Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IRF8
  • Mouse genes Irf8
  • Rat genes Irf8
  • Zfish genes irf8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Irf8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Irf8	IDA		Mouse	PMID:18045875
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IRF8	IDA		Human	PMID:1460054
Molecular Function	GO:0005515	protein binding	IRF8	IPI	UniProtKB:O14896	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRF8	IPI	UniProtKB:Q96CV9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IRF8	IPI	UniProtKB:P17947	Human	PMID:33951726
Molecular Function	GO:0005515	protein binding	Irf8	IPI	UniProtKB:O35284	Mouse	MGI:MGI:5441724|PMID:22992524
Molecular Function	GO:0005515	protein binding	Irf8	IPI	PR:Q60821	Mouse	PMID:18045875
Molecular Function	GO:0005515	protein binding	Irf8	IPI	PR:P37242	Mouse	PMID:25331958
Molecular Function	GO:0005515	protein binding	Irf8	IPI	PR:Q8BG73	Mouse	PMID:25331958
Molecular Function	GO:0005515	protein binding	Irf8	IPI	PR:P25322	Mouse	PMID:25331958
Molecular Function	GO:0005515	protein binding	Irf8	IPI	PR:Q9QUG2	Mouse	PMID:25331958
Molecular Function	GO:0005515	protein binding	Irf8	IPI	PR:P59110	Mouse	PMID:22942423
Molecular Function	GO:0005515	protein binding	Irf8	IPI	PR:Q60674	Mouse	PMID:25331958
Molecular Function	GO:0005515	protein binding	Irf8	IPI	PR:Q8CGN4	Mouse	PMID:25331958
Molecular Function	GO:0005515	protein binding	Irf8	IPI	PR:Q9EQH4	Mouse	PMID:25331958
Molecular Function	GO:0005515	protein binding	Irf8	IPI	PR:Q9QUN3	Mouse	PMID:25331958
Molecular Function	GO:0005515	protein binding	Irf8	IPI	PR:Q63943	Mouse	PMID:25331958
Molecular Function	GO:0005515	protein binding	Irf8	IPI	PR:Q61096	Mouse	PMID:25331958
Molecular Function	GO:0005515	protein binding	Irf8	IPI	MGI:MGI:2444450	Mouse	PMID:25331958
Molecular Function	GO:0005515	protein binding	Irf8	IPI	PR:Q99P68	Mouse	PMID:25331958
Molecular Function	GO:0005515	protein binding	Irf8	IPI	PR:P17433	Mouse	PMID:25331958
Molecular Function	GO:0005515	protein binding	Irf8	IPI	PR:P07141	Mouse	PMID:25331958
Molecular Function	GO:0005515	protein binding	Irf8	IPI	PR:P41183	Mouse	PMID:25331958
Molecular Function	GO:0005515	protein binding	Irf8	IPI	PR:O70237	Mouse	PMID:25331958
Molecular Function	GO:0005515	protein binding	Irf8	IPI	RGD:1359607	Rat	PMID:15688197|RGD:9586722
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IRF8	IDA		Human	PMID:1460054
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Irf8	IDA		Mouse	PMID:25331958
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	IRF8	IDA		Human	PMID:28473536
Cellular Component	GO:0005737	cytoplasm	IRF8	IDA		Human	PMID:25122610
Cellular Component	GO:0005654	nucleoplasm	IRF8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	IRF8	IDA		Human	PMID:25122610
Cellular Component	GO:0005634	nucleus	Irf8	IDA		Mouse	PMID:25331958
Cellular Component	GO:0005634	nucleus	Irf8	IDA		Mouse	PMID:18045875
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Irf8	IMP	MGI:MGI:1926332	Mouse	PMID:9348310
Biological Process	GO:0071346	cellular response to type II interferon	IRF8	IDA		Human	PMID:25122610
Biological Process	GO:0071346	cellular response to type II interferon	Irf8	IEP		Rat	PMID:21261980|RGD:5128727
Biological Process	GO:0042742	defense response to bacterium	Irf8	IMP	MGI:MGI:1926332	Mouse	PMID:18045875
Biological Process	GO:0042832	defense response to protozoan	Irf8	IMP	MGI:MGI:1926332	Mouse	PMID:9348310
Biological Process	GO:0097028	dendritic cell differentiation	Irf8	IMP		Mouse	MGI:MGI:3654212|PMID:12461077
Biological Process	GO:0002316	follicular B cell differentiation	Irf8	IGI	UniProtKB:P17433	Mouse	MGI:MGI:6303891|PMID:31000603
Biological Process	GO:0002314	germinal center B cell differentiation	Irf8	IGI	UniProtKB:P17433	Mouse	MGI:MGI:6303891|PMID:31000603
Biological Process	GO:0030097	hemopoiesis	irf8	IMP	ZFIN:ZDB-GENO-150504-10	Zfish	PMID:25615614
Biological Process	GO:0006955	immune response	Irf8	IMP		Mouse	MGI:MGI:3654212|PMID:12461077
Biological Process	GO:0006955	immune response	Irf8	IMP	MGI:MGI:1926332	Mouse	PMID:12393690
Biological Process	GO:0032615	interleukin-12 production	Irf8	IMP	MGI:MGI:1926332	Mouse	PMID:9348310
Biological Process	GO:0030225	macrophage differentiation	irf8	IMP	ZFIN:ZDB-MRPHLNO-111212-2	Zfish	PMID:21079149
Biological Process	GO:0030225	macrophage differentiation	irf8	IMP	ZFIN:ZDB-MRPHLNO-111212-2	Zfish	PMID:25488917
Biological Process	GO:0030225	macrophage differentiation	irf8	IMP	ZFIN:ZDB-MRPHLNO-111212-2	Zfish	PMID:24879123
Biological Process	GO:0014005	microglia development	irf8	IMP	ZFIN:ZDB-GENO-150504-10	Zfish	PMID:25615614
Biological Process	GO:0061515	myeloid cell development	irf8	IMP	ZFIN:ZDB-GENO-150504-10	Zfish	PMID:25615614
Biological Process	GO:0030099	myeloid cell differentiation	Irf8	IMP	MGI:MGI:1926332	Mouse	PMID:12393690
Biological Process	GO:0002573	myeloid leukocyte differentiation	irf8	IMP	ZFIN:ZDB-MRPHLNO-111212-3	Zfish	PMID:22694745
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IRF8	IDA		Human	PMID:1460054
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IRF8	IDA		Human	PMID:25122610
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Irf8	IGI	MGI:MGI:1918708	Mouse	PMID:25331958
Biological Process	GO:0006909	phagocytosis	Irf8	IMP	MGI:MGI:1926332	Mouse	PMID:18045875
Biological Process	GO:0002273	plasmacytoid dendritic cell differentiation	Irf8	IMP		Mouse	MGI:MGI:3641477|PMID:12538667
Biological Process	GO:0043065	positive regulation of apoptotic process	Irf8	IDA		Rat	PMID:21261980|RGD:5128727
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Irf8	IPI	PR:Q60821	Mouse	PMID:18045875
Biological Process	GO:0032735	positive regulation of interleukin-12 production	Irf8	IMP	MGI:MGI:1926332	Mouse	PMID:9348310
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IRF8	IDA		Human	PMID:25122610
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Irf8	IGI	UniProtKB:P17433	Mouse	MGI:MGI:6303891|PMID:31000603
Biological Process	GO:0032729	positive regulation of type II interferon production	Irf8	IMP	MGI:MGI:1926332	Mouse	PMID:9348310
Biological Process	GO:0045649	regulation of macrophage differentiation	irf8	IMP	ZFIN:ZDB-MRPHLNO-111212-2	Zfish	PMID:22658594
Biological Process	GO:0045658	regulation of neutrophil differentiation	irf8	IMP	ZFIN:ZDB-MRPHLNO-111212-2	Zfish	PMID:21079149
Biological Process	GO:0032479	regulation of type I interferon production	Irf8	IMP		Mouse	MGI:MGI:3654212|PMID:12461077
Biological Process	GO:0009617	response to bacterium	Irf8	IMP	MGI:MGI:1926332	Mouse	PMID:9348310
Biological Process	GO:0032609	type II interferon production	Irf8	IMP	MGI:MGI:1926332	Mouse	PMID:9348310

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern