Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IRX1
  • Mouse genes Irx1
  • Rat genes Irx1
  • Zfish genes irx1a,irx1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Irx1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IRX1	IDA		Human	PMID:20440264
Molecular Function	GO:0043565	sequence-specific DNA binding	IRX1	IDA		Human	PMID:28473536
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	IRX1	IDA		Human	PMID:28473536
Biological Process	GO:0007417	central nervous system development	irx1a	IMP		Zfish	PMID:15497138
Biological Process	GO:0021953	central nervous system neuron differentiation	irx1a	IMP	ZFIN:ZDB-MRPHLNO-060630-3,ZFIN:ZDB-MRPHLNO-070613-1	Zfish	PMID:17685478
Biological Process	GO:0031076	embryonic camera-type eye development	irx1a	IMP		Zfish	PMID:15497138
Biological Process	GO:0035118	embryonic pectoral fin morphogenesis	irx1a	IMP		Zfish	PMID:15497138
Biological Process	GO:0042462	eye photoreceptor cell development	irx1a	IMP	ZFIN:ZDB-MRPHLNO-060630-3	Zfish	PMID:16457994
Biological Process	GO:0042462	eye photoreceptor cell development	irx1a	IMP	ZFIN:ZDB-MRPHLNO-070613-1	Zfish	PMID:16457994
Biological Process	GO:0030902	hindbrain development	irx1b	IGI	ZFIN:ZDB-MRPHLNO-060918-1,ZFIN:ZDB-MRPHLNO-100423-1	Zfish	PMID:19152797
Biological Process	GO:0042472	inner ear morphogenesis	irx1a	IMP		Zfish	PMID:15497138
Biological Process	GO:0001656	metanephros development	Irx1	IEP		Mouse	MGI:MGI:3758158|PMID:17875669
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IRX1	IDA		Human	PMID:20440264
Biological Process	GO:0007399	nervous system development	irx1a	IDA		Zfish	PMID:15242793
Biological Process	GO:0072272	proximal/distal pattern formation involved in metanephric nephron development	Irx1	IEP		Mouse	MGI:MGI:3758158|PMID:17875669
Biological Process	GO:0051726	regulation of cell cycle	irx1b	IGI	ZFIN:ZDB-GENO-210317-18	Zfish	PMID:31450023
Biological Process	GO:0051726	regulation of cell cycle	irx1a	IGI	ZFIN:ZDB-GENO-210317-18	Zfish	PMID:31450023
Biological Process	GO:0060041	retina development in camera-type eye	irx1a	IMP	ZFIN:ZDB-MRPHLNO-070613-1	Zfish	PMID:16457994
Biological Process	GO:0060041	retina development in camera-type eye	irx1a	IMP	ZFIN:ZDB-MRPHLNO-060630-3	Zfish	PMID:16457994
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	irx1a	IMP	ZFIN:ZDB-MRPHLNO-120315-1	Zfish	PMID:21046643
Biological Process	GO:0072086	specification of loop of Henle identity	Irx1	IEP		Mouse	MGI:MGI:3758158|PMID:17875669

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern