Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ISG15
  • Mouse genes Isg15
  • Rat genes Isg15
  • Zfish genes isg15
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Isg15

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005178	integrin binding	ISG15	IPI	UniProtKB:P20701	Human	PMID:29100055
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:P41226	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:Q9UMW8	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:O75688	Human	PMID:16872604
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:P41226	Human	PMID:17597759
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:P46934	Human	PMID:18305167
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:O75369	Human	PMID:19270716
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:P03495	Human	PMID:20133869
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:Q6TQR6	Human	PMID:21245344
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:Q6TQR6	Human	PMID:21266548
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:P03502	Human	PMID:21808041
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:Q9UMW8	Human	PMID:25307056
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:P41226	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:Q9UMW8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:P0C6U8:PRO_0000338257	Human	PMID:28438633
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:K0BWD0	Human	PMID:28931677
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:P0C6U8:PRO_0000338257	Human	PMID:30644842
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:Q9UMW8	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:K9N7C7:PRO_0000422441	Human	PMID:31765674
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:P41226	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:Q9UMW8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:P0DTD1:PRO_0000449621	Human	PMID:32428392
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:P0C6X7:PRO_0000037311	Human	PMID:32726803
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:P0DTD1:PRO_0000449621	Human	PMID:32726803
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:Q14653	Human	PMID:32726803
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:O60260-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:P0DTD1:PRO_0000449621	Human	PMID:32845033
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:Q9BYX4	Human	PMID:33727702
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:P0DTD1:PRO_0000449621	Human	PMID:34270554
Molecular Function	GO:0005515	protein binding	ISG15	IPI	UniProtKB:P0DTD1:PRO_0000449621	Human	PMID:34663977
Molecular Function	GO:0005515	protein binding	Isg15	IPI	UniProtKB:Q9WTV6	Mouse	MGI:MGI:5558960|PMID:24533902
Molecular Function	GO:0005515	protein binding	Isg15	IPI	UniProtKB:P0DTD1:PRO_0000449621	Mouse	MGI:MGI:6695859|PMID:32428392
Molecular Function	GO:0005515	protein binding	Isg15	IPI	UniProtKB:P0DTD1:PRO_0000449621	Mouse	MGI:MGI:6488751|PMID:32845033
Molecular Function	GO:0005515	protein binding	Isg15	IPI	UniProtKB:P0C6X7:PRO_0000037311|UniProtKB:P0DTD1:PRO_0000449621|UniProtKB:Q9WTV6	Mouse	MGI:MGI:6695688|PMID:32726803
Molecular Function	GO:0005515	protein binding	Isg15	IPI	UniProtKB:K9N638:PRO_0000422456|UniProtKB:P0C6U8:PRO_0000338257	Mouse	MGI:MGI:6467693|PMID:28438633
Molecular Function	GO:0005515	protein binding	Isg15	IPI	PR:Q9QZU9	Mouse	PMID:15485925
Molecular Function	GO:0031386	protein tag	ISG15	IDA		Human	PMID:16407192
Molecular Function	GO:0031386	protein tag	Isg15	IDA		Mouse	PMID:16139798
Cellular Component	GO:0005576	extracellular region	ISG15	IDA		Human	PMID:22859821
Biological Process	GO:0042742	defense response to bacterium	ISG15	IMP		Human	PMID:22859821
Biological Process	GO:0042742	defense response to bacterium	Isg15	IMP		Mouse	MGI:MGI:5437528|PMID:22859821
Biological Process	GO:0051607	defense response to virus	ISG15	IMP		Human	PMID:19357168
Biological Process	GO:0051607	defense response to virus	ISG15	IDA		Human	PMID:33727702
Biological Process	GO:0051607	defense response to virus	Isg15	IMP		Mouse	MGI:MGI:3702368|PMID:17227866
Biological Process	GO:0045087	innate immune response	ISG15	IDA		Human	PMID:28724761
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISG15	IDA		Human	PMID:29100055
Biological Process	GO:0032020	ISG15-protein conjugation	ISG15	IDA		Human	PMID:16122702
Biological Process	GO:0032020	ISG15-protein conjugation	ISG15	IDA		Human	PMID:16407192
Biological Process	GO:0032020	ISG15-protein conjugation	ISG15	IDA		Human	PMID:21543490
Biological Process	GO:0032020	ISG15-protein conjugation	ISG15	IMP		Human	PMID:22859821
Biological Process	GO:0032020	ISG15-protein conjugation	ISG15	IDA		Human	PMID:33727702
Biological Process	GO:0032020	ISG15-protein conjugation	Isg15	IDA		Mouse	MGI:MGI:5297292|PMID:22022510
Biological Process	GO:0032020	ISG15-protein conjugation	Isg15	IDA		Mouse	PMID:16139798
Biological Process	GO:0019941	modification-dependent protein catabolic process	Isg15	IDA		Mouse	PMID:15485925
Biological Process	GO:0031397	negative regulation of protein ubiquitination	ISG15	IDA		Human	PMID:18305167
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	ISG15	IMP		Human	PMID:28724761
Biological Process	GO:0045071	negative regulation of viral genome replication	ISG15	IMP		Human	PMID:19357168
Biological Process	GO:0045071	negative regulation of viral genome replication	ISG15	IDA		Human	PMID:33727702
Biological Process	GO:0030501	positive regulation of bone mineralization	Isg15	IMP		Mouse	MGI:MGI:4943600|PMID:21402791
Biological Process	GO:0045648	positive regulation of erythrocyte differentiation	Isg15	IMP		Mouse	MGI:MGI:5297292|PMID:22022510
Biological Process	GO:0032728	positive regulation of interferon-beta production	ISG15	IDA		Human	PMID:33727702
Biological Process	GO:0032733	positive regulation of interleukin-10 production	ISG15	IDA		Human	PMID:29100055
Biological Process	GO:0032461	positive regulation of protein oligomerization	ISG15	IDA		Human	PMID:33727702
Biological Process	GO:0032729	positive regulation of type II interferon production	ISG15	IDA		Human	PMID:29100055
Biological Process	GO:0070585	protein localization to mitochondrion	ISG15	IDA		Human	PMID:33727702
Biological Process	GO:0032649	regulation of type II interferon production	ISG15	IMP		Human	PMID:22859821
Biological Process	GO:0009617	response to bacterium	Isg15	IEP		Mouse	PMID:23012479
Biological Process	GO:0034340	response to type I interferon	ISG15	IDA		Human	PMID:22859821
Biological Process	GO:0009615	response to virus	ISG15	IEP		Human	PMID:28724761
Biological Process	GO:0009615	response to virus	ISG15	IDA		Human	PMID:33727702

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern