molecular Function	GO:0043559	insulin binding	Insr	IMP		Rat	PMID:12850498\|RGD:1580595
Molecular Function	GO:0043559	insulin binding	Insr	IDA		Rat	PMID:17023527\|RGD:1600765
Molecular Function	GO:0043559	insulin binding	Insr	IMP		Rat	PMID:17023527\|RGD:1600765
Molecular Function	GO:0043559	insulin binding	Insr	IDA		Rat	PMID:2180315\|RGD:14981592
Molecular Function	GO:0043559	insulin binding	Insr	IDA		Rat	PMID:3275643\|RGD:2293184
Molecular Function	GO:0005009	insulin receptor activity	INSR	IDA		Human	PMID:6849137
Molecular Function	GO:0005009	insulin receptor activity	INSR	IDA		Human	PMID:8440175
Molecular Function	GO:0005009	insulin receptor activity	Insr	IDA		Mouse	PMID:35248691
Molecular Function	GO:0005009	insulin receptor activity	Insr	IDA		Mouse	PMID:2557333
Molecular Function	GO:0005009	insulin receptor activity	Insr	IDA		Mouse	PMID:23886629
Molecular Function	GO:0005009	insulin receptor activity	Insr	IMP		Rat	PMID:12850498\|RGD:1580595
Molecular Function	GO:0005009	insulin receptor activity	Insr	IDA		Rat	PMID:12891559\|RGD:1299201
Molecular Function	GO:0005009	insulin receptor activity	Insr	IDA		Rat	PMID:17023527\|RGD:1600765
Molecular Function	GO:0005009	insulin receptor activity	Insr	IMP		Rat	PMID:17023527\|RGD:1600765
Molecular Function	GO:0005009	insulin receptor activity	Insr	IDA		Rat	PMID:3275643\|RGD:2293184
Molecular Function	GO:0043560	insulin receptor substrate binding	INSR	IPI	UniProtKB:P35568	Human	PMID:7493946
Molecular Function	GO:0043560	insulin receptor substrate binding	INSR	IPI	UniProtKB:P35568	Human	PMID:7537849
Molecular Function	GO:0043560	insulin receptor substrate binding	INSR	IPI	UniProtKB:P35568	Human	PMID:7559478
Molecular Function	GO:0043560	insulin receptor substrate binding	Insr	IMP		Rat	PMID:12850498\|RGD:1580595
Molecular Function	GO:0031994	insulin-like growth factor I binding	INSR	IPI	UniProtKB:P05019	Human	PMID:8452530
Molecular Function	GO:0031995	insulin-like growth factor II binding	INSR	IPI	UniProtKB:P01344	Human	PMID:12138094
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	INSR	IDA		Human	PMID:8452530
Molecular Function	GO:0031405	lipoic acid binding	Insr	IPI	CHEBI:16494	Rat	PMID:17274632\|RGD:2290477
Molecular Function	GO:0140677	molecular function activator activity	Insr	IDA		Mouse	PMID:18838380
Molecular Function	GO:0140677	molecular function activator activity	Insr	IGI	MGI:MGI:99454	Mouse	PMID:9038347
Molecular Function	GO:0140677	molecular function activator activity	Insr	IDA		Mouse	PMID:8448209
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	INSR	IPI	UniProtKB:P27986	Human	PMID:7537849
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	INSR	IPI	UniProtKB:P27986	Human	PMID:8276809
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P27986	Human	PMID:10500481
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P35570	Human	PMID:10660596
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P35570	Human	PMID:11136729
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P18031	Human	PMID:11163213
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:Q9UNH7	Human	PMID:11279102
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P22413	Human	PMID:11289049
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:Q9BX66	Human	PMID:11374898
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P18031	Human	PMID:11506178
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P18031	Human	PMID:11579209
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P19174	Human	PMID:11796522
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P27986	Human	PMID:11796522
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P18031	Human	PMID:12237455
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P18031	Human	PMID:12634852
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P19174	Human	PMID:14568990
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P18031	Human	PMID:14722096
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P18031	Human	PMID:15588987
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P29353	Human	PMID:15629149
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P35570	Human	PMID:15629149
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P18031	Human	PMID:16582879
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P35568	Human	PMID:16582879
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P18031	Human	PMID:16926280
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P18031	Human	PMID:17092689
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P35570	Human	PMID:17135270
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P18031	Human	PMID:17159996
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P18031	Human	PMID:17481567
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P18031	Human	PMID:19029027
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:Q99490	Human	PMID:21720388
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P18031	Human	PMID:21806020
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:Q3V6T2	Human	PMID:25187647
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:Q15323	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:Q15256	Human	PMID:28065597
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:Q8NEJ0	Human	PMID:28065597
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P08069	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P14616	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P18031	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P27986	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:Q06124	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:Q06124	Human	PMID:7493946
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P29353	Human	PMID:7537849
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P35568	Human	PMID:7935368
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P01317	Human	PMID:8452530
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P05019	Human	PMID:8452530
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P18031	Human	PMID:8702689
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P18031	Human	PMID:8999839
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:Q13322	Human	PMID:9506989
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P19174	Human	PMID:9593725
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P27986	Human	PMID:9593725
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:P29353	Human	PMID:9593725
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:Q06124	Human	PMID:9593725
Molecular Function	GO:0005515	protein binding	INSR	IPI	UniProtKB:Q9NRF2	Human	PMID:9742218
Molecular Function	GO:0005515	protein binding	Insr	IPI	UniProtKB:Q8K0B2	Mouse	MGI:MGI:5543853\|PMID:24078630
Molecular Function	GO:0005515	protein binding	Insr	IPI	UniProtKB:Q1XH17	Mouse	MGI:MGI:5474153\|PMID:23354051
Molecular Function	GO:0005515	protein binding	Insr	IPI	UniProtKB:P49817	Mouse	MGI:MGI:6324005\|PMID:31217420
Molecular Function	GO:0005515	protein binding	Insr	IPI	UniProtKB:Q60760	Mouse	MGI:MGI:5508317\|PMID:8621530
Molecular Function	GO:0005515	protein binding	Insr	IPI	UniProtKB:Q60760	Mouse	MGI:MGI:3847873\|PMID:15664450
Molecular Function	GO:0005515	protein binding	Insr	IPI	UniProtKB:O88307	Mouse	MGI:MGI:5811185\|PMID:27322061
Molecular Function	GO:0005515	protein binding	Insr	IPI	UniProtKB:Q62417	Mouse	MGI:MGI:1201213\|PMID:9447983
Molecular Function	GO:0005515	protein binding	Insr	IPI	UniProtKB:P49817	Mouse	MGI:MGI:6383357\|PMID:17699617
Molecular Function	GO:0005515	protein binding	Insr	IPI	PR:O35716	Mouse	PMID:15169905
Molecular Function	GO:0005515	protein binding	Insr	IPI	PR:P51637	Mouse	PMID:16455755
Molecular Function	GO:0005515	protein binding	Insr	IPI	PR:O08917	Mouse	PMID:16455755
Molecular Function	GO:0005515	protein binding	Insr	IPI	PR:Q9JID9	Mouse	PMID:10196204
Molecular Function	GO:0005515	protein binding	Insr	IPI	PR:P05017	Mouse	PMID:22428016
Molecular Function	GO:0005515	protein binding	Insr	IPI	PR:Q91VH2	Mouse	PMID:12917015
Molecular Function	GO:0005515	protein binding	Insr	IPI	PR:O35718	Mouse	PMID:15169905
Molecular Function	GO:0005515	protein binding	Insr	IPI	RGD:3705	Rat	PMID:15665515\|RGD:1580591
Molecular Function	GO:0005515	protein binding	Insr	IPI	RGD:2869	Rat	PMID:22173225\|RGD:10045990
Molecular Function	GO:0005515	protein binding	Insr	IPI	UniProtKB:O35567	Rat	PMID:25687571\|RGD:10047347
Molecular Function	GO:0005515	protein binding	Insr	IPI	UniProtKB:Q62689	Rat	PMID:8912646\|RGD:8553635
Molecular Function	GO:0019904	protein domain specific binding	INSR	IPI	UniProtKB:Q14449	Human	PMID:16246733
Molecular Function	GO:0019904	protein domain specific binding	Insr	IPI	RGD:61869	Rat	PMID:9748281\|RGD:61620
Molecular Function	GO:0004672	protein kinase activity	Insr	IDA		Rat	PMID:17429032\|RGD:2307034
Molecular Function	GO:0019901	protein kinase binding	Insr	IPI	RGD:61925	Rat	PMID:17318260\|RGD:2307035
Molecular Function	GO:0019901	protein kinase binding	Insr	IPI	RGD:620795	Rat	PMID:19952103\|RGD:2325147
Molecular Function	GO:0019903	protein phosphatase binding	Insr	IMP		Rat	PMID:12850498\|RGD:1580595
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	Insr	IDA		Mouse	PMID:23886629
Molecular Function	GO:0004713	protein tyrosine kinase activity	INSR	IMP		Human	PMID:7537849
Molecular Function	GO:0004713	protein tyrosine kinase activity	INSR	IDA		Human	PMID:8496180
Molecular Function	GO:0004713	protein tyrosine kinase activity	Insr	IDA		Mouse	PMID:18838380
Molecular Function	GO:0004713	protein tyrosine kinase activity	Insr	IDA		Mouse	PMID:8448209
Molecular Function	GO:0004713	protein tyrosine kinase activity	Insr	IGI	MGI:MGI:99454	Mouse	PMID:9038347
Molecular Function	GO:0004713	protein tyrosine kinase activity	Insr	IDA		Rat	PMID:18657188\|RGD:2307023
Molecular Function	GO:0004713	protein tyrosine kinase activity	Insr	IDA		Rat	PMID:2180315\|RGD:14981592
Molecular Function	GO:0044877	protein-containing complex binding	INSR	IPI	ComplexPortal:CPX-1134	Human	PMID:19406747
Molecular Function	GO:0044877	protein-containing complex binding	Insr	IPI	RGD:2917	Rat	PMID:3516142\|RGD:2307042
Molecular Function	GO:0051425	PTB domain binding	INSR	IPI	UniProtKB:P29353	Human	PMID:7559478
Cellular Component	GO:0005901	caveola	INSR	IDA		Human	PMID:15182363
Cellular Component	GO:0005901	caveola	Insr	IDA		Mouse	PMID:16513830
Cellular Component	GO:0044297	cell body	Insr	IDA		Rat	PMID:19406747\|RGD:13210538
Cellular Component	GO:0031410	cytoplasmic vesicle	Insr	IDA		Rat	PMID:15520221\|RGD:2306052
Cellular Component	GO:0005829	cytosol	Insr	IDA		Rat	PMID:15665515\|RGD:1580591
Cellular Component	GO:0030425	dendrite	Insr	IDA		Rat	PMID:19406747\|RGD:13210538
Cellular Component	GO:0032590	dendrite membrane	Insr	IDA		Rat	PMID:19188609\|RGD:12907552
Cellular Component	GO:0005768	endosome	Insr	IDA		Rat	PMID:15665515\|RGD:1580591
Cellular Component	GO:0009897	external side of plasma membrane	Insr	IDA		Rat	PMID:19188609\|RGD:12907552
Cellular Component	GO:0070062	extracellular exosome	INSR	HDA		Human	PMID:20458337
Cellular Component	GO:0005899	insulin receptor complex	INSR	IMP		Human	PMID:15069075
Cellular Component	GO:0005899	insulin receptor complex	INSR	IDA		Human	PMID:1898103
Cellular Component	GO:0005899	insulin receptor complex	INSR	IDA		Human	PMID:19406747
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Insr	IDA		Rat	PMID:18657188\|RGD:2307023
Cellular Component	GO:0016020	membrane	INSR	IDA		Human	PMID:8452530
Cellular Component	GO:0016020	membrane	Insr	IDA		Mouse	MGI:MGI:1201213\|PMID:9447983
Cellular Component	GO:0043025	neuronal cell body	Insr	IDA		Rat	PMID:19406747\|RGD:13210538
Cellular Component	GO:0043025	neuronal cell body	Insr	IDA		Rat	PMID:12021765\|RGD:628530
Cellular Component	GO:0043025	neuronal cell body	Insr	IDA		Rat	PMID:18479783\|RGD:10045894
Cellular Component	GO:0032809	neuronal cell body membrane	Insr	IDA		Rat	PMID:19188609\|RGD:12907552
Cellular Component	GO:0005635	nuclear envelope	INSR	IDA		Human	PMID:19406747
Cellular Component	GO:0031981	nuclear lumen	INSR	IDA		Human	PMID:19406747
Cellular Component	GO:0005634	nucleus	Insr	IDA		Rat	PMID:18798337\|RGD:2307021
Cellular Component	GO:0005886	plasma membrane	INSR	IDA		Human	PMID:9092559
Cellular Component	GO:0005886	plasma membrane	INSR	IDA		Human	PMID:23137377
Cellular Component	GO:0005886	plasma membrane	Insr	IDA		Mouse	PMID:35248691
Cellular Component	GO:0005886	plasma membrane	Insr	IDA		Mouse	PMID:2557333
Cellular Component	GO:0005886	plasma membrane	Insr	IDA		Mouse	PMID:24078630
Cellular Component	GO:0005886	plasma membrane	Insr	IDA		Mouse	PMID:14562105
Cellular Component	GO:0005886	plasma membrane	Insr	IDA		Rat	PMID:15520221\|RGD:2306052
Cellular Component	GO:0005886	plasma membrane	Insr	IDA		Rat	PMID:15665515\|RGD:1580591
Cellular Component	GO:0005886	plasma membrane	Insr	IDA		Rat	PMID:6364984\|RGD:14701029
Cellular Component	GO:0043235	receptor complex	INSR	IDA		Human	PMID:23382219
Cellular Component	GO:0045202	synapse	Insr	IDA		Rat	PMID:16978790\|RGD:2307039
Cellular Component	GO:0060417	yolk	Insr	IDA		Rat	PMID:1448116\|RGD:14700803
Biological Process	GO:0032147	activation of protein kinase activity	INSR	IMP		Human	PMID:9819385
Biological Process	GO:0032148	activation of protein kinase B activity	INSR	IDA		Human	PMID:7556070
Biological Process	GO:0030325	adrenal gland development	Insr	IGI	UniProtKB:Q60751	Mouse	MGI:MGI:5493430\|PMID:23300479
Biological Process	GO:0000380	alternative mRNA splicing, via spliceosome	Insr	IEP		Rat	PMID:23633480\|RGD:9685423
Biological Process	GO:0097242	amyloid-beta clearance	Insr	IMP		Rat	PMID:19406747\|RGD:13210538
Biological Process	GO:0009887	animal organ morphogenesis	Insr	IMP	MGI:MGI:1857204	Mouse	PMID:12101187
Biological Process	GO:0071363	cellular response to growth factor stimulus	Insr	IDA		Mouse	PMID:19744960
Biological Process	GO:0032869	cellular response to insulin stimulus	INSR	IDA		Human	PMID:8440175
Biological Process	GO:0034224	cellular response to zinc ion starvation	Insr	IEP		Rat	PMID:21893222\|RGD:151667428
Biological Process	GO:0021549	cerebellum development	Insr	IEP		Rat	PMID:23397157\|RGD:10403039
Biological Process	GO:0043009	chordate embryonic development	insra	IMP	ZFIN:ZDB-MRPHLNO-090611-2,ZFIN:ZDB-MRPHLNO-090611-3	Zfish	PMID:18687786
Biological Process	GO:0043009	chordate embryonic development	insrb	IMP	ZFIN:ZDB-MRPHLNO-090611-2,ZFIN:ZDB-MRPHLNO-090611-3	Zfish	PMID:18687786
Biological Process	GO:0097062	dendritic spine maintenance	Insr	IGI	UniProtKB:P24062	Rat	PMID:19406747\|RGD:13210538
Biological Process	GO:0048589	developmental growth	insra	IMP	ZFIN:ZDB-MRPHLNO-090611-2,ZFIN:ZDB-MRPHLNO-090611-3	Zfish	PMID:18687786
Biological Process	GO:0048589	developmental growth	insrb	IMP	ZFIN:ZDB-MRPHLNO-090611-2,ZFIN:ZDB-MRPHLNO-090611-3	Zfish	PMID:18687786
Biological Process	GO:1990402	embryonic liver development	Insr	IEP		Rat	PMID:1448116\|RGD:14700803
Biological Process	GO:0008544	epidermis development	Insr	IMP		Mouse	PMID:23906066
Biological Process	GO:0031017	exocrine pancreas development	Insr	IMP	MGI:MGI:1857204	Mouse	PMID:12101187
Biological Process	GO:0045444	fat cell differentiation	Insr	IEP		Rat	PMID:17286602\|RGD:2307036
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	INSR	IDA		Human	PMID:9092559
Biological Process	GO:0006094	gluconeogenesis	insra	IGI	ZFIN:ZDB-GENE-061013-59	Zfish	PMID:30102881
Biological Process	GO:0006094	gluconeogenesis	insra	IMP	ZFIN:ZDB-GENO-200114-1	Zfish	PMID:30102881
Biological Process	GO:0042593	glucose homeostasis	INSR	IMP		Human	PMID:7693131
Biological Process	GO:0042593	glucose homeostasis	Insr	IDA		Rat	PMID:18256749\|RGD:2307027
Biological Process	GO:0006096	glycolytic process	insrb	IMP	ZFIN:ZDB-GENO-200114-2	Zfish	PMID:30102881
Biological Process	GO:0006096	glycolytic process	insra	IMP	ZFIN:ZDB-GENO-200114-1	Zfish	PMID:30102881
Biological Process	GO:0003007	heart morphogenesis	INSR	IMP		Human	PMID:7693131
Biological Process	GO:0021766	hippocampus development	Insr	IEP		Rat	PMID:22042446\|RGD:10403040
Biological Process	GO:0008286	insulin receptor signaling pathway	INSR	IDA		Human	PMID:20455999
Biological Process	GO:0008286	insulin receptor signaling pathway	INSR	IDA		Human	PMID:6849137
Biological Process	GO:0008286	insulin receptor signaling pathway	INSR	IDA		Human	PMID:8440175
Biological Process	GO:0008286	insulin receptor signaling pathway	Insr	IDA		Mouse	PMID:18838380
Biological Process	GO:0008286	insulin receptor signaling pathway	Insr	IDA		Mouse	PMID:35248691
Biological Process	GO:0008286	insulin receptor signaling pathway	Insr	IDA		Mouse	PMID:8448209
Biological Process	GO:0008286	insulin receptor signaling pathway	Insr	IGI	MGI:MGI:99454	Mouse	PMID:9038347
Biological Process	GO:0008286	insulin receptor signaling pathway	Insr	IDA		Mouse	PMID:23886629
Biological Process	GO:0008286	insulin receptor signaling pathway	Insr	IMP	MGI:MGI:1857204	Mouse	PMID:12488434
Biological Process	GO:0008286	insulin receptor signaling pathway	Insr	IMP		Rat	PMID:12850498\|RGD:1580595
Biological Process	GO:0008286	insulin receptor signaling pathway	Insr	IDA		Rat	PMID:12891559\|RGD:1299201
Biological Process	GO:0008286	insulin receptor signaling pathway	Insr	IEP		Rat	PMID:15520221\|RGD:2306052
Biological Process	GO:0008286	insulin receptor signaling pathway	Insr	IMP		Rat	PMID:19406747\|RGD:13210538
Biological Process	GO:0008286	insulin receptor signaling pathway	Insr	IEP		Rat	PMID:26300412\|RGD:11529553
Biological Process	GO:0008286	insulin receptor signaling pathway	Insr	IEP		Rat	PMID:29896241\|RGD:14700925
Biological Process	GO:0001889	liver development	Insr	IEP		Rat	PMID:6364984\|RGD:14701029
Biological Process	GO:0097421	liver regeneration	Insr	IEP		Rat	PMID:23633480\|RGD:9685423
Biological Process	GO:0008584	male gonad development	Insr	IGI	UniProtKB:Q60751	Mouse	MGI:MGI:5493430\|PMID:23300479
Biological Process	GO:0030238	male sex determination	Insr	IMP	MGI:MGI:1857204	Mouse	PMID:14628051
Biological Process	GO:2000252	negative regulation of feeding behavior	Insr	IMP		Rat	PMID:12021765\|RGD:628530
Biological Process	GO:0010629	negative regulation of gene expression	Insr	IMP		Rat	PMID:17585961\|RGD:2290473
Biological Process	GO:0045719	negative regulation of glycogen biosynthetic process	Insr	IEP		Rat	PMID:26300412\|RGD:11529553
Biological Process	GO:0001933	negative regulation of protein phosphorylation	Insr	IMP		Rat	PMID:17585961\|RGD:2290473
Biological Process	GO:0032410	negative regulation of transporter activity	Insr	IMP		Rat	PMID:19049803\|RGD:2307019
Biological Process	GO:1990535	neuron projection maintenance	Insr	IGI	ComplexPortal:CPX-1134,UniProtKB:P01308	Rat	PMID:19188609\|RGD:12907552
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	Insr	IDA		Mouse	PMID:10100151
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	INSR	IDA		Human	PMID:8496180
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Insr	IMP		Rat	PMID:12850498\|RGD:1580595
Biological Process	GO:0030335	positive regulation of cell migration	INSR	IMP		Human	PMID:12138094
Biological Process	GO:0008284	positive regulation of cell population proliferation	INSR	IMP		Human	PMID:12138094
Biological Process	GO:0008284	positive regulation of cell population proliferation	INSR	IDA		Human	PMID:17925406
Biological Process	GO:0048639	positive regulation of developmental growth	INSR	IMP		Human	PMID:7693131
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Insr	IGI	UniProtKB:Q60751	Mouse	MGI:MGI:5493430\|PMID:23300479
Biological Process	GO:0046326	positive regulation of glucose import	INSR	IDA		Human	PMID:3518947
Biological Process	GO:0045725	positive regulation of glycogen biosynthetic process	INSR	IDA		Human	PMID:17925406
Biological Process	GO:0045725	positive regulation of glycogen biosynthetic process	Insr	IMP		Mouse	MGI:MGI:4438697\|PMID:20032056
Biological Process	GO:0045821	positive regulation of glycolytic process	INSR	IMP		Human	PMID:7693131
Biological Process	GO:0010560	positive regulation of glycoprotein biosynthetic process	Insr	IMP		Rat	PMID:19049803\|RGD:2307019
Biological Process	GO:0043406	positive regulation of MAP kinase activity	INSR	IMP		Human	PMID:17001305
Biological Process	GO:0043410	positive regulation of MAPK cascade	INSR	IMP		Human	PMID:11500939
Biological Process	GO:0043410	positive regulation of MAPK cascade	INSR	IDA		Human	PMID:20455999
Biological Process	GO:0051446	positive regulation of meiotic cell cycle	Insr	IGI	UniProtKB:Q60751	Mouse	MGI:MGI:5493430\|PMID:23300479
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	INSR	IMP		Human	PMID:11500939
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	Insr	IMP		Mouse	PMID:23906066
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	INSR	IMP		Human	PMID:10747347
Biological Process	GO:0042327	positive regulation of phosphorylation	Insr	IDA		Rat	PMID:12435589\|RGD:729325
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	INSR	IMP		Human	PMID:11500939
Biological Process	GO:0001934	positive regulation of protein phosphorylation	INSR	IDA		Human	PMID:7556070
Biological Process	GO:0043243	positive regulation of protein-containing complex disassembly	Insr	IGI	UniProtKB:P06213	Rat	PMID:19406747\|RGD:13210538
Biological Process	GO:0002092	positive regulation of receptor internalization	INSR	IDA		Human	PMID:25401701
Biological Process	GO:0060267	positive regulation of respiratory burst	INSR	IDA		Human	PMID:9092559
Biological Process	GO:0046777	protein autophosphorylation	INSR	IDA		Human	PMID:6849137
Biological Process	GO:0046777	protein autophosphorylation	INSR	IMP		Human	PMID:7537849
Biological Process	GO:0046777	protein autophosphorylation	INSR	IDA		Human	PMID:8496180
Biological Process	GO:0046777	protein autophosphorylation	Insr	IMP		Rat	PMID:12850498\|RGD:1580595
Biological Process	GO:0046777	protein autophosphorylation	Insr	IDA		Rat	PMID:12891559\|RGD:1299201
Biological Process	GO:0046777	protein autophosphorylation	Insr	IDA		Rat	PMID:17919343\|RGD:2290474
Biological Process	GO:0046777	protein autophosphorylation	Insr	IDA		Rat	PMID:2180315\|RGD:14981592
Biological Process	GO:0046777	protein autophosphorylation	Insr	IDA		Rat	PMID:3275643\|RGD:2293184
Biological Process	GO:0006468	protein phosphorylation	Insr	IDA		Rat	PMID:12891559\|RGD:1299201
Biological Process	GO:0006468	protein phosphorylation	Insr	IEP		Rat	PMID:22546076\|RGD:14700935
Biological Process	GO:0031623	receptor internalization	Insr	IDA		Mouse	PMID:17264162
Biological Process	GO:0006898	receptor-mediated endocytosis	Insr	IMP		Rat	PMID:19406747\|RGD:13210538
Biological Process	GO:0006355	regulation of DNA-templated transcription	INSR	IMP		Human	PMID:12881524
Biological Process	GO:0045995	regulation of embryonic development	INSR	IMP		Human	PMID:7693131
Biological Process	GO:2000194	regulation of female gonad development	Insr	IGI	UniProtKB:Q60751	Mouse	MGI:MGI:5493430\|PMID:23300479
Biological Process	GO:0006111	regulation of gluconeogenesis	Insr	IEP		Rat	PMID:29896241\|RGD:14700925
Biological Process	GO:0010310	regulation of hydrogen peroxide metabolic process	Insr	IDA		Rat	PMID:17919343\|RGD:2290474
Biological Process	GO:0014823	response to activity	Insr	IEP		Rat	PMID:17603294\|RGD:2307031
Biological Process	GO:0032355	response to estradiol	Insr	IEP		Rat	PMID:17931855\|RGD:2307028
Biological Process	GO:0045471	response to ethanol	Insr	IEP		Rat	PMID:19185210\|RGD:2307017
Biological Process	GO:0032094	response to food	Insr	IEP		Rat	PMID:19880292\|RGD:4107735
Biological Process	GO:0051384	response to glucocorticoid	Insr	IEP		Rat	PMID:18401942\|RGD:2307026
Biological Process	GO:0009749	response to glucose	Insr	IEP		Rat	PMID:12435589\|RGD:729325
Biological Process	GO:0009725	response to hormone	Insr	IEP		Rat	PMID:18672341\|RGD:2307022
Biological Process	GO:0001666	response to hypoxia	Insr	IEP		Rat	PMID:25352008\|RGD:14700927
Biological Process	GO:0032868	response to insulin	Insr	IEP		Rat	PMID:12435589\|RGD:729325
Biological Process	GO:0032868	response to insulin	Insr	IEP		Rat	PMID:1280238\|RGD:15036814
Biological Process	GO:0032868	response to insulin	Insr	IEP		Rat	PMID:18923314\|RGD:2307020
Biological Process	GO:0010042	response to manganese ion	Insr	IEP		Rat	PMID:6368536\|RGD:2307040
Biological Process	GO:0031667	response to nutrient levels	Insr	IDA		Rat	PMID:15520221\|RGD:2306052
Biological Process	GO:0031667	response to nutrient levels	Insr	IEP		Rat	PMID:19088253\|RGD:2307018
Biological Process	GO:0031667	response to nutrient levels	Insr	IEP		Rat	PMID:25160038\|RGD:14700926
Biological Process	GO:0031667	response to nutrient levels	Insr	IEP		Rat	PMID:26300412\|RGD:11529553
Biological Process	GO:0010033	response to organic substance	Insr	IEP		Rat	PMID:30717198\|RGD:14701030
Biological Process	GO:1904638	response to resveratrol	Insr	IEP		Rat	PMID:25352008\|RGD:14700927
Biological Process	GO:0042594	response to starvation	Insr	IEP		Rat	PMID:1280238\|RGD:15036814
Biological Process	GO:0033574	response to testosterone	Insr	IEP		Rat	PMID:17673259\|RGD:2307030
Biological Process	GO:0034612	response to tumor necrosis factor	Insr	IMP		Rat	PMID:17761893\|RGD:2307032
Biological Process	GO:1902438	response to vanadate(3-)	Insr	IEP		Rat	PMID:2180315\|RGD:14981592
Biological Process	GO:0033280	response to vitamin D	Insr	IEP		Rat	PMID:18638371\|RGD:2307025
Biological Process	GO:0046718	viral entry into host cell	INSR	IMP		Human	PMID:17001305

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.