Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ISL1
  • Mouse genes Isl1
  • Rat genes Isl1
  • Zfish genes isl1a,isl1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Isl1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043425	bHLH transcription factor binding	ISL1	IPI	UniProtKB:Q13562	Human	PMID:16321656
Molecular Function	GO:0003682	chromatin binding	Isl1	IDA		Mouse	PMID:18434421
Molecular Function	GO:0003682	chromatin binding	Isl1	IDA		Mouse	PMID:19620969
Molecular Function	GO:0003682	chromatin binding	Isl1	IDA		Mouse	PMID:21734270
Molecular Function	GO:0003677	DNA binding	Isl1	IDA		Mouse	PMID:19620969
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Isl1	IDA		Mouse	PMID:15659653
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Isl1	IDA		Rat	PMID:19619559|RGD:8553931
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISL1	IDA		Human	PMID:19619559
Molecular Function	GO:0030331	nuclear estrogen receptor binding	Isl1	IDA		Rat	PMID:11043578|RGD:8554127
Molecular Function	GO:0016922	nuclear receptor binding	Isl1	IDA		Rat	PMID:11043578|RGD:8554127
Molecular Function	GO:0016922	nuclear receptor binding	Isl1	IPI	UniProtKB:P10589	Rat	PMID:11043578|RGD:8554127
Molecular Function	GO:1990841	promoter-specific chromatin binding	Isl1	IDA		Mouse	MGI:MGI:5825419|PMID:24643061
Molecular Function	GO:0005515	protein binding	ISL1	IPI	UniProtKB:Q969G2	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	ISL1	IPI	UniProtKB:Q8NB15	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ISL1	IPI	UniProtKB:Q969G2	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	ISL1	IPI	UniProtKB:Q8NB15	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ISL1	IPI	UniProtKB:Q969G2	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ISL1	IPI	UniProtKB:Q86U70-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ISL1	IPI	UniProtKB:Q8NB15	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Isl1	IPI	UniProtKB:P50481|UniProtKB:P70662	Mouse	MGI:MGI:5508589|PMID:18583962
Molecular Function	GO:0005515	protein binding	Isl1	IPI	UniProtKB:Q63934	Mouse	MGI:MGI:5825419|PMID:24643061
Molecular Function	GO:0005515	protein binding	Isl1	IPI	UniProtKB:P31360|UniProtKB:Q63955	Mouse	MGI:MGI:5825419|PMID:24643061
Molecular Function	GO:0005515	protein binding	Isl1	IPI	UniProtKB:P70662	Mouse	MGI:MGI:4455093|PMID:20211142
Molecular Function	GO:0005515	protein binding	Isl1	IPI	PR:P70662	Mouse	PMID:19666821
Molecular Function	GO:0005515	protein binding	Isl1	IPI	PR:Q5FW52	Mouse	PMID:22343712
Molecular Function	GO:0005515	protein binding	Isl1	IPI	PR:O55203-2	Mouse	PMID:9192866
Molecular Function	GO:0005515	protein binding	Isl1	IPI	MGI:MGI:96628	Mouse	PMID:15659653
Molecular Function	GO:0005515	protein binding	Isl1	IPI	PR:O55203-1	Mouse	PMID:9192866
Molecular Function	GO:0005515	protein binding	Isl1	IPI	PR:P70662	Mouse	PMID:9192866
Molecular Function	GO:0005515	protein binding	Isl1	IPI	PR:Q9WTV7	Mouse	PMID:10431247
Molecular Function	GO:0005515	protein binding	Isl1	IPI	PR:P42227	Mouse	PMID:15659653
Molecular Function	GO:0005515	protein binding	Isl1	IPI	RGD:1310359	Rat	PMID:9315627|RGD:1581795
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISL1	IDA		Human	PMID:19619559
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Isl1	IDA		Rat	PMID:19619559|RGD:8553931
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISL1	IPI	UniProtKB:Q13562	Human	PMID:19619559
Molecular Function	GO:0043565	sequence-specific DNA binding	Isl1	IDA		Mouse	MGI:MGI:5825419|PMID:24643061
Molecular Function	GO:0043565	sequence-specific DNA binding	Isl1	IDA		Rat	PMID:1691825|RGD:61640
Molecular Function	GO:0043565	sequence-specific DNA binding	Isl1	IDA		Rat	PMID:7759514|RGD:2303513
Molecular Function	GO:0043565	sequence-specific DNA binding	Isl1	IDA		Rat	PMID:9514122|RGD:2303514
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISL1	IDA		Human	PMID:28473536
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	Isl1	IDA		Rat	PMID:18539116|RGD:155230693
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Isl1	IDA		Mouse	MGI:MGI:7339313|PMID:18539116
Cellular Component	GO:0000785	chromatin	Isl1	IDA		Mouse	MGI:MGI:7339313|PMID:18539116
Cellular Component	GO:0005634	nucleus	Isl1	IDA		Mouse	MGI:MGI:5827898|PMID:14664703
Cellular Component	GO:0005634	nucleus	Isl1	IDA		Mouse	PMID:23610558
Cellular Component	GO:0005634	nucleus	Isl1	IDA		Mouse	PMID:10536059
Cellular Component	GO:0005634	nucleus	Isl1	IDA		Mouse	PMID:17928203
Cellular Component	GO:0005634	nucleus	Isl1	IDA		Mouse	PMID:24821700
Cellular Component	GO:0005634	nucleus	Isl1	IDA		Mouse	PMID:25433207
Cellular Component	GO:0005634	nucleus	Isl1	IDA		Mouse	PMID:12900460
Cellular Component	GO:0005634	nucleus	Isl1	IDA		Mouse	PMID:18434421
Cellular Component	GO:0005634	nucleus	Isl1	IDA		Mouse	PMID:15659653
Cellular Component	GO:0005634	nucleus	Isl1	IDA		Mouse	PMID:14702043
Cellular Component	GO:0005634	nucleus	Isl1	IDA		Mouse	PMID:19666821
Cellular Component	GO:0005634	nucleus	Isl1	IDA		Rat	PMID:7759514|RGD:2303513
Cellular Component	GO:0005634	nucleus	isl1a	IDA		Zfish	PMID:16893913
Cellular Component	GO:0005634	nucleus	isl1a	IDA		Zfish	PMID:15547934
Cellular Component	GO:0005634	nucleus	isl1a	IDA		Zfish	PMID:15580554
Cellular Component	GO:0005667	transcription regulator complex	Isl1	IDA		Rat	PMID:18539116|RGD:155230693
Biological Process	GO:0055011	atrial cardiac muscle cell differentiation	isl1a	IMP	ZFIN:ZDB-GENO-090528-4	Zfish	PMID:19395641
Biological Process	GO:0060413	atrial septum morphogenesis	Isl1	IGI	UniProtKB:Q02248	Mouse	MGI:MGI:3829137|PMID:17519333
Biological Process	GO:0048675	axon extension	isl1a	IMP	ZFIN:ZDB-MRPHLNO-060728-1,ZFIN:ZDB-MRPHLNO-060728-2	Zfish	PMID:16672347
Biological Process	GO:0031103	axon regeneration	Isl1	IEP		Rat	PMID:10363827|RGD:2311122
Biological Process	GO:0060070	canonical Wnt signaling pathway	Isl1	IGI	MGI:MGI:88276	Mouse	PMID:19620969
Biological Process	GO:0060913	cardiac cell fate determination	ISL1	IDA		Human	PMID:19571884
Biological Process	GO:0060913	cardiac cell fate determination	Isl1	IMP		Mouse	PMID:19620969
Biological Process	GO:0060379	cardiac muscle cell myoblast differentiation	Isl1	IMP		Mouse	PMID:19620969
Biological Process	GO:0003215	cardiac right ventricle morphogenesis	Isl1	IGI	UniProtKB:Q02248	Mouse	MGI:MGI:3829137|PMID:17519333
Biological Process	GO:0008283	cell population proliferation	Isl1	IDA		Mouse	PMID:15659653
Biological Process	GO:0071385	cellular response to glucocorticoid stimulus	Isl1	IEP		Rat	PMID:19619559|RGD:8553931
Biological Process	GO:0003203	endocardial cushion morphogenesis	Isl1	IGI	UniProtKB:Q02248	Mouse	MGI:MGI:3829137|PMID:17519333
Biological Process	GO:0031018	endocrine pancreas development	isl1a	IMP	ZFIN:ZDB-GENO-090527-7	Zfish	PMID:23518338
Biological Process	GO:0031017	exocrine pancreas development	isl1a	IGI	ZFIN:ZDB-GENO-090527-7,ZFIN:ZDB-MRPHLNO-130122-2,ZFIN:ZDB-MRPHLNO-130805-1	Zfish	PMID:23518338
Biological Process	GO:0031017	exocrine pancreas development	isl1a	IMP	ZFIN:ZDB-MRPHLNO-080118-2	Zfish	PMID:17942484
Biological Process	GO:0097154	GABAergic neuron differentiation	isl1a	IMP	ZFIN:ZDB-MRPHLNO-060728-1,ZFIN:ZDB-MRPHLNO-060728-2	Zfish	PMID:16672347
Biological Process	GO:0007507	heart development	Isl1	IMP	MGI:MGI:2182246	Mouse	PMID:14667410
Biological Process	GO:0003007	heart morphogenesis	Isl1	IGI	MGI:MGI:108075	Mouse	PMID:16687132
Biological Process	GO:0060384	innervation	Isl1	IMP		Mouse	MGI:MGI:3815381|PMID:18849985
Biological Process	GO:0048762	mesenchymal cell differentiation	Isl1	IMP	MGI:MGI:2182246	Mouse	PMID:9000074
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Isl1	IGI	MGI:MGI:88276	Mouse	PMID:19620969
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Isl1	IMP		Rat	PMID:23270756|RGD:13210526
Biological Process	GO:0050728	negative regulation of inflammatory response	Isl1	IMP		Mouse	MGI:MGI:5437583|PMID:22727192
Biological Process	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	Isl1	IDA		Rat	PMID:11043578|RGD:8554127
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Isl1	IMP		Mouse	MGI:MGI:3815381|PMID:18849985
Biological Process	GO:0045665	negative regulation of neuron differentiation	Isl1	IGI	MGI:MGI:109156	Mouse	PMID:14766174
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	Isl1	IDA		Rat	PMID:11043578|RGD:8554127
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Isl1	IMP		Mouse	MGI:MGI:3815381|PMID:18849985
Biological Process	GO:0001755	neural crest cell migration	Isl1	IGI	MGI:MGI:108075	Mouse	PMID:16687132
Biological Process	GO:0048666	neuron development	isl1a	IMP	ZFIN:ZDB-MRPHLNO-060728-1	Zfish	PMID:22728160
Biological Process	GO:0030182	neuron differentiation	Isl1	IGI	MGI:MGI:102524	Mouse	PMID:18434416
Biological Process	GO:0030182	neuron differentiation	Isl1	IGI	MGI:MGI:109156	Mouse	PMID:14766174
Biological Process	GO:0030182	neuron differentiation	Isl1	IMP	MGI:MGI:3574771,MGI:MGI:3797783	Mouse	PMID:18367596
Biological Process	GO:0030182	neuron differentiation	Isl1	IMP	MGI:MGI:2182246	Mouse	PMID:8565076
Biological Process	GO:0048663	neuron fate commitment	Isl1	IGI	MGI:MGI:109156	Mouse	PMID:14766174
Biological Process	GO:0048665	neuron fate specification	Isl1	IMP		Mouse	MGI:MGI:3815381|PMID:18849985
Biological Process	GO:0048665	neuron fate specification	isl1a	IMP	ZFIN:ZDB-MRPHLNO-060728-3	Zfish	PMID:25825735
Biological Process	GO:0048665	neuron fate specification	isl1a	IMP	ZFIN:ZDB-MRPHLNO-060728-1,ZFIN:ZDB-MRPHLNO-060728-2	Zfish	PMID:16672347
Biological Process	GO:0048665	neuron fate specification	isl1a	IGI	ZFIN:ZDB-MRPHLNO-060728-1,ZFIN:ZDB-MRPHLNO-060728-2,ZFIN:ZDB-MRPHLNO-060728-4	Zfish	PMID:16672347
Biological Process	GO:0003151	outflow tract morphogenesis	Isl1	IGI	UniProtKB:Q02248	Mouse	MGI:MGI:3829137|PMID:17519333
Biological Process	GO:0003148	outflow tract septum morphogenesis	Isl1	IGI	UniProtKB:Q02248	Mouse	MGI:MGI:3829137|PMID:17519333
Biological Process	GO:0031016	pancreas development	Isl1	IMP	MGI:MGI:2182246	Mouse	PMID:9000074
Biological Process	GO:0003322	pancreatic A cell development	isl1a	IMP	ZFIN:ZDB-GENO-090527-7	Zfish	PMID:23518338
Biological Process	GO:0003324	pancreatic D cell development	isl1a	IMP	ZFIN:ZDB-GENO-090527-7	Zfish	PMID:23518338
Biological Process	GO:0048936	peripheral nervous system neuron axonogenesis	Isl1	IMP		Mouse	MGI:MGI:3815381|PMID:18849985
Biological Process	GO:0048936	peripheral nervous system neuron axonogenesis	isl1a	IMP	ZFIN:ZDB-MRPHLNO-060728-3	Zfish	PMID:21108318
Biological Process	GO:0048936	peripheral nervous system neuron axonogenesis	isl1a	IMP	ZFIN:ZDB-GENO-110207-17	Zfish	PMID:21108318
Biological Process	GO:0048935	peripheral nervous system neuron development	Isl1	IGI	MGI:MGI:102525	Mouse	PMID:21734270
Biological Process	GO:0060037	pharyngeal system development	Isl1	IGI	UniProtKB:Q02248	Mouse	MGI:MGI:3829137|PMID:17519333
Biological Process	GO:0021983	pituitary gland development	Isl1	IMP	MGI:MGI:2182246	Mouse	PMID:9806931
Biological Process	GO:0045766	positive regulation of angiogenesis	Isl1	IMP		Mouse	MGI:MGI:5437583|PMID:22727192
Biological Process	GO:0045597	positive regulation of cell differentiation	Isl1	IMP		Mouse	MGI:MGI:5636080|PMID:25775587
Biological Process	GO:0008284	positive regulation of cell population proliferation	Isl1	IDA		Mouse	PMID:15659653
Biological Process	GO:0043388	positive regulation of DNA binding	Isl1	IDA		Mouse	PMID:15659653
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	Isl1	IMP		Rat	PMID:23270756|RGD:13210526
Biological Process	GO:0071657	positive regulation of granulocyte colony-stimulating factor production	Isl1	IDA		Mouse	MGI:MGI:5437583|PMID:22727192
Biological Process	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	Isl1	IDA		Mouse	MGI:MGI:5437583|PMID:22727192
Biological Process	GO:0032024	positive regulation of insulin secretion	ISL1	IDA		Human	PMID:19619559
Biological Process	GO:0032024	positive regulation of insulin secretion	Isl1	IMP		Rat	PMID:11978636|RGD:729103
Biological Process	GO:0032730	positive regulation of interleukin-1 alpha production	Isl1	IDA		Mouse	MGI:MGI:5437583|PMID:22727192
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Isl1	IDA		Mouse	MGI:MGI:5437583|PMID:22727192
Biological Process	GO:0032735	positive regulation of interleukin-12 production	Isl1	IDA		Mouse	MGI:MGI:5437583|PMID:22727192
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Isl1	IDA		Mouse	MGI:MGI:5437583|PMID:22727192
Biological Process	GO:1901258	positive regulation of macrophage colony-stimulating factor production	Isl1	IDA		Mouse	MGI:MGI:5437583|PMID:22727192
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISL1	IGI	UniProtKB:Q01851-2	Human	PMID:23805044
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISL1	IGI	UniProtKB:Q12837-1	Human	PMID:23805044
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Isl1	IMP		Mouse	MGI:MGI:3815381|PMID:18849985
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Isl1	IMP		Mouse	MGI:MGI:5827898|PMID:14664703
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Isl1	IMP		Mouse	MGI:MGI:5825419|PMID:24643061
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Isl1	IGI	MGI:MGI:102524	Mouse	PMID:18434421
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Isl1	IDA		Mouse	PMID:22343712
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Isl1	IDA		Mouse	PMID:19620969
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Isl1	IDA		Rat	PMID:16613990|RGD:2311120
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Isl1	IGI	UniProtKB:P50481	Rat	PMID:18539116|RGD:155230693
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Isl1	IDA		Rat	PMID:19619559|RGD:8553931
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Isl1	IDA		Mouse	MGI:MGI:5437583|PMID:22727192
Biological Process	GO:0032729	positive regulation of type II interferon production	Isl1	IDA		Mouse	MGI:MGI:5437583|PMID:22727192
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	Isl1	IDA		Mouse	PMID:15659653
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	Isl1	IDA		Mouse	MGI:MGI:5437583|PMID:22727192
Biological Process	GO:0006355	regulation of DNA-templated transcription	Isl1	IDA		Rat	PMID:7759514|RGD:2303513
Biological Process	GO:0010468	regulation of gene expression	Isl1	IMP	MGI:MGI:2182246	Mouse	PMID:19666821
Biological Process	GO:0010468	regulation of gene expression	Isl1	IMP	MGI:MGI:3817457	Mouse	PMID:19666821
Biological Process	GO:0008016	regulation of heart contraction	isl1a	IMP	ZFIN:ZDB-MRPHLNO-060728-1	Zfish	PMID:23455426
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	Isl1	IMP		Mouse	MGI:MGI:5688210|PMID:26193633
Biological Process	GO:0003266	regulation of secondary heart field cardioblast proliferation	Isl1	IMP	MGI:MGI:2447758	Mouse	PMID:19620969
Biological Process	GO:0031290	retinal ganglion cell axon guidance	Isl1	IMP	MGI:MGI:3790243	Mouse	PMID:18434421
Biological Process	GO:0003139	secondary heart field specification	ISL1	IMP		Human	PMID:20520780
Biological Process	GO:0048880	sensory system development	Isl1	IMP		Mouse	MGI:MGI:3815381|PMID:18849985
Biological Process	GO:0060931	sinoatrial node cell development	Isl1	IMP		Mouse	MGI:MGI:5688210|PMID:26193633
Biological Process	GO:0060931	sinoatrial node cell development	isl1a	IMP		Zfish	PMID:23077655|ZFIN:ZDB-PUB-121030-16
Biological Process	GO:0021527	spinal cord association neuron differentiation	isl1a	IMP	ZFIN:ZDB-MRPHLNO-060728-2	Zfish	PMID:25149090
Biological Process	GO:0021520	spinal cord motor neuron cell fate specification	Isl1	IGI	MGI:MGI:102673	Mouse	PMID:19666821
Biological Process	GO:0021522	spinal cord motor neuron differentiation	Isl1	IMP	MGI:MGI:2182246	Mouse	PMID:8565076
Biological Process	GO:0021522	spinal cord motor neuron differentiation	isl1a	IGI	ZFIN:ZDB-GENE-980526-112,ZFIN:ZDB-MRPHLNO-050201-3,ZFIN:ZDB-MRPHLNO-070810-3	Zfish	PMID:17376808
Biological Process	GO:0021522	spinal cord motor neuron differentiation	isl1a	IMP	ZFIN:ZDB-MRPHLNO-060728-2	Zfish	PMID:25149090
Biological Process	GO:0021522	spinal cord motor neuron differentiation	isl1a	IMP	ZFIN:ZDB-MRPHLNO-060728-1,ZFIN:ZDB-MRPHLNO-060728-2	Zfish	PMID:16672347
Biological Process	GO:0048863	stem cell differentiation	Isl1	IMP	MGI:MGI:2182246	Mouse	PMID:9000074
Biological Process	GO:0006366	transcription by RNA polymerase II	Isl1	IDA		Mouse	PMID:22343712
Biological Process	GO:0021559	trigeminal nerve development	Isl1	IMP		Mouse	MGI:MGI:3815381|PMID:18849985
Biological Process	GO:0003323	type B pancreatic cell development	isl1a	IMP	ZFIN:ZDB-GENO-090527-7	Zfish	PMID:23518338
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	Isl1	IGI	UniProtKB:Q02248	Mouse	MGI:MGI:3829137|PMID:17519333
Biological Process	GO:0021524	visceral motor neuron differentiation	Isl1	IGI	MGI:MGI:109156	Mouse	PMID:14766174

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern