Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Irf1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes IRF1
- Mouse genes Irf1
- Rat genes Irf1
- Zfish genes irf1a,irf1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Irf1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Irf1	IDA		Mouse	PMID:14568984
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IRF1	IMP		Human	PMID:15509808
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IRF1	IDA		Human	PMID:32385160
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Irf1	IDA		Mouse	PMID:17159910
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Irf1	IDA		Mouse	PMID:14568984
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Irf1	IDA		Mouse	MGI:MGI:5806342\|PMID:27693356
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Irf1	IMP		Mouse	MGI:MGI:6357088\|PMID:30635240
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Irf1	IDA		Mouse	MGI:MGI:5774628\|PMID:25774715
Molecular Function	GO:0005515	protein binding	IRF1	IPI	UniProtKB:P03129	Human	PMID:10702232
Molecular Function	GO:0005515	protein binding	IRF1	IPI	UniProtKB:Q09472	Human	PMID:15509808
Molecular Function	GO:0005515	protein binding	IRF1	IPI	UniProtKB:P63165	Human	PMID:17942705
Molecular Function	GO:0005515	protein binding	IRF1	IPI	UniProtKB:Q14653	Human	PMID:32878885
Molecular Function	GO:0005515	protein binding	IRF1	IPI	UniProtKB:Q16236	Human	PMID:32911434
Molecular Function	GO:0005515	protein binding	Irf1	IPI	UniProtKB:Q13114\|UniProtKB:Q14145	Mouse	MGI:MGI:5292417\|PMID:21903422
Molecular Function	GO:0005515	protein binding	Irf1	IPI	UniProtKB:Q15327	Mouse	MGI:MGI:5294529\|PMID:20599664
Molecular Function	GO:0005515	protein binding	Irf1	IPI	UniProtKB:P22366	Mouse	MGI:MGI:3691368\|PMID:17018642
Molecular Function	GO:0005515	protein binding	Irf1	IPI	PR:Q99J95	Mouse	PMID:23154982
Molecular Function	GO:0005515	protein binding	Irf1	IPI	PR:Q9ESU6	Mouse	PMID:23154982
Molecular Function	GO:0005515	protein binding	Irf1	IPI	RGD:1309799	Rat	PMID:19843519\|RGD:5128776
Molecular Function	GO:0005515	protein binding	irf1b	IPI	ZFIN:ZDB-GENE-040219-3	Zfish	PMID:27496972
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IRF1	IMP		Human	PMID:15509808
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IRF1	IDA		Human	PMID:18035482
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IRF1	IDA		Human	PMID:32385160
Molecular Function	GO:0043565	sequence-specific DNA binding	Irf1	IDA		Mouse	PMID:17159910
Molecular Function	GO:0043565	sequence-specific DNA binding	Irf1	IDA		Rat	PMID:11880315\|RGD:5128716
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IRF1	IDA		Human	PMID:32385160
Molecular Function	GO:0000976	transcription cis-regulatory region binding	irf1b	IGI	ZFIN:ZDB-GENE-030721-3	Zfish	PMID:27496972
Molecular Function	GO:0000976	transcription cis-regulatory region binding	irf1b	IGI	ZFIN:ZDB-GENE-071128-2	Zfish	PMID:27496972
Cellular Component	GO:0000785	chromatin	IRF1	IDA		Human	PMID:18035482
Cellular Component	GO:0005737	cytoplasm	Irf1	IDA		Mouse	MGI:MGI:3691368\|PMID:17018642
Cellular Component	GO:0005634	nucleus	Irf1	IDA		Mouse	MGI:MGI:3691368\|PMID:17018642
Cellular Component	GO:0005634	nucleus	Irf1	IMP		Mouse	MGI:MGI:6357088\|PMID:30635240
Cellular Component	GO:0005634	nucleus	Irf1	IDA		Rat	PMID:11880315\|RGD:5128716
Cellular Component	GO:0005634	nucleus	irf1b	IDA		Zfish	PMID:25535281
Biological Process	GO:0006915	apoptotic process	IRF1	IDA		Human	PMID:19851330
Biological Process	GO:0043374	CD8-positive, alpha-beta T cell differentiation	Irf1	IMP	MGI:MGI:1857205	Mouse	PMID:11359801
Biological Process	GO:0071360	cellular response to exogenous dsRNA	Irf1	IEP		Rat	PMID:11694343\|RGD:5128789
Biological Process	GO:0035458	cellular response to interferon-beta	IRF1	IDA		Human	PMID:18035482
Biological Process	GO:0035458	cellular response to interferon-beta	Irf1	IEP		Rat	PMID:21261980\|RGD:5128727
Biological Process	GO:0071347	cellular response to interleukin-1	Irf1	IDA		Rat	PMID:19843519\|RGD:5128776
Biological Process	GO:0071260	cellular response to mechanical stimulus	IRF1	IEP		Human	PMID:19593445
Biological Process	GO:0071375	cellular response to peptide hormone stimulus	Irf1	IDA		Rat	PMID:11022129\|RGD:5128791
Biological Process	GO:0071300	cellular response to retinoic acid	Irf1	IEP		Rat	PMID:15721283\|RGD:5128785
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Irf1	IDA		Rat	PMID:16978650\|RGD:5128784
Biological Process	GO:0071346	cellular response to type II interferon	Irf1	IEP		Rat	PMID:21261980\|RGD:5128727
Biological Process	GO:0051607	defense response to virus	IRF1	IDA		Human	PMID:21389130
Biological Process	GO:0051607	defense response to virus	IRF1	IDA		Human	PMID:21478870
Biological Process	GO:0051607	defense response to virus	Irf1	IMP		Mouse	MGI:MGI:4881394\|PMID:20451243
Biological Process	GO:0051607	defense response to virus	Irf1	IMP		Mouse	MGI:MGI:6357088\|PMID:30635240
Biological Process	GO:0007565	female pregnancy	Irf1	IEP		Rat	PMID:17651018\|RGD:2290569
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Irf1	IMP		Rat	PMID:15141302\|RGD:5128786
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IRF1	IMP		Human	PMID:18084608
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IRF1	IMP		Human	PMID:22200613
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Irf1	IDA		Mouse	MGI:MGI:3803082\|PMID:18641303
Biological Process	GO:0045590	negative regulation of regulatory T cell differentiation	Irf1	IMP		Mouse	MGI:MGI:3803082\|PMID:18641303
Biological Process	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	Irf1	IMP		Rat	PMID:20980260\|RGD:5128774
Biological Process	GO:0043065	positive regulation of apoptotic process	Irf1	IMP		Rat	PMID:21261980\|RGD:5128727
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IRF1	IMP		Human	PMID:15509808
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IRF1	IMP		Human	PMID:17516545
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IRF1	IMP		Human	PMID:19851330
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IRF1	IDA		Human	PMID:22200613
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IRF1	IMP		Human	PMID:22367195
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Irf1	IMP		Mouse	MGI:MGI:4454517\|PMID:20308629
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Irf1	IDA		Mouse	PMID:14568984
Biological Process	GO:0032728	positive regulation of interferon-beta production	IRF1	IMP		Human	PMID:21389130
Biological Process	GO:0032735	positive regulation of interleukin-12 production	Irf1	IMP	MGI:MGI:1857205	Mouse	PMID:14568984
Biological Process	GO:0032735	positive regulation of interleukin-12 production	Irf1	IDA		Mouse	PMID:14568984
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IRF1	IMP		Human	PMID:15509808
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IRF1	IMP		Human	PMID:32385160
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Irf1	IMP		Mouse	MGI:MGI:6357088\|PMID:30635240
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Irf1	IDA		Mouse	PMID:17159910
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Irf1	IMP		Rat	PMID:11742807\|RGD:619663
Biological Process	GO:0032481	positive regulation of type I interferon production	Irf1	IMP		Mouse	MGI:MGI:3691368\|PMID:17018642
Biological Process	GO:2000564	regulation of CD8-positive, alpha-beta T cell proliferation	Irf1	IMP		Mouse	MGI:MGI:5317515\|PMID:21909274
Biological Process	GO:0051726	regulation of cell cycle	IRF1	IDA		Human	PMID:22200613
Biological Process	GO:0050688	regulation of defense response to virus	irf1b	IDA		Zfish	PMID:25535281
Biological Process	GO:0010468	regulation of gene expression	Irf1	IMP	MGI:MGI:1857205	Mouse	PMID:11359801
Biological Process	GO:0034124	regulation of MyD88-dependent toll-like receptor signaling pathway	Irf1	IMP		Mouse	MGI:MGI:3691368\|PMID:17018642
Biological Process	GO:0060416	response to growth hormone	Irf1	IDA		Rat	PMID:9492014\|RGD:5128792
Biological Process	GO:0009408	response to heat	Irf1	IEP		Rat	PMID:17581221\|RGD:5128783
Biological Process	GO:0009615	response to virus	irf1b	IDA		Zfish	PMID:27496972
Biological Process	GO:0006366	transcription by RNA polymerase II	Irf1	IDA		Mouse	PMID:17159910
Biological Process	GO:0060333	type II interferon-mediated signaling pathway	Irf1	IMP		Mouse	MGI:MGI:5317515\|PMID:21909274

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.