Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IRAK2
  • Mouse genes Irak2
  • Rat genes Irak2
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Irak2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	IRAK2	IPI	UniProtKB:P58753	Human	PMID:11544529
Molecular Function	GO:0005515	protein binding	IRAK2	IPI	UniProtKB:P68467	Human	PMID:18636090
Molecular Function	GO:0005515	protein binding	IRAK2	IPI	UniProtKB:Q9NWZ3	Human	PMID:20485341
Molecular Function	GO:0005515	protein binding	IRAK2	IPI	UniProtKB:P10398	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRAK2	IPI	UniProtKB:P46977	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRAK2	IPI	UniProtKB:P58753	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRAK2	IPI	UniProtKB:Q13148	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRAK2	IPI	UniProtKB:Q5D1E8	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRAK2	IPI	UniProtKB:Q6PDS3	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRAK2	IPI	UniProtKB:Q9H0E2	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRAK2	IPI	UniProtKB:Q9NWZ3	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRAK2	IPI	UniProtKB:Q9Y4K3	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRAK2	IPI	UniProtKB:Q9Y4K3	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	IRAK2	IPI	UniProtKB:Q9Y4K3	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	Irak2	IPI	UniProtKB:P22366	Mouse	MGI:MGI:2149909|PMID:11544529
Molecular Function	GO:0046982	protein heterodimerization activity	IRAK2	IPI	UniProtKB:P51617	Human	PMID:10383454
Molecular Function	GO:0046982	protein heterodimerization activity	IRAK2	IPI	UniProtKB:Q9Y616	Human	PMID:10383454
Molecular Function	GO:0042803	protein homodimerization activity	IRAK2	IPI	UniProtKB:O43187	Human	PMID:10383454
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	IRAK2	IMP		Human	PMID:10383454
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	Irak2	IDA		Mouse	PMID:15082713
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	Irak2	IDA		Mouse	PMID:15082713
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	IRAK2	IMP		Human	PMID:10383454
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IRAK2	IMP		Human	PMID:10383454
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Irak2	IDA		Mouse	PMID:15082713
Biological Process	GO:0001959	regulation of cytokine-mediated signaling pathway	IRAK2	IMP		Human	PMID:10383454
Biological Process	GO:0070555	response to interleukin-1	IRAK2	IMP		Human	PMID:10383454

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern