Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Itga5

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ITGA5
- Mouse genes Itga5
- Rat genes Itga5
- Zfish genes itga5
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Itga5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0050839	cell adhesion molecule binding	Itga5	IDA		Rat	PMID:12821041\|RGD:1300196
Molecular Function	GO:0005154	epidermal growth factor receptor binding	Itga5	IPI	RGD:2543	Rat	PMID:21349584\|RGD:5131469
Molecular Function	GO:0001968	fibronectin binding	itga5	IGI	ZFIN:ZDB-GENE-000426-1,ZFIN:ZDB-GENE-060803-2	Zfish	PMID:19641014
Molecular Function	GO:0005178	integrin binding	Itga5	IPI	PR:Q9Z0T9	Mouse	PMID:8601592
Molecular Function	GO:0005178	integrin binding	Itga5	IPI	PR:O54890	Mouse	PMID:8601592
Molecular Function	GO:0005178	integrin binding	Itga5	IPI	PR:O70309	Mouse	PMID:8601592
Molecular Function	GO:0005178	integrin binding	Itga5	IPI	PR:P09055	Mouse	PMID:8601592
Molecular Function	GO:0005178	integrin binding	Itga5	IPI	RGD:2927	Rat	PMID:18167060\|RGD:2314623
Molecular Function	GO:0005515	protein binding	ITGA5	IPI	UniProtKB:P48745	Human	PMID:12695522
Molecular Function	GO:0005515	protein binding	ITGA5	IPI	UniProtKB:P05556	Human	PMID:12724312
Molecular Function	GO:0005515	protein binding	ITGA5	IPI	UniProtKB:P35555	Human	PMID:12807887
Molecular Function	GO:0005515	protein binding	ITGA5	IPI	UniProtKB:P78536	Human	PMID:14970227
Molecular Function	GO:0005515	protein binding	ITGA5	IPI	UniProtKB:P49747	Human	PMID:16051604
Molecular Function	GO:0005515	protein binding	ITGA5	IPI	UniProtKB:P05556	Human	PMID:16099422
Molecular Function	GO:0005515	protein binding	ITGA5	IPI	UniProtKB:P35555	Human	PMID:17158881
Molecular Function	GO:0005515	protein binding	ITGA5	IPI	UniProtKB:P05106,UniProtKB:P21246	Human	PMID:19141530
Molecular Function	GO:0005515	protein binding	ITGA5	IPI	UniProtKB:O14786	Human	PMID:19175293
Molecular Function	GO:0005515	protein binding	ITGA5	IPI	UniProtKB:P97333	Human	PMID:19175293
Molecular Function	GO:0005515	protein binding	ITGA5	IPI	UniProtKB:P05556	Human	PMID:21947080
Molecular Function	GO:0005515	protein binding	ITGA5	IPI	UniProtKB:Q9H0F6	Human	PMID:21947080
Molecular Function	GO:0005515	protein binding	ITGA5	IPI	UniProtKB:P05556	Human	PMID:22178926
Molecular Function	GO:0005515	protein binding	ITGA5	IPI	UniProtKB:P05556	Human	PMID:22451694
Molecular Function	GO:0005515	protein binding	ITGA5	IPI	UniProtKB:P17813	Human	PMID:22940691
Molecular Function	GO:0005515	protein binding	ITGA5	IPI	UniProtKB:Q99828	Human	PMID:24011356
Molecular Function	GO:0005515	protein binding	ITGA5	IPI	UniProtKB:P05556	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	ITGA5	IPI	UniProtKB:P05556,UniProtKB:P29965	Human	PMID:31331973
Molecular Function	GO:0005515	protein binding	ITGA5	IPI	UniProtKB:P05556,UniProtKB:P0DTC2,UniProtKB:Q9BYF1	Human	PMID:33102950
Molecular Function	GO:0005515	protein binding	Itga5	IPI	UniProtKB:P23242	Mouse	MGI:MGI:5314545\|PMID:22331870
Molecular Function	GO:0005515	protein binding	Itga5	IPI	UniProtKB:P68254	Mouse	MGI:MGI:5644009\|PMID:24163432
Molecular Function	GO:0005515	protein binding	Itga5	IPI	PR:P09055	Mouse	PMID:12904471
Molecular Function	GO:0005515	protein binding	Itga5	IPI	PR:O54890	Mouse	PMID:12867986
Molecular Function	GO:0005515	protein binding	Itga5	IPI	PR:P11276	Mouse	PMID:12867986
Molecular Function	GO:0005515	protein binding	Itga5	IPI	UniProtKB:P48509	Mouse	PMID:17716972
Molecular Function	GO:0046982	protein heterodimerization activity	itga5	IPI	UniProtKB:Q3YAA1	Zfish	PMID:19641014
Molecular Function	GO:0046982	protein heterodimerization activity	itga5	IPI	UniProtKB:Q3YAA1	Zfish	PMID:19747169
Molecular Function	GO:0046982	protein heterodimerization activity	itga5	IPI	UniProtKB:Q3YAA0	Zfish	PMID:19747169
Cellular Component	GO:0009986	cell surface	ITGA5	IDA		Human	PMID:17158881
Cellular Component	GO:0009986	cell surface	ITGA5	HDA		Human	PMID:19581412
Cellular Component	GO:0009986	cell surface	ITGA5	IDA		Human	PMID:20563599
Cellular Component	GO:0009986	cell surface	ITGA5	IDA		Human	PMID:23154389
Cellular Component	GO:0009986	cell surface	ITGA5	HDA		Human	PMID:23658023
Cellular Component	GO:0009986	cell surface	Itga5	IDA		Mouse	MGI:MGI:5469937\|PMID:23023225
Cellular Component	GO:0009986	cell surface	Itga5	IDA		Mouse	PMID:8306881
Cellular Component	GO:0005911	cell-cell junction	ITGA5	IDA		Human	PMID:14970227
Cellular Component	GO:0005737	cytoplasm	Itga5	IDA		Rat	PMID:12821041\|RGD:1300196
Cellular Component	GO:0031410	cytoplasmic vesicle	Itga5	IDA		Mouse	MGI:MGI:5605959\|PMID:12189152
Cellular Component	GO:0005783	endoplasmic reticulum	Itga5	IDA		Mouse	MGI:MGI:5605959\|PMID:12189152
Cellular Component	GO:0009897	external side of plasma membrane	Itga5	IDA		Mouse	PMID:8557754
Cellular Component	GO:0009897	external side of plasma membrane	Itga5	IDA		Mouse	PMID:9553049
Cellular Component	GO:0005925	focal adhesion	ITGA5	IDA		Human	PMID:14970227
Cellular Component	GO:0005925	focal adhesion	ITGA5	IDA		Human	PMID:17158881
Cellular Component	GO:0005925	focal adhesion	ITGA5	HDA		Human	PMID:21423176
Cellular Component	GO:0005925	focal adhesion	ITGA5	IDA		Human	PMID:29162887
Cellular Component	GO:0098978	glutamatergic synapse	Itga5	IDA		Rat	PMID:27518800\|RGD:155230752
Cellular Component	GO:0005794	Golgi apparatus	Itga5	IDA		Mouse	MGI:MGI:5605959\|PMID:12189152
Cellular Component	GO:0034674	integrin alpha5-beta1 complex	ITGA5	IPI		Human	PMID:22451694
Cellular Component	GO:0034674	integrin alpha5-beta1 complex	ITGA5	IDA		Human	PMID:31331973
Cellular Component	GO:0034674	integrin alpha5-beta1 complex	ITGA5	IDA		Human	PMID:33102950
Cellular Component	GO:0008305	integrin complex	Itga5	IDA		Rat	PMID:12821041\|RGD:1300196
Cellular Component	GO:0005886	plasma membrane	ITGA5	IDA		Human	PMID:19141530
Cellular Component	GO:0005886	plasma membrane	Itga5	IDA		Mouse	MGI:MGI:5605959\|PMID:12189152
Cellular Component	GO:0045211	postsynaptic membrane	Itga5	IDA		Rat	PMID:27518800\|RGD:155230752
Cellular Component	GO:0032587	ruffle membrane	ITGA5	IDA		Human	PMID:14970227
Cellular Component	GO:0045202	synapse	Itga5	IDA		Mouse	PMID:12904471
Biological Process	GO:0030325	adrenal gland development	itga5	IMP	ZFIN:ZDB-MRPHLNO-050712-1,ZFIN:ZDB-MRPHLNO-050713-1	Zfish	PMID:22937010
Biological Process	GO:0003401	axis elongation	itga5	IGI	ZFIN:ZDB-GENO-221208-11	Zfish	PMID:35732225
Biological Process	GO:0090245	axis elongation involved in somitogenesis	itga5	IMP	ZFIN:ZDB-MRPHLNO-050620-1,ZFIN:ZDB-MRPHLNO-120823-8	Zfish	PMID:23810535
Biological Process	GO:0051216	cartilage development	itga5	IMP	ZFIN:ZDB-GENO-221208-8	Zfish	PMID:35732225
Biological Process	GO:0051216	cartilage development	itga5	IGI	ZFIN:ZDB-GENO-221208-9	Zfish	PMID:35732225
Biological Process	GO:0051216	cartilage development	itga5	IGI	ZFIN:ZDB-GENO-221208-11	Zfish	PMID:35732225
Biological Process	GO:0051216	cartilage development	itga5	IGI	ZFIN:ZDB-GENO-221208-10	Zfish	PMID:35732225
Biological Process	GO:0023035	CD40 signaling pathway	ITGA5	IDA		Human	PMID:31331973
Biological Process	GO:0007155	cell adhesion	ITGA5	IDA		Human	PMID:19703720
Biological Process	GO:0007155	cell adhesion	Itga5	IDA		Rat	PMID:12821041\|RGD:1300196
Biological Process	GO:0033627	cell adhesion mediated by integrin	ITGA5	IDA		Human	PMID:12807887
Biological Process	GO:0033627	cell adhesion mediated by integrin	ITGA5	IDA		Human	PMID:17158881
Biological Process	GO:0002042	cell migration involved in sprouting angiogenesis	itga5	IMP	ZFIN:ZDB-MRPHLNO-050712-1,ZFIN:ZDB-MRPHLNO-050713-1	Zfish	PMID:22937010
Biological Process	GO:0033631	cell-cell adhesion mediated by integrin	Itga5	IMP		Mouse	PMID:8557754
Biological Process	GO:0031589	cell-substrate adhesion	ITGA5	IMP		Human	PMID:19933311
Biological Process	GO:0007044	cell-substrate junction assembly	Itga5	IDA		Mouse	PMID:12867986
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	itga5	IMP	ZFIN:ZDB-GENO-120120-1	Zfish	PMID:25810090
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	itga5	IGI	ZFIN:ZDB-GENO-150821-4	Zfish	PMID:25810090
Biological Process	GO:0060956	endocardial cell differentiation	itga5	IGI	ZFIN:ZDB-GENO-220222-11	Zfish	PMID:32628938
Biological Process	GO:0001706	endoderm formation	itga5	IMP	ZFIN:ZDB-GENO-221208-4	Zfish	PMID:35732225
Biological Process	GO:0001706	endoderm formation	itga5	IGI	ZFIN:ZDB-GENO-221208-5	Zfish	PMID:35732225
Biological Process	GO:0001706	endoderm formation	itga5	IGI	ZFIN:ZDB-GENO-221208-14	Zfish	PMID:35732225
Biological Process	GO:0035987	endodermal cell differentiation	ITGA5	IMP		Human	PMID:23154389
Biological Process	GO:0085029	extracellular matrix assembly	itga5	IMP	ZFIN:ZDB-GENO-100512-3	Zfish	PMID:19641014
Biological Process	GO:0085029	extracellular matrix assembly	itga5	IMP		Zfish	PMID:19641014
Biological Process	GO:0007565	female pregnancy	Itga5	IEP		Rat	PMID:17715430\|RGD:13593537
Biological Process	GO:0021782	glial cell development	itga5	IMP	ZFIN:ZDB-CRISPR-191009-71,ZFIN:ZDB-CRISPR-191009-72	Zfish	PMID:30924555
Biological Process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	Itga5	IMP		Mouse	PMID:8557754
Biological Process	GO:0034113	heterotypic cell-cell adhesion	ITGA5	IMP		Human	PMID:20563599
Biological Process	GO:0007229	integrin-mediated signaling pathway	ITGA5	IDA		Human	PMID:31331973
Biological Process	GO:0007229	integrin-mediated signaling pathway	Itga5	IDA		Rat	PMID:12821041\|RGD:1300196
Biological Process	GO:0070309	lens fiber cell morphogenesis	itga5	IMP	ZFIN:ZDB-GENO-130129-1	Zfish	PMID:23097490
Biological Process	GO:0002089	lens morphogenesis in camera-type eye	itga5	IMP	ZFIN:ZDB-GENO-130129-1	Zfish	PMID:23097490
Biological Process	GO:0007159	leukocyte cell-cell adhesion	Itga5	IMP		Mouse	PMID:8557754
Biological Process	GO:0007613	memory	Itga5	IMP	MGI:MGI:1857207	Mouse	PMID:12904471
Biological Process	GO:2000811	negative regulation of anoikis	ITGA5	IMP		Human	PMID:15006356
Biological Process	GO:0060037	pharyngeal system development	itga5	IGI	ZFIN:ZDB-GENO-221208-14	Zfish	PMID:35732225
Biological Process	GO:0060037	pharyngeal system development	itga5	IMP	ZFIN:ZDB-GENO-221208-8	Zfish	PMID:35732225
Biological Process	GO:0060037	pharyngeal system development	itga5	IGI	ZFIN:ZDB-GENO-221208-11	Zfish	PMID:35732225
Biological Process	GO:0060037	pharyngeal system development	itga5	IGI	ZFIN:ZDB-GENO-221208-10	Zfish	PMID:35732225
Biological Process	GO:0060037	pharyngeal system development	itga5	IGI	ZFIN:ZDB-GENO-221208-9	Zfish	PMID:35732225
Biological Process	GO:0060037	pharyngeal system development	itga5	IMP	ZFIN:ZDB-GENO-221208-4	Zfish	PMID:35732225
Biological Process	GO:0060037	pharyngeal system development	itga5	IGI	ZFIN:ZDB-GENO-221208-5	Zfish	PMID:35732225
Biological Process	GO:0030335	positive regulation of cell migration	Itga5	IMP		Rat	PMID:18167060\|RGD:2314623
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	Itga5	IMP		Rat	PMID:18167060\|RGD:2314623
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ITGA5	IMP		Human	PMID:10022831
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	ITGA5	IMP		Human	PMID:19460962
Biological Process	GO:0045765	regulation of angiogenesis	Itga5	IGI	RNAcentral:URS0000329B12_10090	Mouse	MGI:MGI:3849520\|PMID:19460962
Biological Process	GO:0060041	retina development in camera-type eye	itga5	IMP	ZFIN:ZDB-CRISPR-191009-71,ZFIN:ZDB-CRISPR-191009-72	Zfish	PMID:30924555
Biological Process	GO:0001501	skeletal system development	itga5	IMP	ZFIN:ZDB-GENO-040930-12	Zfish	PMID:15269787
Biological Process	GO:0032525	somite rostral/caudal axis specification	itga5	IGI	ZFIN:ZDB-GENO-100512-3,ZFIN:ZDB-MRPHLNO-070519-3	Zfish	PMID:23192979
Biological Process	GO:0032525	somite rostral/caudal axis specification	itga5	IGI	ZFIN:ZDB-GENO-100512-2,ZFIN:ZDB-MRPHLNO-070519-3	Zfish	PMID:23192979
Biological Process	GO:0001756	somitogenesis	itga5	IMP	ZFIN:ZDB-GENO-050621-1	Zfish	PMID:15809039
Biological Process	GO:0001756	somitogenesis	itga5	IMP	ZFIN:ZDB-GENO-050621-2	Zfish	PMID:15809039
Biological Process	GO:0001756	somitogenesis	itga5	IGI	ZFIN:ZDB-GENE-000426-1	Zfish	PMID:15809040
Biological Process	GO:0001756	somitogenesis	itga5	IGI	ZFIN:ZDB-GENO-100512-3,ZFIN:ZDB-MRPHLNO-050712-3	Zfish	PMID:23192979
Biological Process	GO:0001756	somitogenesis	itga5	IGI	ZFIN:ZDB-GENO-100512-3,ZFIN:ZDB-MRPHLNO-070519-3	Zfish	PMID:23192979
Biological Process	GO:0001756	somitogenesis	itga5	IGI	ZFIN:ZDB-GENO-050209-19,ZFIN:ZDB-GENO-050622-1	Zfish	PMID:15809039
Biological Process	GO:0001756	somitogenesis	itga5	IGI	ZFIN:ZDB-GENO-100512-2,ZFIN:ZDB-MRPHLNO-050712-3	Zfish	PMID:23192979
Biological Process	GO:0001756	somitogenesis	itga5	IGI	ZFIN:ZDB-GENO-050713-1	Zfish	PMID:15809040
Biological Process	GO:0001756	somitogenesis	itga5	IGI	ZFIN:ZDB-MRPHLNO-050712-3	Zfish	PMID:15809040
Biological Process	GO:0001756	somitogenesis	itga5	IMP	ZFIN:ZDB-MRPHLNO-050712-1,ZFIN:ZDB-MRPHLNO-050713-1	Zfish	PMID:15809040
Biological Process	GO:0001756	somitogenesis	itga5	IGI	ZFIN:ZDB-GENO-100512-2,ZFIN:ZDB-MRPHLNO-070519-3	Zfish	PMID:23192979
Biological Process	GO:0001756	somitogenesis	itga5	IGI	ZFIN:ZDB-GENO-050622-1,ZFIN:ZDB-MRPHLNO-050620-2	Zfish	PMID:15809039
Biological Process	GO:0001944	vasculature development	itga5	IMP	ZFIN:ZDB-MRPHLNO-150722-1	Zfish	PMID:23362312
Biological Process	GO:0001944	vasculature development	itga5	IGI	ZFIN:ZDB-GENE-030616-572	Zfish	PMID:23362312
Biological Process	GO:0035313	wound healing, spreading of epidermal cells	ITGA5	IEP		Human	PMID:14970227

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 08/02/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.