Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Irf3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes IRF3
- Mouse genes Irf3
- Rat genes Irf3
- Zfish genes irf3
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Irf3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001216	DNA-binding transcription activator activity	IRF3	IDA		Human	PMID:8524823
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IRF3	IMP		Human	PMID:17560375
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IRF3	IDA		Human	PMID:8524823
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IRF3	IDA		Human	PMID:8524823
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Irf3	IMP		Mouse	MGI:MGI:5792628\|PMID:27129230
Molecular Function	GO:0042802	identical protein binding	IRF3	IPI	UniProtKB:Q14653	Human	PMID:15841462
Molecular Function	GO:0042802	identical protein binding	IRF3	IPI	UniProtKB:Q14653	Human	PMID:16301520
Molecular Function	GO:0042802	identical protein binding	IRF3	IPI	UniProtKB:Q14653	Human	PMID:18725644
Molecular Function	GO:0042802	identical protein binding	IRF3	IPI	UniProtKB:Q14653	Human	PMID:19416887
Molecular Function	GO:0042802	identical protein binding	IRF3	IPI	UniProtKB:Q14653	Human	PMID:19454348
Molecular Function	GO:0042802	identical protein binding	IRF3	IPI	UniProtKB:Q14653	Human	PMID:20403326
Molecular Function	GO:0042802	identical protein binding	IRF3	IPI	UniProtKB:Q14653	Human	PMID:20581830
Molecular Function	GO:0042802	identical protein binding	IRF3	IPI	UniProtKB:Q14653	Human	PMID:21102435
Molecular Function	GO:0042802	identical protein binding	IRF3	IPI	UniProtKB:Q14653	Human	PMID:21782231
Molecular Function	GO:0042802	identical protein binding	IRF3	IPI	UniProtKB:Q14653	Human	PMID:22000020
Molecular Function	GO:0042802	identical protein binding	IRF3	IPI	UniProtKB:Q14653	Human	PMID:22728658
Molecular Function	GO:0042802	identical protein binding	IRF3	IPI	UniProtKB:Q14653	Human	PMID:23746807
Molecular Function	GO:0042802	identical protein binding	IRF3	IPI	UniProtKB:Q14653	Human	PMID:25609649
Molecular Function	GO:0042802	identical protein binding	IRF3	IPI	UniProtKB:Q14653	Human	PMID:32726803
Molecular Function	GO:0042802	identical protein binding	IRF3	IPI	UniProtKB:Q14653	Human	PMID:34084167
Molecular Function	GO:0042802	identical protein binding	Irf3	IPI	UniProtKB:P70671	Mouse	MGI:MGI:5810255\|PMID:24696485
Molecular Function	GO:0042802	identical protein binding	Irf3	IPI	UniProtKB:P70671	Mouse	MGI:MGI:4367121\|PMID:19890330
Molecular Function	GO:0042802	identical protein binding	Irf3	IPI	UniProtKB:P70671	Mouse	MGI:MGI:4366119\|PMID:19805092
Molecular Function	GO:0042802	identical protein binding	Irf3	IPI	PR:P70671	Mouse	PMID:14556004
Molecular Function	GO:0042802	identical protein binding	Irf3	IPI	PR:P70671	Mouse	PMID:12855817
Molecular Function	GO:0042802	identical protein binding	Irf3	IPI	PR:P70671	Mouse	PMID:12872135
Molecular Function	GO:0140677	molecular function activator activity	IRF3	IDA		Human	PMID:10920266
Molecular Function	GO:0140677	molecular function activator activity	IRF3	IDA		Human	PMID:30699354
Molecular Function	GO:1990841	promoter-specific chromatin binding	Irf3	IDA		Mouse	PMID:18802055
Molecular Function	GO:0005515	protein binding	IRF3	IDA		Human	PMID:10920266
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:Q9UHD2	Human	PMID:15841462
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:Q92793	Human	PMID:16154084
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:Q9Y3R0	Human	PMID:16362036
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:Q9UHD2	Human	PMID:17599067
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:P0C6X7:PRO_0000037311	Human	PMID:17761676
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:Q92793	Human	PMID:17761676
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:Q92793	Human	PMID:18309294
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:Q9UHD2	Human	PMID:18583960
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:Q9BYM8	Human	PMID:18711448
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:Q14164	Human	PMID:19153231
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:Q9UHD2	Human	PMID:19153231
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:Q9UII4	Human	PMID:20308324
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:Q92793	Human	PMID:20581830
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:Q9Y5Q3	Human	PMID:20581830
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:O94826,UniProtKB:P07900,UniProtKB:Q9UHD2	Human	PMID:20628368
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:P06400	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:P28749	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:Q92793	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:Q9UHD2	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:O43765	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:Q7Z434	Human	PMID:22908223
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:Q92793	Human	PMID:23746807
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:P0C6X7:PRO_0000037311	Human	PMID:24622840
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:O14730	Human	PMID:24807708
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:Q9UHD2	Human	PMID:24807708
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:O94826,UniProtKB:P07900,UniProtKB:Q07812\|UniProtKB:P10415	Human	PMID:25609812
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:Q9UHD2	Human	PMID:25803835
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:P19474	Human	PMID:26347139
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:O00571	Human	PMID:27980081
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:Q13114	Human	PMID:27980081
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:Q9H8X9	Human	PMID:29429998
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:Q9H6K1	Human	PMID:29802199
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:Q9NX58	Human	PMID:31413131
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:P05161	Human	PMID:32726803
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:P10914	Human	PMID:32878885
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:P67775	Human	PMID:32878885
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:O60684	Human	PMID:34950606
Molecular Function	GO:0005515	protein binding	IRF3	IPI	UniProtKB:P52292	Human	PMID:34950606
Molecular Function	GO:0019904	protein domain specific binding	IRF3	IPI	UniProtKB:P45481	Human	PMID:11583620
Molecular Function	GO:0042803	protein homodimerization activity	IRF3	IPI	UniProtKB:Q14653	Human	PMID:12062447
Molecular Function	GO:0042803	protein homodimerization activity	IRF3	IDA		Human	PMID:22394562
Molecular Function	GO:0042803	protein homodimerization activity	IRF3	IDA		Human	PMID:30699354
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IRF3	IMP		Human	PMID:17560375
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IRF3	IDA		Human	PMID:8524823
Molecular Function	GO:0043565	sequence-specific DNA binding	IRF3	IDA		Human	PMID:17574024
Molecular Function	GO:0043565	sequence-specific DNA binding	IRF3	IDA		Human	PMID:23332764
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	IRF3	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	irf3	IGI	ZFIN:ZDB-GENE-071128-2	Zfish	PMID:27496972
Molecular Function	GO:0000976	transcription cis-regulatory region binding	irf3	IGI	ZFIN:ZDB-GENE-030721-3	Zfish	PMID:27496972
Molecular Function	GO:0140537	transcription regulator activator activity	IRF3	IDA		Human	PMID:17574024
Cellular Component	GO:0000785	chromatin	IRF3	IDA		Human	PMID:8524823
Cellular Component	GO:0005737	cytoplasm	IRF3	IDA		Human	PMID:9566918
Cellular Component	GO:0005737	cytoplasm	IRF3	IDA		Human	PMID:17079289
Cellular Component	GO:0005737	cytoplasm	IRF3	IDA		Human	PMID:18818105
Cellular Component	GO:0005737	cytoplasm	IRF3	IGI	UniProtKB:P24001-1	Human	PMID:23729669
Cellular Component	GO:0005829	cytosol	IRF3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	IRF3	IDA		Human	PMID:25609812
Cellular Component	GO:0005634	nucleus	IRF3	IDA		Human	PMID:10805757
Cellular Component	GO:0005634	nucleus	IRF3	IDA		Human	PMID:25636800
Cellular Component	GO:0005634	nucleus	IRF3	IDA		Human	PMID:17079289
Cellular Component	GO:0005634	nucleus	IRF3	IDA		Human	PMID:18818105
Cellular Component	GO:0005634	nucleus	Irf3	IDA		Mouse	PMID:21606371
Cellular Component	GO:0005634	nucleus	Irf3	IDA		Mouse	PMID:15661922
Biological Process	GO:0071360	cellular response to exogenous dsRNA	Irf3	IEP		Rat	PMID:18223009\|RGD:5128810
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Irf3	IDA		Mouse	PMID:21606371
Biological Process	GO:0098586	cellular response to virus	IRF3	IDA		Human	PMID:25609812
Biological Process	GO:0098586	cellular response to virus	Irf3	IDA		Mouse	PMID:18802055
Biological Process	GO:0002753	cytosolic pattern recognition receptor signaling pathway	IRF3	IDA		Human	PMID:8524823
Biological Process	GO:0051607	defense response to virus	Irf3	IMP		Mouse	MGI:MGI:5792628\|PMID:27129230
Biological Process	GO:0051607	defense response to virus	Irf3	IMP		Mouse	MGI:MGI:4365354\|PMID:18562536
Biological Process	GO:0051607	defense response to virus	Irf3	IMP		Mouse	MGI:MGI:4881394\|PMID:20451243
Biological Process	GO:0051607	defense response to virus	Irf3	IMP	MGI:MGI:3577601	Mouse	PMID:23770239
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	Irf3	IDA		Mouse	PMID:12855817
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	Irf3	IDA		Mouse	PMID:12872135
Biological Process	GO:0001819	positive regulation of cytokine production	Irf3	IMP		Rat	PMID:20670634\|RGD:5128809
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Irf3	IMP		Mouse	MGI:MGI:5792628\|PMID:27129230
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Irf3	IMP		Rat	PMID:20670634\|RGD:5128809
Biological Process	GO:0032727	positive regulation of interferon-alpha production	Irf3	IMP		Mouse	MGI:MGI:4365354\|PMID:18562536
Biological Process	GO:0032728	positive regulation of interferon-beta production	Irf3	IMP		Mouse	MGI:MGI:4365354\|PMID:18562536
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IRF3	IMP		Human	PMID:17560375
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IRF3	IDA		Human	PMID:8524823
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IRF3	IDA		Human	PMID:9660935
Biological Process	GO:0032481	positive regulation of type I interferon production	IRF3	IDA		Human	PMID:18636090
Biological Process	GO:0032481	positive regulation of type I interferon production	IRF3	IDA		Human	PMID:25636800
Biological Process	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	Irf3	IMP		Mouse	PMID:17618271
Biological Process	GO:0097300	programmed necrotic cell death	Irf3	IMP	MGI:MGI:3577601	Mouse	PMID:23770239
Biological Process	GO:0042981	regulation of apoptotic process	IRF3	IDA		Human	PMID:25609812
Biological Process	GO:0010468	regulation of gene expression	Irf3	IGI	MGI:MGI:1328317	Mouse	PMID:23160154
Biological Process	GO:0010468	regulation of gene expression	Irf3	IGI	MGI:MGI:1929658	Mouse	PMID:23160154
Biological Process	GO:0010468	regulation of gene expression	Irf3	IGI	MGI:MGI:1919762	Mouse	PMID:23160154
Biological Process	GO:0010468	regulation of gene expression	Irf3	IGI	MGI:MGI:1859212	Mouse	PMID:23160154
Biological Process	GO:0050727	regulation of inflammatory response	Irf3	IGI	MGI:MGI:1328317	Mouse	PMID:28069950
Biological Process	GO:0009617	response to bacterium	Irf3	IDA		Mouse	PMID:15661922
Biological Process	GO:0043330	response to exogenous dsRNA	Irf3	IDA		Mouse	PMID:12872135
Biological Process	GO:0043330	response to exogenous dsRNA	Irf3	IDA		Mouse	PMID:12855817
Biological Process	GO:0032496	response to lipopolysaccharide	Irf3	IDA		Mouse	PMID:12855817
Biological Process	GO:0032496	response to lipopolysaccharide	Irf3	IDA		Mouse	PMID:12872135
Biological Process	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	IRF3	IDA		Human	PMID:25636800
Biological Process	GO:0032606	type I interferon production	Irf3	IGI	MGI:MGI:1859212	Mouse	PMID:15800576
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	Irf3	IMP		Mouse	MGI:MGI:5792628\|PMID:27129230

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.