Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ISL2
  • Mouse genes Isl2
  • Rat genes Isl2
  • Zfish genes isl2a,isl2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Isl2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	ISL2	IPI	UniProtKB:Q969G2	Human	PMID:27820671
Molecular Function	GO:0005515	protein binding	ISL2	IPI	UniProtKB:Q969G2	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	ISL2	IPI	UniProtKB:Q86U70-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ISL2	IPI	UniProtKB:Q969G2	Human	PMID:35140242
Molecular Function	GO:0005515	protein binding	Isl2	IPI	UniProtKB:Q63934-1	Mouse	MGI:MGI:5825419|PMID:24643061
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISL2	IDA		Human	PMID:28473536
Cellular Component	GO:0005634	nucleus	Isl2	IDA		Mouse	PMID:25433207
Biological Process	GO:0035476	angioblast cell migration	isl2a	IMP	ZFIN:ZDB-MRPHLNO-171006-1	Zfish	PMID:27126199
Biological Process	GO:0035476	angioblast cell migration	isl2a	IMP	ZFIN:ZDB-GENO-180103-4	Zfish	PMID:27126199
Biological Process	GO:0035476	angioblast cell migration	isl2a	IMP	ZFIN:ZDB-MRPHLNO-171006-1,ZFIN:ZDB-MRPHLNO-171006-2	Zfish	PMID:27126199
Biological Process	GO:0035476	angioblast cell migration	isl2a	IMP	ZFIN:ZDB-GENO-180103-3	Zfish	PMID:27126199
Biological Process	GO:0035476	angioblast cell migration	isl2a	IMP	ZFIN:ZDB-MRPHLNO-171006-2	Zfish	PMID:27126199
Biological Process	GO:0048675	axon extension	isl2a	IMP	ZFIN:ZDB-GENO-080409-2	Zfish	PMID:24513284
Biological Process	GO:0048675	axon extension	isl2a	IMP	ZFIN:ZDB-MRPHLNO-060728-4	Zfish	PMID:16672347
Biological Process	GO:0007411	axon guidance	isl2a	IMP	ZFIN:ZDB-MRPHLNO-060728-4	Zfish	PMID:16672347
Biological Process	GO:0007409	axonogenesis	isl2a	IMP	ZFIN:ZDB-MRPHLNO-130122-2	Zfish	PMID:23136389
Biological Process	GO:0007409	axonogenesis	isl2a	IGI	ZFIN:ZDB-GENE-980526-562,ZFIN:ZDB-GENO-130122-3	Zfish	PMID:23136389
Biological Process	GO:0031017	exocrine pancreas development	isl2a	IGI	ZFIN:ZDB-GENO-090527-7,ZFIN:ZDB-MRPHLNO-130122-2,ZFIN:ZDB-MRPHLNO-130805-1	Zfish	PMID:23518338
Biological Process	GO:0031017	exocrine pancreas development	isl2b	IGI	ZFIN:ZDB-GENO-090527-7,ZFIN:ZDB-MRPHLNO-130122-2,ZFIN:ZDB-MRPHLNO-130805-1	Zfish	PMID:23518338
Biological Process	GO:0045665	negative regulation of neuron differentiation	Isl2	IMP	MGI:MGI:3046260	Mouse	PMID:14766174
Biological Process	GO:0045665	negative regulation of neuron differentiation	Isl2	IGI	MGI:MGI:101791	Mouse	PMID:14766174
Biological Process	GO:0030182	neuron differentiation	Isl2	IMP	MGI:MGI:3046260	Mouse	PMID:14766174
Biological Process	GO:0030182	neuron differentiation	Isl2	IGI	MGI:MGI:101791	Mouse	PMID:14766174
Biological Process	GO:0048663	neuron fate commitment	Isl2	IGI	MGI:MGI:101791	Mouse	PMID:14766174
Biological Process	GO:0048663	neuron fate commitment	Isl2	IMP	MGI:MGI:3046260	Mouse	PMID:14766174
Biological Process	GO:0048665	neuron fate specification	isl2a	IGI	ZFIN:ZDB-MRPHLNO-060728-1,ZFIN:ZDB-MRPHLNO-060728-2,ZFIN:ZDB-MRPHLNO-060728-4	Zfish	PMID:16672347
Biological Process	GO:0048665	neuron fate specification	isl2a	IMP	ZFIN:ZDB-MRPHLNO-060728-4	Zfish	PMID:16672347
Biological Process	GO:0031290	retinal ganglion cell axon guidance	Isl2	IMP	MGI:MGI:3046260	Mouse	PMID:15537545
Biological Process	GO:0003139	secondary heart field specification	isl2b	IMP	ZFIN:ZDB-GENO-190228-10	Zfish	PMID:28106108
Biological Process	GO:0021520	spinal cord motor neuron cell fate specification	Isl2	IGI	MGI:MGI:102673	Mouse	PMID:19666821
Biological Process	GO:0048845	venous blood vessel morphogenesis	isl2a	IMP	ZFIN:ZDB-GENO-180103-3	Zfish	PMID:27126199
Biological Process	GO:0048845	venous blood vessel morphogenesis	isl2a	IMP	ZFIN:ZDB-MRPHLNO-171006-2	Zfish	PMID:27126199
Biological Process	GO:0021524	visceral motor neuron differentiation	Isl2	IGI	MGI:MGI:101791	Mouse	PMID:14766174
Biological Process	GO:0021524	visceral motor neuron differentiation	Isl2	IMP	MGI:MGI:3046260	Mouse	PMID:14766174

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern