Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ITGA2B
  • Mouse genes Itga2b
  • Rat genes Itga2b
  • Zfish genes itga2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Itga2b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0050840	extracellular matrix binding	Itga2b	IMP		Mouse	PMID:15031111
Molecular Function	GO:0070051	fibrinogen binding	Itga2b	IDA		Rat	PMID:11278919|RGD:2316363
Molecular Function	GO:0042802	identical protein binding	ITGA2B	IPI	UniProtKB:P08514	Human	PMID:11606749
Molecular Function	GO:0042802	identical protein binding	ITGA2B	IPI	UniProtKB:P08514	Human	PMID:14681217
Molecular Function	GO:0042802	identical protein binding	ITGA2B	IPI	UniProtKB:P08514	Human	PMID:15067009
Molecular Function	GO:0060090	molecular adaptor activity	ITGA2B	EXP		Human	PMID:11412103
Molecular Function	GO:0005515	protein binding	ITGA2B	IPI	UniProtKB:P05106	Human	PMID:14681217
Molecular Function	GO:0005515	protein binding	ITGA2B	IPI	UniProtKB:P05106	Human	PMID:15379538
Molecular Function	GO:0005515	protein binding	ITGA2B	IPI	UniProtKB:P05106	Human	PMID:19279667
Molecular Function	GO:0005515	protein binding	ITGA2B	IPI	UniProtKB:A0PJX0	Human	PMID:22779914
Molecular Function	GO:0005515	protein binding	ITGA2B	IPI	UniProtKB:O75838	Human	PMID:22779914
Molecular Function	GO:0005515	protein binding	ITGA2B	IPI	UniProtKB:Q96Q77	Human	PMID:22779914
Molecular Function	GO:0005515	protein binding	ITGA2B	IPI	UniProtKB:Q99828	Human	PMID:22779914
Molecular Function	GO:0005515	protein binding	ITGA2B	IPI	UniProtKB:P05106	Human	PMID:30305279
Molecular Function	GO:0005515	protein binding	itga2b	IPI	UniProtKB:Q3LTM5	Zfish	PMID:17626277
Cellular Component	GO:0072562	blood microparticle	ITGA2B	HDA		Human	PMID:22516433
Cellular Component	GO:0009986	cell surface	ITGA2B	HDA		Human	PMID:23382103
Cellular Component	GO:0009986	cell surface	Itga2b	IDA		Mouse	PMID:14751927
Cellular Component	GO:0009986	cell surface	Itga2b	IDA		Rat	PMID:11278919|RGD:2316363
Cellular Component	GO:0009897	external side of plasma membrane	Itga2b	IDA		Mouse	PMID:19360001
Cellular Component	GO:0009897	external side of plasma membrane	Itga2b	IDA		Mouse	PMID:20228271
Cellular Component	GO:0009897	external side of plasma membrane	Itga2b	IDA		Mouse	PMID:12900455
Cellular Component	GO:0009897	external side of plasma membrane	Itga2b	IDA		Mouse	PMID:18971422
Cellular Component	GO:0070062	extracellular exosome	ITGA2B	IDA		Human	PMID:15908444
Cellular Component	GO:0005925	focal adhesion	Itga2b	IDA		Mouse	PMID:15031111
Cellular Component	GO:0008305	integrin complex	itga2b	IDA		Zfish	PMID:17626277
Cellular Component	GO:0005886	plasma membrane	ITGA2B	IDA		Human	GO_REF:0000052
Biological Process	GO:0001525	angiogenesis	itga2b	IMP	ZFIN:ZDB-MRPHLNO-100907-1	Zfish	PMID:19700757
Biological Process	GO:0007596	blood coagulation	itga2b	IMP	ZFIN:ZDB-MRPHLNO-100629-1	Zfish	PMID:20045356
Biological Process	GO:0007596	blood coagulation	itga2b	IGI	ZFIN:ZDB-MRPHLNO-090630-10,ZFIN:ZDB-MRPHLNO-090630-11	Zfish	PMID:19109564
Biological Process	GO:0007160	cell-matrix adhesion	Itga2b	IMP		Mouse	PMID:15031111
Biological Process	GO:0001935	endothelial cell proliferation	itga2b	IMP	ZFIN:ZDB-MRPHLNO-100907-1	Zfish	PMID:19700757
Biological Process	GO:0007229	integrin-mediated signaling pathway	ITGA2B	HDA		Human	PMID:23382103
Biological Process	GO:0070527	platelet aggregation	Itga2b	IMP		Rat	PMID:17924279|RGD:2316357
Biological Process	GO:0002687	positive regulation of leukocyte migration	Itga2b	IMP		Rat	PMID:11705748|RGD:2316361

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern