Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IQGAP2
  • Mouse genes Iqgap2
  • Rat genes Iqgap2
  • Zfish genes iqgap2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Iqgap2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051015	actin filament binding	IQGAP2	IDA		Human	PMID:12515716
Molecular Function	GO:0071933	Arp2/3 complex binding	IQGAP2	IDA		Human	PMID:12515716
Molecular Function	GO:0005516	calmodulin binding	IQGAP2	IPI	UniProtKB:P0DP23	Human	PMID:21299499
Molecular Function	GO:0005516	calmodulin binding	IQGAP2	IPI	UniProtKB:P0DP24	Human	PMID:21299499
Molecular Function	GO:0005516	calmodulin binding	IQGAP2	IPI	UniProtKB:P0DP25	Human	PMID:21299499
Molecular Function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	IQGAP2	IDA		Human	PMID:22493426
Molecular Function	GO:0031267	small GTPase binding	IQGAP2	IDA		Human	PMID:12515716
Cellular Component	GO:0009986	cell surface	IQGAP2	IDA		Human	PMID:12515716
Cellular Component	GO:0005737	cytoplasm	IQGAP2	IDA		Human	PMID:12515716
Cellular Component	GO:0070062	extracellular exosome	IQGAP2	HDA		Human	PMID:19056867
Cellular Component	GO:0030175	filopodium	IQGAP2	IDA		Human	PMID:12515716
Cellular Component	GO:0030027	lamellipodium	IQGAP2	IDA		Human	PMID:12515716
Cellular Component	GO:0005902	microvillus	Iqgap2	IDA		Mouse	PMID:18604197
Biological Process	GO:0034314	Arp2/3 complex-mediated actin nucleation	IQGAP2	IDA		Human	PMID:12515716
Biological Process	GO:0003094	glomerular filtration	iqgap2	IMP	ZFIN:ZDB-MRPHLNO-160318-4	Zfish	PMID:26154927
Biological Process	GO:0003094	glomerular filtration	iqgap2	IMP	ZFIN:ZDB-MRPHLNO-160318-2	Zfish	PMID:26154927
Biological Process	GO:0072015	podocyte development	iqgap2	IMP	ZFIN:ZDB-MRPHLNO-160318-2	Zfish	PMID:26154927
Biological Process	GO:2000249	regulation of actin cytoskeleton reorganization	IQGAP2	IDA		Human	PMID:12515716
Biological Process	GO:0070493	thrombin-activated receptor signaling pathway	IQGAP2	IDA		Human	PMID:12515716

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern