Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IRGM
  • Mouse genes Irgm1
  • Rat genes Irgm
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Irgm1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051434	BH3 domain binding	IRGM	IMP		Human	PMID:25891078
Molecular Function	GO:0050700	CARD domain binding	IRGM	IMP		Human	PMID:25891078
Molecular Function	GO:1901612	cardiolipin binding	Irgm1	IDA		Mouse	MGI:MGI:4354422|PMID:19620982
Molecular Function	GO:0003925	G protein activity	IRGM	IDA		Human	PMID:30612879
Molecular Function	GO:0003924	GTPase activity	IRGM	IDA		Human	PMID:29420192
Molecular Function	GO:0003924	GTPase activity	Irgm1	IDA		Mouse	MGI:MGI:4354422|PMID:19620982
Molecular Function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	Irgm1	IDA		Mouse	MGI:MGI:4354422|PMID:19620982
Molecular Function	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	Irgm1	IDA		Mouse	MGI:MGI:4354422|PMID:19620982
Molecular Function	GO:0005515	protein binding	IRGM	IPI	UniProtKB:Q14457	Human	PMID:25891078
Molecular Function	GO:0005515	protein binding	IRGM	IPI	UniProtKB:Q676U5	Human	PMID:25891078
Molecular Function	GO:0005515	protein binding	IRGM	IPI	UniProtKB:Q6ZNE5	Human	PMID:25891078
Molecular Function	GO:0005515	protein binding	IRGM	IPI	UniProtKB:Q9C0C7	Human	PMID:25891078
Molecular Function	GO:0005515	protein binding	IRGM	IPI	UniProtKB:Q96CV9	Human	PMID:32814053
Molecular Function	GO:0019901	protein kinase binding	IRGM	IPI	UniProtKB:O75385	Human	PMID:25891078
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	IRGM	IDA		Human	PMID:25891078
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	IRGM	IMP		Human	PMID:28389568
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	IRGM	IDA		Human	PMID:25891078
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	IRGM	IDA		Human	PMID:29420192
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	IRGM	IDA		Human	PMID:30612879
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	IRGM	IDA		Human	PMID:32715615
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	IRGM	IDA		Human	PMID:32753672
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	IRGM	IDA		Human	PMID:36221902
Cellular Component	GO:0044754	autolysosome	Irgm1	IDA		Mouse	MGI:MGI:3656111|PMID:16888103
Cellular Component	GO:0005776	autophagosome	Irgm1	IDA		Mouse	MGI:MGI:3656111|PMID:16888103
Cellular Component	GO:0000421	autophagosome membrane	IRGM	IDA		Human	PMID:30612879
Cellular Component	GO:0005829	cytosol	IRGM	IDA		Human	PMID:25891078
Cellular Component	GO:0005794	Golgi apparatus	IRGM	IDA		Human	PMID:28389568
Cellular Component	GO:0000139	Golgi membrane	IRGM	IDA		Human	PMID:28389568
Cellular Component	GO:0000139	Golgi membrane	Irgm1	IDA		Mouse	MGI:MGI:6246109|PMID:24751652
Cellular Component	GO:0005770	late endosome	Irgm1	IDA		Mouse	MGI:MGI:4430426|PMID:20072621
Cellular Component	GO:0005770	late endosome	Irgm1	IDA		Mouse	MGI:MGI:3656111|PMID:16888103
Cellular Component	GO:0005765	lysosomal membrane	Irgm1	IDA		Mouse	MGI:MGI:6834298|PMID:27098192
Cellular Component	GO:0005764	lysosome	Irgm1	IDA		Mouse	MGI:MGI:4430426|PMID:20072621
Cellular Component	GO:0031966	mitochondrial membrane	Irgm1	IDA		Mouse	MGI:MGI:6246109|PMID:24751652
Cellular Component	GO:0005739	mitochondrion	IRGM	IDA		Human	PMID:25891078
Cellular Component	GO:0005739	mitochondrion	IRGM	IDA		Human	PMID:28389568
Cellular Component	GO:0045335	phagocytic vesicle	Irgm1	IDA		Mouse	PMID:19144319
Biological Process	GO:0000045	autophagosome assembly	IRGM	IMP		Human	PMID:16888103
Biological Process	GO:0000045	autophagosome assembly	Irgm1	IDA		Mouse	MGI:MGI:3656111|PMID:16888103
Biological Process	GO:0097352	autophagosome maturation	Irgm1	IDA		Mouse	MGI:MGI:5292307|PMID:21757726
Biological Process	GO:0061762	CAMKK-AMPK signaling cascade	IRGM	IMP		Human	PMID:25891078
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IRGM	IMP		Human	PMID:25891078
Biological Process	GO:0071346	cellular response to type II interferon	Irgm1	IDA		Mouse	PMID:19144319
Biological Process	GO:0098586	cellular response to virus	IRGM	IMP		Human	PMID:28389568
Biological Process	GO:0006952	defense response	Irgm1	IMP	MGI:MGI:3027112	Mouse	PMID:11457893
Biological Process	GO:0042742	defense response to bacterium	IRGM	IMP		Human	PMID:16888103
Biological Process	GO:0042742	defense response to bacterium	IRGM	IMP		Human	PMID:19165925
Biological Process	GO:0042742	defense response to bacterium	IRGM	IDA		Human	PMID:25891078
Biological Process	GO:0042742	defense response to bacterium	IRGM	IDA		Human	PMID:32753672
Biological Process	GO:0042742	defense response to bacterium	IRGM	IDA		Human	PMID:32939830
Biological Process	GO:0042742	defense response to bacterium	Irgm1	IDA		Mouse	MGI:MGI:4354422|PMID:19620982
Biological Process	GO:0042742	defense response to bacterium	Irgm1	IMP		Mouse	MGI:MGI:3656111|PMID:16888103
Biological Process	GO:0050829	defense response to Gram-negative bacterium	IRGM	IMP		Human	PMID:25891078
Biological Process	GO:0045087	innate immune response	IRGM	IMP		Human	PMID:16888103
Biological Process	GO:0045087	innate immune response	Irgm1	IDA		Mouse	MGI:MGI:4354422|PMID:19620982
Biological Process	GO:0160049	negative regulation of cGAS/STING signaling pathway	IRGM	IDA		Human	PMID:32715615
Biological Process	GO:0050687	negative regulation of defense response to virus	IRGM	IDA		Human	PMID:34467632
Biological Process	GO:0050687	negative regulation of defense response to virus	IRGM	IDA		Human	PMID:36221902
Biological Process	GO:0050687	negative regulation of defense response to virus	Irgm1	IMP		Mouse	MGI:MGI:6810721|PMID:34467632
Biological Process	GO:1902034	negative regulation of hematopoietic stem cell proliferation	Irgm1	IMP		Mouse	MGI:MGI:5293213|PMID:21633090
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	IRGM	IDA		Human	PMID:36221902
Biological Process	GO:0050728	negative regulation of inflammatory response	IRGM	IDA		Human	PMID:30612879
Biological Process	GO:0050728	negative regulation of inflammatory response	Irgm1	IMP		Mouse	MGI:MGI:6705154|PMID:33510463
Biological Process	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly	IRGM	IDA		Human	PMID:30612879
Biological Process	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly	Irgm1	IDA		Mouse	MGI:MGI:6282153|PMID:30612879
Biological Process	GO:0032480	negative regulation of type I interferon production	IRGM	IDA		Human	PMID:32715615
Biological Process	GO:0032480	negative regulation of type I interferon production	IRGM	IDA		Human	PMID:34467632
Biological Process	GO:0032480	negative regulation of type I interferon production	Irgm1	IMP		Mouse	MGI:MGI:6705154|PMID:33510463
Biological Process	GO:0032480	negative regulation of type I interferon production	Irgm1	IMP		Mouse	MGI:MGI:5293213|PMID:21633090
Biological Process	GO:0032689	negative regulation of type II interferon production	Irgm1	IMP		Mouse	MGI:MGI:3822251|PMID:18806793
Biological Process	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	IRGM	IMP		Human	PMID:25891078
Biological Process	GO:1901098	positive regulation of autophagosome maturation	IRGM	IMP		Human	PMID:16888103
Biological Process	GO:1901098	positive regulation of autophagosome maturation	Irgm1	IDA		Mouse	MGI:MGI:3656111|PMID:16888103
Biological Process	GO:0010508	positive regulation of autophagy	IRGM	IMP		Human	PMID:16888103
Biological Process	GO:0010508	positive regulation of autophagy	IRGM	IDA		Human	PMID:25891078
Biological Process	GO:0010508	positive regulation of autophagy	IRGM	IMP		Human	PMID:25891078
Biological Process	GO:0010508	positive regulation of autophagy	IRGM	IMP		Human	PMID:28389568
Biological Process	GO:0010508	positive regulation of autophagy	IRGM	IDA		Human	PMID:29420192
Biological Process	GO:0010508	positive regulation of autophagy	Irgm1	IDA		Mouse	MGI:MGI:4354422|PMID:19620982
Biological Process	GO:0010508	positive regulation of autophagy	Irgm1	IMP		Mouse	MGI:MGI:3656111|PMID:16888103
Biological Process	GO:0010508	positive regulation of autophagy	Irgm1	IDA		Mouse	MGI:MGI:6840077|PMID:22874556
Biological Process	GO:0010508	positive regulation of autophagy	Irgm1	IDA		Mouse	MGI:MGI:6246109|PMID:24751652
Biological Process	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	Irgm1	IMP		Mouse	MGI:MGI:3822251|PMID:18806793
Biological Process	GO:1905673	positive regulation of lysosome organization	IRGM	IDA		Human	PMID:32753672
Biological Process	GO:0043032	positive regulation of macrophage activation	Irgm1	IMP		Mouse	MGI:MGI:5907958|PMID:27443879
Biological Process	GO:0043032	positive regulation of macrophage activation	Irgm1	IMP		Mouse	MGI:MGI:6851441|PMID:27439214
Biological Process	GO:1901526	positive regulation of mitophagy	IRGM	IDA		Human	PMID:32939830
Biological Process	GO:1901526	positive regulation of mitophagy	Irgm1	IMP		Mouse	MGI:MGI:6705154|PMID:33510463
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	IRGM	IMP		Human	PMID:25891078
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	IRGM	IMP		Human	PMID:25891078
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IRGM	IMP		Human	PMID:28389568
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	IRGM	IMP		Human	PMID:28389568
Biological Process	GO:0060335	positive regulation of type II interferon-mediated signaling pathway	IRGM	IMP		Human	PMID:16888103
Biological Process	GO:0060335	positive regulation of type II interferon-mediated signaling pathway	Irgm1	IMP		Mouse	MGI:MGI:3656111|PMID:16888103
Biological Process	GO:1904417	positive regulation of xenophagy	IRGM	IDA		Human	PMID:25891078
Biological Process	GO:0031648	protein destabilization	IRGM	IMP		Human	PMID:25891078
Biological Process	GO:0061739	protein lipidation involved in autophagosome assembly	IRGM	IMP		Human	PMID:28389568
Biological Process	GO:0050821	protein stabilization	IRGM	IMP		Human	PMID:25891078
Biological Process	GO:0071211	protein targeting to vacuole involved in autophagy	IRGM	IDA		Human	PMID:29420192
Biological Process	GO:0065003	protein-containing complex assembly	IRGM	IDA		Human	PMID:25891078
Biological Process	GO:0090140	regulation of mitochondrial fission	Irgm1	IDA		Mouse	MGI:MGI:6246109|PMID:24751652
Biological Process	GO:0061635	regulation of protein complex stability	IRGM	IMP		Human	PMID:25891078
Biological Process	GO:0043254	regulation of protein-containing complex assembly	IRGM	IMP		Human	PMID:25891078
Biological Process	GO:0009617	response to bacterium	Irgm1	IEP		Mouse	PMID:23012479
Biological Process	GO:0061912	selective autophagy	Irgm1	IDA		Mouse	MGI:MGI:6834298|PMID:27098192

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern