Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IRX2
  • Mouse genes Irx2
  • Rat genes Irx2
  • Zfish genes irx2a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Irx2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IRX2	IDA		Human	PMID:26560478
Molecular Function	GO:0005515	protein binding	IRX2	IPI	UniProtKB:Q08117-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IRX2	IPI	UniProtKB:Q99471	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IRX2	IPI	UniProtKB:Q9UPG8	Human	PMID:32296183
Molecular Function	GO:0043565	sequence-specific DNA binding	IRX2	IDA		Human	PMID:23332764
Biological Process	GO:0001656	metanephros development	Irx2	IEP		Mouse	MGI:MGI:3758158|PMID:17875669
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IRX2	IDA		Human	PMID:26560478
Biological Process	GO:0035778	pronephric nephron tubule epithelial cell differentiation	irx2a	IMP	ZFIN:ZDB-MRPHLNO-110209-1	Zfish	PMID:31015532
Biological Process	GO:0072272	proximal/distal pattern formation involved in metanephric nephron development	Irx2	IEP		Mouse	MGI:MGI:3758158|PMID:17875669
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	irx2a	IMP	ZFIN:ZDB-MRPHLNO-110209-1	Zfish	PMID:21046643
Biological Process	GO:0072086	specification of loop of Henle identity	Irx2	IEP		Mouse	MGI:MGI:3758158|PMID:17875669

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern