Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IQGAP1
  • Mouse genes Iqgap1
  • Rat genes Iqgap1
  • Zfish genes iqgap1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Iqgap1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	IQGAP1	HDA		Human	PMID:25468996
Molecular Function	GO:0005509	calcium ion binding	IQGAP1	IDA		Human	PMID:18567582
Molecular Function	GO:0005516	calmodulin binding	IQGAP1	IDA		Human	PMID:18567582
Molecular Function	GO:0005078	MAP-kinase scaffold activity	IQGAP1	IPI	UniProtKB:P15056	Human	PMID:18567582
Molecular Function	GO:0051019	mitogen-activated protein kinase binding	Iqgap1	IPI	RGD:70500	Rat	PMID:23987506|RGD:11049533
Molecular Function	GO:0060090	molecular adaptor activity	IQGAP1	IDA		Human	PMID:26242911
Molecular Function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	IQGAP1	IDA		Human	PMID:22493426
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:P15311	Human	PMID:10793131
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:P60953	Human	PMID:12745076
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:P15056	Human	PMID:17563371
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:O08808	Human	PMID:17620407
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:Q99816	Human	PMID:17853893
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:P60953	Human	PMID:18809683
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:P63000	Human	PMID:18809683
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:Q05823	Human	PMID:20875083
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:P00533	Human	PMID:21349850
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:P04626	Human	PMID:21724847
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:P25025	Human	PMID:21876773
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:P60953	Human	PMID:21876773
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:O00592	Human	PMID:22662192
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:O43707	Human	PMID:22662192
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:O60500	Human	PMID:22662192
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:P35222	Human	PMID:22662192
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:Q96QZ7	Human	PMID:22662192
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:Q9NP85	Human	PMID:22662192
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:Q9Y5K6	Human	PMID:22662192
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:O94885	Human	PMID:23333244
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:O60331-4	Human	PMID:23982733
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:P63000	Human	PMID:23982733
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:Q9P258	Human	PMID:25074804
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:P15311,UniProtKB:P25815	Human	PMID:25554515
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:Q86WV1	Human	PMID:26242911
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:Q9Y448	Human	PMID:26242911
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:O43707	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:P60953	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:P63000	Human	PMID:27173435
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:P56945	Human	PMID:28007913
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:P63000	Human	PMID:28007913
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:Q9NUH8	Human	PMID:29033352
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:P60953	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:P63000	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:A8MW99	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:P32243-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:P52954	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:Q12905	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:Q96KN3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:Q96N21	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IQGAP1	IPI	UniProtKB:O43511	Human	PMID:35601831
Molecular Function	GO:0005515	protein binding	Iqgap1	IPI	UniProtKB:P03332	Mouse	MGI:MGI:5508251|PMID:16628219
Molecular Function	GO:0005515	protein binding	Iqgap1	IPI	UniProtKB:P98083	Mouse	MGI:MGI:5508573|PMID:20075861
Molecular Function	GO:0005515	protein binding	Iqgap1	IPI	UniProtKB:Q9R155	Mouse	MGI:MGI:7388224|PMID:35601831
Molecular Function	GO:0005515	protein binding	Iqgap1	IPI	PR:Q0ZLH2	Mouse	PMID:28089576
Molecular Function	GO:0005515	protein binding	Iqgap1	IPI	PR:O88653	Mouse	PMID:24841562
Molecular Function	GO:0005515	protein binding	Iqgap1	IPI	PR:Q9CQ22	Mouse	PMID:24841562
Molecular Function	GO:0005515	protein binding	Iqgap1	IPI	PR:P60766	Mouse	PMID:18604197
Molecular Function	GO:0005515	protein binding	Iqgap1	IPI	RGD:620829	Rat	PMID:12938160|RGD:1304429
Molecular Function	GO:0005515	protein binding	Iqgap1	IPI	RGD:3269	Rat	PMID:20883816|RGD:11049555
Molecular Function	GO:0019904	protein domain specific binding	IQGAP1	IPI	UniProtKB:P15311	Human	PMID:25554515
Molecular Function	GO:0019901	protein kinase binding	IQGAP1	IPI	UniProtKB:P15056	Human	PMID:17563371
Molecular Function	GO:0019901	protein kinase binding	IQGAP1	IPI	UniProtKB:P15056	Human	PMID:18567582
Molecular Function	GO:0019903	protein phosphatase binding	IQGAP1	IPI	UniProtKB:P28827	Human	PMID:16380380
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	IQGAP1	IDA		Human	PMID:17563371
Molecular Function	GO:0044877	protein-containing complex binding	Iqgap1	IPI	RGD:620460	Rat	PMID:15331416|RGD:1600864
Molecular Function	GO:0044548	S100 protein binding	IQGAP1	IPI	UniProtKB:P25815	Human	PMID:25554515
Molecular Function	GO:0031267	small GTPase binding	IQGAP1	IPI	UniProtKB:P60953	Human	PMID:26242911
Molecular Function	GO:0031267	small GTPase binding	Iqgap1	IPI	PR:Q9QUI0	Mouse	PMID:18604197
Cellular Component	GO:0015629	actin cytoskeleton	Iqgap1	IDA		Rat	PMID:15695813|RGD:10047185
Cellular Component	GO:0016324	apical plasma membrane	IQGAP1	IDA		Human	PMID:35601831
Cellular Component	GO:0016324	apical plasma membrane	Iqgap1	IDA		Mouse	MGI:MGI:7388224|PMID:35601831
Cellular Component	GO:0030424	axon	Iqgap1	IDA		Rat	PMID:15695813|RGD:10047185
Cellular Component	GO:0016323	basolateral plasma membrane	Iqgap1	IDA		Mouse	MGI:MGI:7388224|PMID:35601831
Cellular Component	GO:0031252	cell leading edge	Iqgap1	IGI	MGI:MGI:109520	Mouse	PMID:16369480
Cellular Component	GO:0031252	cell leading edge	Iqgap1	IDA		Mouse	PMID:24841562
Cellular Component	GO:0005911	cell-cell junction	Iqgap1	IDA		Mouse	PMID:18604197
Cellular Component	GO:0030864	cortical actin cytoskeleton	Iqgap1	IPI	PR:P46940	Mouse	PMID:28089576
Cellular Component	GO:0005737	cytoplasm	IQGAP1	IDA		Human	PMID:25554515
Cellular Component	GO:0005737	cytoplasm	IQGAP1	IDA		Human	PMID:29033352
Cellular Component	GO:0005737	cytoplasm	Iqgap1	IDA		Mouse	PMID:14516655
Cellular Component	GO:0005737	cytoplasm	Iqgap1	IDA		Mouse	PMID:24841562
Cellular Component	GO:0005737	cytoplasm	Iqgap1	IDA		Mouse	PMID:18604197
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	IQGAP1	IDA		Human	PMID:15121898
Cellular Component	GO:0070062	extracellular exosome	IQGAP1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	IQGAP1	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	IQGAP1	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	IQGAP1	HDA		Human	PMID:23533145
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	IQGAP1	IDA		Human	PMID:22493426
Cellular Component	GO:0005925	focal adhesion	IQGAP1	HDA		Human	PMID:21423176
Cellular Component	GO:0005925	focal adhesion	Iqgap1	IDA		Mouse	PMID:24841562
Cellular Component	GO:0005925	focal adhesion	Iqgap1	IDA		Rat	PMID:23657573|RGD:11049552
Cellular Component	GO:0030426	growth cone	Iqgap1	IDA		Rat	PMID:15695813|RGD:10047185
Cellular Component	GO:0016328	lateral plasma membrane	Iqgap1	IDA		Mouse	PMID:18604197
Cellular Component	GO:0045121	membrane raft	Iqgap1	IDA		Rat	PMID:23657573|RGD:11049552
Cellular Component	GO:0005874	microtubule	IQGAP1	IDA		Human	PMID:21525035
Cellular Component	GO:0015630	microtubule cytoskeleton	Iqgap1	IDA		Rat	PMID:15695813|RGD:10047185
Cellular Component	GO:0030496	midbody	IQGAP1	IDA		Human	PMID:15166316
Cellular Component	GO:0043005	neuron projection	Iqgap1	IGI	MGI:MGI:109520	Mouse	PMID:16369480
Cellular Component	GO:0043005	neuron projection	Iqgap1	IDA		Rat	PMID:15695813|RGD:10047185
Cellular Component	GO:0005634	nucleus	IQGAP1	IDA		Human	PMID:20883816
Cellular Component	GO:0005634	nucleus	IQGAP1	IDA		Human	PMID:29033352
Cellular Component	GO:0005634	nucleus	Iqgap1	IDA		Mouse	MGI:MGI:6114895|PMID:20883816
Cellular Component	GO:0005634	nucleus	Iqgap1	IDA		Rat	PMID:20883816|RGD:11049555
Cellular Component	GO:0005886	plasma membrane	IQGAP1	IDA		Human	PMID:29033352
Cellular Component	GO:0032991	protein-containing complex	Iqgap1	IDA		Rat	PMID:15331416|RGD:1600864
Cellular Component	GO:1990904	ribonucleoprotein complex	Iqgap1	IDA		Mouse	PMID:21709260
Cellular Component	GO:1990904	ribonucleoprotein complex	Iqgap1	IGI	MGI:MGI:2444126	Mouse	PMID:21709260
Cellular Component	GO:0001726	ruffle	IQGAP1	IDA		Human	PMID:25554515
Cellular Component	GO:0001726	ruffle	IQGAP1	IDA		Human	PMID:26242911
Biological Process	GO:0016477	cell migration	IQGAP1	IMP		Human	PMID:26242911
Biological Process	GO:0071277	cellular response to calcium ion	IQGAP1	IDA		Human	PMID:18567582
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	IQGAP1	IMP		Human	PMID:17563371
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	IQGAP1	IMP		Human	PMID:26242911
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	Iqgap1	IMP		Mouse	MGI:MGI:5430891|PMID:17563371
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	Iqgap1	IMP		Mouse	MGI:MGI:5430891|PMID:17563371
Biological Process	GO:0036120	cellular response to platelet-derived growth factor stimulus	Iqgap1	IMP		Mouse	MGI:MGI:5430891|PMID:17563371
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IQGAP1	IMP		Human	PMID:17563371
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IQGAP1	IMP		Human	PMID:18567582
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Iqgap1	IMP		Mouse	MGI:MGI:5430891|PMID:17563371
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Iqgap1	IMP		Mouse	MGI:MGI:5430891|PMID:17563371
Biological Process	GO:0010761	fibroblast migration	Iqgap1	IGI	MGI:MGI:1932697	Mouse	PMID:24841562
Biological Process	GO:0035305	negative regulation of dephosphorylation	Iqgap1	IGI	MGI:MGI:2444126	Mouse	PMID:21709260
Biological Process	GO:1990138	neuron projection extension	IQGAP1	IMP		Human	PMID:15695813
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	Iqgap1	IMP		Mouse	MGI:MGI:5430891|PMID:17563371
Biological Process	GO:1900006	positive regulation of dendrite development	Iqgap1	IMP		Rat	PMID:21430156|RGD:11049556
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	Iqgap1	IMP		Rat	PMID:23657573|RGD:11049552
Biological Process	GO:0043406	positive regulation of MAP kinase activity	Iqgap1	IMP		Rat	PMID:23987506|RGD:11049533
Biological Process	GO:0043410	positive regulation of MAPK cascade	IQGAP1	IMP		Human	PMID:18567582
Biological Process	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	Iqgap1	IMP		Rat	PMID:23657573|RGD:11049552
Biological Process	GO:0045860	positive regulation of protein kinase activity	IQGAP1	IMP		Human	PMID:17563371
Biological Process	GO:0045860	positive regulation of protein kinase activity	Iqgap1	IMP		Mouse	MGI:MGI:5430891|PMID:17563371
Biological Process	GO:1903829	positive regulation of protein localization	Iqgap1	IMP		Rat	PMID:23987506|RGD:11049533
Biological Process	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	Iqgap1	IMP		Rat	PMID:23657573|RGD:11049552
Biological Process	GO:0001817	regulation of cytokine production	Iqgap1	IMP		Mouse	PMID:21709260
Biological Process	GO:0007346	regulation of mitotic cell cycle	IQGAP1	IMP		Human	PMID:20883816
Biological Process	GO:1990776	response to angiotensin	Iqgap1	IEP		Rat	PMID:24247724|RGD:11049550

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern