Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Itga2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ITGA2
- Mouse genes Itga2
- Rat genes Itga2
- Zfish genes itga2.2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Itga2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	Itga2	IDA		Mouse	MGI:MGI:5908788\|PMID:21126803
Molecular Function	GO:0005518	collagen binding	ITGA2	IMP		Human	PMID:11518510
Molecular Function	GO:0005518	collagen binding	Itga2	IDA		Rat	PMID:15591055\|RGD:8693310
Molecular Function	GO:0005518	collagen binding	Itga2	IMP		Rat	PMID:7898055\|RGD:8693319
Molecular Function	GO:0098639	collagen binding involved in cell-matrix adhesion	ITGA2	IMP		Human	PMID:24823363
Molecular Function	GO:0038064	collagen receptor activity	ITGA2	IMP		Human	PMID:11518510
Molecular Function	GO:0005178	integrin binding	Itga2	IMP		Rat	PMID:17118629\|RGD:1625131
Molecular Function	GO:0043236	laminin binding	Itga2	IMP		Rat	PMID:10082128\|RGD:2307408
Molecular Function	GO:0005515	protein binding	ITGA2	IPI	UniProtKB:P05556	Human	PMID:10397731
Molecular Function	GO:0005515	protein binding	ITGA2	IPI	UniProtKB:P05556	Human	PMID:14681217
Molecular Function	GO:0005515	protein binding	ITGA2	IPI	UniProtKB:Q07092	Human	PMID:16754661
Molecular Function	GO:0005515	protein binding	ITGA2	IPI	UniProtKB:P35282	Human	PMID:16754960
Molecular Function	GO:0005515	protein binding	ITGA2	IPI	UniProtKB:P04512	Human	PMID:18587047
Molecular Function	GO:0005515	protein binding	ITGA2	IPI	UniProtKB:P35968	Human	PMID:21596751
Molecular Function	GO:0005515	protein binding	ITGA2	IPI	UniProtKB:P05556	Human	PMID:21947080
Molecular Function	GO:0005515	protein binding	ITGA2	IPI	UniProtKB:Q9H0F6	Human	PMID:21947080
Molecular Function	GO:0005515	protein binding	ITGA2	IPI	UniProtKB:P84092	Human	PMID:26779610
Molecular Function	GO:0005515	protein binding	ITGA2	IPI	UniProtKB:P02469	Human	PMID:7639691
Molecular Function	GO:0044877	protein-containing complex binding	ITGA2	IPI	UniProtKB:P05556,UniProtKB:Q12864	Human	PMID:25336636
Molecular Function	GO:0044877	protein-containing complex binding	Itga2	IMP		Rat	PMID:17118629\|RGD:1625131
Molecular Function	GO:0044877	protein-containing complex binding	Itga2	IDA		Rat	PMID:18234883\|RGD:2303705
Molecular Function	GO:0044877	protein-containing complex binding	Itga2	IDA		Rat	PMID:19027888\|RGD:2307395
Molecular Function	GO:0044877	protein-containing complex binding	Itga2	IDA		Rat	PMID:9388237\|RGD:2307411
Cellular Component	GO:0030424	axon	Itga2	IDA		Rat	PMID:15501602\|RGD:2307400
Cellular Component	GO:0043679	axon terminus	Itga2	IDA		Rat	PMID:15501602\|RGD:2307400
Cellular Component	GO:0045178	basal part of cell	Itga2	IDA		Mouse	PMID:11767049
Cellular Component	GO:0042995	cell projection	Itga2	IDA		Rat	PMID:12851778\|RGD:2307402
Cellular Component	GO:0009986	cell surface	ITGA2	HDA		Human	PMID:19581412
Cellular Component	GO:0009986	cell surface	ITGA2	IDA		Human	PMID:19933311
Cellular Component	GO:0009986	cell surface	ITGA2	IDA		Human	PMID:20563599
Cellular Component	GO:0009986	cell surface	ITGA2	IDA		Human	PMID:21310825
Cellular Component	GO:0009986	cell surface	ITGA2	HDA		Human	PMID:23382103
Cellular Component	GO:0009986	cell surface	ITGA2	HDA		Human	PMID:23658023
Cellular Component	GO:0009986	cell surface	Itga2	IDA		Mouse	MGI:MGI:5469937\|PMID:23023225
Cellular Component	GO:0009986	cell surface	Itga2	IDA		Mouse	PMID:20818394
Cellular Component	GO:0009986	cell surface	Itga2	IDA		Mouse	PMID:28032533
Cellular Component	GO:0009986	cell surface	Itga2	IDA		Rat	PMID:15037024\|RGD:2307401
Cellular Component	GO:0009897	external side of plasma membrane	Itga2	IDA		Mouse	PMID:16973387
Cellular Component	GO:0009897	external side of plasma membrane	Itga2	IDA		Mouse	PMID:14707119
Cellular Component	GO:0009897	external side of plasma membrane	Itga2	IDA		Mouse	PMID:19648922
Cellular Component	GO:0005925	focal adhesion	ITGA2	IDA		Human	PMID:11518510
Cellular Component	GO:0005925	focal adhesion	ITGA2	HDA		Human	PMID:21423176
Cellular Component	GO:0005925	focal adhesion	Itga2	IDA		Rat	PMID:11746505\|RGD:729814
Cellular Component	GO:0034666	integrin alpha2-beta1 complex	ITGA2	IDA		Human	PMID:24823363
Cellular Component	GO:0005634	nucleus	Itga2	IDA		Rat	PMID:12851778\|RGD:2307402
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Itga2	IDA		Rat	PMID:9388237\|RGD:2307411
Cellular Component	GO:0005886	plasma membrane	ITGA2	IDA		Human	PMID:21310825
Cellular Component	GO:0005886	plasma membrane	Itga2	IDA		Rat	PMID:9252524\|RGD:2307415
Cellular Component	GO:0098793	presynapse	Itga2	IDA		Rat	PMID:15501602\|RGD:2307400
Biological Process	GO:0033627	cell adhesion mediated by integrin	ITGA2	IMP		Human	PMID:11518510
Biological Process	GO:0008283	cell population proliferation	Itga2	IEP		Rat	PMID:12856576\|RGD:1582308
Biological Process	GO:0007160	cell-matrix adhesion	ITGA2	IMP		Human	PMID:11518510
Biological Process	GO:0007160	cell-matrix adhesion	ITGA2	IMP		Human	PMID:24823363
Biological Process	GO:0031589	cell-substrate adhesion	ITGA2	IMP		Human	PMID:19933311
Biological Process	GO:0071392	cellular response to estradiol stimulus	Itga2	IEP		Rat	PMID:11341970\|RGD:2307404
Biological Process	GO:0071260	cellular response to mechanical stimulus	Itga2	IEP		Rat	PMID:12856576\|RGD:1582308
Biological Process	GO:0071407	cellular response to organic cyclic compound	Itga2	IEP		Rat	PMID:20959644\|RGD:8693208
Biological Process	GO:0038065	collagen-activated signaling pathway	ITGA2	IMP		Human	PMID:11518510
Biological Process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	Itga2	IMP		Rat	PMID:18234883\|RGD:2303705
Biological Process	GO:0045184	establishment of protein localization	Itga2	IDA		Rat	PMID:10972675\|RGD:2307405
Biological Process	GO:0007565	female pregnancy	Itga2	IEP		Rat	PMID:20959644\|RGD:8693208
Biological Process	GO:0048041	focal adhesion assembly	Itga2	IMP		Rat	PMID:15591055\|RGD:8693310
Biological Process	GO:0070365	hepatocyte differentiation	Itga2	IEP		Rat	PMID:16458388\|RGD:2307397
Biological Process	GO:0006971	hypotonic response	Itga2	IMP		Rat	PMID:18234883\|RGD:2303705
Biological Process	GO:0007229	integrin-mediated signaling pathway	ITGA2	IMP		Human	PMID:24823363
Biological Process	GO:0030879	mammary gland development	Itga2	IEP		Rat	PMID:11341970\|RGD:2307404
Biological Process	GO:0048333	mesodermal cell differentiation	ITGA2	IEP		Human	PMID:23154389
Biological Process	GO:0010694	positive regulation of alkaline phosphatase activity	Itga2	IMP		Rat	PMID:10867645\|RGD:2307406
Biological Process	GO:0045785	positive regulation of cell adhesion	Itga2	IMP		Rat	PMID:19394307\|RGD:2307393
Biological Process	GO:0031346	positive regulation of cell projection organization	Itga2	IMP		Rat	PMID:9878098\|RGD:2307409
Biological Process	GO:0033343	positive regulation of collagen binding	Itga2	IMP		Rat	PMID:19394307\|RGD:2307393
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	Itga2	IMP		Rat	PMID:10867645\|RGD:2307406
Biological Process	GO:0043388	positive regulation of DNA binding	Itga2	IMP		Rat	PMID:19239475\|RGD:2307394
Biological Process	GO:0010634	positive regulation of epithelial cell migration	Itga2	IMP		Rat	PMID:19394307\|RGD:2307393
Biological Process	GO:0050729	positive regulation of inflammatory response	Itga2	IMP		Rat	PMID:18234883\|RGD:2303705
Biological Process	GO:0002687	positive regulation of leukocyte migration	Itga2	IMP		Rat	PMID:10688841\|RGD:2307407
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	Itga2	IMP		Rat	PMID:9284952\|RGD:2307413
Biological Process	GO:0050927	positive regulation of positive chemotaxis	Itga2	IMP		Rat	PMID:9529384\|RGD:2307410
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	Itga2	IMP		Rat	PMID:19239475\|RGD:2307394
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Itga2	IMP		Rat	PMID:19239475\|RGD:2307394
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	Itga2	IMP		Rat	PMID:16263112\|RGD:2307398
Biological Process	GO:0045727	positive regulation of translation	Itga2	IMP		Rat	PMID:10867645\|RGD:2307406
Biological Process	GO:0051971	positive regulation of transmission of nerve impulse	Itga2	IMP		Rat	PMID:15501602\|RGD:2307400
Biological Process	GO:0014075	response to amine	Itga2	IEP		Rat	PMID:9252524\|RGD:2307415
Biological Process	GO:0001666	response to hypoxia	Itga2	IEP		Rat	PMID:16284587\|RGD:1582307
Biological Process	GO:0033591	response to L-ascorbic acid	Itga2	IEP		Rat	PMID:9275042\|RGD:2307414
Biological Process	GO:0014850	response to muscle activity	Itga2	IEP		Rat	PMID:11934598\|RGD:2307403
Biological Process	GO:0014070	response to organic cyclic compound	Itga2	IEP		Rat	PMID:12851778\|RGD:2307402
Biological Process	GO:0071107	response to parathyroid hormone	Itga2	IEP		Rat	PMID:11746505\|RGD:729814
Biological Process	GO:0009410	response to xenobiotic stimulus	Itga2	IEP		Rat	PMID:12941079\|RGD:1302878
Biological Process	GO:0043589	skin morphogenesis	Itga2	IMP		Rat	PMID:17118629\|RGD:1625131
Biological Process	GO:0006929	substrate-dependent cell migration	ITGA2	IMP		Human	PMID:11518510
Biological Process	GO:0042060	wound healing	Itga2	IEP		Rat	PMID:9388237\|RGD:2307411

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.