Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IQSEC1
  • Mouse genes Iqsec1
  • Rat genes Iqsec1
  • Zfish genes iqsec1a,iqsec1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Iqsec1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	IQSEC1	IPI	UniProtKB:P50148	Human	PMID:27265506
Molecular Function	GO:0019901	protein kinase binding	Iqsec1	IPI	UniProtKB:P97820	Mouse	MGI:MGI:6189265|PMID:25490267
Cellular Component	GO:0098978	glutamatergic synapse	Iqsec1	IDA		Mouse	PMID:22886754
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IQSEC1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	IQSEC1	HDA		Human	PMID:19946888
Cellular Component	GO:0005730	nucleolus	IQSEC1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0099092	postsynaptic density, intracellular component	Iqsec1	IDA		Mouse	PMID:22886754
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Iqsec1	IPI		Mouse	PMID:20547133
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Iqsec1	IEP		Mouse	PMID:20547133
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Iqsec1	IMP		Mouse	PMID:20547133
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Iqsec1	IDA		Mouse	PMID:20547133
Biological Process	GO:0001525	angiogenesis	iqsec1b	IGI	ZFIN:ZDB-MRPHLNO-150901-5,ZFIN:ZDB-MRPHLNO-150922-2	Zfish	PMID:24522833
Biological Process	GO:0001525	angiogenesis	iqsec1b	IMP	ZFIN:ZDB-MRPHLNO-150901-4	Zfish	PMID:24522833
Biological Process	GO:0001525	angiogenesis	iqsec1b	IMP	ZFIN:ZDB-MRPHLNO-150901-5	Zfish	PMID:24522833
Biological Process	GO:0001525	angiogenesis	iqsec1b	IGI	ZFIN:ZDB-MRPHLNO-150901-5,ZFIN:ZDB-MRPHLNO-150922-1	Zfish	PMID:24522833
Biological Process	GO:0001525	angiogenesis	iqsec1a	IGI	ZFIN:ZDB-MRPHLNO-150901-5,ZFIN:ZDB-MRPHLNO-150922-1	Zfish	PMID:24522833
Biological Process	GO:0001525	angiogenesis	iqsec1a	IGI	ZFIN:ZDB-MRPHLNO-150901-5,ZFIN:ZDB-MRPHLNO-150922-2	Zfish	PMID:24522833
Biological Process	GO:0060996	dendritic spine development	Iqsec1	IMP		Mouse	MGI:MGI:6414710|PMID:31607425
Biological Process	GO:0001946	lymphangiogenesis	iqsec1b	IMP	ZFIN:ZDB-MRPHLNO-150901-5	Zfish	PMID:24522833
Biological Process	GO:0001946	lymphangiogenesis	iqsec1b	IMP	ZFIN:ZDB-MRPHLNO-150901-4	Zfish	PMID:24522833
Biological Process	GO:0001946	lymphangiogenesis	iqsec1a	IMP	ZFIN:ZDB-MRPHLNO-150922-1	Zfish	PMID:24522833
Biological Process	GO:0001946	lymphangiogenesis	iqsec1a	IMP	ZFIN:ZDB-MRPHLNO-150922-2	Zfish	PMID:24522833
Biological Process	GO:0120183	positive regulation of focal adhesion disassembly	Iqsec1	IMP		Mouse	MGI:MGI:6189265|PMID:25490267
Biological Process	GO:0051549	positive regulation of keratinocyte migration	Iqsec1	IMP		Mouse	MGI:MGI:6189265|PMID:25490267
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	Iqsec1	IMP		Mouse	PMID:20547133
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	Iqsec1	IPI		Mouse	PMID:20547133
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	Iqsec1	IDA		Mouse	PMID:20547133
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	Iqsec1	IEP		Mouse	PMID:20547133
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	Iqsec1	IPI		Mouse	PMID:20547133
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	Iqsec1	IDA		Mouse	PMID:20547133
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	Iqsec1	IEP		Mouse	PMID:20547133
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	Iqsec1	IMP		Mouse	PMID:20547133
Biological Process	GO:0001944	vasculature development	iqsec1b	IGI	ZFIN:ZDB-MRPHLNO-150901-5,ZFIN:ZDB-MRPHLNO-150922-1	Zfish	PMID:24522833
Biological Process	GO:0001944	vasculature development	iqsec1b	IGI	ZFIN:ZDB-MRPHLNO-150901-5,ZFIN:ZDB-MRPHLNO-150922-2	Zfish	PMID:24522833
Biological Process	GO:0001944	vasculature development	iqsec1a	IMP	ZFIN:ZDB-MRPHLNO-150922-1	Zfish	PMID:24522833
Biological Process	GO:0001944	vasculature development	iqsec1a	IMP	ZFIN:ZDB-MRPHLNO-150922-2	Zfish	PMID:24522833
Biological Process	GO:0001944	vasculature development	iqsec1a	IGI	ZFIN:ZDB-MRPHLNO-150901-5,ZFIN:ZDB-MRPHLNO-150922-2	Zfish	PMID:24522833
Biological Process	GO:0001944	vasculature development	iqsec1a	IGI	ZFIN:ZDB-MRPHLNO-150901-5,ZFIN:ZDB-MRPHLNO-150922-1	Zfish	PMID:24522833

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern