Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IRAK3
  • Mouse genes Irak3
  • Rat genes Irak3
  • Zfish genes irak3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Irak3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	IRAK3	IDA		Human	PMID:10383454
Molecular Function	GO:0005524	ATP binding	Irak3	IDA		Mouse	MGI:MGI:2181508|PMID:12054681
Molecular Function	GO:0000287	magnesium ion binding	IRAK3	IDA		Human	PMID:10383454
Molecular Function	GO:0000287	magnesium ion binding	Irak3	IDA		Mouse	MGI:MGI:2181508|PMID:12054681
Molecular Function	GO:0005515	protein binding	IRAK3	IPI	UniProtKB:Q13526	Human	PMID:29686383
Molecular Function	GO:0005515	protein binding	IRAK3	IPI	UniProtKB:Q9Y4K3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Irak3	IPI	UniProtKB:P70196|UniProtKB:Q8R4K2|UniProtKB:Q9NWZ3	Mouse	MGI:MGI:5553230|PMID:23376919
Molecular Function	GO:0005515	protein binding	Irak3	IPI	UniProtKB:Q9QUR7	Mouse	MGI:MGI:6158095|PMID:29686383
Molecular Function	GO:0005515	protein binding	Irak3	IPI	UniProtKB:P70196	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0046982	protein heterodimerization activity	IRAK3	IPI	UniProtKB:O43187	Human	PMID:10383454
Molecular Function	GO:0046982	protein heterodimerization activity	IRAK3	IPI	UniProtKB:P51617	Human	PMID:10383454
Molecular Function	GO:0042803	protein homodimerization activity	IRAK3	IPI	UniProtKB:Q9Y616	Human	PMID:10383454
Molecular Function	GO:0042803	protein homodimerization activity	IRAK3	IDA		Human	PMID:33238146
Molecular Function	GO:0004672	protein kinase activity	Irak3	IDA		Mouse	PMID:12054681
Molecular Function	GO:0019901	protein kinase binding	IRAK3	IPI	UniProtKB:Q9NWZ3	Human	PMID:33238146
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IRAK3	IDA		Human	PMID:10383454
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Irak3	IDA		Mouse	MGI:MGI:2181508|PMID:12054681
Cellular Component	GO:0005737	cytoplasm	IRAK3	IDA		Human	PMID:17379480
Cellular Component	GO:0005737	cytoplasm	Irak3	IDA		Mouse	MGI:MGI:6158095|PMID:29686383
Cellular Component	GO:0005737	cytoplasm	Irak3	IDA		Mouse	MGI:MGI:3843426|PMID:17379480
Cellular Component	GO:0005634	nucleus	IRAK3	IDA		Human	PMID:17379480
Cellular Component	GO:0005634	nucleus	Irak3	IDA		Mouse	MGI:MGI:3843426|PMID:17379480
Cellular Component	GO:0005634	nucleus	Irak3	IDA		Mouse	MGI:MGI:6158095|PMID:29686383
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Irak3	IDA		Mouse	MGI:MGI:2181508|PMID:12054681
Biological Process	GO:0035162	embryonic hemopoiesis	irak3	IMP	ZFIN:ZDB-MRPHLNO-060524-2	Zfish	PMID:16089502
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	IRAK3	IMP		Human	PMID:10383454
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	Irak3	IDA		Mouse	PMID:12054681
Biological Process	GO:0045824	negative regulation of innate immune response	Irak3	IMP		Mouse	MGI:MGI:2183694|PMID:12150927
Biological Process	GO:0032695	negative regulation of interleukin-12 production	IRAK3	IMP		Human	PMID:18156187
Biological Process	GO:0032695	negative regulation of interleukin-12 production	Irak3	IMP		Mouse	MGI:MGI:2183694|PMID:12150927
Biological Process	GO:0032715	negative regulation of interleukin-6 production	IRAK3	IMP		Human	PMID:18156187
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Irak3	IMP		Mouse	MGI:MGI:2183694|PMID:12150927
Biological Process	GO:0010936	negative regulation of macrophage cytokine production	Irak3	IMP		Mouse	MGI:MGI:2183694|PMID:12150927
Biological Process	GO:0043407	negative regulation of MAP kinase activity	IRAK3	IMP		Human	PMID:17379480
Biological Process	GO:0043407	negative regulation of MAP kinase activity	Irak3	IMP		Mouse	MGI:MGI:3843426|PMID:17379480
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	IRAK3	IMP		Human	PMID:10383454
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	IRAK3	IMP		Human	PMID:18156187
Biological Process	GO:0042177	negative regulation of protein catabolic process	IRAK3	IMP		Human	PMID:17379480
Biological Process	GO:0042177	negative regulation of protein catabolic process	IRAK3	IMP		Human	PMID:18156187
Biological Process	GO:0042177	negative regulation of protein catabolic process	Irak3	IMP		Mouse	MGI:MGI:3843426|PMID:17379480
Biological Process	GO:0043242	negative regulation of protein-containing complex disassembly	IRAK3	IMP		Human	PMID:12150927
Biological Process	GO:0034122	negative regulation of toll-like receptor signaling pathway	Irak3	IMP		Mouse	MGI:MGI:2183694|PMID:12150927
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IRAK3	IMP		Human	PMID:15728517
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Irak3	IMP		Mouse	MGI:MGI:2183694|PMID:12150927
Biological Process	GO:0001819	positive regulation of cytokine production	Irak3	IMP		Mouse	MGI:MGI:6158095|PMID:29686383
Biological Process	GO:0010933	positive regulation of macrophage tolerance induction	Irak3	IMP		Mouse	MGI:MGI:2183694|PMID:12150927
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IRAK3	IMP		Human	PMID:10383454
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Irak3	IDA		Mouse	PMID:12054681
Biological Process	GO:0046777	protein autophosphorylation	Irak3	IDA		Mouse	PMID:12054681
Biological Process	GO:0006468	protein phosphorylation	IRAK3	IDA		Human	PMID:10383454
Biological Process	GO:0006468	protein phosphorylation	Irak3	IDA		Mouse	MGI:MGI:2181508|PMID:12054681
Biological Process	GO:0043244	regulation of protein-containing complex disassembly	Irak3	IDA		Mouse	MGI:MGI:2181508|PMID:12054681
Biological Process	GO:0043330	response to exogenous dsRNA	Irak3	IMP		Mouse	MGI:MGI:2183694|PMID:12150927
Biological Process	GO:0070555	response to interleukin-1	IRAK3	IMP		Human	PMID:10383454
Biological Process	GO:0032496	response to lipopolysaccharide	Irak3	IMP		Mouse	MGI:MGI:2183694|PMID:12150927
Biological Process	GO:0032494	response to peptidoglycan	Irak3	IMP		Mouse	MGI:MGI:2183694|PMID:12150927

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern