Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IRF2
  • Mouse genes Irf2
  • Rat genes Irf2
  • Zfish genes irf2,irf2a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Irf2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	IRF2	IDA		Human	PMID:9540062
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IRF2	IMP		Human	PMID:9540062
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IRF2	IMP		Human	PMID:9540062
Molecular Function	GO:0005515	protein binding	IRF2	IPI	UniProtKB:O95352	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRF2	IPI	UniProtKB:P16298	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRF2	IPI	UniProtKB:P85037	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRF2	IPI	UniProtKB:Q01167	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRF2	IPI	UniProtKB:Q01167	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	IRF2	IPI	UniProtKB:P85037	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	IRF2	IPI	UniProtKB:Q01167	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	IRF2	IPI	UniProtKB:P62805	Human	PMID:9540062
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IRF2	IMP		Human	PMID:9540062
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	IRF2	IDA		Human	PMID:28473536
Cellular Component	GO:0005829	cytosol	IRF2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005925	focal adhesion	IRF2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	IRF2	IDA		Human	GO_REF:0000052
Biological Process	GO:0051607	defense response to virus	IRF2	IDA		Human	PMID:21478870
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IRF2	IMP		Human	PMID:9540062
Biological Process	GO:0006355	regulation of DNA-templated transcription	IRF2	IMP		Human	PMID:9540062

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern