Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ISCU
  • Mouse genes Iscu
  • Rat genes Iscu
  • Zfish genes iscub,si:ch211-191d15.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Iscu

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0060090	molecular adaptor activity	ISCU	IDA		Human	PMID:16527810
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:Q9Y697	Human	PMID:11060020
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:Q9Y697	Human	PMID:16527810
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:Q8IWL3	Human	PMID:20668094
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:P38646	Human	PMID:23940031
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:Q8IWL3	Human	PMID:23940031
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:Q9Y697	Human	PMID:23940031
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:P21912	Human	PMID:24606901
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:P00492	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:P0C7W6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:P37198	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:Q08379	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:Q13422	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:Q6A162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:Q6RW13	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:Q7Z6G3-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:Q8IZU0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:Q8N9N5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:Q8TBB1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:Q9UJV3-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:P38646	Human	PMID:26702583
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:P21912	Human	PMID:26749241
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:Q9HD34,UniProtKB:Q9Y697	Human	PMID:29097656
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:Q16595	Human	PMID:31101807
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:P00492	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:A6NEM1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:O76011	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:P37198	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:Q8NA61-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ISCU	IPI	UniProtKB:Q9NRD5	Human	PMID:32296183
Molecular Function	GO:0042803	protein homodimerization activity	ISCU	IDA		Human	PMID:29097656
Molecular Function	GO:0042803	protein homodimerization activity	ISCU	IDA		Human	PMID:34824239
Molecular Function	GO:0042803	protein homodimerization activity	Iscu	IDA		Mouse	MGI:MGI:6867303|PMID:29097656
Molecular Function	GO:0008270	zinc ion binding	ISCU	IDA		Human	PMID:30031876
Cellular Component	GO:0005737	cytoplasm	ISCU	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005737	cytoplasm	ISCU	IDA		Human	PMID:11060020
Cellular Component	GO:0005829	cytosol	ISCU	IDA		Human	PMID:16527810
Cellular Component	GO:0099128	mitochondrial iron-sulfur cluster assembly complex	ISCU	IDA		Human	PMID:21298097
Cellular Component	GO:0099128	mitochondrial iron-sulfur cluster assembly complex	ISCU	IDA		Human	PMID:31101807
Cellular Component	GO:0099128	mitochondrial iron-sulfur cluster assembly complex	Iscu	IDA		Mouse	MGI:MGI:6228237|PMID:21298097
Cellular Component	GO:0099128	mitochondrial iron-sulfur cluster assembly complex	Iscu	IDA		Mouse	MGI:MGI:7327226|PMID:25597503
Cellular Component	GO:0005739	mitochondrion	ISCU	IDA		Human	PMID:11060020
Cellular Component	GO:0005739	mitochondrion	ISCU	IDA		Human	PMID:26702583
Cellular Component	GO:0005739	mitochondrion	Iscu	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Iscu	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Iscu	IDA		Mouse	PMID:17597094
Biological Process	GO:0044571	[2Fe-2S] cluster assembly	ISCU	IDA		Human	PMID:23940031
Biological Process	GO:0044571	[2Fe-2S] cluster assembly	ISCU	IDA		Human	PMID:24971490
Biological Process	GO:0044572	[4Fe-4S] cluster assembly	ISCU	IDA		Human	PMID:23940031
Biological Process	GO:0044572	[4Fe-4S] cluster assembly	Iscu	IDA		Mouse	MGI:MGI:7327226|PMID:25597503
Biological Process	GO:0006879	intracellular iron ion homeostasis	ISCU	IDA		Human	PMID:16517407
Biological Process	GO:0006879	intracellular iron ion homeostasis	ISCU	IDA		Human	PMID:23508953
Biological Process	GO:1904439	negative regulation of iron ion import across plasma membrane	ISCU	IMP		Human	PMID:20436681
Biological Process	GO:1904234	positive regulation of aconitate hydratase activity	ISCU	IMP		Human	PMID:20436681
Biological Process	GO:1902958	positive regulation of mitochondrial electron transport, NADH to ubiquinone	ISCU	IMP		Human	PMID:20436681

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern