Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Irs1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes IRS1
- Mouse genes Irs1
- Rat genes Irs1
- Zfish genes irs1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Irs1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005158	insulin receptor binding	IRS1	IPI	UniProtKB:P06213	Human	PMID:7493946
Molecular Function	GO:0005158	insulin receptor binding	IRS1	IPI	UniProtKB:P06213	Human	PMID:7537849
Molecular Function	GO:0005158	insulin receptor binding	Irs1	IMP		Rat	PMID:12850498\|RGD:1580595
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	IRS1	IPI	UniProtKB:P08069	Human	PMID:7541045
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	Irs1	IPI	RGD:2869	Rat	PMID:15272025\|RGD:1581313
Molecular Function	GO:0140677	molecular function activator activity	Irs1	IGI	MGI:MGI:96575	Mouse	PMID:9038347
Molecular Function	GO:0140677	molecular function activator activity	Irs1	IDA		Mouse	PMID:7542745
Molecular Function	GO:0140677	molecular function activator activity	Irs1	IDA		Mouse	PMID:9399964
Molecular Function	GO:0140677	molecular function activator activity	Irs1	IDA		Mouse	PMID:8649419
Molecular Function	GO:0140677	molecular function activator activity	Irs1	IMP		Mouse	PMID:11784871
Molecular Function	GO:0140677	molecular function activator activity	Irs1	IDA		Mouse	PMID:12483226
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	IRS1	IPI	UniProtKB:P26450	Human	PMID:16043515
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	IRS1	IPI	UniProtKB:P27986	Human	PMID:7782332
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	Irs1	IDA		Mouse	PMID:11375348
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	Irs1	IMP		Rat	PMID:12850498\|RGD:1580595
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	Irs1	IPI	RGD:3329	Rat	PMID:12891559\|RGD:1299201
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	Irs1	IDA		Rat	PMID:1380456\|RGD:8553725
Molecular Function	GO:0001784	phosphotyrosine residue binding	IRS1	IPI	UniProtKB:Q6GX35	Human	PMID:20624904
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:Q8WWQ0	Human	PMID:11018022
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:P27986	Human	PMID:11403293
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:P27986	Human	PMID:11416002
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:P62994	Human	PMID:11694516
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:P27986	Human	PMID:14632132
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:P27986	Human	PMID:16230374
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:P04626	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:P06213	Human	PMID:16582879
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:Q8N3Y1	Human	PMID:18498745
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:P23443	Human	PMID:18952604
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:P27986	Human	PMID:23643389
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:P42336	Human	PMID:23643389
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:P11940	Human	PMID:23770097
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:P03495	Human	PMID:24008843
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:O75815	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:P27986-2	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:Q92569	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:P42336	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:Q06124	Human	PMID:7513703
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:P03070	Human	PMID:7542742
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:Q9PVZ4	Human	PMID:7559478
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:P27986	Human	PMID:7680095
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:P27986	Human	PMID:7680644
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:P06213	Human	PMID:7935368
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:P27986	Human	PMID:8382612
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:P62993	Human	PMID:8388384
Molecular Function	GO:0005515	protein binding	IRS1	IPI	UniProtKB:O14983	Human	PMID:9295312
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:P26450	Mouse	MGI:MGI:3776676\|PMID:18296638
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:Q80UP3	Mouse	MGI:MGI:6201900\|PMID:27739494
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:P26450	Mouse	MGI:MGI:5512948\|PMID:20804756
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:P26450	Mouse	MGI:MGI:3771752\|PMID:18059474
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:Q03963	Mouse	MGI:MGI:4457466\|PMID:20144759
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:Q9JMB0	Mouse	MGI:MGI:6201784\|PMID:25586176
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:Q1XH17	Mouse	MGI:MGI:5474153\|PMID:23354051
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:Q13625-2	Mouse	MGI:MGI:3794024\|PMID:17965023
Molecular Function	GO:0005515	protein binding	Irs1	IPI	PR:P46938	Mouse	PMID:19952108
Molecular Function	GO:0005515	protein binding	Irs1	IPI	PR:P09405	Mouse	PMID:9813005
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:P06213	Rat	PMID:10660596\|RGD:8554016
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:P18031	Rat	PMID:10660596\|RGD:8554016
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:P27986	Rat	PMID:10660596\|RGD:8554016
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:P62993	Rat	PMID:10660596\|RGD:8554016
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:Q06124	Rat	PMID:10660596\|RGD:8554016
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:Q8VDD9	Rat	PMID:11018022\|RGD:8553486
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:P06213	Rat	PMID:11136729\|RGD:8553709
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:Q63787	Rat	PMID:11136729\|RGD:8553709
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:Q63787	Rat	PMID:12446583\|RGD:8553525
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:P27986	Rat	PMID:1380456\|RGD:8553725
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:P06213	Rat	PMID:15629149\|RGD:8553920
Molecular Function	GO:0005515	protein binding	Irs1	IPI	RGD:3395	Rat	PMID:16574739\|RGD:1624976
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:P06213	Rat	PMID:17135270\|RGD:8554559
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:Q13625-2	Rat	PMID:17965023\|RGD:8553729
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:Q04759	Rat	PMID:23352416\|RGD:8553958
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:Q9EPH8	Rat	PMID:23770097\|RGD:8554563
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:Q9JMB0	Rat	PMID:25586176\|RGD:13792529
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:Q80UP3	Rat	PMID:27739494\|RGD:13792526
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:P62993	Rat	PMID:7504175\|RGD:8553791
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:Q06124	Rat	PMID:7504175\|RGD:8553791
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:P62993	Rat	PMID:8491186\|RGD:8553343
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:P39688	Rat	PMID:8631859\|RGD:8553367
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:O14983	Rat	PMID:9295312\|RGD:8554624
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:P11507-1	Rat	PMID:9295312\|RGD:8554624
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:P11507-2	Rat	PMID:9295312\|RGD:8554624
Molecular Function	GO:0005515	protein binding	Irs1	IPI	UniProtKB:Q64578	Rat	PMID:9295312\|RGD:8554624
Molecular Function	GO:0019904	protein domain specific binding	Irs1	IPI	RGD:619758	Rat	PMID:12891559\|RGD:1299201
Molecular Function	GO:0019901	protein kinase binding	Irs1	IDA		Mouse	PMID:14733908
Molecular Function	GO:0019901	protein kinase binding	Irs1	IPI	RGD:2939	Rat	PMID:15701573\|RGD:1641881
Molecular Function	GO:0005080	protein kinase C binding	Irs1	IPI	UniProtKB:P28867	Rat	PMID:18285345\|RGD:8553881
Molecular Function	GO:0044877	protein-containing complex binding	Irs1	IDA		Rat	PMID:15272025\|RGD:1581313
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	Irs1	IDA		Mouse	PMID:7542745
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	Irs1	IGI	MGI:MGI:96575	Mouse	PMID:9038347
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	Irs1	IDA		Mouse	PMID:9399964
Molecular Function	GO:0042169	SH2 domain binding	Irs1	IPI	UniProtKB:P62993	Rat	PMID:8491186\|RGD:8553343
Molecular Function	GO:0030159	signaling receptor complex adaptor activity	IRS1	IDA		Human	PMID:7493946
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	Irs1	IDA		Mouse	PMID:8649419
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	Irs1	IMP		Mouse	PMID:11784871
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	Irs1	IDA		Mouse	PMID:12483226
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	Irs1	IMP		Rat	PMID:18285345\|RGD:8553881
Cellular Component	GO:0005901	caveola	IRS1	IDA		Human	PMID:15182363
Cellular Component	GO:0036064	ciliary basal body	Irs1	IDA		Mouse	PMID:19596798
Cellular Component	GO:0005737	cytoplasm	Irs1	IDA		Mouse	PMID:12878164
Cellular Component	GO:0005829	cytosol	IRS1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Irs1	IDA		Rat	PMID:16445997\|RGD:1581310
Cellular Component	GO:0005899	insulin receptor complex	Irs1	IMP		Rat	PMID:15069075\|RGD:8554248
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Irs1	IDA		Rat	PMID:16445997\|RGD:1581310
Cellular Component	GO:0005654	nucleoplasm	IRS1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Irs1	IDA		Mouse	PMID:12878164
Cellular Component	GO:0005886	plasma membrane	IRS1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Irs1	IDA		Mouse	PMID:11375348
Cellular Component	GO:0005886	plasma membrane	Irs1	IDA		Rat	PMID:16445997\|RGD:1581310
Biological Process	GO:0007568	aging	Irs1	IEP		Rat	PMID:16373446\|RGD:2298927
Biological Process	GO:0007568	aging	Irs1	IEP		Rat	PMID:22015326\|RGD:10045895
Biological Process	GO:0016477	cell migration	Irs1	IGI	MGI:MGI:109334	Mouse	PMID:17662267
Biological Process	GO:1904385	cellular response to angiotensin	Irs1	IEP		Rat	PMID:8579617\|RGD:10046011
Biological Process	GO:1990416	cellular response to brain-derived neurotrophic factor stimulus	Irs1	IEP		Rat	PMID:17467122\|RGD:10045898
Biological Process	GO:0071398	cellular response to fatty acid	Irs1	IMP		Mouse	MGI:MGI:6282942\|PMID:21986524
Biological Process	GO:0071456	cellular response to hypoxia	irs1	IMP	ZFIN:ZDB-MRPHLNO-180717-1	Zfish	PMID:29390112
Biological Process	GO:0032869	cellular response to insulin stimulus	IRS1	IMP		Human	PMID:16814735
Biological Process	GO:0032869	cellular response to insulin stimulus	Irs1	IDA		Mouse	PMID:11375348
Biological Process	GO:0071478	cellular response to radiation	Irs1	IEP		Rat	PMID:17427956\|RGD:10045897
Biological Process	GO:0010631	epithelial cell migration	Irs1	IGI	MGI:MGI:109334	Mouse	PMID:17662267
Biological Process	GO:0008286	insulin receptor signaling pathway	IRS1	IDA		Human	PMID:16516141
Biological Process	GO:0008286	insulin receptor signaling pathway	IRS1	IMP		Human	PMID:16814735
Biological Process	GO:0008286	insulin receptor signaling pathway	IRS1	IDA		Human	PMID:23401856
Biological Process	GO:0008286	insulin receptor signaling pathway	IRS1	IPI	UniProtKB:P06213	Human	PMID:7537849
Biological Process	GO:0008286	insulin receptor signaling pathway	IRS1	IPI	UniProtKB:P06213	Human	PMID:7559478
Biological Process	GO:0008286	insulin receptor signaling pathway	Irs1	IGI	MGI:MGI:96575	Mouse	PMID:9038347
Biological Process	GO:0008286	insulin receptor signaling pathway	Irs1	IMP		Mouse	PMID:33839150
Biological Process	GO:0008286	insulin receptor signaling pathway	Irs1	IMP	MGI:MGI:2136643	Mouse	PMID:8649419
Biological Process	GO:0008286	insulin receptor signaling pathway	Irs1	IMP		Mouse	PMID:7526222
Biological Process	GO:0008286	insulin receptor signaling pathway	Irs1	IDA		Mouse	PMID:7542745
Biological Process	GO:0008286	insulin receptor signaling pathway	Irs1	IDA		Mouse	PMID:9813005
Biological Process	GO:0008286	insulin receptor signaling pathway	Irs1	IDA		Rat	PMID:17925406\|RGD:8553954
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IRS1	IPI	UniProtKB:P08069	Human	PMID:7541045
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Irs1	IMP	MGI:MGI:2136643	Mouse	PMID:7969452
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Irs1	IDA		Mouse	PMID:12483226
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Irs1	IGI	MGI:MGI:96434	Mouse	PMID:7969452
Biological Process	GO:0016042	lipid catabolic process	Irs1	IMP		Mouse	PMID:11375348
Biological Process	GO:0030879	mammary gland development	Irs1	IGI	MGI:MGI:109334	Mouse	PMID:17662267
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	Irs1	IMP		Rat	PMID:15069075\|RGD:8554248
Biological Process	GO:0046676	negative regulation of insulin secretion	IRS1	IDA		Human	PMID:15572028
Biological Process	GO:0046676	negative regulation of insulin secretion	Irs1	IMP		Rat	PMID:12435589\|RGD:729325
Biological Process	GO:0090275	negative regulation of somatostatin secretion	Irs1	IMP		Rat	PMID:12435589\|RGD:729325
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	IRS1	IDA		Human	PMID:7782332
Biological Process	GO:0010634	positive regulation of epithelial cell migration	Irs1	IGI	MGI:MGI:109334	Mouse	PMID:17662267
Biological Process	GO:0032000	positive regulation of fatty acid beta-oxidation	IRS1	IMP		Human	PMID:16814735
Biological Process	GO:0070094	positive regulation of glucagon secretion	Irs1	IMP		Rat	PMID:12435589\|RGD:729325
Biological Process	GO:0046326	positive regulation of glucose import	IRS1	IMP		Human	PMID:16814735
Biological Process	GO:0046326	positive regulation of glucose import	IRS1	IDA		Human	PMID:7493946
Biological Process	GO:0010907	positive regulation of glucose metabolic process	IRS1	IMP		Human	PMID:16814735
Biological Process	GO:0045725	positive regulation of glycogen biosynthetic process	IRS1	IMP		Human	PMID:16814735
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	IRS1	IDA		Human	PMID:7493946
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	Irs1	IMP		Rat	PMID:18285345\|RGD:8553881
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	Irs1	IGI	MGI:MGI:109334	Mouse	PMID:17662267
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	Irs1	IMP		Mouse	PMID:11375348
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	Irs1	IDA		Rat	PMID:1380456\|RGD:8553725
Biological Process	GO:0042327	positive regulation of phosphorylation	Irs1	IDA		Rat	PMID:12435589\|RGD:729325
Biological Process	GO:0043491	protein kinase B signaling	Irs1	IGI	MGI:MGI:1927343	Mouse	PMID:15249583
Biological Process	GO:0043491	protein kinase B signaling	Irs1	IGI	MGI:MGI:87986	Mouse	PMID:15249583
Biological Process	GO:0043491	protein kinase B signaling	Irs1	IGI	MGI:MGI:99454	Mouse	PMID:15249583
Biological Process	GO:0043491	protein kinase B signaling	Irs1	IGI	MGI:MGI:1270849	Mouse	PMID:15249583
Biological Process	GO:0043491	protein kinase B signaling	Irs1	IGI	MGI:MGI:102548	Mouse	PMID:15249583
Biological Process	GO:0034504	protein localization to nucleus	Irs1	IMP		Mouse	PMID:19952108
Biological Process	GO:0034504	protein localization to nucleus	Irs1	IDA		Mouse	PMID:19952108
Biological Process	GO:0010468	regulation of gene expression	Irs1	IMP		Mouse	PMID:11375348
Biological Process	GO:0014823	response to activity	Irs1	IEP		Rat	PMID:22015326\|RGD:10045895
Biological Process	GO:0031000	response to caffeine	Irs1	IDA		Rat	PMID:21940847\|RGD:6483017
Biological Process	GO:0031000	response to caffeine	Irs1	IEP		Rat	PMID:22995397\|RGD:8661261
Biological Process	GO:0032868	response to insulin	IRS1	IDA		Human	PMID:16516141
Biological Process	GO:0043434	response to peptide hormone	Irs1	IDA		Rat	PMID:9295312\|RGD:8554624

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.