Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IRAK1
  • Mouse genes Irak1
  • Rat genes Irak1
  • Zfish genes irak1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Irak1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031072	heat shock protein binding	Irak1	IDA		Rat	PMID:23324889|RGD:7495799
Molecular Function	GO:0042802	identical protein binding	IRAK1	IPI	UniProtKB:P51617	Human	PMID:11397809
Molecular Function	GO:0005149	interleukin-1 receptor binding	Irak1	IPI	PR:P13504	Mouse	PMID:15292196
Molecular Function	GO:0016301	kinase activity	IRAK1	IDA		Human	PMID:12054681
Molecular Function	GO:0016301	kinase activity	IRAK1	IDA		Human	PMID:14625308
Molecular Function	GO:0005515	protein binding	IRAK1	IPI	UniProtKB:Q9H0E2	Human	PMID:10854325
Molecular Function	GO:0005515	protein binding	IRAK1	IPI	UniProtKB:Q9Y4K3	Human	PMID:11397809
Molecular Function	GO:0005515	protein binding	IRAK1	IPI	UniProtKB:Q9Y4K3	Human	PMID:11518704
Molecular Function	GO:0005515	protein binding	IRAK1	IPI	UniProtKB:Q9Y4K3	Human	PMID:12242293
Molecular Function	GO:0005515	protein binding	IRAK1	IPI	UniProtKB:Q96FA3	Human	PMID:12496252
Molecular Function	GO:0005515	protein binding	IRAK1	IPI	UniProtKB:Q9HAT8	Human	PMID:12860405
Molecular Function	GO:0005515	protein binding	IRAK1	IPI	UniProtKB:Q8N2H9-2	Human	PMID:12874243
Molecular Function	GO:0005515	protein binding	IRAK1	IPI	UniProtKB:Q6IA17	Human	PMID:12925853
Molecular Function	GO:0005515	protein binding	IRAK1	IPI	UniProtKB:P59046	Human	PMID:16203735
Molecular Function	GO:0005515	protein binding	IRAK1	IPI	UniProtKB:Q96FA3	Human	PMID:16884718
Molecular Function	GO:0005515	protein binding	IRAK1	IPI	UniProtKB:Q9HAT8	Human	PMID:16884718
Molecular Function	GO:0005515	protein binding	IRAK1	IPI	UniProtKB:Q99836	Human	PMID:17567694
Molecular Function	GO:0005515	protein binding	IRAK1	IPI	UniProtKB:Q8N2H9-2	Human	PMID:19081057
Molecular Function	GO:0005515	protein binding	IRAK1	IPI	UniProtKB:Q9HAT8	Human	PMID:19081057
Molecular Function	GO:0005515	protein binding	IRAK1	IPI	UniProtKB:Q96FA3	Human	PMID:19264966
Molecular Function	GO:0005515	protein binding	IRAK1	IPI	UniProtKB:Q13526	Human	PMID:21743479
Molecular Function	GO:0005515	protein binding	IRAK1	IPI	UniProtKB:P58753	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRAK1	IPI	UniProtKB:Q15306	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRAK1	IPI	UniProtKB:Q86WV6	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRAK1	IPI	UniProtKB:Q8VCW4	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRAK1	IPI	UniProtKB:Q92985	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRAK1	IPI	UniProtKB:Q5D1E7	Human	PMID:22037600
Molecular Function	GO:0005515	protein binding	IRAK1	IPI	UniProtKB:Q3KP66	Human	PMID:28436939
Molecular Function	GO:0005515	protein binding	IRAK1	IPI	UniProtKB:Q96FA3	Human	PMID:29883609
Molecular Function	GO:0005515	protein binding	IRAK1	IPI	UniProtKB:P03316	Human	PMID:33673546
Molecular Function	GO:0005515	protein binding	Irak1	IPI	UniProtKB:Q8BST6	Mouse	MGI:MGI:2388454|PMID:12370331
Molecular Function	GO:0005515	protein binding	Irak1	IPI	UniProtKB:P22366|UniProtKB:Q9QZ06	Mouse	MGI:MGI:1889886|PMID:10854325
Molecular Function	GO:0005515	protein binding	Irak1	IPI	UniProtKB:P22366	Mouse	MGI:MGI:5002402|PMID:21441935
Molecular Function	GO:0005515	protein binding	Irak1	IPI	UniProtKB:P22366	Mouse	MGI:MGI:5305352|PMID:22011580
Molecular Function	GO:0005515	protein binding	Irak1	IPI	UniProtKB:P37889-1|UniProtKB:P70196|UniProtKB:Q3THG9	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Irak1	IPI	UniProtKB:Q8CBB9	Mouse	MGI:MGI:4943343|PMID:21435586
Molecular Function	GO:0005515	protein binding	Irak1	IPI	UniProtKB:Q793I8	Mouse	MGI:MGI:3687915|PMID:12566447
Molecular Function	GO:0005515	protein binding	Irak1	IPI	UniProtKB:P39429	Mouse	MGI:MGI:5565129|PMID:24706909
Molecular Function	GO:0005515	protein binding	Irak1	IPI	PR:Q9ESJ7	Mouse	PMID:11096118
Molecular Function	GO:0046982	protein heterodimerization activity	IRAK1	IPI	UniProtKB:O43187	Human	PMID:10383454
Molecular Function	GO:0046982	protein heterodimerization activity	IRAK1	IPI	UniProtKB:Q9Y616	Human	PMID:10383454
Molecular Function	GO:0042803	protein homodimerization activity	IRAK1	IPI	UniProtKB:P51617	Human	PMID:10383454
Molecular Function	GO:0004672	protein kinase activity	IRAK1	IDA		Human	PMID:12054681
Molecular Function	GO:0004672	protein kinase activity	Irak1	IDA		Mouse	PMID:12054681
Molecular Function	GO:0004672	protein kinase activity	Irak1	IDA		Mouse	PMID:10549626
Molecular Function	GO:0004672	protein kinase activity	Irak1	IDA		Rat	PMID:15793310|RGD:1579809
Molecular Function	GO:0019901	protein kinase binding	IRAK1	IPI	UniProtKB:Q9NWZ3	Human	PMID:33238146
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IRAK1	EXP		Human	PMID:11960013
Cellular Component	GO:0009986	cell surface	IRAK1	IDA		Human	PMID:22851693
Cellular Component	GO:0005829	cytosol	IRAK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005811	lipid droplet	Irak1	IDA		Mouse	MGI:MGI:4943343|PMID:21435586
Cellular Component	GO:0016020	membrane	Irak1	IDA		Mouse	MGI:MGI:3694380|PMID:16831874
Cellular Component	GO:0016020	membrane	Irak1	IDA		Rat	PMID:23324889|RGD:7495799
Cellular Component	GO:0005654	nucleoplasm	IRAK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0032991	protein-containing complex	IRAK1	IDA		Human	PMID:10854325
Cellular Component	GO:0032991	protein-containing complex	Irak1	IDA		Mouse	MGI:MGI:1889886|PMID:10854325
Biological Process	GO:0007250	activation of NF-kappaB-inducing kinase activity	IRAK1	IDA		Human	PMID:11397809
Biological Process	GO:0007568	aging	Irak1	IEP		Rat	PMID:18497707|RGD:7495793
Biological Process	GO:0034605	cellular response to heat	Irak1	IDA		Rat	PMID:23324889|RGD:7495799
Biological Process	GO:0071456	cellular response to hypoxia	Irak1	IEP		Rat	PMID:15793310|RGD:1579809
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Irak1	IEP		Rat	PMID:15793310|RGD:1579809
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Irak1	IDA		Mouse	PMID:15292196
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Irak1	IMP		Rat	PMID:15890643|RGD:1579817
Biological Process	GO:0045087	innate immune response	Irak1	IEP		Mouse	MGI:MGI:3694380|PMID:16831874
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	IRAK1	IMP		Human	PMID:10383454
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	IRAK1	IDA		Human	PMID:14625308
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	Irak1	IDA		Mouse	MGI:MGI:1889886|PMID:10854325
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	Irak1	IDA		Mouse	PMID:12054681
Biological Process	GO:0007254	JNK cascade	Irak1	IMP		Rat	PMID:15890643|RGD:1579817
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IRAK1	IMP		Human	PMID:10383454
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	Irak1	IDA		Mouse	PMID:12855817
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	Irak1	IDA		Mouse	PMID:10549626
Biological Process	GO:0090370	negative regulation of cholesterol efflux	Irak1	IMP		Mouse	MGI:MGI:4411947|PMID:19752193
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Irak1	IMP		Mouse	MGI:MGI:4411947|PMID:19752193
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	IRAK1	IMP		Human	PMID:10383454
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IRAK1	IMP		Human	PMID:22158417
Biological Process	GO:0043507	positive regulation of JUN kinase activity	Irak1	IMP		Mouse	MGI:MGI:3843426|PMID:17379480
Biological Process	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	IRAK1	IMP		Human	PMID:25515214
Biological Process	GO:0043406	positive regulation of MAP kinase activity	Irak1	IMP		Mouse	MGI:MGI:3843426|PMID:17379480
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IRAK1	IDA		Human	PMID:10383454
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Irak1	IDA		Mouse	PMID:12054681
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	IRAK1	IMP		Human	PMID:25515214
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Irak1	IMP		Rat	PMID:15890643|RGD:1579817
Biological Process	GO:0032481	positive regulation of type I interferon production	IRAK1	IMP		Human	PMID:23633945
Biological Process	GO:0046777	protein autophosphorylation	IRAK1	IDA		Human	PMID:12054681
Biological Process	GO:0046777	protein autophosphorylation	IRAK1	IDA		Human	PMID:10383454
Biological Process	GO:0046777	protein autophosphorylation	Irak1	IDA		Mouse	PMID:10549626
Biological Process	GO:0046777	protein autophosphorylation	Irak1	IDA		Mouse	PMID:12054681
Biological Process	GO:0006468	protein phosphorylation	Irak1	IDA		Rat	PMID:15793310|RGD:1579809
Biological Process	GO:0001959	regulation of cytokine-mediated signaling pathway	IRAK1	IMP		Human	PMID:10383454
Biological Process	GO:0070555	response to interleukin-1	IRAK1	IMP		Human	PMID:10383454
Biological Process	GO:0032496	response to lipopolysaccharide	IRAK1	IMP		Human	PMID:10383454
Biological Process	GO:0032496	response to lipopolysaccharide	Irak1	IDA		Mouse	PMID:10549626
Biological Process	GO:0032496	response to lipopolysaccharide	Irak1	IDA		Mouse	PMID:12855817
Biological Process	GO:0032494	response to peptidoglycan	Irak1	IDA		Mouse	PMID:10549626
Biological Process	GO:0034134	toll-like receptor 2 signaling pathway	IRAK1	IMP		Human	PMID:10383454
Biological Process	GO:0034134	toll-like receptor 2 signaling pathway	Irak1	IDA		Mouse	PMID:10549626
Biological Process	GO:0034142	toll-like receptor 4 signaling pathway	Irak1	IDA		Mouse	PMID:10549626
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	IRAK1	IMP		Human	PMID:23633945

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern