Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IRF7
  • Mouse genes Irf7
  • Rat genes Irf7
  • Zfish genes irf7
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Irf7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	Irf7	IDA		Mouse	MGI:MGI:5792628|PMID:27129230
Molecular Function	GO:0003677	DNA binding	IRF7	IMP		Human	PMID:12374802
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IRF7	IDA		Human	PMID:17404045
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Irf7	IMP		Mouse	MGI:MGI:5792628|PMID:27129230
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Irf7	IDA		Mouse	PMID:23042151
Molecular Function	GO:0005515	protein binding	IRF7	IPI	UniProtKB:F5HDE4	Human	PMID:11943871
Molecular Function	GO:0005515	protein binding	IRF7	IPI	UniProtKB:Q9UHD2	Human	PMID:17599067
Molecular Function	GO:0005515	protein binding	IRF7	IPI	UniProtKB:O15111	Human	PMID:18922877
Molecular Function	GO:0005515	protein binding	IRF7	IPI	UniProtKB:Q77M19	Human	PMID:18922877
Molecular Function	GO:0005515	protein binding	IRF7	IPI	UniProtKB:P29128	Human	PMID:19176627
Molecular Function	GO:0005515	protein binding	IRF7	IPI	UniProtKB:P21580	Human	PMID:20392859
Molecular Function	GO:0005515	protein binding	IRF7	IPI	UniProtKB:O00170	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRF7	IPI	UniProtKB:O94822	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRF7	IPI	UniProtKB:P10398	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRF7	IPI	UniProtKB:P51617	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRF7	IPI	UniProtKB:Q86UE8	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRF7	IPI	UniProtKB:Q96A33	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRF7	IPI	UniProtKB:Q9BVS5	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRF7	IPI	UniProtKB:Q9ULE6	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRF7	IPI	UniProtKB:Q9BVS5	Human	PMID:30833792
Molecular Function	GO:0005515	protein binding	Irf7	IPI	UniProtKB:Q60680	Mouse	MGI:MGI:3621577|PMID:16612387
Molecular Function	GO:0005515	protein binding	Irf7	IPI	UniProtKB:Q8C006	Mouse	MGI:MGI:5639149|PMID:25907537
Molecular Function	GO:0005515	protein binding	Irf7	IPI	PR:P22366	Mouse	PMID:16236719
Molecular Function	GO:0005515	protein binding	Irf7	IPI	MGI:MGI:97072	Mouse	PMID:22095711
Molecular Function	GO:0005515	protein binding	Irf7	IPI	PR:P70434	Mouse	PMID:23956435
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IRF7	IDA		Human	PMID:17404045
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	IRF7	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	irf7	IGI	ZFIN:ZDB-GENE-030721-3	Zfish	PMID:27496972
Molecular Function	GO:0000976	transcription cis-regulatory region binding	irf7	IGI	ZFIN:ZDB-GENE-071128-2	Zfish	PMID:27496972
Cellular Component	GO:0005737	cytoplasm	IRF7	IDA		Human	PMID:19176627
Cellular Component	GO:0005737	cytoplasm	IRF7	IGI	UniProtKB:P24001-1	Human	PMID:23729669
Cellular Component	GO:0005829	cytosol	IRF7	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	IRF7	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	IRF7	IDA		Human	PMID:22065573
Biological Process	GO:0051607	defense response to virus	IRF7	IDA		Human	PMID:21478870
Biological Process	GO:0051607	defense response to virus	Irf7	IMP		Mouse	MGI:MGI:5792628|PMID:27129230
Biological Process	GO:0030097	hemopoiesis	irf7	IGI	ZFIN:ZDB-GENE-040426-1518	Zfish	PMID:27462426
Biological Process	GO:0030097	hemopoiesis	irf7	IMP	ZFIN:ZDB-GENO-181011-4	Zfish	PMID:27462426
Biological Process	GO:0030097	hemopoiesis	irf7	IGI	ZFIN:ZDB-MIRNAG-090929-151	Zfish	PMID:27462426
Biological Process	GO:0016064	immunoglobulin mediated immune response	Irf7	IMP	MGI:MGI:3577089	Mouse	PMID:15800576
Biological Process	GO:1902037	negative regulation of hematopoietic stem cell differentiation	irf7	IGI	ZFIN:ZDB-MRPHLNO-141229-2,ZFIN:ZDB-MRPHLNO-150804-5	Zfish	PMID:24165894
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IRF7	IMP		Human	PMID:12374802
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Irf7	IMP		Mouse	MGI:MGI:5792628|PMID:27129230
Biological Process	GO:0032727	positive regulation of interferon-alpha production	IRF7	IDA		Human	PMID:16127453
Biological Process	GO:0032728	positive regulation of interferon-beta production	IRF7	IMP		Human	PMID:22065573
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IRF7	IDA		Human	PMID:16127453
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IRF7	IDA		Human	PMID:17404045
Biological Process	GO:0032481	positive regulation of type I interferon production	IRF7	IDA		Human	PMID:17404045
Biological Process	GO:0032481	positive regulation of type I interferon production	Irf7	IGI	MGI:MGI:1928368	Mouse	PMID:23956435
Biological Process	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	Irf7	IMP		Mouse	PMID:17618271
Biological Process	GO:0002819	regulation of adaptive immune response	IRF7	IDA		Human	PMID:17404045
Biological Process	GO:0010468	regulation of gene expression	Irf7	IGI	MGI:MGI:1859179	Mouse	PMID:23160154
Biological Process	GO:0010468	regulation of gene expression	Irf7	IGI	MGI:MGI:1929658	Mouse	PMID:23160154
Biological Process	GO:0010468	regulation of gene expression	Irf7	IGI	MGI:MGI:1328317	Mouse	PMID:23160154
Biological Process	GO:0010468	regulation of gene expression	Irf7	IGI	MGI:MGI:1919762	Mouse	PMID:23160154
Biological Process	GO:0034124	regulation of MyD88-dependent toll-like receptor signaling pathway	Irf7	IMP		Mouse	MGI:MGI:3575992|PMID:15800576
Biological Process	GO:0034127	regulation of MyD88-independent toll-like receptor signaling pathway	Irf7	IMP		Mouse	MGI:MGI:3575992|PMID:15800576
Biological Process	GO:0045580	regulation of T cell differentiation	irf7	IGI	ZFIN:ZDB-MRPHLNO-141229-2,ZFIN:ZDB-MRPHLNO-150804-5	Zfish	PMID:24165894
Biological Process	GO:0009615	response to virus	irf7	IDA		Zfish	PMID:27496972
Biological Process	GO:0032606	type I interferon production	Irf7	IMP	MGI:MGI:3577089	Mouse	PMID:15800576
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	Irf7	IMP		Mouse	MGI:MGI:5792628|PMID:27129230

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern