Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Itga6

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ITGA6
- Mouse genes Itga6
- Rat genes Itga6
- Zfish genes itga6a,itga6b,itga6l
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Itga6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	ITGA6	HDA		Human	PMID:25468996
Molecular Function	GO:0031994	insulin-like growth factor I binding	ITGA6	IDA		Human	PMID:22351760
Molecular Function	GO:0043236	laminin binding	Itga6	IPI	RGD:628776	Rat	PMID:16608848\|RGD:1600017
Molecular Function	GO:0038132	neuregulin binding	ITGA6	IDA		Human	PMID:20682778
Molecular Function	GO:0005515	protein binding	ITGA6	IPI	UniProtKB:O88572	Human	PMID:15466886
Molecular Function	GO:0005515	protein binding	ITGA6	IPI	UniProtKB:O88572,UniProtKB:Q62656	Human	PMID:15466886
Molecular Function	GO:0005515	protein binding	ITGA6	IPI	UniProtKB:P05556	Human	PMID:15466886
Molecular Function	GO:0005515	protein binding	ITGA6	IPI	UniProtKB:P05556,UniProtKB:P21741	Human	PMID:15466886
Molecular Function	GO:0005515	protein binding	ITGA6	IPI	UniProtKB:Q62656	Human	PMID:15466886
Molecular Function	GO:0005515	protein binding	ITGA6	IPI	UniProtKB:P16144	Human	PMID:21880726
Molecular Function	GO:0005515	protein binding	ITGA6	IPI	UniProtKB:P16144	Human	PMID:2649503
Molecular Function	GO:0005515	protein binding	ITGA6	IPI	UniProtKB:O14817	Human	PMID:9360996
Molecular Function	GO:0005515	protein binding	Itga6	IPI	UniProtKB:P09055	Mouse	MGI:MGI:6294160\|PMID:15466886
Molecular Function	GO:0005515	protein binding	Itga6	IPI	UniProtKB:P40240	Mouse	MGI:MGI:1351541\|PMID:10634791
Molecular Function	GO:0005515	protein binding	Itga6	IPI	UniProtKB:Q61072	Mouse	MGI:MGI:5784998\|PMID:10825303
Molecular Function	GO:0005515	protein binding	Itga6	IPI	PR:P16646	Mouse	PMID:16436605
Molecular Function	GO:0005515	protein binding	Itga6	IPI	PR:A2A863	Mouse	PMID:16436605
Molecular Function	GO:0005515	protein binding	Itga6	IPI	UniProtKB:P48509	Mouse	PMID:17716972
Molecular Function	GO:0044877	protein-containing complex binding	Itga6	IDA		Rat	PMID:13130099\|RGD:1302259
Cellular Component	GO:0005912	adherens junction	Itga6	IDA		Rat	PMID:16608848\|RGD:1600017
Cellular Component	GO:0045178	basal part of cell	Itga6	IDA		Mouse	PMID:11767049
Cellular Component	GO:0009925	basal plasma membrane	Itga6	IDA		Mouse	PMID:11507772
Cellular Component	GO:0009925	basal plasma membrane	Itga6	IDA		Mouse	PMID:21464233
Cellular Component	GO:0005604	basement membrane	Itga6	IDA		Mouse	PMID:9524190
Cellular Component	GO:0016323	basolateral plasma membrane	Itga6	IDA		Mouse	PMID:11891657
Cellular Component	GO:0009986	cell surface	ITGA6	IDA		Human	PMID:19933311
Cellular Component	GO:0009986	cell surface	ITGA6	IDA		Human	PMID:20563599
Cellular Component	GO:0009986	cell surface	ITGA6	IDA		Human	PMID:23154389
Cellular Component	GO:0009986	cell surface	ITGA6	HDA		Human	PMID:23658023
Cellular Component	GO:0009986	cell surface	Itga6	IDA		Mouse	PMID:8306881
Cellular Component	GO:0009897	external side of plasma membrane	Itga6	IDA		Mouse	PMID:19303854
Cellular Component	GO:0009897	external side of plasma membrane	Itga6	IDA		Mouse	PMID:20103531
Cellular Component	GO:0009897	external side of plasma membrane	Itga6	IDA		Mouse	PMID:9553049
Cellular Component	GO:0009897	external side of plasma membrane	Itga6	IDA		Mouse	PMID:8557754
Cellular Component	GO:0030175	filopodium	Itga6	IDA		Rat	PMID:13130099\|RGD:1302259
Cellular Component	GO:0005925	focal adhesion	ITGA6	HDA		Human	PMID:21423176
Cellular Component	GO:0030056	hemidesmosome	Itga6	IDA		Mouse	PMID:22274697
Cellular Component	GO:0034676	integrin alpha6-beta4 complex	Itga6	IDA		Rat	PMID:13130099\|RGD:1302259
Cellular Component	GO:0008305	integrin complex	Itga6	IDA		Mouse	PMID:8707838
Cellular Component	GO:0005886	plasma membrane	ITGA6	IDA		Human	PMID:21310825
Cellular Component	GO:0005886	plasma membrane	Itga6	IDA		Mouse	MGI:MGI:5605959\|PMID:12189152
Cellular Component	GO:0005886	plasma membrane	Itga6	IDA		Mouse	PMID:11891657
Cellular Component	GO:0005886	plasma membrane	Itga6	IDA		Mouse	PMID:12591243
Cellular Component	GO:0005886	plasma membrane	Itga6	IDA		Mouse	PMID:8409377
Cellular Component	GO:0005886	plasma membrane	Itga6	IDA		Mouse	PMID:12670870
Biological Process	GO:0050873	brown fat cell differentiation	Itga6	IDA		Mouse	PMID:18492766
Biological Process	GO:0098609	cell-cell adhesion	Itga6	IMP		Rat	PMID:16557522\|RGD:1600020
Biological Process	GO:0007160	cell-matrix adhesion	Itga6	IMP		Mouse	PMID:16365040
Biological Process	GO:0031589	cell-substrate adhesion	ITGA6	IMP		Human	PMID:19933311
Biological Process	GO:0031668	cellular response to extracellular stimulus	Itga6	IDA		Mouse	PMID:10322635
Biological Process	GO:0071407	cellular response to organic cyclic compound	Itga6	IEP		Rat	PMID:13130099\|RGD:1302259
Biological Process	GO:0010668	ectodermal cell differentiation	ITGA6	IEP		Human	PMID:23154389
Biological Process	GO:0046847	filopodium assembly	Itga6	IMP		Mouse	PMID:16365040
Biological Process	GO:0021782	glial cell development	itga6b	IMP	ZFIN:ZDB-CRISPR-191009-73,ZFIN:ZDB-CRISPR-191104-1	Zfish	PMID:30924555
Biological Process	GO:0050900	leukocyte migration	Itga6	IGI	MGI:MGI:103020	Mouse	PMID:7777057
Biological Process	GO:0050900	leukocyte migration	Itga6	IMP		Mouse	PMID:7621877
Biological Process	GO:0097534	lymphoid lineage cell migration	Itga6	IMP		Mouse	PMID:7621877
Biological Process	GO:0035878	nail development	ITGA6	IMP		Human	PMID:23496044
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	ITGA6	IMP		Human	PMID:21310825
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Itga6	IMP		Mouse	PMID:16365040
Biological Process	GO:0043065	positive regulation of apoptotic process	ITGA6	IGI	UniProtKB:P05556	Human	PMID:19364818
Biological Process	GO:0043065	positive regulation of apoptotic process	ITGA6	IGI	UniProtKB:P18406	Human	PMID:19364818
Biological Process	GO:0043065	positive regulation of apoptotic process	ITGA6	IGI	UniProtKB:P48023	Human	PMID:19364818
Biological Process	GO:0030335	positive regulation of cell migration	ITGA6	IMP		Human	PMID:24091622
Biological Process	GO:0022409	positive regulation of cell-cell adhesion	Itga6	IDA		Mouse	PMID:7669058
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	Itga6	IMP		Rat	PMID:13130099\|RGD:1302259
Biological Process	GO:0043547	positive regulation of GTPase activity	ITGA6	IMP		Human	PMID:25911094
Biological Process	GO:0010976	positive regulation of neuron projection development	Itga6	IMP		Mouse	MGI:MGI:6294160\|PMID:15466886
Biological Process	GO:0042327	positive regulation of phosphorylation	ITGA6	IMP		Human	PMID:21310825
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ITGA6	IMP		Human	PMID:21310825
Biological Process	GO:0060041	retina development in camera-type eye	itga6b	IMP	ZFIN:ZDB-CRISPR-191009-73,ZFIN:ZDB-CRISPR-191104-1	Zfish	PMID:30924555
Biological Process	GO:0007519	skeletal muscle tissue development	itga6a	IGI	ZFIN:ZDB-MRPHLNO-051215-1,ZFIN:ZDB-MRPHLNO-121219-4	Zfish	PMID:23109907
Biological Process	GO:0007519	skeletal muscle tissue development	itga6a	IMP	ZFIN:ZDB-MRPHLNO-121219-4	Zfish	PMID:23109907
Biological Process	GO:0043589	skin morphogenesis	ITGA6	IMP		Human	PMID:23496044

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.