Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IREB2
  • Mouse genes Ireb2
  • Rat genes Ireb2
  • Zfish genes ireb2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ireb2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051539	4 iron, 4 sulfur cluster binding	Ireb2	IDA		Rat	PMID:7665579|RGD:8554346
Molecular Function	GO:0030350	iron-responsive element binding	IREB2	IMP		Human	PMID:23891004
Molecular Function	GO:0030350	iron-responsive element binding	Ireb2	IDA		Mouse	PMID:14726953
Molecular Function	GO:0030350	iron-responsive element binding	Ireb2	IDA		Mouse	PMID:8262972
Molecular Function	GO:0030350	iron-responsive element binding	Ireb2	IDA		Rat	PMID:7665579|RGD:8554346
Molecular Function	GO:0005515	protein binding	IREB2	IPI	UniProtKB:Q9UKA1	Human	PMID:19762596
Molecular Function	GO:0005515	protein binding	IREB2	IPI	UniProtKB:Q9UKA1	Human	PMID:19762597
Molecular Function	GO:0005515	protein binding	IREB2	IPI	UniProtKB:O76071	Human	PMID:23891004
Molecular Function	GO:0005515	protein binding	IREB2	IPI	UniProtKB:Q9DCL2	Human	PMID:23891004
Molecular Function	GO:0001069	regulatory region RNA binding	Ireb2	IPI	RGD:732498	Rat	PMID:16135072|RGD:12904046
Molecular Function	GO:0001069	regulatory region RNA binding	Ireb2	IPI	RGD:733275	Rat	PMID:7523370|RGD:12910701
Molecular Function	GO:0003723	RNA binding	IREB2	IDA		Human	PMID:7983023
Molecular Function	GO:0003723	RNA binding	Ireb2	IDA		Rat	PMID:21753061|RGD:12904028
Cellular Component	GO:0030424	axon	Ireb2	IDA		Rat	PMID:12111837|RGD:12904054
Cellular Component	GO:0005737	cytoplasm	Ireb2	IDA		Mouse	PMID:8262972
Cellular Component	GO:0005829	cytosol	Ireb2	IDA		Mouse	PMID:16144863
Cellular Component	GO:0005829	cytosol	Ireb2	IDA		Rat	PMID:21753061|RGD:12904028
Cellular Component	GO:0005739	mitochondrion	Ireb2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0043025	neuronal cell body	Ireb2	IDA		Rat	PMID:12111837|RGD:12904054
Biological Process	GO:0007568	aging	Ireb2	IEP		Rat	PMID:19943190|RGD:6893272
Biological Process	GO:0007420	brain development	Ireb2	IEP		Rat	PMID:12111837|RGD:12904054
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	Ireb2	IDA		Rat	PMID:10889193|RGD:12910555
Biological Process	GO:0071456	cellular response to hypoxia	Ireb2	IEP		Rat	PMID:22159112|RGD:6893269
Biological Process	GO:0071283	cellular response to iron(III) ion	Ireb2	IDA		Rat	PMID:16135072|RGD:12904046
Biological Process	GO:0071283	cellular response to iron(III) ion	Ireb2	IEP		Rat	PMID:17469137|RGD:12904039
Biological Process	GO:0071287	cellular response to manganese ion	Ireb2	IDA		Rat	PMID:16568477|RGD:12904041
Biological Process	GO:0071287	cellular response to manganese ion	Ireb2	IEP		Rat	PMID:17469137|RGD:12904039
Biological Process	GO:0072705	cellular response to mercaptoethanol	Ireb2	IDA		Rat	PMID:16135072|RGD:12904046
Biological Process	GO:0090650	cellular response to oxygen-glucose deprivation	Ireb2	IDA		Rat	PMID:16135072|RGD:12904046
Biological Process	GO:0071300	cellular response to retinoic acid	Ireb2	IEP		Rat	PMID:22154532|RGD:12904026
Biological Process	GO:0034101	erythrocyte homeostasis	Ireb2	IMP	MGI:MGI:2181660	Mouse	PMID:15831703
Biological Process	GO:0051649	establishment of localization in cell	Ireb2	IGI	MGI:MGI:87879	Mouse	PMID:18177727
Biological Process	GO:0050892	intestinal absorption	Ireb2	IGI	MGI:MGI:87879	Mouse	PMID:18177727
Biological Process	GO:0006879	intracellular iron ion homeostasis	IREB2	IMP		Human	PMID:30915432
Biological Process	GO:0006879	intracellular iron ion homeostasis	Ireb2	IGI	MGI:MGI:87879	Mouse	PMID:14726953
Biological Process	GO:0006879	intracellular iron ion homeostasis	Ireb2	IDA		Mouse	PMID:11175792
Biological Process	GO:0006879	intracellular iron ion homeostasis	Ireb2	IMP	MGI:MGI:2181660	Mouse	PMID:15831703
Biological Process	GO:0006879	intracellular iron ion homeostasis	Ireb2	IMP	MGI:MGI:2181660	Mouse	PMID:14726953
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	Ireb2	IGI	MGI:MGI:2152883	Mouse	PMID:21907140
Biological Process	GO:0017148	negative regulation of translation	Ireb2	IDA		Rat	PMID:7523370|RGD:12910701
Biological Process	GO:0030316	osteoclast differentiation	Ireb2	IEP		Mouse	MGI:MGI:3838421|PMID:19252502
Biological Process	GO:0009791	post-embryonic development	Ireb2	IGI	MGI:MGI:87879	Mouse	PMID:18177727
Biological Process	GO:0006782	protoporphyrinogen IX biosynthetic process	Ireb2	IMP	MGI:MGI:2181660	Mouse	PMID:15831703
Biological Process	GO:0010468	regulation of gene expression	Ireb2	IGI	MGI:MGI:87879	Mouse	PMID:18177727
Biological Process	GO:0006417	regulation of translation	Ireb2	IMP	MGI:MGI:2181660	Mouse	PMID:14726953
Biological Process	GO:0014823	response to activity	Ireb2	IEP		Rat	PMID:24184442|RGD:12904018
Biological Process	GO:0046688	response to copper ion	Ireb2	IEP		Rat	PMID:24024382|RGD:12904019
Biological Process	GO:1990910	response to hypobaric hypoxia	Ireb2	IEP		Rat	PMID:27925282|RGD:12902631
Biological Process	GO:0010040	response to iron(II) ion	Ireb2	IEP		Rat	PMID:19943190|RGD:6893272
Biological Process	GO:0010041	response to iron(III) ion	Ireb2	IDA		Rat	PMID:21753061|RGD:12904028
Biological Process	GO:1904373	response to kainic acid	Ireb2	IEP		Rat	PMID:16328268|RGD:12904043
Biological Process	GO:0032526	response to retinoic acid	Ireb2	IEP		Rat	PMID:19877527|RGD:6893274
Biological Process	GO:0010043	response to zinc ion	Ireb2	IEP		Rat	PMID:24024381|RGD:12904020
Biological Process	GO:0014732	skeletal muscle atrophy	Ireb2	IEP		Rat	PMID:23994517|RGD:12904021

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern