Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IRX3
  • Mouse genes Irx3
  • Rat genes Irx3
  • Zfish genes irx3a,irx3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Irx3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Irx3	IDA		Mouse	MGI:MGI:5288100|PMID:21825130
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Irx3	IDA		Mouse	MGI:MGI:5288100|PMID:21825130
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Irx3	IDA		Mouse	MGI:MGI:5288100|PMID:21825130
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	IRX3	IDA		Human	PMID:28473536
Cellular Component	GO:0030424	axon	Irx3	IDA		Mouse	PMID:19666821
Cellular Component	GO:0005737	cytoplasm	Irx3	IDA		Mouse	PMID:16100003
Cellular Component	GO:0005634	nucleus	Irx3	IDA		Mouse	PMID:16100003
Biological Process	GO:0003167	atrioventricular bundle cell differentiation	Irx3	IMP		Mouse	MGI:MGI:6101691|PMID:26786475
Biological Process	GO:0031018	endocrine pancreas development	irx3a	IMP	ZFIN:ZDB-MRPHLNO-050204-1,ZFIN:ZDB-MRPHLNO-100520-9	Zfish	PMID:20080751
Biological Process	GO:0097009	energy homeostasis	Irx3	IDA		Mouse	MGI:MGI:5565149|PMID:24646999
Biological Process	GO:0007369	gastrulation	irx3a	IMP	ZFIN:ZDB-MRPHLNO-050204-1	Zfish	PMID:15580554
Biological Process	GO:0060932	His-Purkinje system cell differentiation	Irx3	IMP		Mouse	MGI:MGI:6101691|PMID:26786475
Biological Process	GO:0007498	mesoderm development	Irx3	IGI	MGI:MGI:1347470	Mouse	PMID:11124112
Biological Process	GO:0001656	metanephros development	Irx3	IEP		Mouse	MGI:MGI:3758158|PMID:17875669
Biological Process	GO:0045665	negative regulation of neuron differentiation	Irx3	IDA		Mouse	PMID:10830170
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Irx3	IDA		Mouse	MGI:MGI:5288100|PMID:21825130
Biological Process	GO:0030182	neuron differentiation	Irx3	IDA		Mouse	PMID:10830170
Biological Process	GO:1903598	positive regulation of gap junction assembly	Irx3	IMP		Mouse	MGI:MGI:6101691|PMID:26786475
Biological Process	GO:1903598	positive regulation of gap junction assembly	Irx3	IMP		Mouse	MGI:MGI:5288100|PMID:21825130
Biological Process	GO:0045666	positive regulation of neuron differentiation	Irx3	IDA		Mouse	PMID:10830170
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Irx3	IDA		Mouse	MGI:MGI:5288100|PMID:21825130
Biological Process	GO:0035777	pronephric distal tubule development	irx3b	IMP	ZFIN:ZDB-GENO-190704-181	Zfish	PMID:30394875
Biological Process	GO:0039023	pronephric duct morphogenesis	irx3b	IMP	ZFIN:ZDB-MRPHLNO-110815-1,ZFIN:ZDB-MRPHLNO-110815-2	Zfish	PMID:21761484
Biological Process	GO:0039023	pronephric duct morphogenesis	irx3b	IGI	ZFIN:ZDB-GENO-070802-3,ZFIN:ZDB-MRPHLNO-110815-1,ZFIN:ZDB-MRPHLNO-110815-2	Zfish	PMID:21761484
Biological Process	GO:0035778	pronephric nephron tubule epithelial cell differentiation	irx3b	IMP	ZFIN:ZDB-MRPHLNO-110815-1	Zfish	PMID:23160512
Biological Process	GO:0048793	pronephros development	irx3b	IMP	ZFIN:ZDB-MRPHLNO-110815-2	Zfish	PMID:27996936
Biological Process	GO:0072047	proximal/distal pattern formation involved in nephron development	Irx3	IEP		Mouse	MGI:MGI:3758158|PMID:17875669
Biological Process	GO:0003165	Purkinje myocyte development	Irx3	IMP		Mouse	MGI:MGI:6101691|PMID:26786475
Biological Process	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction	Irx3	IMP		Mouse	MGI:MGI:5288100|PMID:21825130
Biological Process	GO:0072086	specification of loop of Henle identity	Irx3	IEP		Mouse	MGI:MGI:3758158|PMID:17875669

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern