Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IRAK4
  • Mouse genes Irak4
  • Rat genes Irak4
  • Zfish genes irak4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Irak4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005149	interleukin-1 receptor binding	Irak4	IPI	PR:P13504	Mouse	PMID:15292196
Molecular Function	GO:0019209	kinase activator activity	IRAK4	IDA		Human	PMID:11960013
Molecular Function	GO:0016301	kinase activity	IRAK4	IDA		Human	PMID:11960013
Molecular Function	GO:0005515	protein binding	IRAK4	IPI	UniProtKB:Q96FA3	Human	PMID:12496252
Molecular Function	GO:0005515	protein binding	IRAK4	IPI	UniProtKB:Q99836	Human	PMID:12860405
Molecular Function	GO:0005515	protein binding	IRAK4	IPI	UniProtKB:Q9HAT8	Human	PMID:12860405
Molecular Function	GO:0005515	protein binding	IRAK4	IPI	UniProtKB:Q96FA3	Human	PMID:19264966
Molecular Function	GO:0005515	protein binding	IRAK4	IPI	UniProtKB:O43187	Human	PMID:20485341
Molecular Function	GO:0005515	protein binding	IRAK4	IPI	UniProtKB:Q99836-1	Human	PMID:20485341
Molecular Function	GO:0005515	protein binding	IRAK4	IPI	UniProtKB:O43187	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRAK4	IPI	UniProtKB:P58753	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRAK4	IPI	UniProtKB:Q8K4B2	Human	PMID:23376919
Molecular Function	GO:0005515	protein binding	IRAK4	IPI	UniProtKB:Q99836	Human	PMID:24316379
Molecular Function	GO:0005515	protein binding	IRAK4	IPI	UniProtKB:Q99836-1	Human	PMID:24316379
Molecular Function	GO:0005515	protein binding	IRAK4	IPI	UniProtKB:Q99836	Human	PMID:25502805
Molecular Function	GO:0005515	protein binding	IRAK4	IPI	UniProtKB:Q99836	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	IRAK4	IPI	UniProtKB:Q99836	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	IRAK4	IPI	UniProtKB:Q99836	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	IRAK4	IPI	UniProtKB:Q96FA3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IRAK4	IPI	UniProtKB:Q96LX8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IRAK4	IPI	UniProtKB:Q99836	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IRAK4	IPI	UniProtKB:Q9C029	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IRAK4	IPI	UniProtKB:Q9UBH0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IRAK4	IPI	UniProtKB:Q9Y616	Human	PMID:33238146
Molecular Function	GO:0005515	protein binding	Irak4	IPI	UniProtKB:P22366	Mouse	MGI:MGI:5305352|PMID:22011580
Molecular Function	GO:0005515	protein binding	Irak4	IPI	UniProtKB:P22366	Mouse	MGI:MGI:4839450|PMID:16306937
Molecular Function	GO:0005515	protein binding	Irak4	IPI	UniProtKB:P22366	Mouse	MGI:MGI:5574431|PMID:24529375
Molecular Function	GO:0005515	protein binding	Irak4	IPI	UniProtKB:Q8K4B2	Mouse	MGI:MGI:5553230|PMID:23376919
Molecular Function	GO:0019901	protein kinase binding	IRAK4	IPI	UniProtKB:P51617	Human	PMID:33238146
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IRAK4	EXP		Human	PMID:11960013
Cellular Component	GO:0009986	cell surface	IRAK4	IDA		Human	PMID:22851693
Cellular Component	GO:0005615	extracellular space	Irak4	IDA		Rat	PMID:23073793|RGD:7495805
Biological Process	GO:0001816	cytokine production	Irak4	IDA		Mouse	PMID:15292196
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Irak4	IDA		Mouse	PMID:15292196
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Irak4	IMP		Rat	PMID:15890643|RGD:1579817
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	IRAK4	IDA		Human	PMID:20485341
Biological Process	GO:0007254	JNK cascade	Irak4	IMP		Rat	PMID:15890643|RGD:1579817
Biological Process	GO:0002446	neutrophil mediated immunity	IRAK4	IMP		Human	PMID:19663824
Biological Process	GO:1990266	neutrophil migration	IRAK4	IMP		Human	PMID:19663824
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	irak4	IDA		Zfish	PMID:15829296
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IRAK4	IMP		Human	PMID:22158417
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Irak4	IMP		Rat	PMID:15890643|RGD:1579817
Biological Process	GO:0009617	response to bacterium	irak4	IDA		Zfish	PMID:15829296

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern