Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IRF6
  • Mouse genes Irf6
  • Rat genes Irf6
  • Zfish genes irf6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Irf6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Irf6	IDA		Mouse	MGI:MGI:4365330|PMID:19036739
Molecular Function	GO:0003677	DNA binding	Irf6	IMP		Mouse	PMID:19036739
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Irf6	IMP		Mouse	PMID:19036739
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Irf6	IDA		Mouse	MGI:MGI:4365330|PMID:19036739
Molecular Function	GO:0005515	protein binding	IRF6	IPI	UniProtKB:P36952	Human	PMID:16049006
Molecular Function	GO:0005515	protein binding	IRF6	IPI	UniProtKB:Q02556	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	Irf6	IPI	UniProtKB:P37238	Mouse	MGI:MGI:6294168|PMID:28526834
Molecular Function	GO:0043565	sequence-specific DNA binding	IRF6	IDA		Human	PMID:28473536
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	IRF6	IDA		Human	PMID:28473536
Cellular Component	GO:0030054	cell junction	IRF6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005737	cytoplasm	IRF6	IDA		Human	PMID:16049006
Cellular Component	GO:0005737	cytoplasm	IRF6	IDA		Human	PMID:18212048
Cellular Component	GO:0005829	cytosol	IRF6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	IRF6	HDA		Human	PMID:19056867
Cellular Component	GO:0005654	nucleoplasm	IRF6	IDA		Human	GO_REF:0000052
Biological Process	GO:0048468	cell development	Irf6	IMP	MGI:MGI:3693324	Mouse	PMID:17041603
Biological Process	GO:0008283	cell population proliferation	Irf6	IGI	MGI:MGI:1891831	Mouse	PMID:17041603
Biological Process	GO:1904888	cranial skeletal system development	Irf6	IMP		Mouse	PMID:17041601
Biological Process	GO:1904888	cranial skeletal system development	irf6	IMP	ZFIN:ZDB-GENO-190801-4	Zfish	PMID:33234718
Biological Process	GO:0048702	embryonic neurocranium morphogenesis	irf6	IMP	ZFIN:ZDB-GENO-130911-9	Zfish	PMID:23154410
Biological Process	GO:0008544	epidermis development	irf6	IMP	ZFIN:ZDB-GENO-210218-3	Zfish	PMID:32582293
Biological Process	GO:0060429	epithelium development	irf6	IMP		Zfish	PMID:19013452
Biological Process	GO:1905748	hard palate morphogenesis	irf6	IMP	ZFIN:ZDB-GENO-190801-4	Zfish	PMID:33234718
Biological Process	GO:0030216	keratinocyte differentiation	Irf6	IMP		Mouse	PMID:17041601
Biological Process	GO:0030216	keratinocyte differentiation	Irf6	IMP	MGI:MGI:3693324	Mouse	PMID:17041603
Biological Process	GO:0030216	keratinocyte differentiation	Irf6	IMP	MGI:MGI:3522096	Mouse	PMID:17041601
Biological Process	GO:0043616	keratinocyte proliferation	Irf6	IMP		Mouse	PMID:17041601
Biological Process	GO:0043616	keratinocyte proliferation	Irf6	IMP	MGI:MGI:3693324	Mouse	PMID:17041603
Biological Process	GO:0043616	keratinocyte proliferation	Irf6	IGI	MGI:MGI:1891831	Mouse	PMID:17041603
Biological Process	GO:0043616	keratinocyte proliferation	Irf6	IMP	MGI:MGI:3522096	Mouse	PMID:17041601
Biological Process	GO:0060173	limb development	Irf6	IMP		Mouse	PMID:17041601
Biological Process	GO:0060644	mammary gland epithelial cell differentiation	Irf6	IEP		Mouse	MGI:MGI:4361977|PMID:18212048
Biological Process	GO:0008285	negative regulation of cell population proliferation	IRF6	IDA		Human	PMID:18212048
Biological Process	GO:0010839	negative regulation of keratinocyte proliferation	Irf6	IGI	MGI:MGI:1891831	Mouse	PMID:17041603
Biological Process	GO:2000647	negative regulation of stem cell proliferation	Irf6	IGI	MGI:MGI:1891831	Mouse	PMID:17041603
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Irf6	IDA		Mouse	MGI:MGI:4365330|PMID:19036739
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IRF6	IDA		Human	PMID:21807998
Biological Process	GO:0060021	roof of mouth development	Irf6	IMP	MGI:4457055	Mouse	PMID:21515572
Biological Process	GO:0043588	skin development	Irf6	IMP		Mouse	PMID:17041601
Biological Process	GO:0043588	skin development	Irf6	IGI	MGI:MGI:1891831	Mouse	PMID:17041603
Biological Process	GO:0043588	skin development	Irf6	IMP	MGI:MGI:3522096	Mouse	PMID:17041601
Biological Process	GO:0043588	skin development	Irf6	IMP	MGI:MGI:3693324	Mouse	PMID:17041603
Biological Process	GO:0072089	stem cell proliferation	Irf6	IGI	MGI:MGI:1891831	Mouse	PMID:17041603

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern