Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ITGA1
  • Mouse genes Itga1
  • Rat genes Itga1
  • Zfish genes itga1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Itga1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005518	collagen binding	Itga1	IMP		Rat	PMID:16200076|RGD:2302138
Molecular Function	GO:0098639	collagen binding involved in cell-matrix adhesion	ITGA1	IMP		Human	PMID:24823363
Molecular Function	GO:0005515	protein binding	ITGA1	IPI	UniProtKB:Q07092	Human	PMID:16754661
Molecular Function	GO:0005515	protein binding	ITGA1	IPI	UniProtKB:P04512	Human	PMID:18587047
Molecular Function	GO:0005515	protein binding	Itga1	IPI	UniProtKB:Q9QUR8	Mouse	MGI:MGI:3710037|PMID:17377534
Molecular Function	GO:0005515	protein binding	Itga1	IPI	PR:Q91V88	Mouse	PMID:11470831
Molecular Function	GO:0005515	protein binding	Itga1	IPI	PR:Q91V88	Mouse	PMID:11546798
Molecular Function	GO:0019903	protein phosphatase binding	ITGA1	IPI	UniProtKB:P17706	Human	PMID:15592458
Molecular Function	GO:0005102	signaling receptor binding	Itga1	IPI	RGD:2277	Rat	PMID:21969374|RGD:7205691
Cellular Component	GO:0001669	acrosomal vesicle	Itga1	IDA		Rat	PMID:9202984|RGD:1581320
Cellular Component	GO:0045178	basal part of cell	Itga1	IDA		Mouse	PMID:11767049
Cellular Component	GO:0009986	cell surface	ITGA1	HDA		Human	PMID:19581412
Cellular Component	GO:0009986	cell surface	ITGA1	IDA		Human	PMID:19933311
Cellular Component	GO:0009986	cell surface	ITGA1	IDA		Human	PMID:20563599
Cellular Component	GO:0009986	cell surface	ITGA1	HDA		Human	PMID:23658023
Cellular Component	GO:0009986	cell surface	Itga1	IDA		Mouse	MGI:MGI:5469937|PMID:23023225
Cellular Component	GO:0009897	external side of plasma membrane	Itga1	IDA		Mouse	PMID:9553049
Cellular Component	GO:0009897	external side of plasma membrane	Itga1	IDA		Mouse	PMID:16973387
Cellular Component	GO:0009897	external side of plasma membrane	Itga1	IDA		Rat	PMID:14991844|RGD:2302385
Cellular Component	GO:0009897	external side of plasma membrane	Itga1	IDA		Rat	PMID:17109120|RGD:2302135
Cellular Component	GO:0070062	extracellular exosome	ITGA1	HDA		Human	PMID:19056867
Cellular Component	GO:0005925	focal adhesion	ITGA1	IDA		Human	PMID:11518510
Cellular Component	GO:0005925	focal adhesion	ITGA1	HDA		Human	PMID:21423176
Cellular Component	GO:0034665	integrin alpha1-beta1 complex	ITGA1	IDA		Human	PMID:24823363
Cellular Component	GO:0016020	membrane	ITGA1	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Itga1	IDA		Rat	PMID:9202984|RGD:1581320
Cellular Component	GO:0045121	membrane raft	Itga1	IDA		Rat	PMID:15836982|RGD:2302139
Cellular Component	GO:0043005	neuron projection	Itga1	IDA		Rat	PMID:14991844|RGD:2302385
Cellular Component	GO:0043204	perikaryon	Itga1	IDA		Rat	PMID:14991844|RGD:2302385
Biological Process	GO:0007155	cell adhesion	Itga1	IMP	MGI:MGI:2661083	Mouse	PMID:10528208
Biological Process	GO:0060326	cell chemotaxis	Itga1	IMP		Rat	PMID:16200076|RGD:2302138
Biological Process	GO:0007160	cell-matrix adhesion	ITGA1	IMP		Human	PMID:24823363
Biological Process	GO:0045123	cellular extravasation	Itga1	IMP	MGI:MGI:2661083	Mouse	PMID:10528208
Biological Process	GO:0008285	negative regulation of cell population proliferation	ITGA1	IMP		Human	PMID:15592458
Biological Process	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	Itga1	IMP		Mouse	MGI:MGI:5488887|PMID:15592458
Biological Process	GO:0048812	neuron projection morphogenesis	Itga1	IMP		Rat	PMID:14564503|RGD:1579850
Biological Process	GO:0030593	neutrophil chemotaxis	Itga1	IMP	MGI:MGI:2661083	Mouse	PMID:10528208
Biological Process	GO:0043410	positive regulation of MAPK cascade	Itga1	IMP		Rat	PMID:14991844|RGD:2302385
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Itga1	IMP		Rat	PMID:14991844|RGD:2302385
Biological Process	GO:0032516	positive regulation of phosphoprotein phosphatase activity	ITGA1	IDA		Human	PMID:15592458
Biological Process	GO:0042311	vasodilation	Itga1	IMP		Rat	PMID:18245559|RGD:2302134

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern