Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Itga4

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ITGA4
- Mouse genes Itga4
- Rat genes Itga4
- Zfish genes itga4
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Itga4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003823	antigen binding	Itga4	IPI	RGD:2318	Rat	PMID:20124479\|RGD:9698434
Molecular Function	GO:0003823	antigen binding	Itga4	IPI	RGD:621290	Rat	PMID:20124479\|RGD:9698434
Molecular Function	GO:0019960	C-X3-C chemokine binding	ITGA4	IDA		Human	PMID:23125415
Molecular Function	GO:0050839	cell adhesion molecule binding	ITGA4	IPI	UniProtKB:P78310	Human	PMID:12869515
Molecular Function	GO:0050839	cell adhesion molecule binding	ITGA4	IMP		Human	PMID:23986478
Molecular Function	GO:0050839	cell adhesion molecule binding	Itga4	IMP		Rat	PMID:9773789\|RGD:9698422
Molecular Function	GO:0001968	fibronectin binding	Itga4	IMP		Mouse	PMID:8145052
Molecular Function	GO:0001968	fibronectin binding	Itga4	IMP		Rat	PMID:9773789\|RGD:9698422
Molecular Function	GO:1990405	protein antigen binding	Itga4	IPI	RGD:2318	Rat	PMID:20124479\|RGD:9698434
Molecular Function	GO:1990405	protein antigen binding	Itga4	IPI	RGD:621290	Rat	PMID:20124479\|RGD:9698434
Molecular Function	GO:0005515	protein binding	ITGA4	IPI	UniProtKB:O43294	Human	PMID:10604475
Molecular Function	GO:0005515	protein binding	ITGA4	IPI	UniProtKB:P49023	Human	PMID:10604475
Molecular Function	GO:0005515	protein binding	ITGA4	IPI	UniProtKB:P05556	Human	PMID:14681217
Molecular Function	GO:0005515	protein binding	ITGA4	IPI	UniProtKB:P26010	Human	PMID:14681217
Molecular Function	GO:0005515	protein binding	ITGA4	IPI	UniProtKB:P05556	Human	PMID:1542691
Molecular Function	GO:0005515	protein binding	ITGA4	IPI	UniProtKB:P26010	Human	PMID:1542691
Molecular Function	GO:0005515	protein binding	ITGA4	IPI	UniProtKB:P05556	Human	PMID:15466886
Molecular Function	GO:0005515	protein binding	ITGA4	IPI	UniProtKB:P05556,UniProtKB:P21741	Human	PMID:15466886
Molecular Function	GO:0005515	protein binding	ITGA4	IPI	UniProtKB:Q62656	Human	PMID:15466886
Molecular Function	GO:0005515	protein binding	ITGA4	IPI	UniProtKB:P05556	Human	PMID:20159608
Molecular Function	GO:0005515	protein binding	ITGA4	IPI	UniProtKB:P49023	Human	PMID:21173240
Molecular Function	GO:0005515	protein binding	ITGA4	IPI	UniProtKB:Q8IZP0-2	Human	PMID:21173240
Molecular Function	GO:0005515	protein binding	ITGA4	IPI	UniProtKB:P26010	Human	PMID:22232704
Molecular Function	GO:0005515	protein binding	ITGA4	IPI	UniProtKB:P84092	Human	PMID:26779610
Molecular Function	GO:0005515	protein binding	ITGA4	IPI	UniProtKB:P04275	Human	PMID:9079671
Molecular Function	GO:0005515	protein binding	Itga4	IPI	RGD:621783	Rat	PMID:20124479\|RGD:9698434
Cellular Component	GO:0009986	cell surface	ITGA4	IDA		Human	PMID:1715889
Cellular Component	GO:0009986	cell surface	ITGA4	IDA		Human	PMID:18308860
Cellular Component	GO:0009986	cell surface	ITGA4	IDA		Human	PMID:20563599
Cellular Component	GO:0009986	cell surface	ITGA4	IDA		Human	PMID:23986478
Cellular Component	GO:0009986	cell surface	Itga4	IDA		Rat	PMID:9773789\|RGD:9698422
Cellular Component	GO:0005911	cell-cell junction	Itga4	IDA		Mouse	PMID:23610556
Cellular Component	GO:0009897	external side of plasma membrane	Itga4	IDA		Mouse	PMID:8557754
Cellular Component	GO:0009897	external side of plasma membrane	Itga4	IDA		Mouse	PMID:7539359
Cellular Component	GO:0070062	extracellular exosome	ITGA4	HDA		Human	PMID:12519789
Cellular Component	GO:0070062	extracellular exosome	ITGA4	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	Itga4	IDA		Rat	PMID:20124479\|RGD:9698434
Cellular Component	GO:0005925	focal adhesion	ITGA4	HDA		Human	PMID:21423176
Cellular Component	GO:0030426	growth cone	Itga4	IDA		Rat	PMID:12486170\|RGD:628409
Cellular Component	GO:0034669	integrin alpha4-beta7 complex	ITGA4	IDA		Human	PMID:18308860
Cellular Component	GO:0034669	integrin alpha4-beta7 complex	ITGA4	IDA		Human	PMID:23986478
Cellular Component	GO:0016020	membrane	ITGA4	HDA		Human	PMID:19946888
Cellular Component	GO:0043025	neuronal cell body	Itga4	IDA		Rat	PMID:12486170\|RGD:628409
Cellular Component	GO:0005886	plasma membrane	ITGA4	IDA		Human	PMID:12869515
Cellular Component	GO:0005886	plasma membrane	Itga4	IDA		Rat	PMID:20124479\|RGD:9698434
Biological Process	GO:0060385	axonogenesis involved in innervation	Itga4	IMP		Rat	PMID:16181811\|RGD:13593536
Biological Process	GO:0001568	blood vessel development	itga4	IMP	ZFIN:ZDB-GENO-201021-1	Zfish	PMID:31582646
Biological Process	GO:0001974	blood vessel remodeling	Itga4	IMP	MGI:MGI:1857206	Mouse	PMID:16529735
Biological Process	GO:0007155	cell adhesion	Itga4	IMP	MGI:MGI:2180843	Mouse	PMID:12021259
Biological Process	GO:0016477	cell migration	Itga4	IMP	MGI:MGI:2180843	Mouse	PMID:12021259
Biological Process	GO:0140039	cell-cell adhesion in response to extracellular stimulus	ITGA4	IGI	UniProtKB:P19320,UniProtKB:Q15109	Human	PMID:11078691
Biological Process	GO:0033631	cell-cell adhesion mediated by integrin	ITGA4	IGI	UniProtKB:P19320,UniProtKB:Q15109	Human	PMID:11078691
Biological Process	GO:0007160	cell-matrix adhesion	ITGA4	IMP		Human	PMID:18308860
Biological Process	GO:0007160	cell-matrix adhesion	ITGA4	IMP		Human	PMID:23986478
Biological Process	GO:0003366	cell-matrix adhesion involved in ameboidal cell migration	ITGA4	IMP		Human	PMID:23986478
Biological Process	GO:1904646	cellular response to amyloid-beta	ITGA4	IGI	UniProtKB:P19320,UniProtKB:Q15109	Human	PMID:11078691
Biological Process	GO:0071345	cellular response to cytokine stimulus	Itga4	IEP		Rat	PMID:12046991\|RGD:9698435
Biological Process	GO:0060710	chorio-allantoic fusion	Itga4	IMP	MGI:MGI:1857206	Mouse	PMID:7539359
Biological Process	GO:1990771	clathrin-dependent extracellular exosome endocytosis	Itga4	IMP		Rat	PMID:20124479\|RGD:9698434
Biological Process	GO:0050904	diapedesis	Itga4	IMP		Rat	PMID:8550078\|RGD:9698438
Biological Process	GO:0060956	endocardial cell differentiation	itga4	IGI	ZFIN:ZDB-GENO-220222-11	Zfish	PMID:32628938
Biological Process	GO:0035987	endodermal cell differentiation	ITGA4	IEP		Human	PMID:23154389
Biological Process	GO:0060324	face development	Itga4	IMP	MGI:MGI:1857206	Mouse	PMID:7539359
Biological Process	GO:0007507	heart development	Itga4	IMP	MGI:MGI:1857206	Mouse	PMID:7539359
Biological Process	GO:0007507	heart development	Itga4	IMP	MGI:MGI:2180843	Mouse	PMID:12021259
Biological Process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	Itga4	IMP		Mouse	PMID:8145052
Biological Process	GO:0034113	heterotypic cell-cell adhesion	ITGA4	IGI	UniProtKB:P19320,UniProtKB:Q15109	Human	PMID:11078691
Biological Process	GO:0034113	heterotypic cell-cell adhesion	ITGA4	IMP		Human	PMID:18308860
Biological Process	GO:0098657	import into cell	Itga4	IMP		Rat	PMID:20124479\|RGD:9698434
Biological Process	GO:0007159	leukocyte cell-cell adhesion	ITGA4	IDA		Human	PMID:1715889
Biological Process	GO:0007159	leukocyte cell-cell adhesion	Itga4	IMP		Mouse	PMID:8562500
Biological Process	GO:0050901	leukocyte tethering or rolling	ITGA4	IMP		Human	PMID:18308860
Biological Process	GO:0090074	negative regulation of protein homodimerization activity	ITGA4	IDA		Human	PMID:12869515
Biological Process	GO:1990138	neuron projection extension	Itga4	IMP		Rat	PMID:16181811\|RGD:13593536
Biological Process	GO:1905351	pericyte cell migration	Itga4	IMP	MGI:MGI:1857206	Mouse	PMID:16529735
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	ITGA4	IMP		Human	PMID:27464494
Biological Process	GO:1903039	positive regulation of leukocyte cell-cell adhesion	Itga4	IMP		Rat	PMID:7680140\|RGD:9698449
Biological Process	GO:0002687	positive regulation of leukocyte migration	Itga4	IMP		Rat	PMID:8550078\|RGD:9698438
Biological Process	GO:1903238	positive regulation of leukocyte tethering or rolling	Itga4	IMP		Rat	PMID:9394821\|RGD:9698423
Biological Process	GO:2000406	positive regulation of T cell migration	Itga4	IMP		Rat	PMID:15263094\|RGD:9698421
Biological Process	GO:2000406	positive regulation of T cell migration	Itga4	IMP		Rat	PMID:8580084\|RGD:9698420
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation	ITGA4	IMP		Human	PMID:27464494
Biological Process	GO:0043113	receptor clustering	ITGA4	IMP		Human	PMID:23986478
Biological Process	GO:0043114	regulation of vascular permeability	itga4	IMP	ZFIN:ZDB-GENO-201021-1	Zfish	PMID:31582646
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	ITGA4	IMP		Human	PMID:23986478
Biological Process	GO:0072678	T cell migration	Itga4	IMP		Mouse	PMID:23661644
Biological Process	GO:1904738	vascular associated smooth muscle cell migration	Itga4	IMP	MGI:MGI:1857206	Mouse	PMID:16529735

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 06/12/2024 MGI 6.13

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.